Reconsidering the Role of Mitochondria in Aging

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734 · see citing works

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491 · see citing works

Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca ²⁺ Responses

Rizzuto, R., Pinton, P., Carrington, W., Fay, F. S., Fogarty, K. E., Lifshitz, L. M., Tuft, R. A., & Pozzan, T. (1998) · Science · doi:10.1126/science.280.5370.1763 · Cited by 2,257 · see citing works

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.

Zhao, J., Brault, J. J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.004 · Cited by 1,489 · see citing works

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482 · see citing works

Metformin improves healthspan and lifespan in mice

Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445 · see citing works

Decline in skeletal muscle mitochondrial function with aging in humans

Short, K. R., Bigelow, M. L., Kahl, J., Singh, R., Coenen-Schimke, J., Raghavakaimal, S., & Nair, K. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501559102 · Cited by 1,333 · see citing works

Telomere dysfunction induces metabolic and mitochondrial compromise

Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., et al. (2011) · Nature · doi:10.1038/nature09787 · Cited by 1,319 · see citing works

Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

Kelly, D. P., & Scarpulla, R. C. (2004) · Genes & Development · doi:10.1101/gad.1177604 · Cited by 1,243 · see citing works

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.016 · Cited by 1,210 · see citing works

Peroxisome Proliferator-Activated Receptor γ Coactivator 1 Coactivators, Energy Homeostasis, and Metabolism

Handschin, C., & Spiegelman, B. M. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0037 · Cited by 1,090 · see citing works

SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α

Nemoto, S., Fergusson, M. M., & Finkel, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501485200 · Cited by 1,047 · see citing works

Mitophagy: mechanisms, pathophysiological roles, and analysis

Ding, W.-X., & Yin, X.-M. (2012) · bchm · doi:10.1515/hsz-2012-0119 · Cited by 1,032 · see citing works

Aconitase and mitochondrial iron–sulphur protein deficiency in Friedreich ataxia

Rötig, A., de Lonlay, P., Chretien, D., Foury, F., Koenig, M., Sidi, D., Munnich, A., & Rustin, P. (1997) · Nature Genetics · doi:10.1038/ng1097-215 · Cited by 991 · see citing works

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

Jaskelioff, M., Muller, F. L., Paik, J.-H., Thomas, E., Jiang, S., Adams, A. C., Sahin, E., Kost-Alimova, M., Protopopov, A., Cadiñanos, J., et al. (2011) · Nature · doi:10.1038/nature09603 · Cited by 857 · cited 1× · see citing works

Supercomplex assembly determines electron flux in the mitochondrial electron transport chain

Lapuente-Brun, E., Moreno-Loshuertos, R., Acín-Pérez, R., Latorre-Pellicer, A., Colás, C., Balsa, E., Perales-Clemente, E., Quirós, P. M., Calvo, E., Rodríguez-Hernández, M. A., et al. (2013) · Science · doi:10.1126/science.1230381 · Cited by 830 · see citing works

Activation of the human mitochondrial transcriptionfactor A gene by nuclear respiratory factors: a potential regulatory linkbetween nuclear and mitochondrial gene expression in organellebiogenesis.

Virbasius, J. V., & Scarpulla, R. C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1309 · Cited by 819 · see citing works

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

Passos, J. F., Saretzki, G., Ahmed, S., Nelson, G., Richter, T., Peters, H., Wappler, I., Birket, M. J., Harold, G., Schaeuble, K., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050110 · Cited by 796 · cited 1× · see citing works

A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy

Ruas, J. L., White, J. P., Rao, R. R., Kleiner, S., Brannan, K. T., Harrison, B. C., Greene, N. P., Wu, J., Estall, J. L., Irving, B. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.050 · Cited by 677 · see citing works

Oxidative capacity and ageing in human muscle

Conley, K. E., Jubrias, S. A., & Esselman, P. C. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00203.x · Cited by 651 · see citing works

Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis

Reznick, R. M., Zong, H., Li, J., Morino, K., Moore, I. K., Yu, H. J., Liu, Z.-X., Dong, J., Mustard, K. J., Hawley, S. A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.008 · Cited by 555 · see citing works

First‐in‐class cardiolipin‐protective compound as a therapeutic agent to restore mitochondrial bioenergetics

