Cited by 745Frailty in Older AdultsAging, Health, and DisabilityAging and Gerontology Research

The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.

Evidence for the Domains Supporting the Construct of Intrinsic Capacity

Cesari, Matteo, Araujo de Carvalho, Islene, Amuthavalli Thiyagarajan, Jotheeswaran, Cooper, Cyrus, Martin, Finbarr C, Reginster, Jean-Yves, Vellas, Bruno, Beard, John R·2018·The Journals of Gerontology: Series A

DOI 10.1093/gerona/gly011

Open this paper in CoChat — free account

Abstract

Healthy ageing can be defined as "the process of developing and maintaining the functional ability that enables wellbeing in older age". Functional ability (i.e., the health-related attributes that enable people to be and to do what they have reason to value) is determined by intrinsic capacity (i.e., the composite of all the physical and mental capacities of an individual), the environment (i.e., all the factors in the extrinsic world that form the context of an individual's life), and the interactions between the two. This innovative model recently proposed by the World Health Organization has the potential to substantially modify the way in which clinical practice is currently conducted, shifting from disease-centered toward function-centered paradigms. By overcoming the multiple limitations affecting the construct of disease, this novel framework may allow the worldwide dissemination of a more proactive and function-based approach toward achieving optimal health status. In order to facilitate the translation of the current theoretical model into practice, it is important to identify the inner nature of its constituting constructs. In this article, we consider intrinsic capacity. Using the International Classification of Functioning, Disability and Health (ICF) framework as background and taking into account available evidence, five domains (i.e., locomotion, vitality, cognition, psychological, sensory) are identified as pivotal for capturing the individual's intrinsic capacity (and therefore also reserves) and, through this, pave the way for its objective measurement.

Integrity signals

Registry

Crossref · 10.1093/gerona/gly011

Cites

81 of 81 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Gait speed and survival in older adults.
Studenski, S. (2011) · JAMA · doi:10.1001/jama.2010.1923 · Cited by 4,558 · cited 1×
“In pooled analyses of nine cohort studies, Studenski and colleagues (58) demonstrated that it is possible to accurately estimate the life expectancy of an older individual by simply knowing age, gender, and gait speed.”
Background
Frailty Consensus: A Call to Action
Morley, J. E., Vellas, B. J., van Kan, G. A., Anker, S. D., Bauer, J. M., Bernabei, R., Cesari, M., Chumlea, W. C., Doehner, W., Evans, J., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.03.022 · Cited by 4,201
Self-citation
Resilient Individuals Use Positive Emotions to Bounce Back From Negative Emotional Experiences.
Tugade, M. M., & Fredrickson, B. L. (2004) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.86.2.320 · Cited by 3,947
International Classification of Functioning, Disability and Health
World Health Organization (2021) · PsycTESTS Dataset · doi:10.1037/t76403-000 · Cited by 3,751
Human Aging: Usual and Successful
Rowe, J. W., & Kahn, R. L. (1987) · Science · doi:10.1126/science.3299702 · Cited by 3,384
The World report on ageing and health: a policy framework for healthy ageing
Beard, J. R., Officer, A., de Carvalho, I. A., Sadana, R., Pot, A. M., Michel, J.-P., Lloyd-Sherlock, P., Epping-Jordan, J. E., Peeters, G. M. E. E. (., Mahanani, W. R., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00516-4 · Cited by 3,287
Self-citation
The World Report on Ageing and Health
Beard, J., Officer, A. M., & Cassels, A. (2016) · The Gerontologist · doi:10.1093/geront/gnw037 · Cited by 2,911
Self-citation
Accumulation of Deficits as a Proxy Measure of Aging
Mitnitski, A. B., Mogilner, A. J., & Rockwood, K. (2001) · The Scientific World JOURNAL · doi:10.1100/tsw.2001.58 · Cited by 2,893 · cited 1×
“For example, the multidimensional nature of the intrinsic capacity model can be found in the comprehensive approach proposed by Rockwood and Mitnitski (71).”
Background
The burden of disease in older people and implications for health policy and practice
Prince, M. J., Wu, F., Guo, Y., Gutiérrez‐Robledo, L. M., O'Donnell, M. J., Sullivan, R. J., & Yusuf, S. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61347-7 · Cited by 2,473

