The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy
Open accessAbstract
Mutations leading to expansion of a poly-glutamine track in Huntingtin (Htt) cause Huntington's disease (HD). Signs of endoplasmic reticulum (ER) stress have been recently reported in animal models of HD, associated with the activation of the unfolded protein response (UPR). Here we have investigated the functional contribution of ER stress to HD by targeting the expression of two main UPR transcription factors, XBP1 and ATF4 (activating transcription factor 4), in full-length mutant Huntingtin (mHtt) transgenic mice. XBP1-deficient mice were more resistant to developing disease features, associated with improved neuronal survival and motor performance, and a drastic decrease in mHtt levels. The protective effects of XBP1 deficiency were associated with enhanced macroautophagy in both cellular and animal models of HD. In contrast, ATF4 deficiency did not alter mHtt levels. Although, XBP1 mRNA splicing was observed in the striatum of HD transgenic brains, no changes in the levels of classical ER stress markers were detected in symptomatic animals. At the mechanistic level, we observed that XBP1 deficiency led to augmented expression of Forkhead box O1 (FoxO1), a key transcription factor regulating autophagy in neurons. In agreement with this finding, ectopic expression of FoxO1 enhanced autophagy and mHtt clearance in vitro. Our results provide strong evidence supporting an involvement of XBP1 in HD pathogenesis probably due to an ER stress-independent mechanism involving the control of FoxO1 and autophagy levels.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452
Self-citationSignal integration in the endoplasmic reticulum unfolded protein response
Ron, D., & Walter, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2199 · Cited by 6,296
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
Hetz, C. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3270 · Cited by 4,093
Self-citationYoshida, H., Matsui, T., Yamamoto, A., Okada, T., & Mori, K. (2001) · Cell · doi:10.1016/s0092-8674(01)00611-0 · Cited by 4,039
Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996 · cited 2×
“Different assays and control experiments were employed to monitor autophagy-related processes following the recommendations described in reference (78).”
MethodSelf-citationEndoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844
Self-citationTFEB Links Autophagy to Lysosomal Biogenesis
Settembre, C., Di Malta, C., Polito, V. A., Arencibia, M. G., Vetrini, F., Erdin, S., Erdin, S. U., Huynh, T., Medina, D., Colella, P., et al. (2011) · Science · doi:10.1126/science.1204592 · Cited by 3,365
An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
Harding, H. P., Zhang, Y., Zeng, H., Novoa, I., Lu, P. D., Calfon, M., Sadri, N., Yun, C., Popko, B., Paules, R., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00105-9 · Cited by 3,323
Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
Harding, H. P., Novoa, I., Zhang, Y., Zeng, H., Wek, R., Schapira, M., & Ron, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00108-8 · Cited by 3,276
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
Calfon, M., Zeng, H., Urano, F., Till, J. H., Hubbard, S. R., Harding, H. P., Clark, S. G., & Ron, D. (2002) · Nature · doi:10.1038/415092a · Cited by 2,820
Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., Baehrecke, E. H., Bahr, B. A., Ballabio, A., et al. (2008) · Autophagy · doi:10.4161/auto.5338 · Cited by 2,230
Self-citationRubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107
Lee, A.-H., Iwakoshi, N. N., & Glimcher, L. H. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7448-7459.2003 · Cited by 2,037
Self-citationZinszner, H., Kuroda, M., Wang, X., Batchvarova, N., Lightfoot, R. T., Remotti, H., Stevens, J. L., & Ron, D. (1998) · Genes & Development · doi:10.1101/gad.12.7.982 · Cited by 2,014
The roles of intracellular protein-degradation pathways in neurodegeneration
Rubinsztein, D. C. (2006) · Nature · doi:10.1038/nature05291 · Cited by 1,625
Kaser, A., Lee, A.-H., Franke, A., Glickman, J. N., Zeissig, S., Tilg, H., Nieuwenhuis, E. E. S., Higgins, D. E., Schreiber, S., Glimcher, L. H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.021 · Cited by 1,411
Self-citation(2004) · doi:10.1016/s0092-8674(04)00452-0 · Cited by 1,356
Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Kakizuka, A., & Ichijo, H. (2002) · Genes & Development · doi:10.1101/gad.992302 · Cited by 1,338
Plasma cell differentiation requires the transcription factor XBP-1
Reimold, A. M., Iwakoshi, N. N., Manis, J., Vallabhajosyula, P., Szomolanyi-Tsuda, E., Gravallese, E. M., Friend, D., Grusby, M. J., Alt, F., & Glimcher, L. H. (2001) · Nature · doi:10.1038/35085509 · Cited by 1,305
Self-citationTLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
Martinon, F., Chen, X., Lee, A.-H., & Glimcher, L. H. (2010) · Nature Immunology · doi:10.1038/ni.1857 · Cited by 996 · cited 1×
“Indeed, XBP1 has been implicated in the control of innate immunity (61), lipid and cholesterol metabolism (54), insulin resistance (62), cell differentiation (13,63,64) and other processes (65).”
