Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882 · see citing works

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500 · see citing works

Protein aggregation and neurodegenerative disease

Ross, C. A., & Poirier, M. A. (2004) · Nature Medicine · doi:10.1038/nm1066 · Cited by 3,454 · see citing works

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

Sreedharan, J., Blair, I. P., Tripathi, V. B., Hu, X., Vance, C., Rogelj, B., Ackerley, S., Durnall, J. C., Williams, K. L., Buratti, E., et al. (2008) · Science · doi:10.1126/science.1154584 · Cited by 2,630 · see citing works

How to Interpret LC3 Immunoblotting

Mizushima, N., & Yoshimori, T. (2007) · Autophagy · doi:10.4161/auto.4600 · Cited by 2,595 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., Baehrecke, E. H., Bahr, B. A., Ballabio, A., et al. (2008) · Autophagy · doi:10.4161/auto.5338 · Cited by 2,230 · see citing works

Autophagy: from phenomenology to molecular understanding in less than a decade

Klionsky, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2245 · Cited by 1,938 · see citing works

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

Axe, E. L., Walker, S. A., Manifava, M., Chandra, P., Roderick, H. L., Habermann, A., Griffiths, G., & Ktistakis, N. T. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200803137 · Cited by 1,885 · see citing works

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

Yamanaka, K., Chun, S. J., Boillee, S., Fujimori-Tonou, N., Yamashita, H., Gutmann, D. H., Takahashi, R., Misawa, H., & Cleveland, D. W. (2008) · Nature Neuroscience · doi:10.1038/nn2047 · Cited by 1,140 · see citing works

At the acidic edge: emerging functions for lysosomal membrane proteins

Eskelinen, E., Tanaka, Y., & Säftig, P. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00005-9 · Cited by 661 · see citing works

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

Filimonenko, M., Stuffers, S., Raiborg, C., Yamamoto, A., Malerød, L., Fisher, E. M. C., Isaacs, A., Brech, A., Stenmark, H., & Simonsen, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200702115 · Cited by 626 · see citing works

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

Zhang, Y., Xu, Y.-F., Cook, C. N., Gendron, T. F., Roettges, P. S., Link, C. D., Lin, W.-L., Tong, J., Castanedes‐Casey, M., Ash, P. E. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900688106 · Cited by 604 · see citing works

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

Sarkar, S., Ravikumar, B., Floto, R. A., & Rubinsztein, D. C. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.110 · Cited by 578 · see citing works

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

Hetz, C., Thielen, P., Matus, S., Nassif, M., Court, F., Kiffin, R., Martinez, G., Cuervo, A. M., Brown, R. H., & Glimcher, L. H. (2009) · Genes & Development · doi:10.1101/gad.1830709 · Cited by 530 · see citing works

Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J

Chow, C. Y., Zhang, Y., Dowling, J. J., Jin, N., Adamska, M., Shiga, K., Szigeti, K., Shy, M. E., Li, J., Zhang, X., et al. (2007) · Nature · doi:10.1038/nature05876 · Cited by 516 · see citing works

Accumulation of SOD1 Mutants in Postnatal Motoneurons Does Not Cause Motoneuron Pathology or Motoneuron Disease

Lino, M. M., Schneider, C., & Caroni, P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-12-04825.2002 · Cited by 424 · see citing works

Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS

Chow, C. Y., Landers, J. E., Bergren, S. K., Sapp, P. C., Grant, A. E., Jones, J. M., Everett, L., Lenk, G. M., McKenna-Yasek, D. M., Weisman, L. S., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.12.010 · Cited by 407 · see citing works

ALS phenotypes with mutations in <i>CHMP2B</i> (charged multivesicular body protein 2B)

Parkinson, N., Ince, P. G., Smith, M. O., Highley, R., Skibinski, G., Andersen, P. M., Morrison, K. E., Pall, H. S., Hardiman, O., Collinge, J., et al. (2006) · Neurology · doi:10.1212/01.wnl.0000231510.89311.8b · Cited by 395 · see citing works

Restricted Expression of G86R Cu/Zn Superoxide Dismutase in Astrocytes Results in Astrocytosis But Does Not Cause Motoneuron Degeneration

Gong, Y. H., Parsadanian, A. S., Andreeva, A., Snider, W. D., & Elliott, J. L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00660.2000 · Cited by 372 · see citing works

A conserved sorting-associated protein is mutant in chorea-acanthocytosis

Rampoldi, L., Dobson‐Stone, C., Rubio, J. P., Danek, A., Chalmers, R. M., Wood, N. W., Verellen, C., Ferrer, X., Malandrini, A., Fabrizi, G. M., et al. (2001) · Nature Genetics · doi:10.1038/88821 · Cited by 350 · see citing works

