Neurocognitive Phenotypes and Genetic Dissection of Disorders of Brain and Behavior

Gene Ontology: tool for the unification of biology

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Complex brain networks: graph theoretical analysis of structural and functional systems

Bullmore, E., & Sporns, O. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2575 · Cited by 11,820 · see citing works

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

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Finding the missing heritability of complex diseases

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The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions

Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615 · see citing works

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821 · see citing works

Common SNPs explain a large proportion of the heritability for human height

Yang, J., Benyamin, B., McEvoy, B. P., Gordon, S., Henders, A. K., Nyholt, D. R., Madden, P. A., Heath, A. C., Martin, N. G., Montgomery, G. W., et al. (2010) · Nature Genetics · doi:10.1038/ng.608 · Cited by 4,446 · see citing works

The Alzheimer’s disease neuroimaging initiative (ADNI): MRI methods

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Automatically Parcellating the Human Cerebral Cortex

Fischl, B. R. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg087 · Cited by 4,208 · see citing works

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

Hindorff, L. A., Sethupathy, P., Junkins, H. A., Ramos, E. M., Mehta, J. P., Collins, F. S., & Manolio, T. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903103106 · Cited by 4,013 · see citing works

Biological, clinical and population relevance of 95 loci for blood lipids

Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., et al. (2010) · Nature · doi:10.1038/nature09270 · Cited by 3,487 · see citing works

Genetic Dissection of Complex Traits

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Beyond diathesis stress: differential susceptibility to environmental influences

Belsky, J., & Pluess, M. (2009) · Psychological Bulletin · doi:10.1037/a0017376 · Cited by 3,039 · see citing works

Toward discovery science of human brain function

Biswal, B. B., Mennes, M., Zuo, X.-N., Gohel, S., Kelly, C., Smith, S. M., Beckmann, C. F., Adelstein, J. S., Buckner, R. L., Colcombe, S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911855107 · Cited by 2,970 · see citing works

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

MAGIC, Speliotes, E. K., on behalf of Procardis Consortium, Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., Jackson, A. U., Allen, H. L., Lindgren, C. M., et al. (2010) · Nature Genetics · doi:10.1038/ng.686 · Cited by 2,912 · see citing works

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I. W., Chen, H., Roix, J. J., Kathiresan, S., Hirschhorn, J. N., Daly, M. J., et al. (2007) · Science · doi:10.1126/science.1142358 · Cited by 2,843 · see citing works

Alzheimer's Disease Neuroimaging Initiative (ADNI)

Petersen, R. C., Aisen, P. S., Beckett, L. A., Donohue, M. C., Gamst, A. C., Harvey, D. J., Jack, C. R., Jagust, W. J., Shaw, L. M., Toga, A. W., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181cb3e25 · Cited by 2,572 · see citing works

Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4

Ophoff, R. A., Terwindt, G. M., Vergouwe, M. N., van Eijk, R., Oefner, P. J., Hoffman, S. M. G., Lamerdin, J. E., Mohrenweiser, H. W., Bulman, D. E., Ferrari, M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81373-2 · Cited by 2,337 · see citing works

The Structure and Dynamics of Networks

Newman, M., Barabási, A.-Ĺ., & Watts, D. J. (2011) · Princeton University Press eBooks · doi:10.1515/9781400841356 · Cited by 2,310 · see citing works

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166 · see citing works

Open Access Series of Imaging Studies (OASIS): Cross-sectional MRI Data in Young, Middle Aged, Nondemented, and Demented Older Adults

Marcus, D. S., Wang, T. H., Parker, J., Csernansky, J. G., Morris, J. C., & Buckner, R. L. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.9.1498 · Cited by 2,163 · see citing works

Animal models of neuropsychiatric disorders

Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works

Heritability in the genomics era — concepts and misconceptions

Visscher, P. M., Hill, W. G., & Wray, N. R. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2322 · Cited by 1,921 · see citing works