Szeto, H. H. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12461 · Cited by 550 · see citing works

Somatic Mitochondrial DNA Mutations in Mammalian Aging

Larsson, N. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060408-093701 · Cited by 543 · see citing works

New insights into the role of mitochondria in aging: mitochondrial dynamics and more

Seo, A. Y., Joseph, A.-M., Dutta, D., Hwang, J. C. Y., Aris, J. P., & Leeuwenburgh, C. (2010) · Journal of Cell Science · doi:10.1242/jcs.070490 · Cited by 522 · cited 1× · see citing works

Functional role of cardiolipin in mitochondrial bioenergetics

Paradies, G., Paradies, V., Benedictis, V. D., Ruggiero, F. M., & Petrosillo, G. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.10.006 · Cited by 505 · see citing works

The Regulation and Physiology of Mitochondrial Proton Leak

Divakaruni, A. S., & Brand, M. D. (2011) · Physiology · doi:10.1152/physiol.00046.2010 · Cited by 484 · see citing works

Autophagy in skeletal muscle

Sandri, M. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.056 · Cited by 451 · see citing works

Mitochondrial DNA–Deletion Mutations Accumulate Intracellularly to Detrimental Levels in Aged Human Skeletal Muscle Fibers

Bua, E., Johnson, J., Herbst, A., Delong, B., McKenzie, D., Salamat, S., & Aiken, J. M. (2006) · The American Journal of Human Genetics · doi:10.1086/507132 · Cited by 442 · see citing works

Mitochondrial Respiratory Supercomplex Association Limits Production of Reactive Oxygen Species from Complex I

Maranzana, E., Barbero, G., Falasca, A. I., Lenaz, G., & Genova, M. L. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4845 · Cited by 425 · see citing works

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

Owusu-Ansah, E., Song, W., & Perrimon, N. (2013) · Cell · doi:10.1016/j.cell.2013.09.021 · Cited by 395 · see citing works

Axis of ageing: telomeres, p53 and mitochondria

Sahin, E., & DePinho, R. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3352 · Cited by 380 · see citing works

Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia

WANAGAT, J., CAO, Z., PATHARE, P., & AIKEN, J. M. (2001) · The FASEB Journal · doi:10.1096/fj.00-0320com · Cited by 378 · see citing works

Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation

Rosca, M. G., Vazquez, E. J., Kerner, J., Parland, W., Chandler, M. P., Stanley, W. C., Sabbah, H. N., & Hoppel, C. L. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn184 · Cited by 373 · see citing works

Mitochondrial biogenesis and healthy aging

López-Lluch, G., Irusta, P. M., Navas, P., & de Cabo, R. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.06.014 · Cited by 364 · see citing works

The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans

Yee, C., Yang, W., & Hekimi, S. (2014) · Cell · doi:10.1016/j.cell.2014.02.055 · Cited by 356 · see citing works

New functions of mitochondria associated membranes in cellular signaling

van Vliet, A. R., Verfaillie, T., & Agostinis, P. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.03.009 · Cited by 353 · see citing works

The clinical maze of mitochondrial neurology

DiMauro, S., Schon, E. A., Carelli, V., & Hirano, M. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.126 · Cited by 351 · see citing works

Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults

Coen, P. M., Jubrias, S. A., Distefano, G., Amati, F., Mackey, D. C., Glynn, N. W., Manini, T. M., Wohlgemuth, S. E., Leeuwenburgh, C., Cummings, S. R., et al. (2013) · The Journals of Gerontology: Series A · doi:10.1093/gerona/gls196 · Cited by 323 · see citing works

Skeletal Muscle Mitochondria and Aging: A Review

Peterson, C. M., Johannsen, D. L., & Ravussin, É. (2012) · Journal of Aging Research · doi:10.1155/2012/194821 · Cited by 318 · see citing works

Targeting mitochondrial cardiolipin and the cytochrome c /cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis

Birk, A., Chao, W. M., Bracken, C., Warren, J. D., & Szeto, H. H. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12468 · Cited by 309 · see citing works

Extensive tissue-related and allele-related mtDNA heteroplasmy suggests positive selection for somatic mutations