ESCRTs and Fab1 Regulate Distinct Steps of Autophagy

Rusten, T. E., Vaccari, T., Lindmo, K., Rodahl, L. M., Nezis, I. P., Sem-Jacobsen, C., Wendler, F., Vincent, J., Brech, A., Bilder, D. H., et al. (2007) · Current Biology · doi:10.1016/j.cub.2007.09.032 · Cited by 332 · see citing works

A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis

Barbeito, L., Pehar, M., Cassina, P., Vargas, M. R., Peluffo, H., Viera, L., Estévez, Á. G., & Beckman, J. S. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.05.003 · Cited by 331 · see citing works

Early endosomes and endosomal coatomer are required for autophagy

Razi, M., Chan, E. Y. W., & Tooze, S. A. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200810098 · Cited by 281 · see citing works

The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport

Rutherford, A. C., Traer, C. J., Wassmer, T., Pattni, K., Bujny, M. V., Carlton, J. G., Stenmark, H., & Cullen, P. J. (2006) · Journal of Cell Science · doi:10.1242/jcs.03153 · Cited by 279 · see citing works

VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P2 in yeast and mouse

Jin, N., Chow, C. Y., Liu, L., Zolov, S. N., Bronson, R. T., Davisson, M. T., Petersen, J. L., Zhang, Y., Park, S., Duex, J. E., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.248 · Cited by 268 · see citing works

Neuron-Specific Expression of Mutant Superoxide Dismutase Is Sufficient to Induce Amyotrophic Lateral Sclerosis in Transgenic Mice

Jaarsma, D., Teuling, E., Haasdijk, E. D., Zeeuw, C. I. D., & Hoogenraad, C. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5258-07.2008 · Cited by 248 · see citing works

PIKfyve Regulation of Endosome‐Linked Pathways

Lartigue, J. D., Polson, H. E. J., Feldman, M. E., Shokat, K. M., Tooze, S. A., Urbé, S., & Clague, M. J. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00915.x · Cited by 243 · see citing works

A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities

Kearney, J. A., Plummer, N. W., Smith, M. R., Kapur, J., Cummins, T., Waxman, S. G., Goldin, A. L., & Meisler, M. H. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00479-6 · Cited by 242 · see citing works

Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice

Zhang, Y., Zolov, S. N., Chow, C. Y., Slutsky, S. G., Richardson, S. C. W., Piper, R. C., Yang, B., Nau, J. J., Westrick, R. J., Morrison, S. J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702275104 · Cited by 234 · see citing works

Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function

Dove, S. K., Dong, K., Kobayashi, T., Williams, F. K., & Michell, R. H. (2009) · Biochemical Journal · doi:10.1042/bj20081950 · Cited by 208 · see citing works

Core Protein Machinery for Mammalian Phosphatidylinositol 3,5-Bisphosphate Synthesis and Turnover That Regulates the Progression of Endosomal Transport

Sbrissa, D., Ikonomov, O. C., Fu, Z., Ijuin, T., Gruenberg, J. E., Takenawa, T., & Shisheva, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611678200 · Cited by 193 · see citing works

SOI1 Encodes a Novel, Conserved Protein That Promotes TGN–Endosomal Cycling of Kex2p and Other Membrane Proteins by Modulating the Function of Two TGN Localization Signals

Brickner, J. H., & Fuller, R. S. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.1.23 · Cited by 171 · see citing works

The Vac14p–Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover

Duex, J. E., Tang, F., & Weisman, L. S. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200512105 · Cited by 158 · see citing works

Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration

Zhang, X., Chow, C. Y., Sahenk, Z., Shy, M. E., Meisler, M. H., & Li, J. (2008) · Brain · doi:10.1093/brain/awn114 · Cited by 136 · see citing works

The Phosphoinositide Kinase PIKfyve/Fab1p Regulates Terminal Lysosome Maturation inCaenorhabditis elegans

Nicot, A.-S., Fares, H., Payrastre, B., Chisholm, A. D., Labouesse, M., & Laporte, J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-12-1120 · Cited by 134 · see citing works

Nutrient Deprivation Induces Neuronal Autophagy and Implicates Reduced Insulin Signaling in Neuroprotective Autophagy Activation

Young, J. E., Martinez, R. A., & Spada, A. R. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806088200 · Cited by 129 · see citing works

TDP-43: an emerging new player in neurodegenerative diseases

Wang, I., Wu, L., & Shen, C. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.09.001 · Cited by 121 · see citing works

Use of p62/SQSTM1 antibodies for neuropathological diagnosis

Kuusisto, E., Kauppinen, T., & Alafuzoff, I. I. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00884.x · Cited by 113 · see citing works

Localized PtdIns 3,5-P2 synthesis to regulate early endosome dynamics and fusion

Ikonomov, O. C., Sbrissa, D., & Shisheva, A. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00019.2006 · Cited by 109 · see citing works

Tau deletion exacerbates the phenotype of Niemann–Pick type C mice and implicates autophagy in pathogenesis

Pacheco, C. D., Elrick, M. J., & Lieberman, A. P. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn423 · Cited by 74 · see citing works

A midlife longevity drug?

