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The Longitudinal Study of Aging in Human Young Adults: Knowledge Gaps and Research Agenda
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A barrier to advancing translation of therapies through human trials is that intervention studies run for months or years, but human aging takes decades to cause disease.
“A barrier to advancing translation of these therapies through human trials is that intervention studies run for months or years, but human aging takes decades to cause disease46–48.”
From Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (2023) · cites this paper as [46]
The section “Why Is it Important to Measure the Pace of Aging in Humans as well as in Animals?” says that age-related diseases arise in later decades and that trials using disease or mortality outcomes would require decades of follow-up. This supports the claimed barrier to translation, but our copy does not establish that intervention studies run for months or years. (LLM, conf=0.86)
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BackgroundThe transcriptional landscape of age in human peripheral blood
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Cited by
Sorted by citations
Belsky, D. W., Caspi, A., Arseneault, L., Baccarelli, A., Corcoran, D. L., Gao, X., Hannon, E., Harrington, H. L., Rasmussen, L. J., Houts, R., et al. (2020) · eLife · doi:10.7554/elife.54870 · Cited by 652
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Self-citationDeterminants of accelerated metabolomic and epigenetic aging in a UK cohort
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Belsky, D. W., Caspi, A., Cohen, H. J., Kraus, W. E., Ramrakha, S., Poulton, R., & Moffitt, T. E. (2017) · Aging Cell · doi:10.1111/acel.12591 · Cited by 114
“But human translation of therapies to slow the biological process of aging will face challenges (Moffitt et al., 2016; Moskalev et al., 2016).”
Self-citationHan, L. K. M., Verhoeven, J. E., Tyrka, A. R., Penninx, B. W. J. H., Wolkowitz, O. M., Månsson, K. N. T., Lindqvist, D., Boks, M. P., Révész, D., Mellon, S. H., et al. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.04.004 · Cited by 104
“First, future studies should include longitudinal designs to increase the reliability and accuracy of measuring aging (Moffitt et al., 2017).”
Brayne, C., & Moffitt, T. E. (2022) · Nature Aging · doi:10.1038/s43587-022-00277-x · Cited by 89
Self-citationLei, M.-K., Beach, S. R. H., & Simons, R. L. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000937 · Cited by 44
Metadata
- Authors
- Moffitt, T. E., Belsky, D. W., Danese, A., Poulton, R., & Caspi, A.
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-10-07
- Volume
- 72
- Issue
- 2
- Pages
- 210-215
- ISSN
- 1079-5006
- 1758-535X
- Cited by
- 117
- References
- 9
- Language
- en
- Funders
- National Institute on Aging (AG032282, AG048895, AG049789)
- Medical Research Council (MR/K00381X)
- Jacobs Foundation
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