Li, M., Schröder, R., Ni, S., Madea, B., & Stoneking, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419651112 · Cited by 273 · see citing works

Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice

Hiona, A., Sanz, A., Kujoth, G. C., Pamplona, R., Seo, A. Y., Hofer, T., Someya, S., Miyakawa, T., Chie, N., Samhan-Arias, A. K., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011468 · Cited by 269 · see citing works

Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress

Shaughnessy, D. T., McAllister, K. A., Worth, L., Haugen, A. C., Meyer, J. N., Domann, F. E., Houten, B. V., Mostoslavsky, R., Bultman, S. J., Baccarelli, A., et al. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1408418 · Cited by 267 · see citing works

Membrane Fatty Acid Unsaturation, Protection against Oxidative Stress, and Maximum Life Span

Pamplona, R., Barja, G., & Portero‐Otín, M. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02118.x · Cited by 264 · see citing works

Quality Control of Mitochondrial ProteostasisPreprint

Baker, M. J., Tatsuta, T., & Langer, T. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007559 · Cited by 260 · see citing works

Aging: Central role for autophagy and the lysosomal degradative system

Rajawat, Y. S., Hilioti, Z., & Bossis, I. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.05.001 · Cited by 247 · see citing works

Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress

Bota, D. A., Van Remmen, H., & Davies, K. J. A. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03638-4 · Cited by 233 · see citing works

Association of mitochondrial DNA levels with frailty and all-cause mortality

Ashar, F. N., Moes, A., Moore, A. Z., Grove, M. L., Chaves, P. H. M., Coresh, J., Newman, A. B., Matteini, A. M., Bandeen‐Roche, K., Boerwinkle, E., et al. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1233-3 · Cited by 225 · see citing works

Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo

Amara, C. E., Shankland, E. G., Jubrias, S. A., Marcinek, D. J., Kushmerick, M. J., & Conley, K. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610131104 · Cited by 223 · see citing works

Metabolic networks of longevity

Houtkooper, R. H., Williams, R. W., & Auwerx, J. (2010) · Cell · doi:10.1016/j.cell.2010.06.029 · Cited by 217 · see citing works

Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans

Gouspillou, G., Sgarioto, N., Kapchinsky, S., Purves‐Smith, F., Norris, B., Pion, C. H., Barbat‐Artigas, S., Lemieux, F., Taivassalo, T., Morais, J. A., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-242750 · Cited by 217 · see citing works

Mitochondrial impairment triggers cytosolic oxidative stress and cell death following proteasome inhibition

Maharjan, S., Oku, M., Tsuda, M., Hoseki, J., & Sakai, Y. (2014) · Scientific Reports · doi:10.1038/srep05896 · Cited by 212 · see citing works

Coenzyme Q deficiency triggers mitochondria degradation by mitophagy

Rodríguez-Hernández, Á., Cordero, M. D., Salviati, L., Artuch, R., Pineda, M., Briones, P., Izquierdo, L. G., Cotán, D., Navas, P., & Sánchez-Alcázar, J. A. (2009) · Autophagy · doi:10.4161/auto.5.1.7174 · Cited by 194 · see citing works

Serendipity and the Discovery of Novel Compounds That Restore Mitochondrial Plasticity

Szeto, H. H., & Birk, A. (2014) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2014.174 · Cited by 191 · see citing works

Mitochondrial uncoupling and lifespan

Mookerjee, S. A., Divakaruni, A. S., Jastroch, M., & Brand, M. D. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.03.010 · Cited by 169 · see citing works

Adaptive plasticity of autophagic proteins to denervation in aging skeletal muscle

O'Leary, M. F., Vainshtein, A., Iqbal, S., Ostojic, O., & Hood, D. A. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00240.2012 · Cited by 165 · see citing works

Mitochondrial Proteostasis in the Control of Aging and Longevity

Jensen, M. B., & Jasper, H. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.006 · Cited by 162 · see citing works

Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.