Show all 81 references

Sorted by citations

Items 201–300 of 744

Weakness May Have a Causal Association With Early Mortality in Older Americans: A Matched Cohort Analysis
McGrath, R., Vincent, B. M., Peterson, M. D., Jurivich, D. A., Dahl, L. J., Hackney, K. J., & Clark, B. C. (2019) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2019.10.016 · Cited by 26
How does social support interact with intrinsic capacity to affect the trajectory of functional ability among older adults? Findings of a population-based longitudinal study
Yu, J., Jin, Y., Si, H., Bian, Y., Liu, Q., Qiao, X., Ji, L., Wang, W., & Wang, C. (2023) · Maturitas · doi:10.1016/j.maturitas.2023.03.005 · Cited by 23
Moving Towards Common Data Elements and Core Outcome Measures in Frailty Research
Muscedere, J., Afilalo, J., de Carvalho, I. A., Cesari, M., Clegg, A. P., Eriksen, H. E., Evans, K., Heckman, G. A., Hirdes, J. P., Kim, P. M., et al. (2020) · The Journal of Frailty & Aging · doi:10.14283/jfa.2019.43 · Cited by 24
Self-citation
Declined intrinsic capacity predicts long-term mortality in Chinese older adults: Beijing Longitudinal Study of Aging
Pan, Y., Li, X., Zhang, L., Li, Y., Tang, Z., & Ma, L. (2024) · Maturitas · doi:10.1016/j.maturitas.2024.108082 · Cited by 22
Patterns of intrinsic capacity trajectory and onset of activities of daily living disability among community-dwelling older adults
Zhang, S., Wu, S., Guo, R., Ding, S., & Wu, Y. X. (2024) · Journal of Global Health · doi:10.7189/jogh.14.04159 · Cited by 22
A Smart Shoe Insole to Monitor Frail Older Adults’ Walking Speed: Results of Two Evaluation Phases Completed in a Living Lab and Through a 12-Week Pilot Study
Piau, A., Steinmeyer, Z., Charlon, Y., Courbet, L., Rialle, V., Lepage, B., Campo, É., & Nourhashémi, F. (2021) · JMIR mhealth and uhealth · doi:10.2196/15641 · Cited by 26
The Biological Rationale for Integrating Intrinsic Capacity Into Frailty Models
Yu, Z., Lozupone, M., Chen, J., Bao, Z., Ruan, Q., & Panza, F. (2025) · Clinical Interventions in Aging · doi:10.2147/cia.s509990 · Cited by 21
Brain Aging, Cardiovascular Diseases, Mixed Dementia, and Frailty in the Oldest Old: From Brain Phenotype to Clinical Expression
Rosa, G., Giannotti, C., Martella, L. A., Massa, F., Serafini, G., Pardini, M., Nobili, F. M., & Monacelli, F. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191075 · Cited by 23
Prospective Associations of Plasma Growth Differentiation Factor 15 With Physical Performance and Cognitive Functions in Older Adults
He, L., Barreto, P. D. S., Sánchez‐Sánchez, J. L., Rolland, Y., Guyonnet, S., Parini, A., Lucas, A., Vellas, B. J., MAPT/DSA Group, Vellas, B. J., et al. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac020 · Cited by 24
Self-citation
Intrinsic capacity rather than intervention exposure influences reversal to robustness among prefrail community-dwelling older adults: A non-randomized controlled study of a multidomain exercise and nutrition intervention
Tay, L., Tay, E., Mah, S. M., Latib, A. B., & Ng, Y. S. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.971497 · Cited by 22
The ICOPE Intrinsic Capacity Screening Tool: Measurement Structure and Predictive Validity of Dependence and Hospitalization
Rodríguez‐Laso, Á., García‐García, F. J., & Rodríguez‐Mañas, L. (2023) · The journal of nutrition health & aging · doi:10.1007/s12603-023-1985-y · Cited by 21
The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background
Banse, S. A., Jackson, E. G., Sedore, C. A., Onken, B., Hall, D., Coleman-Hulbert, A. L., Huynh, P., Garrett, T., Johnson, E., Harinath, G., et al. (2024) · Aging · doi:10.18632/aging.205743 · Cited by 26
Which Sit-to-Stand Test Best Differentiates Functional Capacity in Older People?
Cruz‐Montecinos, C., Torres‐Castro, R., Otto‐Yáñez, M., Barros-Poblete, M., Valencia, C., Campos, A., Jadue, L., Barros, M., Solís‐Navarro, L., & Resqueti, V. (2024) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000002504 · Cited by 21
Proactive interception and care of Frailty and Multimorbidity in older persons: the experience of the European Innovation Partnership on Active and Healthy Ageing and the response of Parma Local Health Trust and Lab through European Projects.
Longobucco, Y., Benedetti, C., Tagliaferri, S., Angileri, V. V., Adorni, E., Pessina, M., Zerbinati, L., Cicala, L., Pelà, G. M., Giacomini, V., et al. (2019) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · doi:10.23750/abm.v90i2.8419 · Cited by 21
Investigating the broad domains of intrinsic capacity, functional ability and environment: An exploratory graph analysis approach for improving analytical methodologies for measuring healthy agingPreprint
Golino, H. F., Thiyagarajan, J. A., Sadana, R., Santos, M. T., Christensen, A. P., & Boker, S. M. (2020) · PsyArXiv (OSF Preprints) · doi:10.31234/osf.io/hj5mc · Cited by 22