Network modelling methods for FMRI

Smith, S. M., Miller, K. L., Salimi-Khorshidi, G., Webster, M., Beckmann, C. F., Nichols, T. E., Ramsey, J. D., & Woolrich, M. W. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.063 · Cited by 1,878 · see citing works

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., et al. (2010) · Nature · doi:10.1038/nature09253 · Cited by 1,525 · see citing works

The Structure and Dynamics of Networks

Boguñá, M. (2007) · Journal of Statistical Physics · doi:10.1007/s10955-006-9267-8 · Cited by 1,507 · see citing works

Why Most Discovered True Associations Are Inflated

Ioannidis, J. P. A. (2008) · Epidemiology · doi:10.1097/ede.0b013e31818131e7 · Cited by 1,495 · see citing works

Replicating genotype–phenotype associations

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Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS

Nicolae, D. L., Gamazon, E., Zhang, W., Duan, S., Dolan, M. E., & Cox, N. J. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000888 · Cited by 1,292 · see citing works

Understanding mechanisms underlying human gene expression variation with RNA sequencing

Pickrell, J. K., Marioni, J. C., Pai, A. A., Degner, J. F., Engelhardt, B. E., Nkadori, E., Veyrieras, J.-B., Stephens, M., Gilad, Y., & Pritchard, J. K. (2010) · Nature · doi:10.1038/nature08872 · Cited by 1,256 · see citing works

Development of distinct control networks through segregation and integration

Fair, D. A., Dosenbach, N. U. F., Church, J. A., Cohen, A. L., Brahmbhatt, S., Miezin, F. M., Barch, D. M., Raichle, M. E., Petersen, S. E., & Schlaggar, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705843104 · Cited by 1,244 · see citing works

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene–disease associations

Denny, J. C., Ritchie, M. D., Basford, M. A., Pulley, J. M., Bastarache, L., Brown-Gentry, K., Wang, D., Masys, D. R., Roden, D. M., & Crawford, D. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq126 · Cited by 1,219 · see citing works

Genome-wide association study identifies eight loci associated with blood pressure

Wellcome Trust Case Control Consortium, Newton-Cheh, C., Johnson, T., Gateva, V., Tobin, M. D., Bochud, M., Coin, L., Najjar, S. S., Zhao, J. H., Heath, S. C., et al. (2009) · Nature Genetics · doi:10.1038/ng.361 · Cited by 1,215 · see citing works

Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies

Winkler, A. M., Kochunov, P., Blangero, J., Almasy, L., Zilles, K., Fox, P. T., Duggirala, R., & Glahn, D. C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.028 · Cited by 1,172 · see citing works

The NCBI dbGaP database of genotypes and phenotypes

Mailman, M., Feolo, M., Jin, Y., Kimura, M., Tryka, K., Bagoutdinov, R., Hao, L., Kiang, A., Paschall, J., Phan, L., et al. (2007) · Nature Genetics · doi:10.1038/ng1007-1181 · Cited by 1,122 · see citing works

Candidate-gene approaches for studying complex genetic traits: practical considerations

Tabor, H. K., Risch, N. J., & Myers, R. M. (2002) · Nature Reviews Genetics · doi:10.1038/nrg796 · Cited by 1,076 · see citing works

Genetic influences on brain structure

Thompson, P. M., Cannon, T. D., Narr, K. L., van Erp, T. G. M., Poutanen, V.-P., HUTTUNEN, M. O., Lönnqvist, J. K., Standertskjöld-Nordenstam, C.-G., Kaprio, J. A., Khaledy, M., et al. (2001) · Nature Neuroscience · doi:10.1038/nn758 · Cited by 1,033 · see citing works

Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia

Reiman, E. M., Chen, K., Alexander, G. E., Caselli, R. J., Bandy, D., Osborne, D., Saunders, A. M., & Hardy, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2635903100 · Cited by 977 · see citing works

