Polypharmacy Among Adults Aged 65 Years and Older in the United States: 1988–2010
Open accessAbstract
BACKGROUND: Older adults frequently have several chronic health conditions which require multiple medications. We illustrated trends in prescription medication use over 20 years in the United States, and described characteristics of older adults using multiple medications in 2009-2010. METHODS: Participants included 13,869 adults aged 65 years and older in the National Health & Nutrition Examination Survey (1988-2010). Prescription medication use was verified by medication containers. Potentially inappropriate medications were defined by the 2003 Beers Criteria. RESULTS: Between 1988 and 2010 the median number of prescription medications used among adults aged 65 and older doubled from 2 to 4, and the proportion taking ≥5 medications tripled from 12.8% (95% confidence interval: 11.1, 14.8) to 39.0% (35.8, 42.3).These increases were driven, in part, by rising use of cardioprotective and antidepressant medications. Use of potentially inappropriate medications decreased from 28.2% (25.5, 31.0) to 15.1% (13.2, 17.3) between 1988 and 2010. Higher medication use was associated with higher prevalence of functional limitation, activities of daily living limitation, and confusion/memory problems in 2009-2010, although these associations did not remain after adjustment for covariates. In multivariable models, older age, number of chronic conditions, and annual health care visits were associated with increased odds of using both 1-4 and ≥5 medications. Additionally, body mass index, higher income-poverty ratio, former smoking, and non-black non-white race were associated with use of ≥5 medications. CONCLUSIONS: Prescription medication use increased dramatically among older adults between 1988 and 2010. Contemporary older adults on multiple medications have worse health status compared with those on less medications, and appear to be a vulnerable population.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The number of older adults with ≥5 concurrent prescriptions had tripled from 20 years ago.
“and this number had tripled from that 20 years ago [3]”
From Benefits of, Barriers to, and Needs for an Artificial Intelligence–Powered Medication Information Voice Chatbot for Older Adults: Interview Study With Geriatrics Experts (2022) · cites this paper as [3]
The Results report that the number of U.S. adults aged 65 and older taking ≥5 medications rose from 3.7 million in 1988–1991 to 15.1 million in 2009–2010—more than a fourfold increase, not a tripling. The proportion of older adults taking ≥5 medications, rather than their number, tripled from 12.8% to 39.0%. (LLM, conf=0.88)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measured39% of older adults had ≥5 concurrent prescriptions.
“One study estimated that 39% of older adults had ≥5 concurrent prescriptions”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Stone, N. J., Robinson, J. G., Lichtenstein, A. H., Bairey Merz, C. N., Blum, C. B., Eckel, R. H., Goldberg, A. C., Gordon, D., Levy, D., Lloyd-Jones, D. M., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437738.63853.7a · Cited by 7,081 · see citing works
Updating the Beers Criteria for Potentially Inappropriate Medication Use in Older Adults
Fick, D. M., Cooper, J. W., Wade, W. E., Waller, J. L., Maclean, J. R., & Beers, M. H. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.22.2716 · Cited by 2,389 · see citing works
US trends in prevalence, awareness, treatment, and control of hypertension, 1988–2008
Egan, B. M. (2010) · JAMA · doi:10.1001/jama.2010.650 · Cited by 2,197 · see citing works
Clinical consequences of polypharmacy in elderly
Maher, R. L., Hanlon, J. T., & Hajjar, E. R. (2013) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2013.827660 · Cited by 1,970 · see citing works
Kaufman, D. W., Kelly, J. P., Rosenberg, L., Anderson, T. E., & Mitchell, A. A. (2002) · JAMA · doi:10.1001/jama.287.3.337 · Cited by 1,845 · see citing works
National health and nutrition examination survey: analytic guidelines, 1999-2010.