Kaeberlein, M. R., & Kennedy, B. K. (2009) · Nature · doi:10.1038/460331a · Cited by 53 · see citing works

Theataxia3Mutation in the N-Terminal Cytoplasmic Domain of Sodium Channel Nav1.6 Disrupts Intracellular Trafficking

Sharkey, L. M., Cheng, X., Drews, V. L., Buchner, D. A., Jones, J. M., Justice, M. J., Waxman, S. G., Dib‐Hajj, S. D., & Meisler, M. H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6026-08.2009 · Cited by 44 · see citing works

The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a

Jones, J. M. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.5.821 · Cited by 30 · see citing works

Amyotrophic lateral sclerosis

Hardiman, O. M., Al‐Chalabi, A., Chiò, A., Corr, E. M., Logroscino, G., Robberecht, W., Shaw, P. J., Simmons, Z., & van den Berg, L. H. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.71 · Cited by 2,191 · see citing works

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

Dong, X., Shen, D., Wang, X., Dawson, T., Li, X., Zhang, Q., Cheng, X., Zhang, Y., Weisman, L. S., Delling, M., et al. (2010) · Nature Communications · doi:10.1038/ncomms1037 · Cited by 637 · see citing works

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

Codogno, P., Mehrpour, M., & Proikas‐Cezanne, T. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3249 · Cited by 545 · see citing works

The different autophagy degradation pathways and neurodegeneration

Fleming, A., Bourdenx, M., Fujimaki, M., Karabiyik, C., Krause, G. J., Lopez, A., Martín‐Segura, A., Puri, C., Scrivo, A., Skidmore, J., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.017 · Cited by 485 · see citing works

Autophagy: A Key Regulator of Homeostasis and Disease: An Overview of Molecular Mechanisms and Modulators

Gómez-Virgilio, L., Silva-Lucero, M.-D.-C., Flores-Morelos, D.-S., Gallardo-Nieto, J., Lopez-Toledo, G., Abarca-Fernandez, A.-M., Zacapala-Gómez, A.-E., Luna-Muñoz, J., Montiel-Sosa, F., Soto-Rojas, L. O., et al. (2022) · Cells · doi:10.3390/cells11152262 · Cited by 431 · see citing works

Autophagosome maturation: An epic journey from the ER to lysosomes

Zhao, Y. G., & Zhang, H. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201810099 · Cited by 362 · see citing works

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

Salminen, A., Kaarniranta, K., Kauppinen, A., Ojala, J. O., Haapasalo, A., Soininen, H. S., & Hiltunen, M. O. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.002 · Cited by 366 · see citing works

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons

Castillo, K., Nassif, M., Valenzuela, V., Rojas, F., Matus, S., Mercado, G., Court, F. A., van Zundert, B., & Hetz, C. A. (2013) · Autophagy · doi:10.4161/auto.25188 · Cited by 338 · see citing works

Autophagosome-Lysosome Fusion

Lőrincz, P., & Juhász, G. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.10.028 · Cited by 328 · see citing works

A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis

Samie, M., Wang, X., Zhang, X., Goschka, A., Li, X., Cheng, X., Gregg, E., Azar, M., Yue, Z., Garrity, A. G., et al. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.08.003 · Cited by 315 · see citing works

Integration of Clearance Mechanisms: The Proteasome and AutophagyPreprint

Wong, E. S. P., & Cuervo, A. M. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a006734 · Cited by 302 · see citing works

The Role of Lipids in the Control of Autophagy

Dall’Armi, C., Devereaux, K. A., & Paolo, G. D. (2013) · Current Biology · doi:10.1016/j.cub.2012.10.041 · Cited by 286 · see citing works

In vivo, Pikfyve generates PI(3,5)P 2 , which serves as both a signaling lipid and the major precursor for PI5P

Zolov, S. N., Bridges, D., Zhang, Y., Lee, W.-W., Riehle, E., Verma, R., Lenk, G. M., Converso‐Baran, K., Weide, T., Albin, R. L., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203106109 · Cited by 235 · see citing works

PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling

Cai, X., Xu, Y., Cheung, A. K., Tomlinson, R., Alcázar-Román, A. R., Murphy, L. O., Billich, A., Zhang, B., Feng, Y., Klumpp, M., et al. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.05.010 · Cited by 225 · see citing works

Phosphatidylinositol 3,5‐bisphosphate: Low abundance, high significance

McCartney, A. J., Zhang, Y., & Weisman, L. S. (2013) · BioEssays · doi:10.1002/bies.201300012 · Cited by 212 · see citing works

Lysosomal size matters

de Araújo, M. E. G., Liebscher, G., Hess, M. W., & Huber, L. A. (2019) · Traffic · doi:10.1111/tra.12714 · Cited by 204 · see citing works

CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis

Genin, E. C., Plutino, M., Bannwarth, S., Villa, E., Barroso, E. C., Roy, M., Ortega-Vila, B., Fragaki, K., Lespinasse, F., Piñero-Martos, E., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201505496 · Cited by 200 · see citing works

The Autophagy Lysosomal Pathway and Neurodegeneration

Finkbeiner, S. (2020) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a033993 · Cited by 196 · see citing works

Phosphoinositide conversion in endocytosis and the endolysosomal system

Wallroth, A., & Haucke, V. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.000629 · Cited by 195 · see citing works

Autophagosome proteins LC3A, LC3B and LC3C have distinct subcellular distribution kinetics and expression in cancer cell lines.

Koukourakis, M. I., Kalamida, D., Giatromanolaki, A., Zois, C. E., Sivridis, E., Pouliliou, S., Mitrakas, A., Gatter, K. C., & Harris, A. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137675 · Cited by 183 · see citing works

PI5P and PI(3,5)P2: Minor, but Essential Phosphoinositides

Hasegawa, J., Strunk, B. S., & Weisman, L. S. (2017) · Cell Structure and Function · doi:10.1247/csf.17003 · Cited by 165 · see citing works

Disrupted neuronal trafficking in amyotrophic lateral sclerosis

Burk, K., & Pasterkamp, R. J. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-01964-7 · Cited by 162 · see citing works

The signaling lipid PI(3,5)P2stabilizes V1–Vosector interactions and activates the V-ATPase

Li, S. C., Diakov, T. T., Xu, T., Tarsio, M., Zhu, W., Couoh‐Cardel, S., Weisman, L. S., & Kane, P. M. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-10-0563 · Cited by 158 · see citing works

Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice

Tanaka, Y., CHAMBERS, J. K., Matsuwaki, T., Yamanouchi, K., & Nishihara, M. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0078-x · Cited by 155 · see citing works

Dysfunction of constitutive and inducible ubiquitin-proteasome system in amyotrophic lateral sclerosis: Implication for protein aggregation and immune response

Bendotti, C., Marino, M., Cheroni, C., Fontana, E., Crippa, V., Poletti, A., & Biasi, S. D. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.10.001 · Cited by 149 · see citing works

Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

Choy, C. H., Saffi, G. T., Gray, M. A., Wallace, C. T., Dayam, R. M., Ou, Z.-Y. A., Lenk, G. M., Puertollano, R., Watkins, S. C., & Botelho, R. J. (2018) · Journal of Cell Science · doi:10.1242/jcs.213587 · Cited by 147 · see citing works

Yunis-Varón Syndrome Is Caused by Mutations in FIG4, Encoding a Phosphoinositide Phosphatase

Campeau, P. M., Lenk, G. M., Lu, J. T., Bae, Y., Burrage, L. C., Turnpenny, P. D., Corona‐Rivera, J. R., Morandi, L. O., Mora, M., Reutter, H. M., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.03.020 · Cited by 148 · see citing works

Targeting autophagy in neurodegenerative diseases

Vidal, R. L., Matus, S., Bargsted, L., & Hetz, C. A. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.09.002 · Cited by 145 · see citing works

The role of PI3P phosphatases in the regulation of autophagy

Vergne, I., & Deretic, V. P. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.02.054 · Cited by 143 · see citing works

Phosphatidylinositol‐3,5‐Bisphosphate: No Longer the Poor PIP2

Ho, C. Y., Alghamdi, T. A., & Botelho, R. J. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01246.x · Cited by 139 · see citing works

Extracellular Vesicles as Delivery Vehicles of Specific Cellular Cargo

Mir, B., & Goettsch, C. (2020) · Cells · doi:10.3390/cells9071601 · Cited by 137 · see citing works

Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits

Sun, Y., Liou, B., Ran, H., Skelton, M. R., Williams, M. T., Vorhees, C. V., Kitatani, K., Hannun, Y. A., Witte, D. P., Xu, Y.-H., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddp580 · Cited by 133 · see citing works