Psychosocial modification of general self-efficacy in older adults: a restricted review
FitzGerald, J., Wells, Y. D., & Ellis, J. M. (2022) · Australasian Journal on Ageing · doi:10.1111/ajag.13052 · Cited by 20
Factors associated with intrinsic capacity impairment in hospitalized older adults: a latent class analysis
Zhu, L., Shen, X., Shi, X., & Ouyang, X. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-05093-z · Cited by 20
The Interplay Between Frailty and Intrinsic Capacity in Aging and HIV Infection
Guaraldi, G., & Milić, J. (2019) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2019.0157 · Cited by 21
Relationship between intrinsic capacity and health-related quality of life among community-dwelling older adults: the moderating role of social support
Yu, J., Jin, Y., Si, H., Bian, Y., Liu, Q., Li, Y., & Wang, C. (2023) · Quality of Life Research · doi:10.1007/s11136-023-03520-z · Cited by 19
Conceptualisation and measurement of healthy ageing: Insights from a systematic literature review
Piriu, A. A., Bufali, M. V., Cappellaro, G., Compagni, A., & Torbica, A. (2025) · Social Science & Medicine · doi:10.1016/j.socscimed.2025.117933 · Cited by 22
Defining Vitality: Associations of Three Operational Definitions of Vitality with Disability in Instrumental Activities of Daily Living and Frailty among Elderly Over a 3-Year Follow-Up (MAPT Study)
Giudici, K. V., Barreto, P. D. S., Soriano, G., Rolland, Y., & Vellas, B. J. (2019) · The journal of nutrition health & aging · doi:10.1007/s12603-019-1175-0 · Cited by 19
Self-citation
Combining Stochastic Resonance Vibration With Exergaming for Motor-Cognitive Training in Long-Term Care; A Sham-Control Randomized Controlled Pilot Trial
de Bruin, E. D., Baur, H., Bruelhart, Y., Luijckx, E., Hinrichs, T., & Rogan, S. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.507155 · Cited by 19
Measuring functional ability in healthy ageing: a nationwide cross-sectional survey in the Philippine older population
Moreno‐Agostino, D., Prina, M. A., Chua, K., Thiyagarajan, J. A., Sadana, R., Officer, A., Kamenov, K., & Cieza, A. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-050827 · Cited by 19
Approaching person-centered clinical practice: A cluster analysis of older inpatients utilizing the measurements of intrinsic capacity
Wu, W., Sun, L., Li, H., Zhang, J., Shen, J., Li, J., & Zhou, Q. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.1045421 · Cited by 20
Multimorbidity, lifestyle, and cognitive function: A cross-cultural study on the role of diabetes, cardiovascular disease, cancer, and chronic respiratory diseases
Ma, H., Mu, X., Jin, Y., Luo, Y., Wu, M., & Han, Z. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.07.053 · Cited by 27
Protein-enriched diet improved muscle endurance and marginally reduced intramuscular adiposity: Results from a randomized controlled trial among middle-aged and older adults
Peng, L., Yu, P.-C., Lee, H., Lin, M.-H., & Chen, L. (2021) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2021.104436 · Cited by 19
Resilience-happiness nexus in community-dwelling middle-aged and older adults: Results from Gan-Dau Healthy Longevity Plan
Chen, Z.-J., Tang, F.-P., Chang, S.-Y., Chung, H.-L., Tsai, W.-H., Chou, S.-S., Yeh, H.-C., & Tung, H.-H. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2023.105162 · Cited by 18
A functional approach to model intrinsic capacity in ageing trajectories
Bernal, M. C., Batista, E., Martínez-Ballesté, A., & Solanas, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-92271-7 · Cited by 18
Intrinsic capacity and its dimensions in relation to functional ability in older adults: A systematic review and meta-analysis
Cheng, Y., Li, W., Xiao, S., Chen, Y., & Qi, X. (2025) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2025.105860 · Cited by 18
Transitions and trajectories in intrinsic capacity states over time: a systematic review
Wang, Y., Tang, N., Shao, M., Song, J., Su, Q., & Gao, Y. (2025) · BMC Geriatrics · doi:10.1186/s12877-025-05938-1 · Cited by 18
The Role of Dietary Patterns in the Contribution of Cardiorespiratory Fitness in Community-Dwelling Older Chinese Adults in Hong Kong
Chan, R., Yau, F. C., Yu, B. W. M., & Woo, J. (2019) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.12.009 · Cited by 18
INtrinsic Capacity and its RElAtionship With Life-SpacE Mobility (INCREASE): a cross-sectional study of community-dwelling older adults in Singapore
Lee, J. Q., Ding, Y. Y., Latib, A. B., Tay, L., & Ng, Y. S. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-054705 · Cited by 18
Healthy Eating Enhances Intrinsic Capacity, Thus Promoting Functional Ability of Retirement Home Residents in Northern Taiwan
Lim, K.-Y., Lo, H., Cheong, I.-F., Wang, Y.-Y., Jian, Z.-R., Chen, I.-C., Chan, Y.-C., Lee, S., Chou, C.-C., & Yang, F. L. (2022) · Nutrients · doi:10.3390/nu14112225 · Cited by 18