Cl, J., Paulose‐Ram, R., Ogden, C. L., Carroll, Kruszon‐Moran, D., Dohrmann, S. M., & Curtin, L. R. (2013) · PubMed · Cited by 1,522 · see citing works
Polypharmacy in elderly patients
Hajjar, E. R., Cafiero, A. C., & Hanlon, J. T. (2007) · The American Journal of Geriatric Pharmacotherapy · doi:10.1016/j.amjopharm.2007.12.002 · Cited by 1,275 · see citing works
Smith, S. C., Jr. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/ahxt-ag78 · Cited by 1,042 · see citing works
Anderson, I. M. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00092-0 · Cited by 940 · see citing works
Luppa, M., Sikorski, C., Luck, T., Ehreke, L., Konnopka, A., Wiese, B., Weyerer, S., König, H.-H., & Riedel-Heller, S. G. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.11.033 · Cited by 855 · see citing works
Potentially Inappropriate Medication Use in the Community-Dwelling Elderly
Zhan, C., Sangl, J., Bierman, A. S., Miller, M. R., Friedman, B. C., Wickizer, S. W., & Meyer, G. S. (2001) · JAMA · doi:10.1001/jama.286.22.2823 · Cited by 548 · see citing works
A Decade of Direct-to-Consumer Advertising of Prescription Drugs
Donohue, J. M., Cevasco, M., & Rosenthal, M. B. (2007) · New England Journal of Medicine · doi:10.1056/nejmsa070502 · Cited by 519 · see citing works
Jyrkkä, J., Enlund, H., Lavikainen, P., Sulkava, R., & Hartikainen, S. (2011) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.2116 · Cited by 417 · see citing works
Prescription Drug Use Continues to Increase: U.S. Prescription Drug Data for 2007-2008
Gu, Q., Dillon, C. F., & Burt, V. L. (2010) · PsycEXTRA Dataset · doi:10.1037/e665492010-001 · Cited by 373 · see citing works
The Effects of Polypharmacy in Older Adults
Hilmer, S. N., & Gnjidic, D. (2008) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2008.224 · Cited by 363 · see citing works
Inappropriate Medication Prescribing for Elderly Ambulatory Care Patients
Goulding, M. R. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.3.305 · Cited by 291 · see citing works
Americans' Attitudes Toward Mental Health Treatment Seeking: 1990–2003
Mojtabai, R. (2007) · Psychiatric Services · doi:10.1176/ps.2007.58.5.642 · Cited by 282 · see citing works
Peretti, S., Judge, R., & Hindmarch, I. (2000) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2000.tb10944.x · Cited by 236 · see citing works
Osborn, R., Moulds, D., Squires, D. A., Doty, M. M., & Anderson, C. (2014) · Health Affairs · doi:10.1377/hlthaff.2014.0947 · Cited by 212 · see citing works
Polypharmacy: a new paradigm for quality drug therapy in the elderly?
Gurwitz, J. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.18.1957 · Cited by 209 · see citing works
Medication Use and Functional Status Decline in Older Adults: A Narrative Review
Peron, E. P., Gray, S. L., & Hanlon, J. T. (2011) · The American Journal of Geriatric Pharmacotherapy · doi:10.1016/j.amjopharm.2011.10.002 · Cited by 136 · see citing works
Long-term Cognitive and Functional Effects of Potentially Inappropriate Medications in Older Women
Koyama, A. K., Steinman, M. A., Ensrud, K. E., Hillier, T. A., & Yaffe, K. S. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt192 · Cited by 95 · see citing works
Bromfield, S. G., Bowling, C. B., Tanner, R. M., Peralta, C. A., Odden, M. C., Oparil, S., & Muntner, P. (2014) · Journal of Clinical Hypertension · doi:10.1111/jch.12281 · Cited by 80 · see citing works
Self-citationChouinard, G. (2006) · PubMed Central · Cited by 57 · see citing works
Loder, E., Weizenbaum, E. L., Frishberg, B. M., Silberstein, S. D., & the American Headache Society Choosing Wisely Task Force (2013) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12278 · Cited by 47 · see citing works
Chouinard, G. (2006) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.4.4.528 · Cited by 33 · see citing works
Amisulpride: a review of its efficacyin schizophrenia
Möller, H. ‐. (2000) · Acta Psychiatrica Scandinavica · doi:10.1111/j.0065-1591.2000.007s021[dash]4.x · Cited by 23 · see citing works
Lim, D., Jung, K., & Shi, Y. (2013) · Psychiatric Services · doi:10.1176/appi.ps.201200438 · Cited by 6 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Johnson CL, Paulose-Ram R, Ogden CL. NHANES: Analytic Guidelines, 1999-2010. Vital & Health Statistics. 2013;2:6.
