Cited by 191Neuroscience and Neuropharmacology ResearchCellular transport and secretionMicrotubule and mitosis dynamics

Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics

Kneussel, Matthias, Wagner, Wolfgang·2013·Nature Reviews Neuroscience

Abstract

Myosins are a large family of actin-based cytoskeletal motors that use energy derived from ATP hydrolysis to generate movement and force. Myosins of classes II, V and VI have specific pre- and postsynaptic roles that are required for synapse function. They also facilitate several forms of synaptic plasticity. Interestingly, the myosins of these classes differ markedly in important aspects of their molecular mechanisms of function. Accordingly, their major roles at synapses are diverse and include the regulation of actin cytoskeleton dynamics in dendritic spines and powering of synaptic cargo transport.

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Crossref · 10.1038/nrn3445

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195 of 195 references verified0 citation errors · 0 not checkable

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  • The actin cytoskeleton provides tracks for myosin-based transport of various cellular materials in and out of spines, including AMPA-type glutamate receptors.

    “In addition, the actin cytoskeleton provides tracks for myosin-based transport of various cellular materials in and out of spines, including AMPA-type glutamate receptors (Kneussel and Wagner, 2013).”

    From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Kneussel and Wagner, 2013

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Authors
Kneussel, M., & Wagner, W.
Affiliations
University Medical Center Hamburg-Eppendorf (DE)
Corresponding author
  • Kneussel, Matthias
  • Wagner, Wolfgang
Venue
Nature Reviews Neuroscience
Published
2013-03-13
Volume
14
Issue
4
Pages
233-247
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2151002019
Cited by
191
References
195
Citations by year
2026: 8 · 2025: 12 · 2024: 10 · 2023: 10 · 2022: 17 · 2021: 19 · 2020: 20 · 2019: 12 · 2018: 16 · 2017: 15 · 2016: 15 · 2015: 15 · 2014: 14 · 2013: 7
FWCI
1.73
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords
myosin II, myosin V, myosin VI, synapses, membrane transport, actin cytoskeleton dynamics, dendritic spines, synaptic plasticity, ATP hydrolysis
MeSH terms
Animals, Humans, Actin Cytoskeleton, Myosins, Neuronal Plasticity, Neurons, Synapses, Protein Transport, Dendritic Spines

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