Joseph, A.-M., Adhihetty, P. J., Wawrzyniak, N. R., Wohlgemuth, S. E., Picca, A., Kujoth, G. C., Prolla, T. A., & Leeuwenburgh, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069327 · Cited by 161 · see citing works

Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging

Umanskaya, A., Santulli, G., Xie, W., Andersson, D. C., Reiken, S. R., & Marks, A. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412754111 · Cited by 157 · see citing works

Free radical theory of aging: dietary implications

Harman, D. (1972) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/25.8.839 · Cited by 154 · see citing works

Altered Neuronal Mitochondrial Coenzyme A Synthesis in Neurodegeneration with Brain Iron Accumulation Caused by Abnormal Processing, Stability, and Catalytic Activity of Mutant Pantothenate Kinase 2

Kotzbauer, P. T., Truax, A. C., Trojanowski, J. Q., & Lee, V. M. ‐. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4265-04.2005 · Cited by 148 · see citing works

Low fatty acid unsaturation protects against lipid peroxidation in liver mitochondria from long-lived species: the pigeon and human case

Pamplona, R., Prat, J., Cadenas, S., Rojas, C., Pérez‐Campo, R., Torres, M. L., & Barja, G. (1996) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(95)01673-2 · Cited by 144 · see citing works

Mitochondrial complex I dysfunction in rat heart with aging: critical role of reactive oxygen species and cardiolipin

Petrosillo, G., Matera, M. G., Moro, N., Ruggiero, F. M., & Paradies, G. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.09.031 · Cited by 138 · see citing works

Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging

Ngo, J. K., Pomatto, L. C. D., & Davies, K. J. A. (2013) · Redox Biology · doi:10.1016/j.redox.2013.01.015 · Cited by 138 · see citing works

The Relationship between Muscle Fiber Type-Specific PGC-1α Content and Mitochondrial Content Varies between Rodent Models and Humans

Gouspillou, G., Sgarioto, N., Norris, B. A., Barbat‐Artigas, S., Aubertin‐Leheudre, M., Morais, J. A., Burelle, Y., Taivassalo, T., & Hepple, R. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103044 · Cited by 133 · see citing works

Is coenzyme Q a key factor in aging?

López‐Lluch, G., Rodríguez‐Aguilera, J. C., Santos‐Ocaña, C., & Navas, P. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.02.003 · Cited by 129 · see citing works

Ageing alters the supramolecular architecture of OxPhos complexes in rat brain cortex

Frenzel, M., Rommelspacher, H., Sugawa, M. D., & Dencher, N. A. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.02.003 · Cited by 127 · see citing works

Degradation of an intramitochondrial protein by the cytosolic proteasome

Azzu, V., & Brand, M. D. (2010) · Journal of Cell Science · doi:10.1242/jcs.060004 · Cited by 122 · see citing works

Mitochondrial Lon protease is a human stress protein

Ngo, J. K., & Davies, K. J. A. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.12.024 · Cited by 117 · see citing works

Supramolecular Organisation of the Mitochondrial Respiratory Chain: A New Challenge for the Mechanism and Control of Oxidative Phosphorylation

Lenaz, G., & Genova, M. L. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-3573-0_5 · Cited by 114 · see citing works

Novel cardiolipin therapeutic protects endothelial mitochondria during renal ischemia and mitigates microvascular rarefaction, inflammation, and fibrosis

Liu, S., Soong, Y., Seshan, S. V., & Szeto, H. H. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00697.2013 · Cited by 110 · see citing works

Mitochondrial iron-sulfur cluster dysfunction in neurodegenerative disease

Isaya, G. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00029 · Cited by 109 · see citing works

Krebs cycle dysfunction shapes epigenetic landscape of chromatin: Novel insights into mitochondrial regulation of aging process

Salminen, A., Kaarniranta, K., Hiltunen, M. O., & Kauppinen, A. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.03.030 · Cited by 96 · see citing works

Mitochondrial biogenesis and PGC-1α deacetylation by chronic treadmill exercise: differential response in cardiac and skeletal muscle

Li, L., Mühlfeld, C., Niemann, B., Pan, R., Li, R., Hilfiker‐Kleiner, D., Chen, Y., & Rohrbach, S. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0213-9 · Cited by 95 · see citing works

Caloric restriction protects mitochondrial function with aging in skeletal and cardiac muscles

Hepple, R. T., Baker, D. J., McConkey, M., Murynka, T., & Norris, R. (2006) · Rejuvenation Research · doi:10.1089/rej.2006.9.219 · Cited by 94 · see citing works