Relationship between self-reported visual impairment and worsening frailty transition states in older people: a longitudinal study
Gonzales-Turín, J. M., Rodríguez‐Laso, Á., Carnicero, J. A. C., García‐García, F. J., & Rodríguez‐Mañas, L. (2021) · Aging Clinical and Experimental Research · doi:10.1007/s40520-020-01768-w · Cited by 18
A Longitudinal View of Successful Aging With HIV: Role of Resilience and Environmental Factors
Mayo, N. E., Brouillette, M., Nadeau, L., Dendukuri, N., Harris, M., Smaill, F., Smith, G. H. R., Thomas, R., Fellows, L. K., & Investigators from the Positive Brain Health Now Study (2021) · Quality of Life Research · doi:10.1007/s11136-021-02970-7 · Cited by 18
Functional ability of older adults based on the World Health Organization framework of healthy ageing: a scoping review
Zhang, W., & Wang, A. (2023) · Journal of Public Health · doi:10.1007/s10389-023-02121-x · Cited by 17
The Longitudinal Aging Study Amsterdam: design and cohort update 2025
Hoogendijk, E. O., van Schoor, N. M., Qi, Y., Visser, M., Swinkels, J. C., Groenou, M. I. B. V., Kok, A. A. L., Holwerda, T. J., Pasman, H. R. W., Onwuteaka-Philipsen, B. D., et al. (2025) · European Journal of Epidemiology · doi:10.1007/s10654-025-01238-5 · Cited by 17
Can aging research generate a theory of health?
Sholl, J. (2021) · History & Philosophy of the Life Sciences · doi:10.1007/s40656-021-00402-w · Cited by 18
Association between resilience and frailty in older age: Findings from the Helsinki Birth Cohort Study
Stenroth, S. M., Pynnönen, K., Haapanen, M. J., Vuoskoski, P., Mikkola, T. M., Eriksson, J. G., & von Bonsdorff, M. B. (2023) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2023.105119 · Cited by 17
New perspectives on frailty in light of the Global Leadership Initiative on Malnutrition, the Global Leadership Initiative on Sarcopenia, and the WHO's concept of intrinsic capacity: A narrative review
Muñoz-Redondo, E., Morgado-Pérez, A., Pérez‐Sáez, M. J., Pascual, J., Tejero-Sánchez, M., Curbelo, Y. G., Terradellas-Fernández, M., Meza-Valderrama, D., Vázquez‐Ibar, O., Annweiler, C., et al. (2023) · Maturitas · doi:10.1016/j.maturitas.2023.107799 · Cited by 17
Life-space mobility among community-dwelling older persons: A scoping review
Wang, G.-M., Teng, M.-Y., Yu, W.-J., Ren, H. L., & Cui, X.-S. (2023) · Geriatric Nursing · doi:10.1016/j.gerinurse.2023.08.021 · Cited by 17
Investigating Resilience Through Intrinsic Capacity Networks in Older Adults
Koivunen, K., Lindeman, K., Välimaa, M., & Rantanen, T. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae048 · Cited by 18
Worldwide cohort studies to support healthy ageing research: data availabilities and gaps
Khalatbari‐Soltani, S., Si, Y., Dominguez, M., Scott, T., & Blyth, F. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102277 · Cited by 19
The assessment and detection rate of intrinsic capacity deficits among older adults: a systematic review and meta-analysis
Tan, F., Wei, X., Zhang, J., Zhao, Y., Tong, X., Michel, J., Shao, R., & Gong, E. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-05088-w · Cited by 17
Physical frailty, genetic predisposition, and incident arrhythmias
Zhang, Y., Liu, M., Li, J., Ruan, L., Wu, X., Zhang, C., & Chen, L. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13499 · Cited by 17
Own attitude toward aging among nursing home residents: results of the SENIOR cohort
Buckinx, F., Charles, A., Rygaert, X., Reginster, J., Adam, S., & Bruyère, O. (2018) · Aging Clinical and Experimental Research · doi:10.1007/s40520-018-1013-y · Cited by 17
Self-citation
Description of frail older people profiles according to four screening tools applied in primary care settings: a cross sectional analysis
Vergara, I., Mateo‐Abad, M., Saucedo-Figueredo, M. C., Machón, M., Montiel‐Luque, A., Vrotsou, K., del Val, M. A. N., Díez-Ruiz, A., Güell, C., Matheu, A., et al. (2019) · BMC Geriatrics · doi:10.1186/s12877-019-1354-1 · Cited by 19
Evaluating quality of life in frailty: applicability and clinimetric properties of the SarQoL® questionnaire
Geerinck, A., Locquet, M., Bruyère, O., Reginster, J., & Beaudart, C. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12687 · Cited by 17
Self-citation
The relationship between intrinsic capacity and functional ability in older adults
Ahmadi, S., Afshar, P. F., Malakouti, K., & Azadbakht, M. (2025) · BMC Geriatrics · doi:10.1186/s12877-025-05709-y · Cited by 16
The vitality domain of intrinsic capacity: A scoping review of conceptual frameworks and measurements
Chew, J. L., Lee, J., Hernandez, H. H. C., Munro, Y. L., Lim, C. L., & Lim, W. S. (2025) · The Journal of Frailty & Aging · doi:10.1016/j.tjfa.2025.100058 · Cited by 16
Frailty and intrinsic capacity: integrating complementary concepts to promote healthy ageing and transformation of care
