Chemical structures and bioactivities of sulfated polysaccharides from marine algae

Jiao, Guangling; Yu, Guangli; Zhang, Junzeng; Ewart, H. Stephen

doi:10.3390/md9020196

Cited by 1,054Seaweed-derived Bioactive CompoundsPolysaccharides Composition and ApplicationsPolysaccharides and Plant Cell Walls

Chemical structures and bioactivities of sulfated polysaccharides from marine algae

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Jiao, Guangling, Yu, Guangli, Zhang, Junzeng, Ewart, H. Stephen·2011·Marine Drugs

DOI 10.3390/md9020196PMC PMC3093253

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Abstract

Sulfated polysaccharides and their lower molecular weight oligosaccharide derivatives from marine macroalgae have been shown to possess a variety of biological activities. The present paper will review the recent progress in research on the structural chemistry and the bioactivities of these marine algal biomaterials. In particular, it will provide an update on the structural chemistry of the major sulfated polysaccharides synthesized by seaweeds including the galactans (e.g., agarans and carrageenans), ulvans, and fucans. It will then review the recent findings on the anticoagulant/antithrombotic, antiviral, immuno-inflammatory, antilipidemic and antioxidant activities of sulfated polysaccharides and their potential for therapeutic application.

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The monosaccharide composition of FCSPs varies among different species of brown seaweeds.
“the monosaccharide composition of FCSPs varies among different species of brown seaweeds.”
From Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds (2011) · cites this paper as [1]
Section 2.3 (page not provided) says brown-algal fucans differ in structure among species and describes differences in their fucose linkages. It does not establish that their monosaccharide composition—the types or proportions of sugars—varies among species. (LLM, conf=0.82)
Experimental — accuracy not yet measured
In addition to fucose, different types of FCSPs may also contain galactose, mannose, xylose, glucose and/or glucuronic acid-usually in minor amounts.
“in addition to fucose, different types of FCSPs may also contain galactose, mannose, xylose, glucose and/or glucuronic acid—usually in minor amounts [1].”
From Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds (2011) · cites this paper as [1]
Section 2.3 describes fucans as having a fucose backbone and notes that their structures vary. Section 3.2 reports fucogalactan, fucoglucuronomannan and fucoglucuronan, but says these polysaccharide types occurred in minor amounts in a preparation—not that their non-fucose sugars were minor constituents of FCSPs. The cited passages also do not establish glucose as a constituent. (LLM, conf=0.82)
Experimental — accuracy not yet measured
The anticancer properties of fucoidans have been established many times by in vitro and in vivo experiments.
“The anticancer properties of fucoidans have been established many times by in vitro and in vivo experiments [9,12,13,31,32,33].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [12]
Fucoidans from different algal species differ in positions and level of sulfation, molecular mass, and sometimes in structures of main carbohydrate chains.
“As a rule, fucoidans from different algal species differ from each other and vary not only in positions and level of sulfation and molecular mass, but sometimes in the structures of the main carbohydrate chains [12,13].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [12]
Ulvan is a water-soluble cell wall polysaccharide found in green seaweeds such as Ulva and Enteromorpha sp.
“Ulvan is a water-soluble cell wall polysaccharide, which is found in green seaweeds, such as Ulva and Enteromorpha sp.(Jiao et al., 2011).”
From The Enzymatic Conversion of Major Algal and Cyanobacterial Carbohydrates to Bioethanol (2016) · cites this paper as Jiao et al., 2011

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Authors: Jiao, G., Yu, G., Zhang, J., & Ewart, H. S.
Affiliations: Institute for Marine Biosciences (CA)
Ocean University of China (CN)
National Research Council Canada (CA)
Corresponding author: Yu, Guangli
Ewart, H. Stephen
ORCID: Yu, Guangli
Zhang, Junzeng
Venue: Marine Drugs
Publisher: MDPI AG
Published: 2011-02-08
Volume: 9
Issue: 2
Pages: 196-223
ISSN: 1660-3397 (ISSN-L)
DOI: 10.3390/md9020196
PMC: PMC3093253
OpenAlex: W2133582510
Cited by: 1,054
References: 190
Citations by year: 2026: 61 · 2025: 70 · 2024: 67 · 2023: 59 · 2022: 93 · 2021: 92 · 2020: 104 · 2019: 86 · 2018: 73 · 2017: 77 · 2016: 64 · 2015: 56 · 2014: 48 · 2013: 54 · 2012: 36
FWCI: 4.75
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Marine Drugs (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
NPARC (acceptedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (31070724)
China Scholarship Council
Program for Changjiang Scholars and Innovative Research Team in University (IRT0944)
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
Keywords: sulfated polysaccharides, seaweed, seaweed polysaccharides, carrageenan, ulvan, fucan, oligosaccharides, structural chemistry, anticoagulant activity, antithrombotic activity, antiviral activity, anti-inflammatory activity, hypolipidemic activity, antioxidant activity, marine biomaterials
MeSH terms: Polysaccharides, Seaweed, Structure-Activity Relationship, Sulfates

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Chemical structures and bioactivities of sulfated polysaccharides from marine algae

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