Autophagosome–lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome

Hasegawa, J., Iwamoto, R., Otomo, T., Nezu, A., Hamasaki, M., & Yoshimori, T. (2016) · The EMBO Journal · doi:10.15252/embj.201593148 · Cited by 129 · see citing works

Protein misfolding disorders and macroautophagy

Menzies, F. M., Moreau, K., & Rubinsztein, D. C. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.10.010 · Cited by 129 · see citing works

Distinctive genetic and clinical features of CMT4J: a severe neuropathy caused by mutations in the PI(3,5)P2 phosphatase FIG4

Nicholson, G. A., Lenk, G. M., Reddel, S., Grant, A. E., Towne, C. F., Ferguson, C., Simpson, E. P., Scheuerle, A. E., Yasick, M., Hoffman, S. N., et al. (2011) · Brain · doi:10.1093/brain/awr148 · Cited by 126 · see citing works

The extended human PTP ome: a growing tyrosine phosphatase family

Alonso, A., & Pulido, R. (2015) · FEBS Journal · doi:10.1111/febs.13600 · Cited by 122 · see citing works

Autophagy as a common pathway in amyotrophic lateral sclerosis

Nguyen, D. K. H., Thombre, R., & Wang, J. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.04.006 · Cited by 110 · see citing works

Pathogenic Mechanism of the FIG4 Mutation Responsible for Charcot-Marie-Tooth Disease CMT4J

Lenk, G. M., Ferguson, C., Chow, C. Y., Jin, N., Jones, J. M., Grant, A. E., Zolov, S. N., Winters, J. J., Giger, R. J., Dowling, J. J., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002104 · Cited by 109 · see citing works

The lipid basis of cell death and autophagy

Lin, Z., Long, F., Kang, R., Klionsky, D. J., Yang, M., & Tang, D. (2023) · Autophagy · doi:10.1080/15548627.2023.2259732 · Cited by 106 · see citing works

Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis

Nassif, M., Valenzuela, V., Rojas-Rivera, D., Vidal, R., Matus, S., Castillo, K., Fuentealba, Y., Kroemer, G., Levine, B., & Hetz, C. (2014) · Autophagy · doi:10.4161/auto.28784 · Cited by 100 · see citing works

Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?

Webster, C. P., Smith, E. F., Shaw, P. J., & Vos, K. J. D. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00123 · Cited by 99 · see citing works

Roles for PI(3,5)P2 in nutrient sensing through TORC1

Jin, N., Mao, K., Jin, Y., Tevzadze, G. G., Kauffman, E. J., Park, S., Bridges, D., Loewith, R., Saltiel, A. R., Klionsky, D. J., et al. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-01-0021 · Cited by 91 · see citing works

Phosphoinositide Phosphatases: Just as Important as the Kinases

Dyson, J. M., Fedele, C. G., Davies, E. M., Becanovic, J., & Mitchell, C. A. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-3012-0_7 · Cited by 93 · see citing works

Inhibition of PIKfyve by YM-201636 Dysregulates Autophagy and Leads to Apoptosis-Independent Neuronal Cell Death

Martin, S., Harper, C. B., May, L. M., Coulson, E. J., Meunier, F. A., & Osborne, S. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060152 · Cited by 89 · see citing works

Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders

van Veen, S., Sørensen, D. M., Holemans, T., Holen, H. W., Palmgren, M. B., & Vangheluwe, P. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00048 · Cited by 89 · see citing works

Regulation of V-ATPase Activity and Organelle pH by Phosphatidylinositol Phosphate Lipids

Banerjee, S., & Kane, P. M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00510 · Cited by 89 · see citing works

The pleiotropic roles of autophagy regulators in melanogenesis

Ho, H., & Ganesan, A. K. (2011) · Pigment Cell &amp; Melanoma Research · doi:10.1111/j.1755-148x.2011.00889.x · Cited by 88 · see citing works

PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin–actin interactions

Hong, N. H., Qi, A., & Weaver, A. M. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201412127 · Cited by 88 · see citing works

Genetic Interaction between MTMR2 and FIG4 Phospholipid Phosphatases Involved in Charcot-Marie-Tooth Neuropathies

Vaccari, I., Dina, G., Tronchère, H., Kaufman, E. L., Chicanne, G., Cerri, F., Wrabetz, L. G., Payrastre, B., Quattrini, A., Weisman, L. S., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002319 · Cited by 87 · see citing works

