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P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder
Open accessAbstract
The P2RX7 gene is located within a region on chromosome 12q24.31 that has been identified as a susceptibility locus for affective disorders by linkage and association studies. P2RX7 is a purinergic ATP-binding calcium channel expressed in neurons as well as in microglial cells in various brain regions. We investigated 29 single nucleotide polymorphisms (SNPs) within the P2RX7 gene and adjacent genes in a sample of 1000 German Caucasian patients suffering from recurrent major depressive disorder (MDD). These were contrasted with diagnosed healthy Caucasian controls from the same population (n=1029). A non-synonymous coding SNP in the P2RX7 gene (rs2230912), previously found to be associated with bipolar disorder, was significantly associated (P=0.0019) with MDD. This polymorphism results in an amino acid exchange in the C-terminal cytosolic domain of the P2RX7 channel protein, suggesting that the observed P2RX7 polymorphism might play a causal role in the development of depression.
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“The polymorphism causes an amino acid exchange from glutamine to arginine at position 460 (Gln460Arg) at long intracellular C-terminal domain of P2X7R, which have been suggested to affect both Ca2+ influx, P2RX7dimerization, and other protein—protein interactions having effects upon P2RX7-mediated signaling [71].”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [71]
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“Lucae et al. (2006) were the first to show the association of the non-synonymous coding single nucleotide polymorphisms (SNP) rs2230912 in the P2X7R gene with MDD [71].”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [71]
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Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988
The Structure of Haplotype Blocks in the Human Genome
Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B., Higgins, J., DeFelice, M., Lochner, A., Faggart, M., et al. (2002) · Science · doi:10.1126/science.1069424 · Cited by 5,863
Genetic Epidemiology of Major Depression: Review and Meta-Analysis
Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1552 · Cited by 3,431
Molecular Physiology of P2X Receptors
North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919
Linkage disequilibrium in finite populations
Hill, W. G., & Robertson, A. (1968) · Theoretical and Applied Genetics · doi:10.1007/bf01245622 · Cited by 2,035
The Cytolytic P 2Z Receptor for Extracellular ATP Identified as a P 2X Receptor (P2X 7 )
Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., & Buell, G. (1996) · Science · doi:10.1126/science.272.5262.735 · Cited by 1,739
A Note on Exact Tests of Hardy-Weinberg Equilibrium
Wigginton, J. E., Cutler, D. J., & Abecasis, G. R. (2005) · The American Journal of Human Genetics · doi:10.1086/429864 · Cited by 1,492
(1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.7.979 · Cited by 1,485 · cited 1×
“Major depressive disorder (MDD) and bipolar disorder (BP) are common psychiatric diseases with lifetime prevalence rates of 16–17% for MDD (1,2) and 1–3.”
BackgroundJACOBI, F., WITTCHEN, H.-U., HÖLTING, C., HÖFLER, M., PFISTER, H., MÜLLER, N., & LIEB, R. (2004) · Psychological Medicine · doi:10.1017/s0033291703001399 · Cited by 1,097
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- Suzuki, 2004, Mechanism of neuroprotection mediated by P2X(7) receptor-activated microglia, J. Pharmacol. Sci., 94, 300P
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Items 201–262 of 262
Candidate region linkage analysis in twins discordant or concordant for depression symptomatology
Christiansen, L., Tan, Q., Kruse, T. A., McGue, M. K., & Christensen, K. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30841 · Cited by 6
Purinergic Signalling in the Central Nervous System
Burnstock, G., & Verkhratsky, A. (2012) · Springer eBooks · doi:10.1007/978-3-642-28863-0_8 · Cited by 6
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Barron, M. L., Werry, E. L., McGregor, I. S., & Kassiou, M. (2013) · Springer eBooks · doi:10.1007/978-3-642-40282-1_31 · Cited by 5
Potential Novel Therapeutics for Bipolar Disorders
Machado‐Vieira, R., Manji, H. K., & Zarate, C. A. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_51 · Cited by 6