Cesari, M., Canevelli, M., Thiyagarajan, J. A., Arai, H., Assantachai, P., Chan, P., Chhetri, J. K., Ferriolli, E., Geffen, L., Gregson, C. L., et al. (2026) · Age and Ageing · doi:10.1093/ageing/afag138 · Cited by 21
Self-citation
Validation of the artificial intelligence–based trauma outcomes predictor (TOP) in patients 65 years and older
Hechi, M. W. E., Gebran, A., Bouardi, H. T., Maurer, L. R., Moheb, M. N. E., Zhuo, Y. D., Dunn, J., Bertsimas, D., Velmahos, G. C., & Kaafarani, H. M. A. (2021) · Surgery · doi:10.1016/j.surg.2021.11.016 · Cited by 19
Association of pre-stroke frailty and health-related factors with post-stroke functional independence among community-dwelling Chinese older adults
Zhang, Q., Xi, G., Huang, J., Xie, Q., & Zhang, Y. (2023) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2023.107130 · Cited by 16
Measures of attributes of locomotor capacity in older people: a systematic literature review following the COSMIN methodology
Honvo, G., Sabico, S., Veronese, N., Bruyère, O., Rizzoli, R., Thiyagarajan, J. A., Mikton, C., Diaz, T., Cooper, C. C., & Reginster, J. (2023) · Age and Ageing · doi:10.1093/ageing/afad139 · Cited by 21
Self-citation
Healthy aging trajectories and their predictors among Chinese older adults: Evidence from a 7-year nationwide prospective cohort study
Wang, X., Xie, J., Shang, M., Yin, P., & Gu, J. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105331 · Cited by 16
Psychometric Properties of Instruments Assessing Intrinsic Capacity: A Systematic Review
Chen, Y., Kukreti, S., Yang, H.-L., Liu, C.-C., Yeh, Y., Fung, X. C. C., Liu, C.-H., Liu, L., Griffiths, M. D., Yang, Y., et al. (2023) · Asian Journal of Social Health and Behavior · doi:10.4103/shb.shb_343_23 · Cited by 16
Obesity paradox of cardiovascular mortality in older adults in the United States: A cohort study using 1997–2018 National Health Interview Survey data linked with the National Death Index
Chen, Y., Koirala, B., Ji, M., Commodore-Mensah, Y. Y., Himmelfarb, C. D., Perrin, N., & Wu, Y. (2024) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2024.104766 · Cited by 19
Peak oxygen uptake, six-minute walk distance, six-meter walk speed, and pulse pressure as predictors of seven year all-cause and cardiovascular mortality in community-living older adults
Woo, J., Yau, F. C., Leung, J. C. S., & Chan, R. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110645 · Cited by 16
Risk factors for sarcopenia in community setting across the life course: A systematic review and a meta-analysis of longitudinal studies
Gao, Y., Huang, Y., An, R., Yang, Y., Chen, X., & Wan, Q. (2025) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2025.105807 · Cited by 16
Advancing Geroscience Research – A Scoping Review of Regulatory Environments for Gerotherapeutics
Muscedere, J., Shorey, C., Duque, G., Kim, P., Lorbergs, A. L., McGlory, C., Merchant, R. A., Newman, J. C., Rolland, Y., & Vellas, B. J. (2025) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2025.100637 · Cited by 15
Self-citation
Patterns of the physical, cognitive, and mental health status of older individuals in a real-life primary care setting and differences in coping styles
Wittlinger, T., Bekić, S., Guljaš, S., Periša, V., Volarić, M., & Majnarić, L. T. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.989814 · Cited by 15
Longitudinal change of intrinsic capacity and associated factors in older Chinese adults: China Health and Retirement Longitudinal Study
Yang, F., Su, Q., Ran, Q., & Hu, Y. (2024) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2024.100214 · Cited by 18
Dietary patterns and intrinsic capacity in older adults: a 6-year prospective cohort study
Kim, J. H., Lee, Y., Kim, M., Won, C. W., Kim, M. K., & Shim, J. (2024) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2024.100314 · Cited by 18
The correlation between frailty trajectories and adverse outcomes in older patients: A systematic review
Zhang, W., Zhou, L., Zhou, Y., Chen, Y., She, K., Zhang, H., Gao, Y., Jiang, D., & Yin, X. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105622 · Cited by 15
Cross-sectional and longitudinal associations between physical activity and intrinsic capacity in healthy older adults from the MAPT study
Raffin, J., Fourteau, M., Giudici, K. V., Rolland, Y., Vellas, B. J., & Barreto, P. D. S. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105724 · Cited by 15
Self-citation
“We can’t carry the weight of the whole world”: illness experiences among Peruvian older adults with symptoms of depression and anxiety
Flores-Flores, O., Zevallos-Morales, A., Carrión, I. V., Pawer, D., Rey, L., Checkley, W., Hurst, J. R., Siddharthan, T., Parodi, J. F., Gallo, J. J., et al. (2020) · International Journal of Mental Health Systems · doi:10.1186/s13033-020-00381-8 · Cited by 15
Physical activity's impact on rural older adult health: The multiple mediating effects of education, income, and psychological capital
