The Protective Effect of Melatonin Against Age-Associated, Sarcopenia-Dependent Tubular Aggregate Formation, Lactate Depletion, and Mitochondrial Changes
Open accessAbstract
To gain insight into the mechanism of sarcopenia and the protective effect of melatonin, the gastrocnemius muscles of young (3-4 months), early-aged (12 months), and old-aged (24 months) wild-type C57BL/6J female mice were examined by magnetic resonance and microscopy. Locomotor activity, lactate production, and nuclear apoptosis were also assessed. The results support the early onset of sarcopenia at 12 months of age, with reduction of muscle fiber number, muscle weight/body weight ratio, lactate, and locomotor activity. Lipid droplet infiltration and autophagosomes were also detected. These changes driven little effects on the early-aged muscle, but they got worse in old-aged animals by the progressive damage of the muscle. Old-aged muscle showed a reduction of the mitochondrial number, a destruction of the mitochondrial cristae, and swelling. Tubular aggregates and nucleic acid fragmentation were the most striking findings in old-aged muscle, reflecting a broad damage with loss of autophagy efficacy. Oral melatonin administration conserved the normal muscular architecture, weight, muscle fiber number, and activity in the old age; it stimulated lactate production, prevented mitochondrial damage and tubular aggregates, and reduced the percentage of apoptotic nuclei in aged muscles. Altogether, gastrocnemius muscle showed age-mediated signs of sarcopenia that were reduced by melatonin treatment.
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In mice, elevated lactate decreased the number of apoptotic nuclei in aged muscle and restored mitochondrial function through activation of the CREB-PGC-1α pathway, thereby helping to mitigate sarcopenia.
“In mice, elevated lactate decreased the number of apoptotic nuclei in aged muscle and restored mitochondrial function through the activation of the CREB-PGC-1α pathway, thereby helping to mitigate sarcopenia [117].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [117]
Cites
THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY
Reynolds, E. S. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.1.208 · Cited by 24,938 · see citing works
Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601 · see citing works
Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., Newman, A. B., et al. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1059 · Cited by 3,083 · cited 1× · see citing works
“This phenomenon was widely observed during mammalian aging (3–6), and it can lead to increased morbidity and mortality (7,8).”
Oxidative damage and mitochondrial decay in aging.
Shigenaga, M. K., Hagen, T. M., & Ames, B. N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.10771 · Cited by 2,055 · see citing works
Melatonin as an antioxidant: under promises but over delivers
Reiter, R. J., Mayo, J. C., Tan, D. X., Sainz, R. M., Alatorre-Jiménez, M. A., & Qin, L. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12360 · Cited by 1,741 · see citing works
Newman, A. B., Kupelian, V., Visser, M., Simonsick, E. M., Goodpaster, B. H., Kritchevsky, S. B., Tylavsky, F. A., Rubin, S. M., Harris, T. B., & on Behalf of the Health, A. A. B. C. S. I. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.1.72 · Cited by 1,692 · see citing works
Visser, M., Goodpaster, B. H., Kritchevsky, S. B., Newman, A. B., Nevitt, M., Rubin, S. M., Simonsick, E. M., Harris, T. B., & Study, F. T. H. A. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.3.324 · Cited by 1,403 · see citing works
Mitchell, W. K., Williams, J., Atherton, P., Larvin, M., Lund, J., & Narici, M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00260 · Cited by 1,377 · see citing works
Extrapineal melatonin: sources, regulation, and potential functions