Cited by
Sorted by citations
By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13702 · Cited by 2,609 · see citing works
Gut microbiome pattern reflects healthy ageing and predicts survival in humans
Wilmanski, T. M., Diener, C., Rappaport, N., Patwardhan, S., Wiedrick, J. T., Lapidus, J., Earls, J. C., Zimmer, A., Glusman, G., Robinson, M., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00348-0 · Cited by 693 · see citing works
An update on the clinical consequences of polypharmacy in older adults: a narrative review
Wastesson, J. W., Morin, L., Tan, E. C. K., & Johnell, K. (2018) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2018.1546841 · Cited by 617 · see citing works
The silent epidemic of chronic pain in older adults
Domenichiello, A. F., & Ramsden, C. E. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.04.006 · Cited by 438 · see citing works
The epidemiology of polypharmacy in older adults: register-based prospective cohort study
Morin, L., Johnell, K., Laroche, M., Fastbom, J., & Wastesson, J. W. (2018) · Clinical Epidemiology · doi:10.2147/clep.s153458 · Cited by 390 · see citing works
Sen, A., Jetté, N., Husain, M., & Sander, J. W. A. S. (2020) · The Lancet · doi:10.1016/s0140-6736(19)33064-8 · Cited by 379 · see citing works
Association between polypharmacy and death: A systematic review and meta-analysis
Leelakanok, N., Holcombe, A. L., Lund, B. C., Gu, X., & Schweizer, M. L. (2017) · Journal of the American Pharmacists Association · doi:10.1016/j.japh.2017.06.002 · Cited by 355 · see citing works
Charoo, N. A., Ali, S. F. B., Mohamed, E. M., Kuttolamadom, M. A., Ozkan, T., Khan, M. A., & Rahman, Z. (2020) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2020.1764027 · Cited by 270 · see citing works
Clinical Outcomes Associated with Medication Regimen Complexity in Older People: A Systematic Review
Wimmer, B. C., Cross, A. J., Jokanovic, N., Wiese, M. D., George, J., Johnell, K., Diug, B. O., & Bell, J. S. (2016) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14682 · Cited by 231 · see citing works
Long-Term Use of Cardiovascular Drugs
Rosselló, X., Pocock, S., & Julian, D. G. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.07.018 · Cited by 167 · see citing works
Age and the aging process significantly alter the small bowel microbiome
Leite, G., Pimentel, M., Barlow, G. M., Chang, C. Y.-Y., Hosseini, A., Wang, J., Parodi, G., Sedighi, R., Rezaie, A. R., & Mathur, R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109765 · Cited by 158 · see citing works
Lim, L. M., McStea, M., Chung, W. W., Azmi, N. N., Aziz, S. A. A., Alwi, S., Kamarulzaman, A., Kamaruzzaman, S. B., Chua, S. S., & Rajasuriar, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173466 · Cited by 128 · see citing works
Prevalence and trends of polypharmacy in U.S. adults, 1999–2018
Wang, X., Liu, K., Shirai, K., Tang, C., Hu, Y., Wang, Y., Hao, Y., & Dong, J.-Y. (2023) · Global Health Research and Policy · doi:10.1186/s41256-023-00311-4 · Cited by 121 · see citing works
Cardiovascular and skeletal muscle health with lifelong exercise.
Gries, K. J., Raue, U., Perkins, R., Lavin, K., Overstreet, B., D'Acquisto, L., Graham, B., Finch, W. H., Kaminsky, L., Trappe, T., et al. (2018) · Journal of applied physiology · doi:10.1152/japplphysiol.00174.2018 · Cited by 90 · see citing works
Wimmer, B. C., Bell, J. S., Fastbom, J., Wiese, M. D., & Johnell, K. (2015) · Annals of Pharmacotherapy · doi:10.1177/1060028015621071 · Cited by 120 · see citing works
Gao, L., Maidment, I. D., Matthews, F. E., Robinson, L. A., & Brayne, C. (2017) · Age and Ageing · doi:10.1093/ageing/afx158 · Cited by 118 · see citing works
“Inactive” ingredients in oral medications
Reker, D., Blum, S. M., Steiger, C., Anger, K. E., Sommer, J. M., Fanikos, J. R., & Traverso, G. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau6753 · Cited by 114 · see citing works
