Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics
Abstract
Myosins are a large family of actin-based cytoskeletal motors that use energy derived from ATP hydrolysis to generate movement and force. Myosins of classes II, V and VI have specific pre- and postsynaptic roles that are required for synapse function. They also facilitate several forms of synaptic plasticity. Interestingly, the myosins of these classes differ markedly in important aspects of their molecular mechanisms of function. Accordingly, their major roles at synapses are diverse and include the regulation of actin cytoskeleton dynamics in dendritic spines and powering of synaptic cargo transport.
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The actin cytoskeleton provides tracks for myosin-based transport of various cellular materials in and out of spines, including AMPA-type glutamate receptors.
“In addition, the actin cytoskeleton provides tracks for myosin-based transport of various cellular materials in and out of spines, including AMPA-type glutamate receptors (Kneussel and Wagner, 2013).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Kneussel and Wagner, 2013
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- Authors
- Kneussel, M., & Wagner, W.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Kneussel, Matthias
- Wagner, Wolfgang
- Venue
- Nature Reviews Neuroscience
- Published
- 2013-03-13
- Volume
- 14
- Issue
- 4
- Pages
- 233-247
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2151002019
- Cited by
- 191
- References
- 195
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 10 · 2023: 10 · 2022: 17 · 2021: 19 · 2020: 20 · 2019: 12 · 2018: 16 · 2017: 15 · 2016: 15 · 2015: 15 · 2014: 14 · 2013: 7
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- myosin II, myosin V, myosin VI, synapses, membrane transport, actin cytoskeleton dynamics, dendritic spines, synaptic plasticity, ATP hydrolysis
- MeSH terms
- Animals, Humans, Actin Cytoskeleton, Myosins, Neuronal Plasticity, Neurons, Synapses, Protein Transport, Dendritic Spines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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