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Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis

Belsky, Daniel W, Huffman, Kim M, Pieper, Carl F, Shalev, Idan, Kraus, William E·2018·The Journals of Gerontology: Series A
DOI 10.1093/gerona/glx096
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Abstract

Biological aging measures have been proposed as proxies for extension of healthy life span in trials of geroprotective therapies that aim to slow aging. Several methods to measure biological aging show promise but it is not known if these methods are sensitive to changes caused by geroprotective therapy. We conducted analysis of two proposed methods to quantify biological aging using data from a recently concluded trial of an established geroprotector, caloric restriction. We obtained data from the National Institute on Aging CALERIE randomized trial through its public-access biobank (https://calerie.duke.edu/). The CALERIE trial randomized N = 220 nonobese adults to 25% caloric restriction (n = 145; 11.7% caloric restriction was achieved, on average) or to maintain current diet (n = 75) for 2 years. We analyzed biomarker data collected at baseline, 12-, and 24-month follow-up assessments. We applied published biomarker algorithms to these data to calculate two biological age measures, Klemera-Doubal Method Biological Age and homeostatic dysregulation. Intent-to-treat analysis using mixed-effects growth models of within-person change over time tested if caloric restriction slowed increase in measures of biological aging across follow-up. Analyses of both measures indicated caloric restriction slowed biological aging. Weight loss did not account for the observed effects. Results suggest future directions for testing of geroprotective therapies in humans.

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  • Previous reports on CALERIE establish that CR intervention improved participants' cardiometabolic health and slowed aging-related changes in physiological system integrity.

    “Our previous reports on CALERIE establish that CR intervention improved participants’ cardiometabolic health and slowed aging-related changes in physiological system integrity26,31,32.”

    From Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (2023) · cites this paper as [31]

  • Despite imperfect adherence, treatment group participants experienced substantial and sustained weight loss and related changes in body and tissue composition, broad improvement in cardiometabolic health and a slowing of aging-related physiological changes.

    “Despite this imperfect adherence, treatment group participants experienced substantial and sustained weight loss and related changes in body and tissue composition, broad improvement in cardiometabolic health and a slowing of aging-related physiological changes26,31,44,45.”

    From Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (2023) · cites this paper as [31]

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Metadata

Authors
Belsky, D. W., Huffman, K. M., Pieper, C. F., Shalev, I., & Kraus, W. E.
Venue
The Journals of Gerontology: Series A
Publisher
Oxford University Press (OUP)
Published
2017-05-22
Volume
73
Issue
1
Pages
4-10
ISSN
  • 1079-5006
  • 1758-535X
DOI
10.1093/gerona/glx096
Cited by
185
References
10
Language
en
Funders
  • NIA (P30AG028716, R01AG032282)
  • CALERIE Research Network (U24AG047121)

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