The DOI matches its Crossref record; 105 of the 106 references it cites were found in a registry or an index.
Structure, biology, evolution, and medical importance of sulfated fucans and galactans
Abstract
Sulfated fucans and galactans are strongly anionic polysaccharides found in marine organisms. Their structures vary among species, but their major features are conserved among phyla. Sulfated fucans are found in marine brown algae and echinoderms, whereas sulfated galactans occur in red and green algae, marine angiosperms, tunicates (ascidians), and sea urchins. Polysaccharides with 3-linked, beta-galactose units are highly conserved in some taxonomic groups of marine organisms and show a strong tendency toward 4-sulfation in algae and marine angiosperms, and 2-sulfation in invertebrates. Marine algae mainly express sulfated polysaccharides with complex, heterogeneous structures, whereas marine invertebrates synthesize sulfated fucans and sulfated galactans with regular repetitive structures. These polysaccharides are structural components of the extracellular matrix. Sulfated fucans and galactans are involved in sea urchin fertilization acting as species-specific inducers of the sperm acrosome reaction. Because of this function the structural evolution of sulfated fucans could be a component in the speciation process. The algal and invertebrate polysaccharides are also potent anticoagulant agents of mammalian blood and represent a potential source of compounds for antithrombotic therapies.
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“This research is necessary for the solution of problems of standardization of preparations on the basis of fucoidans, which have attracted attention as practically nontoxic natural products [25,26,27] with antitumor, immunomodulatory, and other useful properties [24,28,29,30].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [24]
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Algae as nutritional and functional food sources: revisiting our understanding.
Wells, M. L., Potin, P., Craigie, J. S., Raven, J. A., Merchant, S. S., Helliwell, K. E., Smith, A. G., Camire, M. E., & Brawley, S. H. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-016-0974-5 · Cited by 1,562
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Metadata
- Authors
- Pomin, V. H., & Mourao, P. A. S.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- ORCID
- Pomin, V. H
- Venue
- Glycobiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-08-29
- Volume
- 18
- Issue
- 12
- Pages
- 1016-1027
- ISSN
- 0959-6658 (ISSN-L)
- 1460-2423
- OpenAlex
- W2142595031
- Cited by
- 356
- References
- 106
- Citations by year
- 2026: 26 · 2025: 17 · 2024: 13 · 2023: 14 · 2022: 16 · 2021: 11 · 2020: 16 · 2019: 19 · 2018: 29 · 2017: 24 · 2016: 25 · 2015: 30 · 2014: 30 · 2013: 23 · 2012: 24
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Glycobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- sulfated fucans, sulfated galactans, anionic polysaccharides, marine algae, marine invertebrates, extracellular matrix, acrosome reaction, sea urchin fertilization, anticoagulant activity, antithrombotic agents, sulfation patterns, beta-galactose
- MeSH terms
- Phaeophyceae, Animals, Anticoagulants, Galactans, Models, Biological, Phylogeny, Polysaccharides, Sea Urchins, Structure-Activity Relationship, Evolution, Molecular
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