Sun, Y. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1173217 · Cited by 17
Intrinsic Capacity as a Composite Outcome Measure: Opportunities and Challenges
Beard, J., & Chen, M. (2023) · The journal of nutrition health & aging · doi:10.1007/s12603-023-1923-z · Cited by 14
Self-citation
Digging into the intrinsic capacity concept: Can it be applied to Alzheimer’s disease?
López‐Ortiz, S., Caruso, G., Emanuele, E., Menéndez, H., Peñín‐Grandes, S., Guerrera, C. S., Caraci, F., Nisticò, R., Lucía, A., Santos‐Lozano, A., et al. (2024) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2024.102574 · Cited by 14
Association between intrinsic capacity and oral health in older patients in a frailty clinic
Miyahara, S., Maeda, K., Kawamura, K., Matsui, Y., Satake, S., Arai, H., & Umegaki, H. (2024) · European Geriatric Medicine · doi:10.1007/s41999-024-00956-5 · Cited by 14
Neutrophil-to-lymphocyte ratio and lymphocyte count as an alternative to body mass index for screening malnutrition in older adults living in the community
Borda, M. G., Salazar‐Londoño, S., Sanchis, P. L., Baldera, J. P., Venegas‐Sanabria, L. C., Tarazona‐Santabalbina, F. J., Aarsland, D., Martin-Marco, A., & Pérez‐Zepeda, M. U. (2024) · European Journal of Nutrition · doi:10.1007/s00394-024-03392-0 · Cited by 14
Trajectories of intrinsic capacity decline and related factors in old persons: A 15-year community-based cohort study in Beijing
Li, Y., Zhang, T., Li, M., Shen, R., Wang, X., Zhuo, C., Wang, Y., Yan, F., Liu, Z., & Huang, Y. (2025) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2025.100526 · Cited by 14
Combating frailty and sarcopenia in aging populations: Switching to a more positive paradigm
Woo, J. (2019) · Aging Medicine · doi:10.1002/agm2.12052 · Cited by 14
The plasticity of ageing and the rediscovery of ground-state prevention
Blasimme, A. (2021) · History & Philosophy of the Life Sciences · doi:10.1007/s40656-021-00414-6 · Cited by 18
Using real-world accelerometry-derived diurnal patterns of physical activity to evaluate disability in multiple sclerosis
Keller, J. L., Tian, F., Fitzgerald, K. C., Mische, L., Ritter, J., Costello, M. G., Mowry, E. M., Zippunikov, V., & Zackowski, K. M. (2022) · Journal of Rehabilitation and Assistive Technologies Engineering · doi:10.1177/20556683211067362 · Cited by 14
Associations Between Multidomain Lifestyle Interventions and Intrinsic Capacity Domains During Aging: A Narrative Review
Fourteau, M., Giudici, K. V., Rolland, Y., Vellas, B. J., & Barreto, P. D. S. (2020) · Journal of Aging Research and Lifestyle · doi:10.14283/jarlife.2020.6 · Cited by 13
Self-citation
Evaluating the design of the Integrated Care for Older People: a theory of change approach
Barreto, S. E. G., Tinoco, E., Rojas-Calixto, O., Deniss-Navarro, Z., Avila-Avila, A., & Gutiérrez, J. P. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1166196 · Cited by 13
Intrinsic capacity and risk of death: Focus on the impact of using different diagnostic criteria for the nutritional domain
Sánchez‐Rodríguez, D., Demonceau, C., Bruyère, O., Cavalier, E., Reginster, J., & Beaudart, C. (2023) · Maturitas · doi:10.1016/j.maturitas.2023.107817 · Cited by 13
Self-citation
The development of intrinsic capacity measures for longitudinal research: The Longitudinal Aging Study Amsterdam
Qi, Y., Schaap, L. S., Schalet, B. D., Hoogendijk, E. O., Deeg, D. J. H., Visser, M., Koivunen, K., Huisman, M. A., & van Schoor, N. M. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112599 · Cited by 16
Health profile of older adults assisted by the Elderly Caregiver Program of Health Care Network of the City of São Paulo
de Andrade, S. C. V., Marcucci, R. M. B., Faria, L. D. F. C., Paschoal, S. M. P., Rebustini, F., & de Melo, R. C. (2020) · Einstein (São Paulo) · doi:10.31744/einstein_journal/2020ao5256 · Cited by 13
Challenges of promoting healthy aging and healthy longevity in the communities
Chen, L. (2022) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2022.104624 · Cited by 13
PLAN: Preparing and Living for Aging Now; A descriptive study investigating older adults' readiness to plan for aging and frailty
Frechman, E., Dietrich, M. S., Buck, H. G., Rhoten, B. A., & Maxwell, C. A. (2022) · Geriatric Nursing · doi:10.1016/j.gerinurse.2022.07.008 · Cited by 14
Muscle Endurance and Self-Perceived Fatigue Predict Decline in Gait Speed and Activities of Daily Living After 1-Year Follow-Up: Results From the BUTTERFLY Study
Knoop, V., Costenoble, A., Debain, A., Bravenboer, B., Jansen, B., Scafoglieri, A., Bautmans, I., Gerontopole Brussels Study Group, Bautmans, I., Verté, D., et al. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac224 · Cited by 13
Evaluating the impact of aerobic and resistance green exercises on the fitness, aerobic and intrinsic capacity of older individuals