Acuña-Castroviejo, D., Escames, G., Venegas, C., Díaz-Casado, M. E., Lima‐Cabello, E., López, L. C., Rosales‐Corral, S., Tan, D., & Reiter, R. J. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1579-2 · Cited by 1,086 · see citing works
Self-citationHUGHES, V. A., Frontera, W. R., Wood, M., Evans, W. J., Dallal, G. E., Roubenoff, R., & Singh, M. A. F. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.5.b209 · Cited by 924 · see citing works
How Muscle Structure and Composition Influence Meat and Flesh Quality
Listrat, A., Lebret, B., Louveau, I., Astruc, T., Bonnet, M., Lefaucheur, L., Picard, B. B., & Bugeon, J. (2016) · The Scientific World JOURNAL · doi:10.1155/2016/3182746 · Cited by 878 · see citing works
Sarcopenia: characteristics, mechanisms and functional significance
Narici, M. V., & Maffulli, N. (2010) · British Medical Bulletin · doi:10.1093/bmb/ldq008 · Cited by 827 · see citing works
Sarcopenia: etiology, clinical consequences, intervention, and assessment
Lang, T., Streeper, T., Cawthon, P. M., Baldwin, K., Taaffe, D. R., & Harris, T. B. (2009) · Osteoporosis International · doi:10.1007/s00198-009-1059-y · Cited by 780 · see citing works
Roubenoff, R., & HUGHES, V. A. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.12.m716 · Cited by 687 · see citing works
Melatonin: The chemical expression of darkness
Reiter, R. J. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90087-9 · Cited by 634 · see citing works
Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials
Marzetti, E., Calvani, R., Cesari, M., Buford, T. W., Lorenzi, M., Behnke, B. J., & Leeuwenburgh, C. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.024 · Cited by 627 · see citing works
Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations
Venegas, C., García, J. A. G., Escames, G., Ortiz, F., López, A., Doerrier, C., García‐Corzo, L., López, L. C., Reiter, R. J., & Acuña-Castroviejo, D. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00931.x · Cited by 580 · see citing works
Self-citationReview Article: Sarcopenia: Causes, Consequences, and Preventions
Marcell, T. J. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.10.m911 · Cited by 536 · see citing works
A Clinical Frailty Index in Aging Mice: Comparisons With Frailty Index Data in Humans
Whitehead, J. C., Hildebrand, B. A., Sun, M., Rockwood, M. R. H., Rose, R. A., Rockwood, K. J., & Howlett, S. E. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt136 · Cited by 514 · see citing works
Inflammaging: disturbed interplay between autophagy and inflammasomes
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2012) · Aging · doi:10.18632/aging.100444 · Cited by 511 · see citing works
The role of DNA damage and repair in aging through the prism of Koch-like criteria
Moskalev, A. A., Shaposhnikov, M. V., Plyusnina, E. N., Zhavoronkov, A., Budovsky, A., Yanai, H., & Fraifeld, V. E. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.02.001 · Cited by 387 · see citing works
Effects of motor unit losses on strength in older men and women
Doherty, T. J., Vandervoort, A. A., Taylor, A. W., & Brown, W. F. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.74.2.868 · Cited by 379 · see citing works
A modification of Mallory's connective tissue stain with a discussion of the principles involved
Crossmon, G. C. (1937) · The Anatomical Record · doi:10.1002/ar.1090690105 · Cited by 371 · see citing works
Effects of Ageing on the Motor Unit: A Brief Review
Doherty, T. J., Vandervoort, A. A., & Brown, W. F. (1993) · Canadian Journal of Applied Physiology · doi:10.1139/h93-029 · Cited by 359 · see citing works
Genetic Control of Melatonin Synthesis in the Pineal Gland of the Mouse
Ebihara, S., Marks, T. N., Hudson, D. J., & Menaker, M. (1986) · Science · doi:10.1126/science.3941912 · Cited by 354 · see citing works
Martı́n, M., Macías, M. J., Escames, G., León, J., & Acuña-Castroviejo, D. (2000) · The FASEB Journal · doi:10.1096/fj.99-0865fje · Cited by 347 · see citing works