Temperament and developmental psychopathology

Nigg, J. T. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01612.x · Cited by 971 · see citing works

Heritability of the Big Five Personality Dimensions and Their Facets: A Twin Study

Jang, K. L., Livesley, W. J., & Vemon, P. A. (1996) · Journal of Personality · doi:10.1111/j.1467-6494.1996.tb00522.x · Cited by 939 · see citing works

Working memory, attention control, and the N-back task: a question of construct validity

Kane, M. J., Conway, A. R. A., Miura, T. K., & Colflesh, G. J. H. (2007) · Journal of Experimental Psychology: Learning, Memory, and Cognition · doi:10.1037/0278-7393.33.3.615 · Cited by 933 · see citing works

The Resting Brain: Unconstrained yet Reliable

Shehzad, Z. E., Kelly, C. A. M., Reiss, P. T., Gee, D. G., Gotimer, K., Uddin, L. Q., Lee, S. H., Margulies, D. S., Roy, A. K., Biswal, B. B., et al. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn256 · Cited by 913 · see citing works

Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs

Saccone, S. F., Hinrichs, A. L., Saccone, N. L., Chase, G. A., Konvicka, K., Madden, P. A. F., Breslau, N., Johnson, E. O., Hatsukami, D., Pomerleau, O., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddl438 · Cited by 850 · see citing works

Molecular networks as sensors and drivers of common human diseases

Schadt, E. E. (2009) · Nature · doi:10.1038/nature08454 · Cited by 806 · see citing works

Functional organization of the transcriptome in human brain

Oldham, M. C., Konopka, G., Iwamoto, K., Langfelder, P., Kato, T., Horvath, S., & Geschwind, D. H. (2008) · Nature Neuroscience · doi:10.1038/nn.2207 · Cited by 752 · see citing works

Mapping determinants of human gene expression by regional and genome-wide association

Cheung, V. G., Spielman, R. S., Ewens, K. G., Weber, T. M., Morley, M. P., & Burdick, J. T. (2005) · Nature · doi:10.1038/nature04244 · Cited by 588 · see citing works

Defining functional areas in individual human brains using resting functional connectivity MRI

Cohen, A. L., Fair, D. A., Dosenbach, N. U. F., Miezin, F. M., Dierker, D., Van Essen, D. C., Schlaggar, B. L., & Petersen, S. E. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.01.066 · Cited by 582 · see citing works

How reliable are the results from functional magnetic resonance imaging?

Bennett, C. M., & Miller, M. B. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05446.x · Cited by 579 · see citing works

Conservation and evolution of gene coexpression networks in human and chimpanzee brains

Oldham, M. C., Horvath, S., & Geschwind, D. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605938103 · Cited by 566 · see citing works

Natural variation in human gene expression assessed in lymphoblastoid cells

Cheung, V. G., Conlin, L. K., Weber, T. M., Arcaro, M., Jen, K., Morley, M. P., & Spielman, R. S. (2003) · Nature Genetics · doi:10.1038/ng1094 · Cited by 550 · see citing works

Big correlations in little studies: Inflated fMRI correlations reflect low statistical power – Commentary on Vul et al. (2009)

Yarkoni, T. (2009) · Perspectives on Psychological Science · doi:10.1111/j.1745-6924.2009.01127.x · Cited by 549 · see citing works

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2

Walters, R. G., Jacquemont, S., Valsesia, A., de Smith, A. J., Martinet, D., Andersson, J., Falchi, M., Chen, F., Andrieux, J., Lobbens, S., et al. (2010) · Nature · doi:10.1038/nature08727 · Cited by 543 · see citing works

Towards a network theory of cognition

McIntosh, A. R. (2000) · Neural Networks · doi:10.1016/s0893-6080(00)00059-9 · Cited by 500 · see citing works

A survey of genetic human cortical gene expression

Myers, A. J., Gibbs, J. R., Webster, J. A., Rohrer, K., Zhao, A., Marlowe, L., Kaleem, M., Leung, D., Bryden, L., Nath, P., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.16 · Cited by 479 · see citing works