Ayaz, E. Y., Dinçer, B., Mete, E., Benli, R. K., Cinbaz, G., Karacan, E., Cankül, A., & Mesçi, B. (2023) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2023.105281 · Cited by 13
Randomized Controlled Trial of Exercise and Nutrition Supplementation on Physical and Cognitive Function in Older Chinese Adults Aged 50 Years and Older
Woo, J., Chan, R., Ong, S., Bragt, M. C. E., Bos, R., Parikh, P., & de Groot, C. P. G. M. (2019) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2019.08.001 · Cited by 13
Development and Validation of the Chinese Frailty Screening Scale: A Study among Community-Dwelling Older Adults in Shanghai
Ye, B., Wang, Y., Chen, H., Chen, Y., Yan, H., Fu, H., Bao, Z., & Gao, J. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191811811 · Cited by 12
Unsuccessful ageing: from frailty to cardiovascular disease
Afilalo, J. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae098 · Cited by 12
Validation of intrinsic capacity and healthy sleep pattern in middle-aged and older adults: a longitudinal Chinese study assessing healthy ageing
Chen, X.-L., Li, J., Sun, S., Zhang, X., Chen, J., Wang, L., Yang, Z.-Q., Ni, S.-H., & Lu, L. (2024) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2024.100365 · Cited by 14
A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial
Fanning, J. T., Rejeski, W. J., Chen, S., Nicklas, B. J., Walkup, M. P., Axtell, R. S., Fielding, R. A., Glynn, N. W., King, A. C., Manini, T. M., et al. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz050 · Cited by 12
Ageing with HIV: health implications and evolving care needs
Ahmad, A., Neelamegam, M., & Rajasuriar, R. (2020) · Journal of the International AIDS Society · doi:10.1002/jia2.25621 · Cited by 12
Towards a core outcome set (COS) for intrinsic capacity (IC) intervention studies in adults in midlife and beyond: a scoping review to identify frequently used outcomes and measurement tools
Sánchez‐Rodríguez, D., Bruyère, O., Surquin, M., Reginster, J., & Beaudart, C. (2024) · Aging Clinical and Experimental Research · doi:10.1007/s40520-023-02681-8 · Cited by 12
Self-citation
Intrinsic capacity and survival among older adults with gastrointestinal malignancies: The Cancer and Aging Resilience Evaluation registry
Maheshwari, S., Dai, C., Giri, S., Harmon, C., Tucker, A., Fowler, M. E., Outlaw, D., & Williams, G. R. (2024) · Cancer · doi:10.1002/cncr.35427 · Cited by 11
The relationship between intrinsic capacity and sarcopenia in middle-aged and older Chinese populations: the mediating influence of a novel nutritional index
Ding, H., Li, C., & Zhao, X. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1605158 · Cited by 11
Functional Limitations among European Older Adults: Cross-Country Differences in Health Improvements and Social Environment Influence
Rueda-Salazar, S., Spijker, J., & Devolder, D. (2022) · The Journal of Frailty & Aging · doi:10.14283/jfa.2022.55 · Cited by 11
Intrinsic capacity transitions predict overall and cause-specific mortality, incident disability, and healthcare utilization
Hwang, A., Chen, L.-Y., Tseng, S., Huang, C.-Y., Yen, K.-H., Chen, L., Lin, M.-H., & Peng, L. (2024) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2024.100359 · Cited by 11
Association of handgrip strength asymmetry and weakness with intrinsic capacity impairment among older adults in China
Li, D., Wang, Y., Guo, S., Ren, Z., Su, B., Zhang, L., Talifu, Z., & Zheng, X. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112656 · Cited by 11
The NESTORE e-Coach: Designing a Multi-Domain Pathway to Well-Being in Older Age
Angelini, L., Kamali, M. E., Mugellini, E., Khaled, O. A., Röcke, C., Porcelli, S., Mastropietro, A., Rizzo, G., Boqué, N., Bas-Prior, J. M. D., et al. (2022) · Technologies · doi:10.3390/technologies10020050 · Cited by 15
PROTOCOL: Health, social care and technological interventions to improve functional ability of older adults: Evidence and gap map
Welch, V. A., Howe, T. E., Marcus, S., Mathew, C. M., Sadana, R., Rogers, M., Sheehy, L., Borg, J., Pottie, K. C., Coon, J. T., et al. (2019) · Campbell Systematic Reviews · doi:10.1002/cl2.1054 · Cited by 11
Cognitive function, daily function and physical and mental health in older adults: A comparison of venue and home-visit community surveys in Metropolitan Tokyo
Sakuma, N., Inagaki, H., Ogawa, M., Edahiro, A., Ura, C., Sugiyama, M., Miyamae, F., Suzuki, H., Watanabe, Y., Shinkai, S., et al. (2021) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2021.104617 · Cited by 11
Normative data for isometric strength of 8 different muscle groups and their usefulness as a predictor of loss of autonomy among physically active nursing home residents: the SENIOR cohort.
Buckinx, F., Croisier, J., Charles, A., Pétermans, J., Reginster, J., Rygaert, X., & Bruyère, O. (2019) · PubMed Central · Cited by 11
Self-citation

