Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila
Abstract
Tauopathies, including Alzheimer's disease and fronto-temporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), are a group of neurodegenerative disorders characterized by the presence of intraneuronal filamentous inclusions of aberrantly phosphorylated-tau. Tau is a neuronal microtubule-associated protein involved in microtubule assembly and stabilization. Currently, the molecular mechanisms underlying tau-mediated cellular toxicity remain elusive. To address the determinants of tau neurotoxicity, we first characterized the cellular alterations resulting from the over-expression of a mutant form of human tau associated with FTDP-17 (tau V337M) in Drosophila. We found that the over-expression of tau V337M, in Drosophila larval motor neurons, induced disruption of the microtubular network at presynaptic nerve terminals and changes in neuromuscular junctions morphological features. Secondly, we performed a misexpression screen to identify genetic modifiers of the tau V337M-mediated rough eye phenotype. The screening of 1250 mutant Drosophila lines allowed us to identify several components of the cytoskeleton, and particularly from the actin network, as specific modifiers of tau V337M-induced neurodegeneration. Furthermore, we found that numerous tau modulators identified in our screen were involved in the maintenance of synaptic function. Taken together, these findings suggest that disruption of the microtubule network in presynaptic nerve terminals could constitute early events in the pathological process leading to synaptic dysfunction in tau V337M pathology.
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Inhibition or genetic reduction of GSK-3β ameliorates tau-related deficits.
“many investigators have shown that either inhibition or genetic reduction of GSK-3β ameliorates tau-related deficits (94–99).”
From Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation (2011) · cites this paper as [98]
The References (ref. 13) list a study reporting that GSK-3β inhibition reverses axonal-transport defects and behavioural phenotypes in Drosophila, supporting the inhibition part of the claim. But this paper’s Discussion (p. 565–566) says its screen did not identify GSK-3β modifiers; it does not report that genetic reduction of GSK-3β ameliorates tau-related deficits. (LLM, conf=0.78)
Experimental — accuracy not yet measuredHere we report novel modifiers distinct from those identified in two recent reports that also screened for genetic modifiers of tau-induced neurodegeneration in Drosophila.
“Here we report novel modifiers distinct from those identified in two recent reports that also screened for genetic modifiers of tau-induced neurodegeneration in Drosophila (52,98).”
From Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation (2011) · cites this paper as [98]
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- Authors
- Blard, O., Feuillette, S., Bou, J., Chaumette, B., Frébourg, T., Campion, D., & Lecourtois, M.
- Affiliations
- Inserm (FR)
- Corresponding author
- Lecourtois, Magalie
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-02-19
- Volume
- 16
- Issue
- 5
- Pages
- 555-566
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2112207786
- Cited by
- 110
- References
- 45
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 8 · 2014: 9 · 2013: 9 · 2012: 8
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Molecular Genetics (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Sanofi
- Région Normandie
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- tauopathy, FTDP-17, cytoskeleton, actin networks, presynaptic terminals, neuromuscular junction, synaptic dysfunction, genetic modifiers, rough eye phenotype, Alzheimer's disease
- MeSH terms
- Animals, Cytoskeletal Proteins, Cytoskeleton, Drosophila melanogaster, Eye, Female, Humans, Larva, Male, Methionine, Nerve Degeneration, Neuromuscular Junction, Peptides, Phenotype, Phosphorylation, Valine, tau Proteins, Molecular Chaperones, Mutant Proteins
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