Genomewide Association Studies: History, Rationale, and Prospects for Psychiatric Disorders

Psychiatric GWAS Consortium Coordinating Committee (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08091354 · Cited by 450 · see citing works

Genetic control over the resting brain

Glahn, D. C., Winkler, A. M., Kochunov, P., Almasy, L., Duggirala, R., Carless, M. A., Curran, J. C., Olvera, R. L., Laird, A. R., Smith, S. M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909969107 · Cited by 450 · see citing works

Dissection of genetically complex traits with extremely large pools of yeast segregants

Ehrenreich, I. M., Torabi, N., Jia, Y., Kent, J. D., Martis, S., Shapiro, J. A., Gresham, D., Caudy, A. A., & Kruglyak, L. (2010) · Nature · doi:10.1038/nature08923 · Cited by 438 · see citing works

Genetic influences on human brain structure: A review of brain imaging studies in twins

Peper, J. S., Brouwer, R. M., Boomsma, D. I., Kahn, R. S., & Pol, H. E. H. (2007) · Human Brain Mapping · doi:10.1002/hbm.20398 · Cited by 429 · see citing works

Toward constructing an endophenotype strategy for bipolar disorders

Hasler, G., Drevets, W. C., Gould, T. D., Gottesman, I. I., & Manji, H. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.006 · Cited by 423 · see citing works

Genetics of brain fiber architecture and intellectual performance

Chiang, M.-C., Barysheva, M., Shattuck, D. W., Lee, A. D., Madsen, S. K., Avedissian, C., Klunder, A. D., Toga, A. W., McMahon, K. L., de Zubicaray, G. I., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4184-08.2009 · Cited by 406 · see citing works

Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD

Saccone, N. L., Culverhouse, R. C., Schwantes-An, T.-H., Cannon, D. S., Chen, X., Cichon, S., Giegling, I., Han, S., Han, Y., Keskitalo-Vuokko, K., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001053 · Cited by 395 · see citing works

The Human Phenome Project

Freimer, N., & Sabatti, C. (2003) · Nature Genetics · doi:10.1038/ng0503-15 · Cited by 372 · see citing works

Temperament, Personality and Developmental Psychopathology: A Review Based on the Conceptual Dimensions Underlying Childhood Traits

Pauw, S. S. W. D., & Mervielde, I. (2010) · Child Psychiatry & Human Development · doi:10.1007/s10578-009-0171-8 · Cited by 364 · see citing works

Genetic Inheritance of Gene Expression in Human Cell Lines

Monks, S. A., Leonardson, A. S., Zhu, H., Cundiff, P., Pietrusiak, P., Edwards, S. W., Phillips, J. W., Sachs, A. B., & Schadt, E. E. (2004) · The American Journal of Human Genetics · doi:10.1086/426461 · Cited by 354 · see citing works

Ontologies in biology: design, applications and future challenges

Bard, J., & Rhee, S. Y. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1295 · Cited by 352 · see citing works

Human genetics illuminates the paths to metabolic disease

O’Rahilly, S. (2009) · Nature · doi:10.1038/nature08532 · Cited by 324 · see citing works

Genetic Control of Human Brain Transcript Expression in Alzheimer Disease

Webster, J. A., Gibbs, J. R., Clarke, J., Ray, M., Zhang, W., Holmans, P., Rohrer, K., Zhao, A., Marlowe, L., Kaleem, M., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.03.011 · Cited by 304 · see citing works

Deciphering the Genetic Basis of Alzheimer's Disease

Selkoe, D. J., & Podlisny, M. B. (2002) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.3.022502.103022 · Cited by 293 · see citing works

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks

Yang, X., Deignan, J. L., Qi, H., Zhu, J., Qian, S., Zhong, J., Torosyan, G., Majid, S., Falkard, B., Kleinhanz, R. R., et al. (2009) · Nature Genetics · doi:10.1038/ng.325 · Cited by 288 · see citing works