Authors: Cesari, M., Araujo de Carvalho, I., Amuthavalli Thiyagarajan, J., Cooper, C., Martin, F. C., Reginster, J.-Y., Vellas, B., & Beard, J. R.
Affiliations: Université Toulouse III - Paul Sabatier (FR)
Department of Ageing and Life Course, World Health Organization, Geneva, Switzerland
MRC Lifecourse Epidemiology Unit (GB)
King's College London (GB)
University of Liège (BE)
World Health Organization (CH)
Corresponding author: Cesari, Matteo
ORCID: Cesari, Matteo
Cooper, Cyrus
Martin, Finbarr C
Reginster, Jean-Yves
Vellas, Bruno
Beard, John R
Venue: The Journals of Gerontology: Series A
Publisher: Oxford University Press (OUP)
Published: 2018-02-02
Volume: 73
Issue: 12
Pages: 1653-1660
ISSN: 1079-5006 (ISSN-L)
1758-535X
DOI: 10.1093/gerona/gly011
OpenAlex: W2791724957
Cited by: 745
References: 81
Citations by year: 2026: 148 · 2025: 113 · 2024: 105 · 2023: 100 · 2022: 83 · 2021: 76 · 2020: 59 · 2019: 48 · 2018: 11
FWCI: 5.47
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: The Journals of Gerontology Series A (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
ORBi (University of Liège) (submittedVersion)
Funders: World Health Organization
National Institute for Health and Care Research (NF-SI-0508-10082, NF-SI-0513-10085)
Medical Research Council (MC_UU_12011/1)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
Keywords: intrinsic capacity, healthy aging, functional capacity, International Classification of Functioning, Disability and Health, locomotion, vitality, cognition, psychological capacity, sensory function, older adults
MeSH terms: Frailty, Healthy Aging, Activities of Daily Living, Aged, Aged, 80 and over, Attitude to Health, Disability Evaluation, Female, Health Services for the Aged, Humans, Male, Models, Biological, Risk Factors, United States, Geriatric Assessment, Needs Assessment, Resilience, Psychological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Evidence for the Domains Supporting the Construct of Intrinsic Capacity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks