Regional Hippocampal Atrophy and Higher Levels of Plasma Amyloid-Beta Are Associated With Subjective Memory Complaints in Nondemented Elderly Subjects
Open accessAbstract
BACKGROUND: Evidence suggests a link between the presence of subjective memory complaints (SMC) and lower volume of the hippocampus, one of the first regions to show neuropathological lesions in Alzheimer's disease. However, it remains unknown whether this pattern of hippocampal atrophy is regionally specific and whether SMC are also paralleled by changes in peripheral levels of amyloid-beta (Aβ). METHODS: The volume of hippocampal subregions and plasma Aβ levels were cross-sectionally compared between elderly individuals with (SMC(+); N = 47) and without SMC (SMC(-); N = 48). Significant volume differences in hippocampal subregions were further correlated with plasma Aβ levels and with objective memory performance. RESULTS: Individuals with SMC exhibited significantly higher Aβ1-42 concentrations and lower volumes of CA1, CA4, dentate gyrus, and molecular layer compared with SMC(-) participants. Regression analyses further showed significant associations between lower volume of the dentate gyrus and both poorer memory performance and higher plasma Aβ1-42 levels in SMC(+) participants. CONCLUSIONS: The presence of SMC, lower volumes of specific hippocampal regions, and higher plasma Aβ1-42 levels could be conditions associated with aging vulnerability. If such associations are confirmed in longitudinal studies, the combination may be markers recommending clinical follow-up in nondemented older adults.
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SCD is associated with a significant reduction in the volume of the cholinergic basal forebrain and the CA1 region of the hippocampus compared with HCs.
“The findings have converged to suggest that SCD is associated with a significant reduction in the volume of the cholinergic basal forebrain and the CA1 region of the hippocampus compared with HCs [87–90].”
From Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease (2020) · cites this paper as [87]
The Abstract (p. 1) reports significantly lower CA1 volume in elderly participants with subjective memory complaints than in those without complaints; the Discussion (p. 4) confirms this comparison. The paper does not report a reduction in cholinergic basal forebrain volume, so it supports only the CA1 part of the claim. (LLM, conf=0.88)
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Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease
Wang, X., Huang, W., Su, L., Xing, Y., Jessen, F., Sun, Y., Shu, N., & Han, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00395-3 · Cited by 265 · see citing works
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Yang, L., Yan, Y., Wang, Y., Hu, X., Lu, J., Chan, P., Yan, T., & Han, Y. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00975 · Cited by 182 · see citing works
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- Authors
- Cantero, J. L., Iglesias, J. E., Van Leemput, K., & Atienza, M.
- Affiliations
- Harvard University (US)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-03-04
- Volume
- 71
- Issue
- 9
- Pages
- 1210-1215
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC4978360
- OpenAlex
- W2292533497
- Cited by
- 63
- References
- 49
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 10 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 3 · 2016: 2
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Communities in ADDI (Universidad del Pais Vasco) (submittedVersion, other-oa)
- Communities in ADDI (University of the Basque Country) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion)
- Hispana (submittedVersion, other-oa)
- HighWire Press Open Archive (submittedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion, other-oa)
- Funders
- National Institutes of Health
- National Center for Research Resources (P41-RR14075)
- National Institute of Biomedical Imaging and Bioengineering (R01EB013565)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- subjective memory complaints, hippocampal atrophy, plasma amyloid-beta, amyloid-beta 42, dentate gyrus, CA1, CA4, molecular layer, memory performance, non-demented elderly
- MeSH terms
- Aged, Aging, Alzheimer Disease, Atrophy, Brain, Cross-Sectional Studies, Diagnosis, Differential, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Sensitivity and Specificity, Biomarkers, Amyloid beta-Peptides
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