Substance Use among Older Adults: An Update on Prevalence, Etiology, Assessment, and Intervention
Kuerbis, A. (2019) · Gerontology · doi:10.1159/000504363 · Cited by 105 · see citing works
McCarthy, C., Clyne, B., Boland, F., Moriarty, F., Flood, M., Wallace, E., Smith, S. M., & for the SPPiRE Study team (2022) · PLoS Medicine · doi:10.1371/journal.pmed.1003862 · Cited by 106 · see citing works
Polypharmacy and patterns of prescription medication use among cancer survivors
Murphy, C. C., Fullington, H. M., Álvarez, C. A., Betts, A. C., Lee, S. J. C., Haggstrom, D. A., & Halm, E. A. (2018) · Cancer · doi:10.1002/cncr.31389 · Cited by 102 · see citing works
Deprescribing in older adults with polypharmacy
Hung, A., Kim, Y. H., & Pavon, J. M. (2024) · BMJ · doi:10.1136/bmj-2023-074892 · Cited by 127 · see citing works
McNicholl, I. R., Gandhi, M., Hare, C. B., Greene, M. L., & Pierluissi, E. (2017) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.2043 · Cited by 97 · see citing works
Trends in multimorbidity and polypharmacy in the Flemish-Belgian population between 2000 and 2015
van den Akker, M., Vaes, B., Goderis, G., Pottelbergh, G. V., Burghgraeve, T. D., & Henrard, S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212046 · Cited by 94 · see citing works
A review of systemic medications that may modulate the risk of glaucoma
Wu, A. M., Khawaja, A. P., Pasquale, L. R., & Stein, J. D. (2019) · Eye · doi:10.1038/s41433-019-0603-z · Cited by 94 · see citing works
Non-adherence to medication regimens among older African-American adults
Bazargan, M., Smith, J. P., Yazdanshenas, H., Movassaghi, M., Martins, D., & Orum, G. (2017) · BMC Geriatrics · doi:10.1186/s12877-017-0558-5 · Cited by 90 · see citing works
Korhonen, M. J., Robinson, J. G., Annis, I. E., Hickson, R. P., Bell, J. S., Hartikainen, J. E. K., & Fang, G. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.07.783 · Cited by 88 · see citing works
The activities of drug inactive ingredients on biological targets
Pottel, J., Armstrong, D., Zou, L., Fekete, A., Huang, X., Torosyan, H., Bednarczyk, D., Whitebread, S., Bhhatarai, B., Liang, G., et al. (2020) · Science · doi:10.1126/science.aaz9906 · Cited by 90 · see citing works
Prevalence and determinants of polypharmacy in Switzerland: data from the CoLaus study
Castioni, J., Marques-Vidal, P. M., Abolhassani, N., Vollenweider, P., & Waeber, G. (2017) · BMC Health Services Research · doi:10.1186/s12913-017-2793-z · Cited by 84 · see citing works
do Nascimento, R. C. R. M., Campos, J. Á. D. B., Guerra, A. A., Gomes, I. C., Silveira, M. R., Costa, E. A., Leite, S. N., Costa, K. S., Soeiro, O. M., Guibu, I. A., et al. (2017) · Revista de Saúde Pública · doi:10.11606/s1518-8787.2017051007136 · Cited by 95 · see citing works
The composition of polypharmacy: A register-based study of Swedes aged 75 years and older
Wastesson, J. W., Cedazo-Mı́nguez, Á., Fastbom, J., Maioli, S., & Johnell, K. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194892 · Cited by 81 · see citing works
Pereira, B. C., Isreb, A., Isreb, M., Forbes, R. T., Oga, E. F., & Alhnan, M. A. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000236 · Cited by 79 · see citing works
Prevalence and factors associated with polypharmacy in the older people: 2006–2014
Carmona‐Torres, J. M., Cobo‐Cuenca, A. I., Recio‐Andrade, B., Laredo‐Aguilera, J. A., Martins, M. M., & Rodríguez‐Borrego, M. A. (2018) · Journal of Clinical Nursing · doi:10.1111/jocn.14371 · Cited by 78 · see citing works
Schöttker, B., Saum, K.-U., Muhlack, D. C., Hoppe, L. K., Holleczek, B., & Brenner, H. (2017) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-017-2266-7 · Cited by 77 · see citing works
Napping in Older Adults: a Review of Current Literature
Zhang, Z., Xiao, X., Ma, W., & Li, J. (2020) · Current Sleep Medicine Reports · doi:10.1007/s40675-020-00183-x · Cited by 75 · see citing works
How Chronic Is Polypharmacy in Old Age? A Longitudinal Nationwide Cohort Study