The neurobiology of amyotrophic lateral sclerosis

Bento‐Abreu, A., Damme, P. V., Bosch, L. V. D., & Robberecht, W. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07260.x · Cited by 85 · see citing works

Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis

Bradford, C. M., Ramos, I., Cross, A. K., Haddock, G., McQuaid, S., Nicholas, A. P., & Woodroofe, M. N. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.05.007 · Cited by 85 · see citing works

FUS, TARDBP, and SOD1 mutations in a Taiwanese cohort with familial ALS

Tsai, C.-P., Soong, B., Lin, K., Tu, P., Lin, J.-L., & Lee, Y. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.04.009 · Cited by 80 · see citing works

Inositol Polyphosphate Phosphatases in Human Disease

Hakim, S., Bertucci, M. C., Conduit, S. E., Vuong, D. L., & Mitchell, C. A. (2012) · Current topics in microbiology and immunology · doi:10.1007/978-94-007-5025-8_12 · Cited by 76 · see citing works

Therapeutic neuroprotective agents for amyotrophic lateral sclerosis

Pandya, R. S., Zhu, H., Li, W., Bowser, R. P., Friedlander, R. M., & Wang, X. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1415-0 · Cited by 77 · see citing works

Phosphatidylinositol 4-Kinases Are Required for Autophagic Membrane Trafficking

Wang, K., Yang, Z., Liu, X., Mao, K., Nair, U., & Klionsky, D. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.371591 · Cited by 76 · see citing works

Charcot–Marie–Tooth disease and intracellular traffic

Bucci, C., Bakke, O., & Progida, C. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.03.003 · Cited by 76 · see citing works

Inositol lipid phosphatases in membrane trafficking and human disease

Billcliff, P. G., & Lowe, M. (2014) · Biochemical Journal · doi:10.1042/bj20140361 · Cited by 75 · see citing works

Differential regulation of autophagy during metabolic stress in astrocytes and neurons

Kulkarni, A., Dong, A., Kulkarni, V. V., Chen, J., Laxton, O., Anand, A., & Maday, S. (2019) · Autophagy · doi:10.1080/15548627.2019.1703354 · Cited by 77 · see citing works

Melanosome transport and regulation in development and disease

Tian, X., Cui, Z., Liu, S., Zhou, J., & Cui, R. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107707 · Cited by 75 · see citing works

The Key Role of Astrocytes in Amyotrophic Lateral Sclerosis and Their Commitment to Glutamate Excitotoxicity

Provenzano, F., Torazza, C., Bonifacino, T., Bonanno, G., & Milanese, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015430 · Cited by 74 · see citing works

Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study

Raina, A., Zhao, X., Grove, M. L., Bressler, J., Gottesman, R. F., Guan, W., Pankow, J. S., Boerwinkle, E., Mosley, T. H., & Fornage, M. (2017) · Clinical Epigenetics · doi:10.1186/s13148-016-0302-6 · Cited by 67 · see citing works

Amyotrophic Lateral Sclerosis: New Insights into Underlying Molecular Mechanisms and Opportunities for Therapeutic Intervention

Cozzolino, M., Pesaresi, M. G., Gerbino, V., Großkreutz, J., & Carrı̀, M. T. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4328 · Cited by 65 · see citing works

Pairing phosphoinositides with calcium ions in endolysosomal dynamics

Shen, D., Wang, X., & Xu, H. (2011) · BioEssays · doi:10.1002/bies.201000152 · Cited by 62 · see citing works

Coordination of inter-organelle communication and lipid fluxes by OSBP-related proteins

Arora, A., Taskinen, J., & Olkkonen, V. M. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101146 · Cited by 61 · see citing works

Role of Cathepsin D in U18666A-induced Neuronal Cell Death

Amritraj, A., Wang, Y., Revett, T. J., Vergote, D., Westaway, D. A., & Kar, S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.412460 · Cited by 63 · see citing works

Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration

Ferguson, C., Lenk, G. M., Jones, J. M., Grant, A. E., Winters, J. J., Dowling, J. J., Giger, R. J., & Meisler, M. H. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds179 · Cited by 62 · see citing works

The Vac14-interaction Network Is Linked to Regulators of the Endolysosomal and Autophagic Pathway

Schulze, U., Vollenbröker, B., Braun, D. A., Le, T., Granado, D., Kremerskothen, J., Fränzel, B., Klosowski, R., Barth, J., Fufezan, C., et al. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.034108 · Cited by 62 · see citing works

Dysregulation of the Autophagy-Endolysosomal System in Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases

Otomo, A., Pan, L., & Hadano, S. (2012) · Neurology Research International · doi:10.1155/2012/498428 · Cited by 60 · see citing works

Amyotrophic lateral sclerosis pathogenesis: a journey through the secretory pathway

Nassif, M., Matus, S., Castillo, K., & Hetz, C. (2010) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2009.2991 · Cited by 60 · see citing works

Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?