Mitochondria hyperfusion and elevated autophagic activity are key mechanisms for cellular bioenergetic preservation in centenarians

Sgarbi, G., Matarrese, P., Pinti, M., Lanzarini, C., Ascione, B., Gibellini, L., Dika, E., Patrizi, A., Tommasino, C., Capri, M., et al. (2014) · Aging · doi:10.18632/aging.100654 · Cited by 90 · see citing works

Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration

Bernales, S., Morales-Soto, M. A., & McCullagh, E. (2012) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2012.00005 · Cited by 78 · see citing works

Chronic activation of AMP-activated kinase as a strategy for slowing aging

McCarty, M. F. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.01.043 · Cited by 77 · see citing works

Energy Metabolism and the Burden of Multimorbidity in Older Adults: Results From the Baltimore Longitudinal Study of Aging

Fabbri, E., An, Y., Schrack, J. A., González‐Freire, M., Zoli, M., Simonsick, E. M., Guralnik, J. M., Boyd, C. M., Studenski, S. A., & Ferrucci, L. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu209 · Cited by 71 · see citing works

Aging Research—Where Do We Stand and Where Are We Going?

Guarente, L. (2014) · Cell · doi:10.1016/j.cell.2014.08.041 · Cited by 65 · see citing works

A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations

Lawless, C., Jurk, D., Gillespie, C. S., Shanley, D., Saretzki, G., von Zglinicki, T., & Passos, J. F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032117 · Cited by 62 · see citing works

The destiny of Ca2+ released by mitochondria

Takeuchi, A., Kim, B., & Matsuoka, S. (2014) · Journal of Physiological Sciences · doi:10.1007/s12576-014-0326-7 · Cited by 56 · see citing works

NAD+ Deficiency in Age-Related Mitochondrial Dysfunction

Prolla, T. A., & Denu, J. M. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.005 · Cited by 55 · see citing works

The Lack of CuZnSOD Leads to Impaired Neurotransmitter Release, Neuromuscular Junction Destabilization and Reduced Muscle Strength in Mice

Shi, Y., Ivannikov, M. V., Walsh, M. E., Liu, Y., Zhang, Y., Jaramillo, C. A., Macleod, G. T., & Remmen, H. V. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100834 · Cited by 54 · see citing works

Altered FoF1 ATP synthase and susceptibility to mitochondrial permeability transition pore during ischaemia and reperfusion in aging cardiomyocytes

Fernández‐Sanz, C., Castellano, J. M., Miró‐Casas, E., Núñez, E., Inserte, J., Vázquez, J., David Garcia-dorado, A., & Ruiz‐Meana, M. (2015) · Thrombosis and Haemostasis · doi:10.1160/th14-10-0901 · Cited by 53 · see citing works

The Physiological Role of Mitophagy: New Insights into Phosphorylation Events

Hirota, Y., Kang, D., & Kanki, T. (2012) · International Journal of Cell Biology · doi:10.1155/2012/354914 · Cited by 50 · see citing works

Partial Reversal of Skeletal Muscle Aging by Restoration of Normal NAD + Levels

Mendelsohn, A. R., & Larrick, J. W. (2014) · Rejuvenation Research · doi:10.1089/rej.2014.1546 · Cited by 48 · see citing works

mtDNA mutations in human aging and longevity: controversies and new perspectives opened by high-throughput technologies

Sevini, F., Giuliani, C., Vianello, D., Giampieri, E., Santoro, A., Biondi, F., Garagnani, P., Passarino, G., Luiselli, D., Capri, M., et al. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.03.022 · Cited by 46 · see citing works

Somatic Point Mutations in mtDNA Control Region Are Influenced by Genetic Background and Associated with Healthy Aging: A GEHA Study

Rose, G., Romeo, G., Dato, S., Crocco, P., Bruni, A. C., Hervonen, A., Majamaa, K., Sevini, F., Franceschi, C., & Passarino, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013395 · Cited by 46 · see citing works

Recent Progress in Metabolic Signaling Pathways Regulating Aging and Life Span

Newgard, C. B., & Pessin, J. E. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu058 · Cited by 43 · see citing works