Wastesson, J. W., Morin, L., Laroche, M., & Johnell, K. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15717 · Cited by 74 · see citing works
Al‐Azayzih, A., Alamoori, R., & Altawalbeh, S. M. (2019) · Pharmacy Practice · doi:10.18549/pharmpract.2019.2.1439 · Cited by 75 · see citing works
Wimmer, B. C., Bell, J. S., Fastbom, J., Wiese, M. D., & Johnell, K. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv219 · Cited by 73 · see citing works
Gudala, M., Ross, M. E. T., Mogalla, S., Lyons, M., Ramaswamy, P., & Roberts, K. (2022) · JMIR Aging · doi:10.2196/32169 · Cited by 71 · see citing works
Deprescribing in the Older Patient: A Narrative Review of Challenges and Solutions
Wu, H. C., O’Donnell, L. K., Fujita, K., Masnoon, N., & Hilmer, S. N. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s253177 · Cited by 72 · see citing works
Trends in Polypharmacy in Japan: A Nationwide Retrospective Study
Onoue, H., Koyama, T., Zamami, Y., Hagiya, H., Tatebe, Y., Mikami, N., Shinomiya, K., Kitamura, Y., Hinotsu, S., Sendo, T., et al. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15569 · Cited by 67 · see citing works
Kua, K. P., Saw, P. S., & Lee, S. W. H. (2019) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-019-00829-z · Cited by 69 · see citing works
Artificial Intelligence in Drug Treatment
Romm, E. L., & Tsigelny, I. F. (2019) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010919-023746 · Cited by 69 · see citing works
Factors associated with polypharmacy in elderly home‐care patients
Komiya, H., Umegaki, H., Asai, A., Kanda, S., Maeda, K., Shimojima, T., Nomura, H., & Kuzuya, M. (2017) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13132 · Cited by 69 · see citing works
Drumond, N., van Riet‐Nales, D. A., Karapinar‐Çarkit, F., & Stegemann, S. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.02.029 · Cited by 66 · see citing works
Polypharmacy and Gait Performance in Community–dwelling Older Adults
George, C. J., & Verghese, J. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14957 · Cited by 61 · see citing works
Polypharmacy among the elderly
Zabihi, A., Hosseini, S., Jafarian Amiri, S., & Bijani, A. (2018) · Journal of Mid-life Health · doi:10.4103/jmh.jmh_87_17 · Cited by 60 · see citing works
Race and fall risk: data from the National Health and Aging Trends Study (NHATS)
Sun, D. Q., Huang, J., Varadhan, R., & Agrawal, Y. (2016) · Age and Ageing · doi:10.1093/ageing/afv173 · Cited by 60 · see citing works
Older Patient and Caregiver Perspectives on Medication Value and Deprescribing: A Qualitative Study
Pickering, A. N., Hamm, M., Dawdani, A., Hanlon, J. T., Thorpe, C. T., Gellad, W. F., & Radomski, T. R. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16370 · Cited by 59 · see citing works
Polypharmacy and pattern of medication use in community‐dwelling older adults: A systematic review
Hsu, H., Chen, K., Belcastro, F. P., & Chen, Y. (2020) · Journal of Clinical Nursing · doi:10.1111/jocn.15595 · Cited by 58 · see citing works
Maxwell, C. J., Mondor, L., Kone, A. P., Hogan, D. B., & Wodchis, W. P. (2021) · PLoS ONE · doi:10.1371/journal.pone.0250567 · Cited by 58 · see citing works
Natural Language Processing as an Emerging Tool to Detect Late-Life Depression
DeSouza, D. D., Robin, J., Gumus, M., & Yeung, A. T. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.719125 · Cited by 59 · see citing works
Clinician knowledge and behaviors related to the 4Ms framework of Age‐Friendly Health Systems
Lesser, S., Zakharkin, S. O., Louie, C., Escobedo, M. R., Whyte, J. J., & Fulmer, T. T. (2021) · Journal of the American Geriatrics Society · doi:10.1111/jgs.17571 · Cited by 57 · see citing works
Wouters, H., Hilmer, S. N., Gnjidic, D., van Campen, J. P., Teichert, M., van der Meer, H. G., Schaap, L. S., Huisman, M. A., Comijs, H. C., Denig, P., et al. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz019 · Cited by 57 · see citing works
