The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
Cancer epigenetics
Abstract
The field of cancer epigenetics is evolving rapidly on several fronts. Advances in our understanding of chromatin structure, histone modification, transcriptional activity and DNA methylation have resulted in an increasingly integrated view of epigenetics. In response to these insights, epigenetic therapy is expanding to include combinations of histone deacetylase inhibitors and DNA methyltransferase inhibitors. Zebularine, an orally administerable DNA methyltransferase inhibitor, has been a very promising recent addition to our arsenal of potentially useful drugs for epigenetic therapy. Aberrant DNA methylation patterns provide three powerful diagnostic applications as classification markers, sensitive detection markers, and risk assessment markers. Classification studies continue to increase in marker complexity, now incorporating microarrays, high-throughput bisulfite genomic sequencing and mass spectrometry, as the field moves to human epigenome projects. Sensitive detection technology has expanded from primarily blood-based cancer detection to include applications on a wide diversity of sample sources and is now also making inroads as a molecular risk assessment tool.
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Citations
Cites
2 retracted
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RetractedGene expression profiling predicts clinical outcome of breast cancer
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The fundamental role of epigenetic events in cancer
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Cited by
Epigenetics and the biological definition of gene×environment interactions
Meaney, M. J. (2010) · Child Development · doi:10.1111/j.1467-8624.2009.01381.x · Cited by 1,239
Epigenetics and the environmental regulation of the genome and its function
Zhang, T.-Y., & Meaney, M. J. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163625 · Cited by 565
Epigenetics and human disease: translating basic biology into clinical applications
Rodenhiser, D. (2006) · Canadian Medical Association Journal · doi:10.1503/cmaj.050774 · Cited by 473
Dietary Polyphenols May Affect DNA Methylation
Fang, M., Chen, D., & Yang, C. S. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.1.223s · Cited by 462
Metabolic Shifts in Immunity and Inflammation
Kominsky, D. J., Campbell, E. L., & Colgan, S. P. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903002 · Cited by 416
Metadata
- Authors
- Laird, P. W.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-04-15
- Volume
- 14
- Issue
- suppl_1
- Pages
- R65-R76
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W4211231408
- Cited by
- 398
- References
- 158
- FWCI
- 16.82
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