The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice

Lopez-Dominguez, J. A., Ramsey, J. J., Tran, D., Imai, D. M., Koehne, A. L., Laing, S. T., Griffey, S. M., Kim, K., Taylor, S. L., Hagopian, K., et al. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu177 · Cited by 39 · see citing works

The Influence of Dietary Lipid Composition on Skeletal Muscle Mitochondria From Mice Following 1 Month of Calorie Restriction

Chen, Y., Hagopian, K., McDonald, R. B., Bibus, D. M., López‐Lluch, G., Villalba, J. M., Navas, P., & Ramsey, J. J. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls113 · Cited by 32 · see citing works

Fuse or die: Shaping mitochondrial fate during starvation

Rambold, A. S., Kostelecky, B., & Lippincott‐Schwartz, J. (2011) · Communicative & Integrative Biology · doi:10.4161/cib.17667 · Cited by 31 · see citing works

Transmission from centenarians to their offspring of mtDNA heteroplasmy revealed by ultra-deep sequencing

Giuliani, C., Barbieri, C., Li, M., Bucci, L., Monti, D., Passarino, G., Luiselli, D., Franceschi, C., Stoneking, M., & Garagnani, P. (2014) · Aging · doi:10.18632/aging.100661 · Cited by 29 · see citing works

Altered myoplasmic Ca2+ handling in rat fast-twitch skeletal muscle fibres during disuse atrophy

Weiss, N., Andrianjafiniony, T., Dupré-Aucouturier, S., Pouvreau, S., Dominique Desplanches, C., & Jacquemond, V. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0764-x · Cited by 25 · see citing works

Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity

Gómez, A. G., Sánchez-Román, I., Gómez, J., Cruces, J., Maté, I., Lopez‐Torres, M., Naudí, A., Portero‐Otín, M., Pamplona, R., la Fuente, M. D., et al. (2014) · Aging Cell · doi:10.1111/acel.12205 · Cited by 25 · see citing works

Increased mitochondrial matrix-directed superoxide production by fatty acid hydroperoxides in skeletal muscle mitochondria

Bhattacharya, A., Lustgarten, M. S., Shi, Y., Liu, Y., Jang, Y. C., Pulliam, D. A., Jernigan, A., & Remmen, H. V. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.014 · Cited by 22 · see citing works

Alterations in proton leak, oxidative status and uncoupling protein 3 content in skeletal muscle subsarcolemmal and intermyofibrillar mitochondria in old rats

Crescenzo, R., Bianco, F., Mazzoli, A., Giacco, A., Liverini, G., & Iossa, S. (2014) · BMC Geriatrics · doi:10.1186/1471-2318-14-79 · Cited by 21 · see citing works

Stability of Mitochondrial Membrane Proteins in Terrestrial Vertebrates Predicts Aerobic Capacity and Longevity

Kitazoe, Y., Kishino, H., Hasegawa, M., Matsui, A., Lane, N. J., & Tanaka, M. (2011) · Genome Biology and Evolution · doi:10.1093/gbe/evr079 · Cited by 20 · see citing works

Low Levels of mtDNA Deletion Mutations in ETS Normal Fibers from Aged Rats

Pak, J. W., & Aiken, J. M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.049 · Cited by 9 · see citing works

Measuring biological aging in humans: a quest

Ferrucci, L., Gonzalez‐Freire, M., Fabbri, E., Simonsick, E., Tanaka, T., Moore, Z., Salimi, S., Sierra, F., & de Cabo, R. (2020) · Aging Cell · doi:10.1111/acel.13080 · Cited by 781 · see citing works

Healthy aging: The ultimate preventative medicine

Kaeberlein, M., Rabinovitch, P. S., & Martin, G. M. (2015) · Science · doi:10.1126/science.aad3267 · Cited by 341 · see citing works

Prioritizing Functional Capacity as a Principal End Point for Therapies Oriented to Older Adults With Cardiovascular Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association

Forman, D. E., Arena, R., Boxer, R., Dolansky, M. A., Eng, J. J., Fleg, J. L., Haykowsky, M., Jahangir, A., Kaminsky, L. A., Kitzman, D. W., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000483 · Cited by 319 · see citing works

Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function

Grevendonk, L., Connell, N. J., McCrum, C., Fealy, C. E., Bilet, L., Bruls, Y. M. H., Mevenkamp, J., Schrauwen-Hinderling, V. B., Jörgensen, J. A., Moonen-Kornips, E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24956-2 · Cited by 298 · see citing works

The impact of low-protein high-carbohydrate diets on aging and lifespan

Le Couteur, D. G., Solon-Biet, S., Cogger, V. C., Mitchell, S. J., Senior, A., de Cabo, R., Raubenheimer, D., & Simpson, S. J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2120-y · Cited by 209 · see citing works

Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity

López-Lluch, G. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.12.005 · Cited by 103 · see citing works

³¹P Magnetic Resonance Spectroscopy Assessment of Muscle Bioenergetics as a Predictor of Gait Speed in the Baltimore Longitudinal Study of Aging

Choi, S., Reiter, D. A., Shardell, M., Simonsick, E. M., Studenski, S., Spencer, R. G., Fishbein, K. W., & Ferrucci, L. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw059 · Cited by 92 · see citing works

Muscle mitochondrial energetics predicts mobility decline in well-functioning older adults: the baltimore longitudinal study of aging

Tian, Q., Mitchell, B. A., Zampino, M., Fishbein, K. W., Spencer, R. G., & Ferrucci, L. (2022) · Aging Cell · doi:10.1111/acel.13552 · Cited by 78 · see citing works

Protective Effects of Ghrelin on Fasting-Induced Muscle Atrophy in Aging Mice

Wu, C.-S., Wei, Q., Wang, H., Kim, D. M., Balderas, M., Wu, G., Lawler, J., Safe, S., Guo, S., Devaraj, S., et al. (2020) · The Journals of Gerontology: Series A · doi:10.1093/gerona/gly256 · Cited by 81 · see citing works

In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial

Roshanravan, B., Liu, S. Z., Ali, A. S., Shankland, E. G., Goss, C., Amory, J. K., Robertson, H. T., Marcinek, D. J., & Conley, K. E. (2021) · PLOS ONE · doi:10.1371/journal.pone.0253849 · Cited by 38 · see citing works

Dietary fat composition influences glomerular and proximal convoluted tubule cell structure and autophagic processes in kidneys from calorie-restricted mice

Calvo-Rubio, M., Burón, M. I., López-Lluch, G., Navas, P., de Cabo, R., Ramsey, J. J., Villalba, J. M., & González-Reyes, J. A. (2016) · Aging Cell · doi:10.1111/acel.12451 · Cited by 26 · see citing works

Stress turns on the heat: Regulation of mitochondrial biogenesis and UCP1 by ROS in adipocytes

Palacios-Ortega, S., Chouchani, E. T., & Boudina, S. (2016) · Adipocyte · doi:10.1080/21623945.2016.1273298 · Cited by 41 · see citing works

Resveratrol protects cardiomyocytes from oxidative stress through SIRT1 and mitochondrial biogenesis signaling pathways

Li, Y., Zhu, W. J., Tao, J., Xin, P., Liu, M., Li, J.-B., & Wei, M. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.07.042 · Cited by 102 · see citing works

Mitochondrial biogenesis factor PGC-1α suppresses spinal morphine tolerance by reducing mitochondrial superoxide

Kashiwagi, Y., Yi, H., Liu, S., Takahashi, K., Hayashi, K., Ikegami, D., Zhu, X., Gu, J., & Hao, S. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113622 · Cited by 20 · see citing works

Induction of mitochondrial heat shock proteins and mitochondrial biogenesis in endothelial cells upon acute methylglyoxal stress: Evidence for hormetic autofeedbackPreprint

Bulkescher, R., Fleming, T., Rodemer, C., Medert, R., Freichel, M., Mayer, M. P., Szendroedi, J., Herzig, S., & Zemva, J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.30.470545

Exercise-induced reductions in mitochondrial ADP sensitivity contribute to the induction of gene expression and mitochondrial biogenesis through enhanced mitochondrial H2O2 emission

Miotto, P. M., & Holloway, G. P. (2019) · Mitochondrion · doi:10.1016/j.mito.2018.03.003 · Cited by 30 · see citing works