Cited by 745Frailty in Older AdultsAging, Health, and DisabilityAging and Gerontology Research

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Evidence for the Domains Supporting the Construct of Intrinsic Capacity

Cesari, Matteo, Araujo de Carvalho, Islene, Amuthavalli Thiyagarajan, Jotheeswaran, Cooper, Cyrus, Martin, Finbarr C, Reginster, Jean-Yves, Vellas, Bruno, Beard, John R·2018·The Journals of Gerontology: Series A

DOI 10.1093/gerona/gly011

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Abstract

Healthy ageing can be defined as "the process of developing and maintaining the functional ability that enables wellbeing in older age". Functional ability (i.e., the health-related attributes that enable people to be and to do what they have reason to value) is determined by intrinsic capacity (i.e., the composite of all the physical and mental capacities of an individual), the environment (i.e., all the factors in the extrinsic world that form the context of an individual's life), and the interactions between the two. This innovative model recently proposed by the World Health Organization has the potential to substantially modify the way in which clinical practice is currently conducted, shifting from disease-centered toward function-centered paradigms. By overcoming the multiple limitations affecting the construct of disease, this novel framework may allow the worldwide dissemination of a more proactive and function-based approach toward achieving optimal health status. In order to facilitate the translation of the current theoretical model into practice, it is important to identify the inner nature of its constituting constructs. In this article, we consider intrinsic capacity. Using the International Classification of Functioning, Disability and Health (ICF) framework as background and taking into account available evidence, five domains (i.e., locomotion, vitality, cognition, psychological, sensory) are identified as pivotal for capturing the individual's intrinsic capacity (and therefore also reserves) and, through this, pave the way for its objective measurement.

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Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Gait speed and survival in older adults.
Studenski, S. (2011) · JAMA · doi:10.1001/jama.2010.1923 · Cited by 4,558 · cited 1×
“In pooled analyses of nine cohort studies, Studenski and colleagues (58) demonstrated that it is possible to accurately estimate the life expectancy of an older individual by simply knowing age, gender, and gait speed.”
Background
Frailty Consensus: A Call to Action
Morley, J. E., Vellas, B. J., van Kan, G. A., Anker, S. D., Bauer, J. M., Bernabei, R., Cesari, M., Chumlea, W. C., Doehner, W., Evans, J., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.03.022 · Cited by 4,201
Self-citation
Resilient Individuals Use Positive Emotions to Bounce Back From Negative Emotional Experiences.
Tugade, M. M., & Fredrickson, B. L. (2004) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.86.2.320 · Cited by 3,947
International Classification of Functioning, Disability and Health
World Health Organization (2021) · PsycTESTS Dataset · doi:10.1037/t76403-000 · Cited by 3,751
Human Aging: Usual and Successful
Rowe, J. W., & Kahn, R. L. (1987) · Science · doi:10.1126/science.3299702 · Cited by 3,384
The World report on ageing and health: a policy framework for healthy ageing
Beard, J. R., Officer, A., de Carvalho, I. A., Sadana, R., Pot, A. M., Michel, J.-P., Lloyd-Sherlock, P., Epping-Jordan, J. E., Peeters, G. M. E. E. (., Mahanani, W. R., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00516-4 · Cited by 3,287
Self-citation
The World Report on Ageing and Health
Beard, J., Officer, A. M., & Cassels, A. (2016) · The Gerontologist · doi:10.1093/geront/gnw037 · Cited by 2,911
Self-citation
Accumulation of Deficits as a Proxy Measure of Aging
Mitnitski, A. B., Mogilner, A. J., & Rockwood, K. (2001) · The Scientific World JOURNAL · doi:10.1100/tsw.2001.58 · Cited by 2,893 · cited 1×
“For example, the multidimensional nature of the intrinsic capacity model can be found in the comprehensive approach proposed by Rockwood and Mitnitski (71).”
Background
The burden of disease in older people and implications for health policy and practice
Prince, M. J., Wu, F., Guo, Y., Gutiérrez‐Robledo, L. M., O'Donnell, M. J., Sullivan, R. J., & Yusuf, S. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61347-7 · Cited by 2,473

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Authors: Cesari, M., Araujo de Carvalho, I., Amuthavalli Thiyagarajan, J., Cooper, C., Martin, F. C., Reginster, J.-Y., Vellas, B., & Beard, J. R.
Affiliations: Université Toulouse III - Paul Sabatier (FR)
Department of Ageing and Life Course, World Health Organization, Geneva, Switzerland
MRC Lifecourse Epidemiology Unit (GB)
King's College London (GB)
University of Liège (BE)
World Health Organization (CH)
Corresponding author: Cesari, Matteo
ORCID: Cesari, Matteo
Cooper, Cyrus
Martin, Finbarr C
Reginster, Jean-Yves
Vellas, Bruno
Beard, John R
Venue: The Journals of Gerontology: Series A
Publisher: Oxford University Press (OUP)
Published: 2018-02-02
Volume: 73
Issue: 12
Pages: 1653-1660
ISSN: 1079-5006 (ISSN-L)
1758-535X
DOI: 10.1093/gerona/gly011
OpenAlex: W2791724957
Cited by: 745
References: 81
Citations by year: 2026: 148 · 2025: 113 · 2024: 105 · 2023: 100 · 2022: 83 · 2021: 76 · 2020: 59 · 2019: 48 · 2018: 11
FWCI: 5.47
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: The Journals of Gerontology Series A (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
ORBi (University of Liège) (submittedVersion)
Funders: World Health Organization
National Institute for Health and Care Research (NF-SI-0508-10082, NF-SI-0513-10085)
Medical Research Council (MC_UU_12011/1)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
Keywords: intrinsic capacity, healthy aging, functional capacity, International Classification of Functioning, Disability and Health, locomotion, vitality, cognition, psychological capacity, sensory function, older adults
MeSH terms: Frailty, Healthy Aging, Activities of Daily Living, Aged, Aged, 80 and over, Attitude to Health, Disability Evaluation, Female, Health Services for the Aged, Humans, Male, Models, Biological, Risk Factors, United States, Geriatric Assessment, Needs Assessment, Resilience, Psychological

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