NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease
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Disarrangement in functions and quality control of mitochondria at synapses are early events in Alzheimer's disease (AD) pathobiology. We reported that a 20-22 kDa NH2-tau fragment mapping between 26 and 230 amino acids of the longest human tau isoform (aka NH2htau): (i) is detectable in cellular and animal AD models, as well in synaptic mitochondria and cerebrospinal fluids (CSF) from human AD subjects; (ii) is neurotoxic in primary hippocampal neurons; (iii) compromises the mitochondrial biology both directly, by inhibiting the ANT-1-dependent ADP/ATP exchange, and indirectly, by impairing their selective autophagic clearance (mitophagy). Here, we show that the extensive Parkin-dependent turnover of mitochondria occurring in NH2htau-expressing post-mitotic neurons plays a pro-death role and that UCHL-1, the cytosolic Ubiquitin-C-terminal hydrolase L1 which directs the physiological remodeling of synapses by controlling ubiquitin homeostasis, critically contributes to mitochondrial and synaptic failure in this in vitro AD model. Pharmacological or genetic suppression of improper mitophagy, either by inhibition of mitochondrial targeting to autophagosomes or by shRNA-mediated silencing of Parkin or UCHL-1 gene expression, restores synaptic and mitochondrial content providing partial but significant protection against the NH2htau-induced neuronal death. Moreover, in mitochondria from human AD synapses, the endogenous NH2htau is stably associated with Parkin and with UCHL-1. Taken together, our studies show a causative link between the excessive mitochondrial turnover and the NH2htau-induced in vitro neuronal death, suggesting that pathogenetic tau truncation may contribute to synaptic deterioration in AD by aberrant recruitment of Parkin and UCHL-1 to mitochondria making them more prone to detrimental autophagic clearance.
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Mitochondrial damage in AD may be caused by Aβ-production and tau phosphorylation.
“Mitochondrial damage in AD may be caused by Aβ-production and tau phosphorylation. 104”
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Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376 · see citing works
Ubiquitin is phosphorylated by PINK1 to activate parkin
Koyano, F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., et al. (2014) · Nature · doi:10.1038/nature13392 · Cited by 1,477 · see citing works
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
Tanaka, A., Cleland, M. M., Xu, S., Narendra, D. P., Suen, D.-F., Karbowski, M., & Youle, R. J. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201007013 · Cited by 1,369 · see citing works
A Role for Ubiquitin in Selective Autophagy
Kirkin, V., McEwan, D. G., Novak, I., & Đikić, I. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.026 · Cited by 1,227 · see citing works
Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
Wang, X., Su, B., Lee, H.-G., Li, X., Perry, G., Smith, M. A., & Zhu, X. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1357-09.2009 · Cited by 1,224 · see citing works
PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
Wang, X., Winter, D., Ashrafi, G., Schlehe, J. S., Wong, Y. L., Selkoe, D. J., Rice, S. E., Steen, J. A. J., LaVoie, M. J., & Schwarz, T. L. (2011) · Cell · doi:10.1016/j.cell.2011.10.018 · Cited by 1,161 · see citing works
Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy
Chan, N. C., Salazar, A. M., Pham, A. H., Sweredoski, M. J., Kolawa, N. J., Graham, R. L. J., Hess, S., & Chan, D. C. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr048 · Cited by 993 · see citing works
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
Bingol, B., Tea, J. S., Phu, L., Reichelt, M., Bakalarski, C. E., Song, Q., Foreman, O., Kirkpatrick, D. S., & Sheng, M. (2014) · Nature · doi:10.1038/nature13418 · Cited by 855 · see citing works
Wang, X., Su, B., Siedlak, S. L., Moreira, P. I., Fujioka, H., Wang, Y., Casadesus, G., & Zhu, X. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804871105 · Cited by 835 · see citing works
Liu, Y., Fallon, L., Lashuel, H. A., Liu, Z., & Lansbury, P. T. (2002) · Cell · doi:10.1016/s0092-8674(02)01012-7 · Cited by 786 · see citing works
S -Nitrosylation of Parkin Regulates Ubiquitination and Compromises Parkin's Protective Function
Chung, K. K. K., Thomas, B., Li, X., Pletniková, O., Troncoso, J. C., Marsh, L., Dawson, V. L., & Dawson, T. M. (2004) · Science · doi:10.1126/science.1093891 · Cited by 765 · see citing works
Dopamine covalently modifies and functionally inactivates parkin
LaVoie, M. J., Ostaszewski, B. L., Weihofen, A., Schlossmacher, M. G., & Selkoe, D. J. (2005) · Nature Medicine · doi:10.1038/nm1314 · Cited by 722 · see citing works
Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
Du, H., Guo, L., Yan, S., Sosunov, A. A., McKhann, G. M., & ShiDu Yan, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006586107 · Cited by 704 · see citing works
Rhein, V., Song, X., Wiesner, A., Ittner, L. M., Baysang, G., Meier, F., Ozmen, L., Bluethmann, H., Dröse, S., Brandt, U., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905529106 · Cited by 655 · see citing works
Calkins, M. J., Manczak, M., Mao, P., Shirendeb, U., & Reddy, P. H. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr381 · Cited by 646 · see citing works
Misko, A. L., Jiang, S., Wegorzewska, I., Milbrandt, J., & Baloh, R. H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6248-09.2010 · Cited by 643 · see citing works
Yoshii, S. R., Kishi, C., Ishihara, N., & Mizushima, N. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.209338 · Cited by 612 · see citing works
Castegna, A., Aksenov, M., Aksenova, M., Thongboonkerd, V., Klein, J. B., Pierce, W. M., Booze, R., Markesbery, W. R., & Butterfield, D. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00914-0 · Cited by 581 · see citing works
Choi, J., Levey, A. I., Weintraub, S. T., Rees, H. D., Gearing, M., Chin, L.-S., & Li, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314124200 · Cited by 568 · see citing works
Proteasome inhibition by paired helical filament‐tau in brains of patients with Alzheimer's disease
Keck, S., Nitsch, R., Grune, T., & Ullrich, O. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01642.x · Cited by 483 · see citing works
Zhu, J.-H., Horbinski, C., Guo, F.-L., Watkins, S. C., Uchiyama, Y., & Chu, C. T. (2007) · American Journal of Pathology · doi:10.2353/ajpath.2007.060524 · Cited by 469 · see citing works
Tai, H., Serrano‐Pozo, A., Hashimoto, T., Frosch, M. P., Spires‐Jones, T. L., & Hyman, B. T. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.06.033 · Cited by 456 · see citing works
Mańczak, M., & Reddy, P. H. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds072 · Cited by 453 · see citing works
Chinta, S. J., Mallajosyula, J. K., Rane, A., & Andersen, J. K. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.09.061 · Cited by 451 · see citing works
Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis
Palikaras, K., & Tavernarakis, N. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.021 · Cited by 428 · see citing works
Gong, B., Cao, Z., Zheng, P., Vitolo, O. V., Liu, S., Staniszewski, A., Moolman, D. L., Zhang, H., Shelanski, M. L., & Arancio, O. (2006) · Cell · doi:10.1016/j.cell.2006.06.046 · Cited by 424 · see citing works
Reddy, P. H., Tripathi, R., Troung, Q., Tirumala, K., Reddy, T. P., Anekonda, V., Shirendeb, U. P., Calkins, M. J., Reddy, A. P., Mao, P., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.011 · Cited by 394 · see citing works
Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron
Osaka, H. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg211 · Cited by 363 · see citing works
Manczak, M., & Reddy, P. H. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds360 · Cited by 348 · see citing works
Autoregulation of Parkin activity through its ubiquitin‐like domain
Chaugule, V. K., Burchell, L., Barber, K. R., Sidhu, A., Leslie, S. J., Shaw, G. S., & Walden, H. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.204 · Cited by 339 · see citing works
Cai, Q., Zakaria, H. M., Simone, A., & Sheng, Z. (2012) · Current Biology · doi:10.1016/j.cub.2012.02.005 · Cited by 332 · see citing works
Mitochondrial alterations in Alzheimer's disease
Baloyannis, S. J. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9204 · Cited by 318 · see citing works
Reddy, P. H. (2011) · Brain Research · doi:10.1016/j.brainres.2011.07.052 · Cited by 300 · see citing works
Zhu, J., Wang, K. Z. Q., & Chu, C. T. (2013) · Autophagy · doi:10.4161/auto.24135 · Cited by 295 · see citing works
