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The rate of aging: the rate of deficit accumulation does not change over the adult life span

Mitnitski, Arnold, Rockwood, Kenneth·2016·Biogerontology
DOI 10.1007/s10522-015-9583-y
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Abstract

People age at different rates. We have proposed that rates of aging can be quantified by the rate at which individuals accumulate health deficits. Earlier estimates, using cross-sectional analyses suggested that deficits accumulated exponentially, at an annual rate of 3.5%. Here, we estimate the rate of deficit accumulation using longitudinal data from the Canadian National Population Health Survey. By analyzing age-specific trajectories of deficit accumulation in people aged 20 years and over (n = 13,668) followed biannually for 16 years, we found that the longitudinal average annual rate of deficit accumulation was 4.5% (±0.75%). This estimate was notably stable during the adult life span. The corresponding average doubling time in the number of deficits was 15.4 (95% CI 14.82-16.03) years, roughly 30% less than we had reported from the cross-sectional analysis. Earlier work also established that the average number of deficits accumulated by individuals (N), equals the product of the intensity of environmental stresses (λ) causing damage to the organism, by the average recovery time (W). At the individual level, changes in deficit accumulation can be attributed to both changes in environmental stresses and changes in recovery time. By contrast, at the population level, changes in the number of deficits are proportional to the changes in recovery time. In consequence, we propose here that the average recovery time, W doubles approximately every 15.4 years, independently of a…

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  • Aging is manifested as a progressive functional decline leading to exponentially increasing prevalence and incidence of chronic age-related diseases and disease-specific mortality.

    “Aging is manifested as a progressive functional decline leading to exponentially increasing prevalence1,2 and incidence of chronic age-related diseases (e.g., cancers, diabetes, cardiovascular diseases, etc.3–5) and disease-specific mortality6.”

    From Longitudinal Analysis of Blood Markers Reveals Progressive Loss of Resilience and Predicts Human Lifespan Limit (2021) · cites this paper as [1]

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Research works printed but not linked: 39

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Metadata

Authors
Mitnitski, A., & Rockwood, K.
Venue
Biogerontology
Publisher
Springer Science and Business Media LLC
Published
2015-05-14
Volume
17
Issue
1
Pages
199-204
ISSN
  • 1389-5729
  • 1573-6768
DOI
10.1007/s10522-015-9583-y
Cited by
140
References
5
Language
en
Licence
www.springer.com/tdm (tdm)
Funders
Canadian Institutes of Health Rsearch (MOP24388)

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