Self-citationVisser, M., & Schaap, L. A. (2011) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2011.03.006 · Cited by 320 · see citing works
Buford, T. W., Anton, S. D., Judge, A. R., Marzetti, E., Wohlgemuth, S. E., Carter, C. S., Leeuwenburgh, C., Pahor, M., & Manini, T. M. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.004 · Cited by 295 · see citing works
Roseboom, P. H., Namboodiri, M. A. A., Zimonjic, D. B., Popescu, N. C., Rodríguez, I. R., Gastel, J. A., & Klein, D. C. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00273-3 · Cited by 295 · see citing works
Reduced oxidative damage in ALS by high‐dose enteral melatonin treatment
Weishaupt, J. H., Bartels, C., Pölking, E., Dietrich, J., Rohde, G., Pöeggeler, B., Mertens, N., Sperling, S., Bohn, M., Huether, G., et al. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00377.x · Cited by 284 · see citing works
López, A., García, J. A., Escames, G., Venegas, C., Ortiz, F., López, L. C., & Acuña-Castroviejo, D. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00647.x · Cited by 277 · see citing works
Self-citationMartı́n, M., Macías, M. J., León, J., Escames, G., Khaldy, H., & Acuña-Castroviejo, D. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00138-8 · Cited by 261 · see citing works
Self-citationGarcía, J. A. G., Volt, H., Venegas, C., Doerrier, C., Escames, G., López, L. C., & Acuña-Castroviejo, D. (2015) · The FASEB Journal · doi:10.1096/fj.15-273656 · Cited by 224 · see citing works
Self-citationA Procedure for Creating a Frailty Index Based on Deficit Accumulation in Aging Mice
Parks, R. J., Fares, E., MacDonald, J. K., Ernst, M. C., Sinal, C. J., Rockwood, K. J., & Howlett, S. E. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr193 · Cited by 194 · see citing works
Escames, G., León, J., Macías, M. J., Khaldy, H., & Acuña-Castroviejo, D. (2003) · The FASEB Journal · doi:10.1096/fj.02-0692fje · Cited by 191 · see citing works
Self-citationMuscle as a consumer of lactate
Gladden, L. B. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200004000-00008 · Cited by 181 · see citing works
Resistance training, sarcopenia, and the mitochondrial theory of aging
Johnston, A. P. W., De Lisio, M., & Parise, G. (2008) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h07-141 · Cited by 174 · see citing works
Galley, H. F., Lowes, D. A., Allen, L., Cameron, G. A., Aucott, L. S., & Webster, N. R. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12134 · Cited by 162 · see citing works
Marzetti, E., Calvani, R., Bernabei, R., & Leeuwenburgh, C. (2011) · Gerontology · doi:10.1159/000330064 · Cited by 159 · see citing works
Clinically Relevant Frailty Index for Mice
Liu, H., Graber, T. G., Ferguson-Stegall, L. M., & Thompson, L. V. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt188 · Cited by 159 · see citing works
Escames, G., López, L. C., Tapias, V., Utrilla, P., Reiter, R., Hitos, A. B., León, J., Rodríguez, M. I., & Acuña-Castroviejo, D. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00281.x · Cited by 158 · see citing works
Self-citationLatt, S. A., Stetten, G., Juergens, L. A., et al. (1975) · Journal of Histochemistry & Cytochemistry · doi:10.1177/23.7.1095650 · Cited by 158 · see citing works
Exercise and melatonin in humans: reciprocal benefits
Escames, G., Öztürk, G., Baño‐Otálora, B., Pozo, M. J., Madrid, J. A., Reiter, R. J., Serrano, E. R., Concepción‐Huertas, M., & Acuña-Castroviejo, D. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00924.x · Cited by 155 · see citing works
Self-citationMelatonin role in the mitochondrial function
Acuña-Castroviejo, D. (2006) · Frontiers in bioscience · doi:10.2741/2116 · Cited by 155 · see citing works
Self-citationVolt, H., García, J. A., Doerrier, C., Díaz-Casado, M. E., Guerra‐Librero, A., López, L. C., Escames, G., Tresguerres, J. A. F., & Acuña-Castroviejo, D. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12303 · Cited by 150 · see citing works