BackgroundSelf-citationRegulation of Hepatic Lipogenesis by the Transcription Factor XBP1
Lee, A.-H., Scapa, E. F., Cohen, D. E., & Glimcher, L. H. (2008) · Science · doi:10.1126/science.1158042 · Cited by 977
Self-citationKouroku, Y., Fujita, E., Tanida, I., Ueno, T., Isoai, A., Kumagai, H., Ogawa, S., Kaufman, R. J., Kominami, E., & Momoi, T. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401984 · Cited by 934
Cargo recognition failure is responsible for inefficient autophagy in Huntington’s disease
Martinez-Vicente, M., Talloczy, Z., Wong, E., Tang, G., Koga, H., Kaushik, S., de Vries, R., Arias, E., Harris, S., Sulzer, D., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2528 · Cited by 885
Self-citationXBP1 Controls Diverse Cell Type- and Condition-Specific Transcriptional Regulatory Networks
Acosta-Alvear, D., Zhou, Y., Blais, A., Tsikitis, M., Lents, N. H., Arias, C., Lennon, C. J., Kluger, Y., & Dynlacht, B. D. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.011 · Cited by 850
ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology
Yang, X., Matsuda, K., Bialek, P., Jacquot, S., Masuoka, H. C., Schinke, T., Li, L., Brancorsini, S., Sassone-Corsi, P., Townes, T. M., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00344-7 · Cited by 820
Autophagy gone awry in neurodegenerative diseases
Wong, E., & Cuervo, A. M. (2010) · Nature Neuroscience · doi:10.1038/nn.2575 · Cited by 815
Self-citationSelective striatal neuronal loss in a YAC128 mouse model of Huntington disease
Slow, E. J. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg169 · Cited by 800
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease
Tanaka, M., Machida, Y., Niu, S., Ikeda, T., Jana, N. R., Doi, H., Kurosawa, M., Nekooki, M., & Nukina, N. (2004) · Nature Medicine · doi:10.1038/nm985 · Cited by 782
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity
Zhao, Y., Yang, J., Liao, W., Liu, X., Zhang, H., Wang, S., Wang, D., Feng, J., Yu, L., & Zhu, W.-G. (2010) · Nature Cell Biology · doi:10.1038/ncb2069 · Cited by 606
FoxO transcription factors in the maintenance of cellular homeostasis during aging
Salih, D. A., & Brunet, A. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.02.005 · Cited by 604
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
Sarkar, S., Perlstein, E. O., Imarisio, S., Pineau, S., Cordenier, A., Maglathlin, R. L., Webster, J. A., Lewis, T. A., O'Kane, C. J., Schreiber, S. L., et al. (2007) · Nature Chemical Biology · doi:10.1038/nchembio883 · Cited by 596
The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α
Hetz, C., Martinon, F., Rodriguez, D., & Glimcher, L. H. (2011) · Physiological Reviews · doi:10.1152/physrev.00001.2011 · Cited by 569
Self-citationHetz, C., Thielen, P., Matus, S., Nassif, M., Court, F., Kiffin, R., Martinez, G., Cuervo, A. M., Brown, R. H., & Glimcher, L. H. (2009) · Genes & Development · doi:10.1101/gad.1830709 · Cited by 530 · cited 5×
“We have reported that XBP1 deficiency improves motor performance and survival of an ALS mouse model (49).”