Analysis of polypharmacy effects in older patients using Japanese Adverse Drug Event Report database
Abe, J., Umetsu, R., Uranishi, H., Suzuki, H., Nishibata, Y., Kato, Y., Ueda, N., Sasaoka, S., Hatahira, H., Motooka, Y., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0190102 · Cited by 54 · see citing works
Rane, P. P., Guha, S., Chatterjee, S., & Aparasu, R. R. (2016) · Research in Social and Administrative Pharmacy · doi:10.1016/j.sapharm.2016.02.012 · Cited by 56 · see citing works
Urfer, M., Elzi, L., Dell‐Kuster, S., & Bassetti, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166359 · Cited by 56 · see citing works
A Literature Review of the Potential Impact of Medication on Vitamin D Status
Wakeman, M. P. (2021) · Risk Management and Healthcare Policy · doi:10.2147/rmhp.s316897 · Cited by 55 · see citing works
Updates in nutrition and polypharmacy
Little, M. O. (2017) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000425 · Cited by 55 · see citing works
The association between polypharmacy and malnutrition(risk) in older people: A systematic review
Kok, W. E., Haverkort, E. B., Algra, Y. A., Mollema, J., Hollaar, V. R. Y., Naumann, E., de van der Schueren, M. A. E., & Jerković-Ćosić, K. (2022) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2022.03.007 · Cited by 55 · see citing works
Patel, T., Ivo, J., Faisal, S., McDougall, A., Carducci, J., Pritchard, S., & Chang, F. (2020) · Journal of Medical Internet Research · doi:10.2196/18073 · Cited by 49 · see citing works
Kristensen, A. M. D., Bovin, A., Zwisler, A., Cerquira, C., Torp-Pedersen, C. T., Bøtker, H. E., Gustafsson, I., Veien, K. T., Thomsen, K. K., Olsen, M. H., et al. (2020) · Trials · doi:10.1186/s13063-020-4214-6 · Cited by 53 · see citing works
Blood Pressure in Older Adults: the Importance of Frailty
Odden, M. C., Beilby, P. R., & Peralta, C. A. (2015) · Current Hypertension Reports · doi:10.1007/s11906-015-0564-y · Cited by 53 · see citing works
Self-citationDysphagia in Hospitalized Older Patients: Associated Factors and Nutritional Interventions
Eglseer, D., Halfens, R. J. G., Schols, J. M. G. A., & Lohrmann, C. (2017) · The journal of nutrition health & aging · doi:10.1007/s12603-017-0928-x · Cited by 53 · see citing works
Spotlight on the Challenges of Depression following Retirement and Opportunities for Interventions
Dang, L., Ananthasubramaniam, A., & Mezuk, B. R. (2022) · Clinical Interventions in Aging · doi:10.2147/cia.s336301 · Cited by 57 · see citing works
Lim, Y.-J., Kim, H.-Y., Choi, J., Lee, J. S., Ahn, A.-L., Oh, E.-J., Cho, D.-Y., & Kweon, H.-J. (2016) · Korean Journal of Family Medicine · doi:10.4082/kjfm.2016.37.6.329 · Cited by 52 · see citing works
Franchi, C., Marcucci, M., Mannucci, P. M., Tettamanti, M., Pasina, L., Fortino, I., Bortolotti, A., Merlino, L. G., & Nobili, A. (2015) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3938 · Cited by 50 · see citing works
Polypharmacy Reduction Strategies
Levy, H. B. (2017) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2017.01.007 · Cited by 56 · see citing works
Potentially inappropriate medication use among hypertensive older African-American adults
Bazargan, M., Smith, J. L., & King, E. (2018) · BMC Geriatrics · doi:10.1186/s12877-018-0926-9 · Cited by 49 · see citing works
Morin, L., Todd, A., Barclay, S. I. G., Wastesson, J. W., Fastbom, J., & Johnell, K. (2019) · Cancer · doi:10.1002/cncr.32044 · Cited by 50 · see citing works
Varga, Š., Alcusky, M. J., Keith, S. W., Hegarty, S., Canale, S. D., Lombardi, M., & Maio, V. (2017) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13365 · Cited by 49 · see citing works
Child, S. T., Nicklett, E. J., Stauber, D. B., & Ward, D. M. (2021) · American Public Health Association eBooks · doi:10.2105/9780875533162ch09 · Cited by 49 · see citing works
Associations of body fat and skeletal muscle with hypertension