Deng, Z., Sheehan, P., Chen, S., & Yue, Z. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0232-6 · Cited by 61 · see citing works

Phosphoinositides: multipurpose cellular lipids with emerging roles in cell death

Phan, T. K., Williams, S. A., Bindra, G. K., Lay, F. T., Poon, I. K. H., & Hulett, M. D. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-018-0269-2 · Cited by 60 · see citing works

De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics

Rowland, L. A., Guilherme, A., Henriques, F. D. S., DiMarzio, C., Munroe, S., Wetoska, N., Kelly, M., Reddig, K. R., Hendricks, G. M., Pan, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37016-8 · Cited by 60 · see citing works

A PI(3,5)P2 reporter reveals PIKfyve activity and dynamics on macropinosomes and phagosomes

Vines, J. H., Maib, H., Buckley, C. M. F., Guého, A., Zhou, Z., Soldati, T., Murray, D. H., & King, J. (2023) · The Journal of Cell Biology · doi:10.1083/jcb.202209077 · Cited by 57 · see citing works

PIPs in neurological diseases

Waugh, M. G. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.02.002 · Cited by 57 · see citing works

Finding the Middle Ground for Autophagic Fusion Requirements

Corona, A. K., & Jackson, W. T. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.07.001 · Cited by 56 · see citing works

Interaction of the late endo-lysosomal lipid PI(3,5)P2 with the Vph1 isoform of yeast V-ATPase increases its activity and cellular stress tolerance

Banerjee, S., Clapp, K., Tarsio, M., & Kane, P. M. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.008552 · Cited by 57 · see citing works

Peroxisomal Dysfunction in Neurological Diseases and Brain Aging

Uzor, N.-E., McCullough, L. D., & Tsvetkov, A. S. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00044 · Cited by 56 · see citing works

Complex Relations Between Phospholipids, Autophagy, and Neutral Lipids

Shatz, O., Holland, P., Elazar, Z., & Simonsen, A. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.08.001 · Cited by 55 · see citing works

Amyotrophic lateral sclerosis: an update on recent genetic insights

Iguchi, Y., Katsuno, M., Ikenaka, K., Ishigaki, S., & Sobue, G. (2013) · Journal of Neurology · doi:10.1007/s00415-013-7112-y · Cited by 55 · see citing works

Glia-specific autophagy dysfunction in ALS

Strohm, L., & Behrends, C. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.05.024 · Cited by 53 · see citing works

Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P2 and PI(5)P

Zhang, Y., McCartney, A. J., Zolov, S. N., Ferguson, C., Meisler, M. H., Sutton, M. A., & Weisman, L. S. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.200 · Cited by 53 · see citing works

FIG4 regulates lysosome membrane homeostasis independent of phosphatase function

Bharadwaj, R., Cunningham, K. M., Zhang, K., & Lloyd, T. E. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv505 · Cited by 53 · see citing works

Congenital CNS hypomyelination and reduced number of mature oligodendrocytes in mice null for the phosphatidylinositol phosphatase Fig4

Winters, J. J., Ferguson, C. J., Lenk, G. M., Giger-Mateeva, V. I., Shrager, P., Meisler, M., & Giger, R. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1482-11.2011 · Cited by 49 · see citing works

Ebola virus requires phosphatidylinositol (3,5) bisphosphate production for efficient viral entry

Qiu, S., Leung, A., Bo, Y., Kozak, R. A., Anand, S. P., Warkentin, C., Salambanga, F. R. D., Cui, J. Y., Kobinger, G., Kobasa, D., et al. (2017) · Virology · doi:10.1016/j.virol.2017.09.028 · Cited by 52 · see citing works

Deciphering the Role of Autophagy in Treatment of Resistance Mechanisms in Glioblastoma

Khan, I., Baig, M. H., Mahfooz, S., Rahim, M., Karaçam, B., Elbasan, E. B., Ulasov, I. V., Dong, J.-J., & Hatiboğlu, M. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031318 · Cited by 50 · see citing works

PIKfyve and its Lipid Products in Health and in Sickness

Shisheva, A. (2012) · Current topics in microbiology and immunology · doi:10.1007/978-94-007-5025-8_7 · Cited by 50 · see citing works

Several Routes to the Same Destination: Inhibition of Phagosome-Lysosome Fusion by Mycobacterium tuberculosis

Carranza, C., & Chávez‐Galán, L. (2018) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2018.12.003 · Cited by 50 · see citing works

