The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Immunoreactivity in mammals of two typical plant glyco-epitopes, core alpha(1,3)-fucose and core xylose
Abstract
The presence of nonmammalian core alpha(1,3)-fucose and core xylose glyco-epitopes on glycans N-linked to therapeutic glycoproteins produced in plants has raised the question of their immunogenicity in human therapy. We address this question by studying the distribution of these N-glycans in pea, rice, and maize (which are the crops intended for the production of therapeutic proteins) and by reinvestigating their immunogenicity in rodents. We found that immunization with a model glycoprotein, horseradish peroxidase, elicits in C57BL/6 mice and rats the production of antibodies (Abs) specific for core alpha(1,3)-fucose and core xylose epitopes. Furthermore, we demonstrated that about 50% of nonallergic blood donors contains in their sera Abs specific for core xylose, whereas 25% have Abs against core alpha(1,3)-fucose. These Abs probably result from sensitization to environmental antigens. Although the immunological significance of these data is too speculative at the moment, the presence of such Abs might introduce some limitations to the use of plant-derived biopharmaceutical glycoproteins, such as an accelerated clearance during human therapy.
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Cites
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Galactose-extended glycans of antibodies produced by transgenic plants
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Biosynthesis and Immunolocalization of Lewis a-ContainingN-Glycans in the Plant Cell
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Cited by
The production of recombinant pharmaceutical proteins in plants
Ma, J. K.-C., Drake, P. M. W., & Christou, P. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1177 · Cited by 960
The Role of Protein Glycosylation in Allergy
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Metadata
- Authors
- Bardor, M.
- Venue
- Glycobiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-12-17
- Volume
- 13
- Issue
- 6
- Pages
- 427-434
- ISSN
- 0959-6658 (ISSN-L)
- 1460-2423
- OpenAlex
- W2165832011
- Cited by
- 334
- References
- 21
- FWCI
- 9.55
- Type
- journal article
- Language
- en
- Open access
- closed
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