Self-citationImpact of Longevity Interventions on a Validated Mouse Clinical Frailty Index
Kane, A. E., Hilmer, S. N., Boyer, D., Gavin, K., Nines, D., Howlett, S. E., de Cabo, R., & Mitchell, S. J. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu315 · Cited by 144 · see citing works
Sarcopenia—Understanding the Dynamics of Aging Muscle
Roubenoff, R. (2001) · JAMA · doi:10.1001/jama.286.10.1230 · Cited by 135 · see citing works
Khaldy, H., León, J., Escames, G., Bikjdaouene, L., García, J. J., & Acuña-Castroviejo, D. (2002) · Neuroendocrinology · doi:10.1159/000048238 · Cited by 118 · see citing works
Self-citationRodríguez, M. I., Carretero, M., Escames, G., López, L. C., y Aibar, M. D. M., Tan, D., Reiter, R. J., & Acuña-Castroviejo, D. (2006) · Free Radical Research · doi:10.1080/10715760600936359 · Cited by 111 · see citing works
Self-citationMelatonin prevents mitochondrial dysfunction and insulin resistance in rat skeletal muscle
Teodoro, B. G., Baraldi, F. G., Sampaio, I. H., Bomfim, L. H. M., Queiroz, A. L., Passos, M. A., Carneiro, E. M., Alberici, L. C., Gomis, R., Amaral, F. G., et al. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12157 · Cited by 106 · see citing works
Yamada, Y., Yoshida, T., Yokoyama, K., Watanabe, Y., Miyake, M., Yamagata, E., Yamada, M., Kimura, M., & Study, K.-K. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw125 · Cited by 104 · see citing works
Rodríguez, M. I., Escames, G., López, L. C., López, A., García, J. A. G., Ortiz, F., Sánchez, V., Romeu, M., & Acuña-Castroviejo, D. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.04.003 · Cited by 102 · see citing works
Self-citationFeridooni, H. A., Sun, M., Rockwood, K. J., & Howlett, S. E. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu161 · Cited by 88 · see citing works
Tubular aggregates in skeletal muscle: Just a special type of protein aggregates?
Schiaffino, S. (2011) · Neuromuscular Disorders · doi:10.1016/j.nmd.2011.10.005 · Cited by 87 · see citing works
Chevessier, F., Marty, I., Paturneau-Jouas, M., Hantaı̈, D., & Verdière‐Sahuqué, M. (2004) · Neuromuscular Disorders · doi:10.1016/j.nmd.2003.11.007 · Cited by 86 · see citing works
Gómez‐Cabrera, M. C., Garcia-Valles, R., Rodríguez‐Mañas, L., García‐García, F. J., González, G. O., Salvador‐Pascual, A., Tarazona‐Santabalbina, F. J., & Viña, J. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw337 · Cited by 81 · see citing works
Sayed, R. K. A., de Leonardis, E. C., Guerrero-Martinez, J. A., Rahim, I., Mokhtar, D. M., Saleh, A. M., Abdalla, K. E. H., Pozo, M. J., Escames, G., López, L. C., et al. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.07.007 · Cited by 78 · see citing works
Self-citationKovanen, V., Suominen, H., Risteli, J., & Risteli, L. (1988) · Collagen and Related Research · doi:10.1016/s0174-173x(88)80026-8 · Cited by 74 · see citing works
Age-related appearance of tubular aggregates in the skeletal muscle of almost all male inbred mice
Agbulut, O., Destombes, J., Thiesson, D., & Butler-Browne, G. S. (2000) · Histochemistry and Cell Biology · doi:10.1007/s004180000211 · Cited by 72 · see citing works
Figueiredo, P., Ferreira, R. M., Appell, H.-J., & Duarte, J. A. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.4.350 · Cited by 65 · see citing works
Leonardo-Mendonça, R. C., Ocaña-Wilhelmi, J., de Haro, T., Galván, C. D. T., Guerra-Hernández, E. J., Rusanova, I., Fernández‐Ortiz, M., Sayed, R. K. A., Escames, G., & Acuña-Castroviejo, D. (2017) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2016-0677 · Cited by 61 · see citing works
Self-citationEffects of aging on the lateral transmission of force in rat skeletal muscle
Zhang, C., & Gao, Y. (2014) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2014.01.026 · Cited by 60 · see citing works