Han, T. S., Algindan, Y., Govan, L., Hankey, C., & Lean, M. E. J. (2018) · Journal of Clinical Hypertension · doi:10.1111/jch.13456 · Cited by 48 · see citing works
Understanding and Preventing ( N -Nitrosodimethylamine) NDMA Contamination of Medications
White, C. M. (2019) · Annals of Pharmacotherapy · doi:10.1177/1060028019892222 · Cited by 48 · see citing works
A comparison of potential psychiatric drug interactions from six drug interaction database programs
Monteith, S., & Glenn, T. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.03.041 · Cited by 47 · see citing works
Rahman, S., Singh, K., Dhingra, S., Charan, J., Sharma, P., Islam, S., Jahan, D., Iskandar, K., Samad, N., & Haque, M. (2020) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s272908 · Cited by 47 · see citing works
Barriers and enablers of older adults initiating a deprescribing conversation
Ailabouni, N. J., Weir, K. R., Reeve, E., Turner, J. P., Norton, J. W., & Gray, S. L. (2021) · Patient Education and Counseling · doi:10.1016/j.pec.2021.06.021 · Cited by 47 · see citing works
Functional Status and Antihypertensive Therapy in Older Adults: A New Perspective on Old Data
Charlesworth, C. J., Peralta, C. A., & Odden, M. C. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv177 · Cited by 46 · see citing works
Self-citationResearch Priorities for Optimizing Geriatric Pharmacotherapy: An International Consensus
Tan, E. C. K., Sluggett, J. K., Johnell, K., Onder, G., Elseviers, M. M., Morin, L., Vetrano, D. L., Wastesson, J. W., Fastbom, J., Taipale, H. T., et al. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.12.002 · Cited by 46 · see citing works
Low‐Value Proton Pump Inhibitor Prescriptions Among Older Adults at a Large Academic Health System
Mafi, J. N., May, F. P., Kahn, K. L., Chong, M. C., Corona, E., Yang, L., Mongare, M. M., Nair, V., Reynolds, C. A., Gupta, R., et al. (2019) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16117 · Cited by 47 · see citing works
Al-Dahshan, A., Al-Kubiasi, N., Zaidan, M., Saeed, W. E., Kehyayan, V., & Bougmiza, I. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234386 · Cited by 46 · see citing works
Onder, G., Marengoni, A., Russo, P., Esposti, L. D., Fini, M., Monaco, A., Bonassi, S., Palmer, K., Marrocco, W., Pozzi, G., et al. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.08.009 · Cited by 44 · see citing works
Iqbal, A., Richardson, C. L., Iqbal, Z., O’Keefe, H., Hanratty, B., Matthews, F. E., & Todd, A. (2023) · BMC Geriatrics · doi:10.1186/s12877-023-03835-z · Cited by 43 · see citing works
Martín‐Pérez, M., López‐de‐Andrés, A., Hernández‐Barrera, V., Jiménez‐García, R., Jiménez‐Trujillo, I., Palacios‐Ceña, D., & Carrasco‐Garrido, P. (2016) · Revista Española de Geriatría y Gerontología · doi:10.1016/j.regg.2016.07.006 · Cited by 43 · see citing works
Polypharmacy in older patients at primary care units in Brazil
Gomes, M. S., Amorim, W. W., Souza, R. M., Gama, R. S., Graia, L. T., Queiroga, H. M., & Oliveira, M. G. (2019) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-018-00780-5 · Cited by 43 · see citing works
Bhagavathula, A. S., Tesfaye, W. H., Vidyasagar, K., & Fialová, D. (2022) · Gerontology · doi:10.1159/000521214 · Cited by 42 · see citing works
Wastesson, J. W., Canudas‐Romo, V., Lindahl‐Jacobsen, R., & Johnell, K. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.07.015 · Cited by 42 · see citing works
Sevilla‐Sánchez, D., Molist‐Brunet, N., Amblàs-Novellas, J., Poch, P. R., Espaulella‐Panicot, J., & Codina‐Jané, C. (2016) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-016-2136-8 · Cited by 42 · see citing works
Chen, E. Y. H., Sluggett, J. K., Ilomäki, J., Hilmer, S. N., Corlis, M. E., Picton, L., Dean, L., Alderman, C. P., Farinola, N., Gailer, J., et al. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s158417 · Cited by 42 · see citing works
Impact of Tablet Size and Shape on the Swallowability in Older Adults