Loss of Fig4 in both Schwann cells and motor neurons contributes to CMT4J neuropathy

Vaccari, I., Carbone, A., Previtali, S. C., Mironova, Y. A., Alberizzi, V., Noseda, R., Rivellini, C., Bianchi, F., Del Carro, U., D'Antonio, M., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddu451 · Cited by 49 · see citing works

Phosphatidylinositol 3-Phosphatase Myotubularin-related Protein 6 (MTMR6) Is Regulated by Small GTPase Rab1B in the Early Secretory and Autophagic Pathways

Mochizuki, Y., Ohashi, R., Kawamura, T., Iwanari, H., Kodama, T., Naito, M., & Hamakubo, T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.395087 · Cited by 49 · see citing works

Host cell cytosolic immune response during Plasmodium liver stage development

Agop‐Nersesian, C., Niklaus, L., Wacker, R., & Heussler, V. T. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuy007 · Cited by 49 · see citing works

WIPI1 promotes fission of endosomal transport carriers and formation of autophagosomes through distinct mechanisms

Leo, M. G. D., Berger, P., & Mayer, A. (2021) · Autophagy · doi:10.1080/15548627.2021.1886830 · Cited by 50 · see citing works

Implications of autophagy for glomerular aging and disease

Weide, T., & Huber, T. B. (2011) · Cell and Tissue Research · doi:10.1007/s00441-010-1115-0 · Cited by 47 · see citing works

Synaptojanin 1 Is Required for Endolysosomal Trafficking of Synaptic Proteins in Cone Photoreceptor Inner Segments

George, A. A., Hayden, S., Holzhausen, L. C., Ma, E. Y., Suzuki, S. C., & Brockerhoff, S. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084394 · Cited by 47 · see citing works

Biogenesis of lysosome‐related organelles complex‐1 (BORC) regulates late endosomal/lysosomal size through PIKfyve‐dependent phosphatidylinositol‐3,5‐bisphosphate

Yordanov, T. E., Hipolito, V. E. B., Liebscher, G., Vogel, G. F., Stasyk, T., Herrmann, C., Geley, S., Teis, D., Botelho, R. J., Hess, M. W., et al. (2019) · Traffic · doi:10.1111/tra.12679 · Cited by 46 · see citing works

Autophagy and lipids: tightening the knot

Rodríguez‐Navarro, J. A., & Cuervo, A. M. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0219-7 · Cited by 46 · see citing works

PIKfyve, a Class III Lipid Kinase, Is Required for TLR-Induced Type I IFN Production via Modulation of ATF3

Cai, X., Xu, Y., Kim, Y., Loureiro, J., & Huang, Q. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302411 · Cited by 46 · see citing works

Computational model for autophagic vesicle dynamics in single cells

Martin, K. R., Barua, D., Kauffman, A. L., Westrate, L. M., Posner, R. G., Hlavacek, W. S., & MacKeigan, J. P. (2012) · Autophagy · doi:10.4161/auto.22532 · Cited by 45 · see citing works

Distinct pathogenic processes between Fig4-deficient motor and sensory neurons

Katona, I., Zhang, X., Bai, Y., Shy, M. E., Guo, J., Yan, Q., Hatfield, J. S., Kupsky, W. J., & Li, J. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07651.x · Cited by 44 · see citing works

Neuroinflammation in Amyotrophic Lateral Sclerosis: Role of Redox (dys)Regulation

D’Ambrosi, N., Cozzolino, M., & Carrı̀, M. T. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7271 · Cited by 44 · see citing works

Autophagy and cell-autonomy in mouse models of PI(3, 5)P2 deficiency

Ferguson, C. (2011) · Deep Blue (University of Michigan)

PtdIns(3,5)P2and autophagy in mouse models of neurodegeneration

Ferguson, C., Lenk, G. M., & Meisler, M. H. (2010) · Autophagy · doi:10.4161/auto.6.1.10626 · Cited by 32 · see citing works

Mouse Models of PI(3,5)P2 Deficiency with Impaired Lysosome Function

Lenk, G. M., & Meisler, M. H. (2013) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-397926-1.00014-7 · Cited by 40 · see citing works

Early-onset neuroinflammation drives neurodegeneration caused by lysosomal PI(3,5)P2 insufficiency

Wong, B., Payne, M., Silva, A., Kurniawan, E., Eidman, A. S., Pizzo, D. P., Rajupalem, R., Lenk, G. M., Paulo, J. A., Khan, T., et al. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107467

Mutations in PI(3,5)P2 Signaling and Neurodegeneration in Mouse and Human.

Chow, C. Y. (2008) · Deep Blue (University of Michigan)