P2RX7 Dynamics in CNS Disorders: Molecular Insights and Therapeutic Perspectives
Mithaiwala, A., Thakur, J., & Godad, A. P. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05330-5 · Cited by 4
Emerging neurobiological targets in psychiatric treatment
Zoysa, A. I. D., Govinnage, J., Giorlando, F., Dodd, S., Narayanaswamy, J., & Berk, M. (2026) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2026.112767 · Cited by 4
Kristóf, Z., Szabó, D., Sperlágh, B., Török, D., & Gonda, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104687 · Cited by 5
Role of calcium metabolism in premenstrual syndrome
Bocchieri, E., & Thys‐Jacobs, S. (2008) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.3.5.645 · Cited by 4
Genetic Determinants of Depression
López‐León, S. (2008) · RePub (Erasmus University Rotterdam) · Cited by 4
Exonic variants of the P2RX7 gene in familial multiple sclerosis
Gómez‐Pinedo, U., Torre‐Fuentes, L., Matías‐Guiu, J. A., Pytel, V., Ojeda-Hernández, D. D., Selma-Calvo, B., Montero‐Escribano, P., Vidorreta-Ballesteros, L., & Matías‐Guiu, J. (2025) · Neurología · doi:10.1016/j.nrl.2022.10.001 · Cited by 3
Genetic Analysis of the PI3K/AKT/mTOR Signaling Pathway
Hutz, J. (2010) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7rn35v1 · Cited by 3
Biological Alterations in Depression
Benton, C. S., & Wiltshire, T. (2011) · InTech eBooks · doi:10.5772/27658 · Cited by 3
The neuronal transporter gene SLC6A15 confers risk to major depression
Lucae, S., Kohli, M. A., Schmidt, M., Sämann, P., Demirkan, A., Hek, K., Salyakina, D., Ripke, S., Roeske, D., van Duijn, C. M., et al. (2009) · Pharmacopsychiatry · doi:10.1055/s-0029-1240169 · Cited by 3
Saba, R., & Booth, S. A. (2013) · Future Neurology · doi:10.2217/fnl.13.25 · Cited by 3
Refojo, D., & Deussing, J. M. (2011) · Frontiers in neuroscience · doi:10.1201/b11232-2 · Cited by 3
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Zannas, A. S., Jia, M., Hafner, K., Baumert, J. J., Wiechmann, T., Pape, J. C., Arloth, J., Ködel, M., Martinelli, S., Roitman, M., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/484709 · Cited by 3
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Neuroinflammation in Mood Disorders
Hopper, A. T., JONES, K. A., Campbell, B. M., & Li, G. (2013) · Annual reports in medicinal chemistry · doi:10.1016/b978-0-12-417150-3.00020-x · Cited by 2
Holsboer‐Trachsler, E., & Holsboer, F. (2011) · Springer eBooks · doi:10.1007/978-3-642-19844-1_53 · Cited by 2
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Utge, S. (2012) · Työväentutkimus Vuosikirja · Cited by 2
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Holsboer, F. (2008) · Springer eBooks · doi:10.1007/978-3-540-68748-1_9 · Cited by 2
Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived neurons and astrocytesPreprint
Kesavan, J., Watters, O., Dinkel, K., Hamacher, M., Prehn, J. H. M., Henshall, D. C., & Engel, T. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.28.437391 · Cited by 2
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Nürnberger, J. I. (2012) · Oxford University Press eBooks · doi:10.1093/med/9780199797608.003.0080 · Cited by 1
Yang, D., Zhou, H., Pu, J., Liu, Y., Gui, S., Wang, D., Tao, X., Li, Z., Zhong, X., Wei, T., et al. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01244-0 · Cited by 1
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Lei, C., Liu, Y., Ma, Q., Chen, Z., Kong, Q., Jia, Y., Wang, X., Li, X., Xue, Z., & Chen, J. (2023) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2023.100284 · Cited by 1
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Machado‐Vieira, R., Henter, I. D., Baumann, J., Latov, D. R., Wheeler‐Castillo, C., & Zarate, C. A. (2011) · Wiley eBooks · doi:10.1002/9780470975114.ch21 · Cited by 1
Domingos, L. B. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2020.tde-19082020-223048 · Cited by 1
Vater, M., Rost, N., Eckstein, G., Sauer, S., Tontsch, A., Erhardt, A., Lucae, S., Brückl, T. M., Klopstock, T., Sämann, P. G., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.22.595390 · Cited by 1
Genetics Behind Mood Disorders - Candidate Gene Studies of Bipolar and Major Depressive Disorders
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Neurobiologic Foundations of Mood Disorders
Polan, H. J., Duman, R. S., & Schatzberg, A. F. (2015) · Wiley eBooks · doi:10.1002/9781118753378.ch21