BackgroundMethodInfluentialSelf-citationWheeler, V. C. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.4.503 · Cited by 469
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1
Shibata, M., Lu, T., Furuya, T., Degterev, A., Mizushima, N., Yoshimori, T., MacDonald, M., Yankner, B., & Yuan, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600364200 · Cited by 458
FoxO Transcription Factors Promote Autophagy in Cardiomyocytes
Sengupta, A., Molkentin, J. D., & Yutzey, K. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.024406 · Cited by 428
Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome
Hetz, C., & Glimcher, L. H. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.08.021 · Cited by 413
Self-citationAtwal, R. S., Xia, J., Pinchev, D., Taylor, J., Epand, R. M., & Truant, R. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm217 · Cited by 387
Complex Inhibitory Effects of Nitric Oxide on Autophagy
Sarkar, S., Korolchuk, V. I., Renna, M., Imarisio, S., Fleming, A., Williams, A., Garcia-Arencibia, M., Rose, C., Luo, S., Underwood, B. R., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.04.029 · Cited by 383
Regulation of basal cellular physiology by the homeostatic unfolded protein response
Rutkowski, D. T., & Hegde, R. S. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201003138 · Cited by 370
Polyglutamine neurodegeneration: protein misfolding revisited
Williams, A. J., & Paulson, H. L. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.07.004 · Cited by 341
Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins
Hoffstrom, B. G., Kaplan, A., Letso, R., Schmid, R. S., Turmel, G. J., Lo, D. C., & Stockwell, B. R. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.467 · Cited by 310
Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity
Duennwald, M. L., & Lindquist, S. (2008) · Genes & Development · doi:10.1101/gad.1673408 · Cited by 299
Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction
Zhou, Y., Lee, J., Reno, C. M., Sun, C., Park, S. W., Chung, J., Lee, J., Fisher, S. J., White, M. F., Biddinger, S. B., et al. (2011) · Nature Medicine · doi:10.1038/nm.2293 · Cited by 295
Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain
Mao, X., Fujiwara, Y., Chapdelaine, A., Yang, H., & Orkin, S. H. (2001) · Blood · doi:10.1182/blood.v97.1.324 · Cited by 291
Tsai, Y. C., Fishman, P. S., Thakor, N. V., & Oyler, G. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212235200 · Cited by 283
Lessons from animal models of Huntington's disease
Rubinsztein, D. C. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(01)02625-7 · Cited by 283
Mutant huntingtin and mitochondrial dysfunction
Bossy-Wetzel, E., Petrilli, A., & Knott, A. B. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.09.004 · Cited by 268
Modulating stress responses by the UPRosome: A matter of life and death
Woehlbier, U., & Hetz, C. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2011.03.001 · Cited by 264
Self-citationInsulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity
Henis-Korenblit, S., Zhang, P., Hansen, M., McCormick, M., Lee, S.-J., Cary, M., & Kenyon, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002575107 · Cited by 239
Protein folding stress in neurodegenerative diseases: a glimpse into the ER
Matus, S., Glimcher, L. H., & Hetz, C. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.01.003 · Cited by 226
Self-citationYoshizawa, T., Hinoi, E., Jung, D. Y., Kajimura, D., Ferron, M., Seo, J., Graff, J. M., Kim, J. K., & Karsenty, G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39366 · Cited by 221
JNK regulates FoxO-dependent autophagy in neurons
Xu, P., Das, M., Reilly, J., & Davis, R. J. (2011) · Genes & Development · doi:10.1101/gad.1984311 · Cited by 216
Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore
Barrientos, S. A., Martinez, N. W., Yoo, S., Jara, J. S., Zamorano, S., Hetz, C., Twiss, J. L., Alvarez, J., & Court, F. A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4065-10.2011 · Cited by 207
Self-citationAutophagy for tissue homeostasis and neuroprotection
Mariño, G., Madeo, F., & Kroemer, G. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.10.001 · Cited by 195
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins
Maiese, K., Chong, Z. Z., & Shang, Y. C. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.03.002 · Cited by 182
Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation
Kouroku, Y. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.13.1505 · Cited by 177
Rrs1 Is Involved in Endoplasmic Reticulum Stress Response in Huntington Disease
Carnemolla, A., Fossale, E., Agostoni, E., Michelazzi, S., Calligaris, R., De Maso, L., Del Sal, G., MacDonald, M. E., & Persichetti, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.018325 · Cited by 164
Mechanism of ER Stress-Induced Brain Damage by IP3 Receptor
Higo, T., Hamada, K., Hisatsune, C., Nukina, N., Hashikawa, T., Hattori, M., Nakamura, T., & Mikoshiba, K. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.010 · Cited by 161
Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat
Rodriguez, D., Rojas-Rivera, D., & Hetz, C. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.11.012 · Cited by 160
Self-citationReijonen, S., Putkonen, N., Nørremølle, A., Lindholm, D., & Korhonen, L. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.12.025 · Cited by 159
Lee, H., Noh, J.-Y., Oh, Y., Kim, Y., Chang, J.-W., Chung, C.-W., Lee, S.-T., Kim, M., Ryu, H., & Jung, Y.-K. (2012) · Human Molecular Genetics · doi:10.1093/hmg/ddr445 · Cited by 157
Isolation of autophagic vacuoles from rat liver: morphological and biochemical characterization.
Marzella, L., Ahlberg, J., & Glaumann, H. (1982) · The Journal of Cell Biology · doi:10.1083/jcb.93.1.144 · Cited by 149
Hetz, C. A., Lee, A., Gonzalez-Romero, D., Thielen, P., Castilla, J., Soto, C. A., & Glimcher, L. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711094105 · Cited by 145
Self-citationActivation of the unfolded protein response enhances motor recovery after spinal cord injury
Valenzuela, V., Collyer, E., Armentano, D., Parsons, G., Court, F. A., & Hetz, C. A. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.8 · Cited by 139
Self-citationProtein misfolding disorders and macroautophagy
Menzies, F. M., Moreau, K., & Rubinsztein, D. C. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.10.010 · Cited by 129
Converging pathways in the occurrence of endoplasmic reticulum (ER) stress in Huntington's disease.