Hummler, H., Stillhart, C., Meilicke, L., Grimm, M. F., Krause, E., Mannaa, M., Gollasch, M., Weitschies, W., & Page, S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041042 · Cited by 41 · see citing works
de Almeida, N. A., Reiners, A. A. O., Azevedo, R. C. D. S., da Silva, A. M. C., Cardoso, J. D. C., & de Souza, L. C. (2017) · Revista Brasileira de Geriatria e Gerontologia · doi:10.1590/1981-22562017020.160086 · Cited by 41 · see citing works
Overprescribed Medications for US Adults: Four Major Examples
Safer, D. J. (2019) · Journal of Clinical Medicine Research · doi:10.14740/jocmr3906 · Cited by 41 · see citing works
Kardas, P., Urbański, F., Lichwierowicz, A., Chudzyńska, E., Kardas, G., & Czech, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.655364 · Cited by 41 · see citing works
Aljeaidi, M. S., Haaksma, M. L., & Tan, E. C. K. (2022) · Quality of Life Research · doi:10.1007/s11136-022-03136-9 · Cited by 40 · see citing works
Evidence of a gabapentinoid and diuretic prescribing cascade among older adults with lower back pain
Read, S. H., Giannakeas, V., Pop, P., Bronskill, S. E., Herrmann, N., Chen, S. D. M., Luke, M. J., Wu, W., McCarthy, L. M., Austin, P. C., et al. (2021) · Journal of the American Geriatrics Society · doi:10.1111/jgs.17312 · Cited by 40 · see citing works
Comorbidity of patients with noncommunicable diseases in general practice. Eurasian guidelines
Drapkina, O. M., Васильевна, К. А., Калинина, А. М., Avdeev, S. N., Викторович, А. М., Алексеева, Л. И., Almazova, I. I., Andreenko, Е. Y., Antipushina, D. N., Balanova, Y. А., et al. (2024) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2024-3996 · Cited by 49 · see citing works
Polypharmacy in Nursing Home Residents: What Is the Way Forward?
Cherubini, A., Corsonello, A., & Lattanzio, F. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.07.008 · Cited by 39 · see citing works
An Update on Medication Use in Older Adults: a Narrative Review
Barry, H. E., & Hughes, C. M. (2021) · Current Epidemiology Reports · doi:10.1007/s40471-021-00274-5 · Cited by 38 · see citing works
Genetic basis of falling risk susceptibility in the UK Biobank Study
Trajanoska, K., Seppala, L. J., Medina‐Gómez, C., Hsu, Y., Zhou, S., van Schoor, N. M., de Groot, C. P. G. M., Karasik, D., Richards, J. B., Kiel, D. P., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-01256-x · Cited by 40 · see citing works
Lee, H., Baek, Y., Kim, J. H., Liao, T., Lau, W. C. Y., Man, K. K. C., Qin, X. S., Wood, S., Ilomäki, J., Bell, J. S., et al. (2023) · Age and Ageing · doi:10.1093/ageing/afad014 · Cited by 37 · see citing works
Assessment and Management of Cancer Pain in Older Adults: Strategies for Success
Brant, J. M. (2018) · Asia-Pacific Journal of Oncology Nursing · doi:10.4103/apjon.apjon_11_18 · Cited by 37 · see citing works
- Authors
- Charlesworth, C. J., Smit, E., Lee, D. S. H., Alramadhan, F., & Odden, M. C.
- Affiliations
- Oregon State University (US)
- Corresponding author
- Odden, Michelle C.
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-03-01
- Volume
- 70
- Issue
- 8
- Pages
- 989-995
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC4573668
- OpenAlex
- W2137024248
- Cited by
- 570
- References
- 29
- Citations by year
- 2026: 28 · 2025: 33 · 2024: 49 · 2023: 54 · 2022: 43 · 2021: 119 · 2020: 64 · 2019: 66 · 2018: 42 · 2017: 27 · 2016: 32 · 2015: 12
- FWCI
- 18.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institute on Aging (K01AG039387)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- polypharmacy, older adults, prescription drug use, potentially inappropriate medications, Beers criteria, temporal trends, chronic disease, functional limitations, activities of daily living, cognitive impairment, cardioprotective drugs, antidepressants, health care utilization, sociodemographic factors
- MeSH terms
- Aged, Aged, 80 and over, Female, Humans, Male, Time Factors, United States, Polypharmacy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