Novel Therapeutic Strategies for Bipolar Disorder
Machado‐Vieira, R., Manji, H. K., & Zarate, C. A. (2010) · Wiley eBooks · doi:10.1002/9780470661277.ch30
Pharmacogenetics of Antidepressant Drugs
Fabbri, C., Minarini, A., Matsumoto, Y., & Serretti, A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-386882-4.00026-8
Välimäki, E. (2015) · Työväentutkimus Vuosikirja
Exploring the biological basis of affective disorders
Mazin, W., & Mosekilde, E. (2008)
NEW THERAPEUTIC TARGETS FOR BIPOLAR DISORDER
Carvalho, A. F. (2014) · Debates em Psiquiatria · doi:10.25118/2236-918x-4-2-3
Ribeiro, D. E., Müller, H. K., Elfving, B., Joca, S. R. L., & Wegener, G. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/395194
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Carvalho, A. F. (2014) · Debates em Psiquiatria · doi:10.25118/2763-9037.2014.v4.247
Holsboer‐Trachsler, E., & Holsboer, F. (2008) · Springer eBooks · doi:10.1007/978-3-540-68748-1_28
Meyer‐Lindenberg, A., & Tost, H. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.12847956.14199062
Apter, A. S., & Kronenberg, S. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.2281957.1903055
Miyata, T. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737807033.793574103
Roncalho, A. L. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2022.tde-12072022-152441
Exonic variants of the P2RX7 gene in familial multiple sclerosis
Gómez‐Pinedo, U., Torre‐Fuentes, L., Matías‐Guiu, J. A., Pytel, V., Ojeda-Hernández, D. D., Selma-Calvo, B., Montero‐Escribano, P., Vidorreta-Ballesteros, L., & Matías‐Guiu, J. (2022) · Neurología (English Edition) · doi:10.1016/j.nrleng.2022.12.001
Martinetz, S. (2014) · University of Regensburg Publication Server (University of Regensburg) · doi:10.5283/epub.30767
Quast, C. (2014) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.16546
Zhu, L., Mao, Q., Luo, Z., Chen, B., ZHANG, Y., Lu, X., Liu, P., Ji, J., Wang, X., Wang, K., et al. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121327
Extracellular ATP in psychiatric disorders
von Mücke-Heim, I.-A., & Deussing, J. M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30250-3.00015-1
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Zhu, Y., Liao, L., Liu, X., Sheng, H., Sun, D., Li, J., Chen, Q., Zhang, C., Wang, S., Zhang, Y., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03584-6
ATP and major affective disorders: the involvement of P2X receptors in pathophysiology
Mattova, S., Šimko, P., Colzi, E., Štammová, E., Urbanská, N., Grigoroiu‐Serbânescu, M., Coppi, E., & Kisková, T. (2026) · Purinergic Signalling · doi:10.1007/s11302-026-10147-5
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Sunzeri, F. (2026) · Springer eBooks · doi:10.1007/978-3-032-14465-2_3
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Grätz, V. (2013) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3768
Metadata
- Authors
- Lucae, S., Salyakina, D., Barden, N., Harvey, M., Gagné, B., Labbé, M., Binder, E. B., Uhr, M., Paez-Pereda, M., Sillaber, I., Ising, M., Brückl, T., Lieb, R., Holsboer, F., & Müller-Myhsok, B.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Centre hospitalier de l'Université Laval (CA)
- Corresponding author
- Müller-Myhsok, Bertram
- ORCID
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-07-05
- Volume
- 15
- Issue
- 16
- Pages
- 2438-2445
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2172099127
- Cited by
- 261
- References
- 49
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 4 · 2023: 10 · 2022: 10 · 2021: 12 · 2020: 8 · 2019: 6 · 2018: 15 · 2017: 9 · 2016: 10 · 2015: 16 · 2014: 17 · 2013: 18 · 2012: 23
- FWCI
- 9.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Human Molecular Genetics (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Funders
- Bundesministerium für Bildung und Forschung (01GS0481)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- P2X7 receptor, major depressive disorder, single nucleotide polymorphisms, genetic susceptibility, microglia, bipolar disorder, non-synonymous variants
- MeSH terms
- Adult, Major Depressive Disorder, Female, Gene Frequency, Genotype, Haplotypes, Humans, Genetic Linkage, Male, Middle Aged, Phenotype, Recurrence, Linkage Disequilibrium, Logistic Models, Case-Control Studies, Age of Onset, Receptors, Purinergic P2, Polymorphism, Single Nucleotide, Receptors, Purinergic P2X7
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