The neurobiology of individual differences in complex behavioral traits

Hariri, A. R. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135335 · Cited by 273 · see citing works

Neuroimaging endophenotypes: Strategies for finding genes influencing brain structure and function

Glahn, D. C., Thompson, P. M., & Blangero, J. (2007) · Human Brain Mapping · doi:10.1002/hbm.20401 · Cited by 259 · see citing works

GENETIC AND ENVIRONMENTAL INFLUENCES ON HUMAN BEHAVIORAL DIFFERENCES

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Cognitive functions and corticostriatal circuits: insights from Huntington's disease

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Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional–executive network function in Alzheimer’s disease

Wolk, D. A., Dickerson, B. C., Initiative, T. A. D. N., Weiner, M., Aiello, M., Aisen, P., Albert, M. S., Alexander, G., Anderson, H. S., Anderson, K., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001412107 · Cited by 248 · see citing works

The Quantitative Evaluation of Functional Neuroimaging Experiments: The NPAIRS Data Analysis Framework

Strother, S. C., Anderson, J., Hansen, L. K., Kjems, U., Kustra, R., Sidtis, J. J., Frutiger, S. A., Muley, S., LaConte, S. M., & Rottenberg, D. (2002) · NeuroImage · doi:10.1006/nimg.2001.1034 · Cited by 244 · see citing works

Phenomics: the systematic study of phenotypes on a genome-wide scale

Bilder, R. M., Sabb, F. W., Cannon, T. D., London, E. D., Jentsch, J. D., Parker, D. S., Poldrack, R. A., Evans, C. J., & Freimer, N. B. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.01.027 · Cited by 234 · see citing works

SCAN: SNP and copy number annotation

Gamazon, E. R., Zhang, W., Konkashbaev, A. I., Duan, S., Kistner, E. O., Nicolae, D. L., Dolan, M. E., & Cox, N. J. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp644 · Cited by 230 · see citing works

Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriers

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Widespread Evidence for Non-Additive Genetic Variation in Cloninger’s and Eysenck’s Personality Dimensions using a Twin Plus Sibling Design

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Statistical Estimation of Correlated Genome Associations to a Quantitative Trait Network

Kim, S. Y., & Xing, E. P. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000587 · Cited by 218 · see citing works

Analysis of whole genome biomarker expression in blood and brain

Rollins, B. L., Martin, M. V., Morgan, L. Z., & Vawter, M. P. (2010) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31062 · Cited by 217 · see citing works

The quantitative evaluation of functional neuroimaging experiments: The NPAIRS data analysis framework

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Neuroscience in the era of functional genomics and systems biology

Geschwind, D. H., & Konopka, G. (2009) · Nature · doi:10.1038/nature08537 · Cited by 213 · see citing works

Amygdalar and hippocampal substrates of anxious temperament differ in their heritability

Oler, J. A., Fox, A. S., Shelton, S. E., Rogers, J., Dyer, T. D., Davidson, R. J., Shelledy, W., Oakes, T. R., Blangero, J., & Kalin, N. H. (2010) · Nature · doi:10.1038/nature09282 · Cited by 208 · see citing works

Endophenotypes for psychiatric disorders: ready for primetime?

Bearden, C. E., & Freimer, N. B. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.04.004 · Cited by 206 · see citing works

Neurocognitive Endophenotypes for Bipolar Disorder Identified in Multiplex Multigenerational Families

Glahn, D. C., Almasy, L. A., Barguil, M., Hare, E., Peralta, J. M., Kent, J. W., Dassori, A. M., Contreras, J., Pacheco, A., Lanzagorta, N., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.184 · Cited by 202 · see citing works

Mouse Phenome Database

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A genome-wide association study of Cloninger's temperament scales: Implications for the evolutionary genetics of personality

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