Yamada, Y., Kemnitz, J. W., Weindruch, R. H., Anderson, R. M., Schoeller, D. A., & Colman, R. J. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx059 · Cited by 59 · see citing works
Skeletal muscle apoptotic response to physical activity: potential mechanisms for protection
Quadrilatero, J., Alway, S. E., & Dupont‐Versteegden, E. E. (2011) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h11-064 · Cited by 52 · see citing works
Long-lived Ames dwarf mouse exhibits increased antioxidant defense in skeletal muscle
Romanick, M. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.02.001 · Cited by 51 · see citing works
Melatonin as a Potential Agent in the Treatment of Sarcopenia
Coto‐Montes, A. M., Boga, J. A., Tan, D., & Reiter, R. J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101771 · Cited by 51 · see citing works
Leonardo-Mendonça, R. C., Martínez-Nicolás, A., Galván, C. D. T., Ocaña-Wilhelmi, J., Rusanova, I., Guerra-Hernández, E. J., Escames, G., & Acuña-Castroviejo, D. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1069830 · Cited by 40 · see citing works
Self-citationLópez, A., Ortiz, F., Doerrier, C., Venegas, C., Fernández‐Ortiz, M., Aranda‐Martínez, P., Díaz-Casado, M. E., Fernández-Gil, B. I., Barriocanal‐Casado, E., Escames, G., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183090 · Cited by 38 · see citing works
Self-citationProgress of Age-Related Changes in Properties of Motor Units in the Gastrocnemius Muscle of Rats
Sugiura, M., & Kanda, K. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00947.2003 · Cited by 32 · see citing works
Masuda, S., Hayashi, T., Egawa, T., & Taguchi, S. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2008.12.003 · Cited by 26 · see citing works
Centrally nucleated fibers (CNFs) compensate the fragility of myofibers in mdx mouse
Narita, S., & Yorifuji, H. (1999) · Neuroreport · doi:10.1097/00001756-199910190-00020 · Cited by 25 · see citing works
Novotová, M., Zahradnı́k, I., Brochier, G., et al. (2002) · European Journal of Cell Biology · doi:10.1078/0171-9335-00230 · Cited by 22 · see citing works
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Wang, J., Jia, D., Zhang, Z., & Wang, D. (2025) · Metabolites · doi:10.3390/metabo15010059 · Cited by 23 · see citing works
- Authors
- Sayed, R. K. A., Fernández-Ortiz, M., Diaz-Casado, M. E., Rusanova, I., Rahim, I., Escames, G., López, L. C., Mokhtar, D. M., & Acuña-Castroviejo, D.
- Affiliations
- Universidad de Granada (ES)
- Instituto de Biotecnología, Centro de Investigación Biomédica, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, Spain
- University of Sciences and Technology Houari Boumediene (DZ)
- Assiut University (EG)
- Venue
- The Journals of Gerontology Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-05-21
- Volume
- 73
- Issue
- 10
- Pages
- 1330-1338
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2793166473
- Cited by
- 45
- References
- 72
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 4 · 2018: 2
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed (publishedVersion)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, other-oa)
- Funders
- Egyptian Cultural Bureau in Madrid
- Egyptian Ministry of Higher Education
- Cultural Affairs and the Missions Sector
- Instituto de Salud Carlos III (RD12/0043/0005, PI13-00981, PI16-00519, CB/10/00238)
- Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía (CTS-101)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sarcopenia, melatonin, aging, gastrocnemius, tubular aggregates, mitochondrial damage, apoptosis, autophagy, lipid droplets, muscle fiber number, locomotor activity, mitochondrial cristae
- MeSH terms
- Aging, Animals, Female, Magnetic Resonance Imaging, Melatonin, Mice, Inbred C57BL, Mitochondria, Muscle, Motor Activity, Muscle, Skeletal, Muscle Fibers, Skeletal, Lactic Acid, Protective Agents, Microscopy, Electron, Transmission, Mice, Sarcopenia
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