Associations between depression severity and purinergic receptor P2RX7 gene polymorphisms
Abstract
Background Major depressive disorder (MDD) and bipolar disorder (BPD) have significant genetic predisposition. The P2RX7 gene (coding for P2X7 purinergic receptor) has been suggested as a susceptibility gene for both MDD and BPD. In the current study the genetic effects of rs2230912 (Gln460Arg) and rs1653625 (located in the 3' untranslated region of the P2RX7 gene) were explored in mood disorders.Methods Genotype frequencies were established in 315 patients (195 with MDD and 120 with BPD diagnosis) and in 373 controls. Depression severity was assessed by the clinician-rated Montgomery-Åsberg Depression Rating Scale (MADRS) and by the self-report Hospital Anxiety and Depression Scale (HADS).Results In the case-control analysis we did not find any significant differences between genotype frequencies of either BPD or MDD cases and controls. However, BPD patients carrying at least one rs2230912G-allele scored higher on both MADRS and HADS-depression scale (nominal p-value was 0.028 and 0.003, respectively). The rs1653625AA genotype was also associated with higher depression scores in the BPD group (nominal p-value of MADRS: 0.019, HADS-depression: 0.017). After correction for multiple testing, the association between rs2230912 and HADS-depression score remained significant in the BPD group (p<0.006); this genetic effect explained 9% of the variance (partial η(2)=0.09). In the MDD group we did not find any significant genetic effect.Limitations The relatively small number of BPD patients warrants for a replication study.Conclusions Our genetic association study supports the association between P2RX7 gene and severity of depressive symptoms in BPD patients.
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The association between the severity of depressive symptoms and polymorphisms in the P2X7R gene was demonstrated in patients diagnosed with bipolar disorder.
“As mentioned, the association between the severity of depressive symptoms and polymorphisms in the P2X7R gene was also demonstrated in patients diagnosed with BD [73].”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [73]
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- Authors
- Halmai, Z., Dome, P., Vereczkei, A., Abdul-Rahman, O., Szekely, A., Gonda, X., Faludi, G., Sasvari-Szekely, M., & Nemoda, Z.
- Affiliations
- Semmelweis University (HU)
- ORCID
- Vereczkei, Andrea
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 150
- Issue
- 1
- Pages
- 104-109
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W1986284223
- Cited by
- 55
- References
- 42
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 3 · 2015: 4 · 2014: 7 · 2013: 1
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- Semmelweis University Repository (Semmelweis University) (submittedVersion)
- Funders
- Magyar Tudományos Akadémia
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- P2X7 receptor, major depressive disorder, bipolar disorder, depression severity, genetic polymorphism, 3' untranslated region, genetic susceptibility, mood disorders
- MeSH terms
- Adult, Bipolar Disorder, Major Depressive Disorder, Female, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Psychiatric Status Rating Scales, Severity of Illness Index, Case-Control Studies, Genetic Predisposition to Disease, Receptors, Purinergic P2X7
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