Vidal, R. L., Caballero, B., Couve, A., & Hetz, C. (2011) · Current molecular medicine · doi:10.2174/156652411794474419 · Cited by 127
Self-citationHuh, W. J., Esen, E., Geahlen, J. H., Bredemeyer, A. J., Lee, A., Shi, G., Konieczny, S. F., Glimcher, L. H., & Mills, J. C. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.08.050 · Cited by 125
Self-citationSasaki, S. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181d44992 · Cited by 121
Fine Structure of the Autophagosome
Eskelinen, E. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-157-4_2 · Cited by 111
IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease
Sadagurski, M., Cheng, Z., Rozzo, A., Palazzolo, I., Kelley, G. R., Dong, X., Krainc, D., & White, M. F. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46305 · Cited by 107
Atwal, R. S., & Truant, R. (2008) · Autophagy · doi:10.4161/auto.5201 · Cited by 94
Metzler, M., Gan, L., Mazarei, G., Graham, R. K., Liu, L., Bissada, N., Lu, G., Leavitt, B. R., & Hayden, M. R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1589-10.2010 · Cited by 90
Huntingtin Interacts with the Cue Domain of gp78 and Inhibits gp78 Binding to Ubiquitin and p97/VCP
Yang, H., Liu, C., Zhong, Y., Luo, S., Monteiro, M. J., & Fang, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008905 · Cited by 88
Graham, R. K., Slow, E., Deng, Y., Bissada, N., Lu, G., Pearson, J., Shehadeh, J., Leavitt, B. R., Raymond, L. A., & Hayden, M. R. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.08.007 · Cited by 85
Arsham, A. M., & Neufeld, T. P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006068 · Cited by 84
Early and Late Events Induced by PolyQ-expanded Proteins
Bertoni, A., Giuliano, P., Galgani, M., Rotoli, D., Ulianich, L., Adornetto, A., Santillo, M. R., Porcellini, A., & Avvedimento, V. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.156521 · Cited by 70
Cho, K. J., Lee, B. I., Cheon, S. Y., Kim, H. W., Kim, H. J., & Kim, G. W. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.07.048 · Cited by 63
Expression analysis of novel striatal-enriched genes in Huntington disease
Mazarei, G., Neal, S. J., Bečanović, K., Luthi‐Carter, R., Simpson, E. M., & Leavitt, B. R. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp527 · Cited by 56
Lajoie, P., & Snapp, E. L. (2011) · Journal of Cell Science · doi:10.1242/jcs.087510 · Cited by 54
Impaired ATF6α processing, decreased Rheb and neuronal cell cycle re-entry in Huntington's disease
Fernández-Fernández, M. R., Ferrer, I., & Lucas, J. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.08.014 · Cited by 45
Omi, K., Hachiya, N., Tokunaga, K., & Kaneko, K. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.061 · Cited by 37
Targeting autophagy in ALS: A complex mission
Nassif, M., & Hetz, C. A. (2011) · Autophagy · doi:10.4161/auto.7.4.14700 · Cited by 35
Self-citation
Cited by
Mechanisms, regulation and functions of the unfolded protein response
Hetz, C., Zhang, K., & Kaufman, R. J. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0250-z · Cited by 2,666
Self-citationProtein misfolding in the endoplasmic reticulum as a conduit to human disease
Wang, M., & Kaufman, R. J. (2016) · Nature · doi:10.1038/nature17041 · Cited by 1,630
UPR, autophagy, and mitochondria crosstalk underlies the ER stress response
Senft, D., & Ronai, Z. A. (2015) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.01.002 · Cited by 1,121
ER stress and the unfolded protein response in neurodegeneration
Hetz, C., & Saxena, S. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.99 · Cited by 1,013
Self-citationTargeting the unfolded protein response in disease
Hetz, C., Chevet, E., & Harding, H. P. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3976 · Cited by 910
Self-citation
Metadata
- Authors
- Vidal, R. L., Figueroa, A., Court, F. A., Thielen, P., Molina, C., Wirth, C., Caballero, B., Kiffin, R., Segura-Aguilar, J., Cuervo, A. M., Glimcher, L. H., & Hetz, C.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-02-14
- Volume
- 21
- Issue
- 10
- Pages
- 2245-2262
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2117378242
- Cited by
- 285
- References
- 85
- FWCI
- 7.93
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