Parkin Interacts with Ambra1 to Induce Mitophagy
Van Humbeeck, C., Cornelissen, T., Hofkens, H., Mandemakers, W., Gevaert, K., De Strooper, B., & Vandenberghe, W. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1917-11.2011 · Cited by 287 · see citing works
Ko, H. S., Lee, Y., Shin, J., Karuppagounder, S. S., Gadad, B. S., Koleske, A. J., Pletniková, O., Troncoso, J. C., Dawson, V. L., & Dawson, T. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006083107 · Cited by 286 · see citing works
The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer’s disease
Wang, X., Su, B., Zheng, L., Perry, G. L., Smith, M. A., & Zhu, X. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05867.x · Cited by 278 · see citing works
Trushina, E. V., Nemutlu, E., Zhang, S., Christensen, T. A., Camp, J. J., Mesa, J., Siddiqui, A., Tamura, Y., Sesaki, H., Wengenack, T. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032737 · Cited by 268 · see citing works
Park, S.-Y., & Ferreira, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1125-05.2005 · Cited by 262 · see citing works
Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy
Choubey, V., Safiulina, D., Vaarmann, A., Cagalinec, M., Warȩski, P., Kuum, M., Zharkovsky, A., & Kaasik, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.132514 · Cited by 261 · see citing works
The role of estrogens on the proliferation of human breast tumor cells (MCF-7)
Soto, A. M., & Sonnenschein, C. (1985) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(85)90265-1 · Cited by 254 · see citing works
NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation
Amadoro, G., Ciotti, M. T., Costanzi, M., Cestari, V., Calissano, P., & Canu, N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511065103 · Cited by 243 · see citing works
Self-citationAbnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's Disease
Zhu, X., Perry, G., Smith, M. A., & Wang, X. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-129005 · Cited by 242 · see citing works
Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease Brain
Rohn, T. T., Rissman, R. A., Davis, M. C., Kim, Y., Cotman, C. W., & Head, E. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0549 · Cited by 242 · see citing works
Proteomics Analysis of the Alzheimer's Disease Hippocampal Proteome
Rukhsana Sultana, A., Debra Boyd-kimball, A., Cai, J., Pierce, W. M. J., Klein, J. B., Merchant, M. L., & Butterfield, D. A. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-11203 · Cited by 231 · see citing works
Reversal of long-term dendritic spine alterations in Alzheimer disease models
Smith, D. L., Pozueta, J., Gong, B., Arancio, O., & Shelanski, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908706106 · Cited by 229 · see citing works
Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease
de la Monte, S. M., Luong, T., Neely, T. R., Robinson, D., & Wands, J. R. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780140 · Cited by 227 · see citing works
Kabuta, T., Furuta, A., Aoki, S., Furuta, K., & Wada, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801918200 · Cited by 227 · see citing works
Alterations in the common fragile site gene Parkin in ovarian and other cancers
Denison, S. R., Wang, F., Becker, N. A., Schüle, B., Kock, N., Phillips, L. A., Klein, C., & Smith, D. I. (2003) · Oncogene · doi:10.1038/sj.onc.1207072 · Cited by 224 · see citing works
Dynamics of the Degradation of Ubiquitinated Proteins by Proteasomes and Autophagy
Myeku, N., & Figueiredo‐Pereira, M. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.149252 · Cited by 221 · see citing works
An automated colorimetric microassay for neuronotrophic factors
Manthorpe, M., Fagnani, R., Skaper, S. D., & Varon, S. S. (1986) · Developmental Brain Research · doi:10.1016/0165-3806(86)90208-7 · Cited by 219 · see citing works
Rakovic, A., Shurkewitsch, K., Seibler, P., Grünewald, A., Zanon, A., Hagenah, J., Krainc, D., & Klein, C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.391680 · Cited by 218 · see citing works
Early N-Terminal Changes and Caspase-6 Cleavage of Tau in Alzheimer's Disease
Horowitz, P. M., Patterson, K. R., Guillozet-Bongaarts, A. L., Reynolds, M. R., Carroll, C. A., Weintraub, S. T., Bennett, D. A., Cryns, V. L., Berry, R. W., & Binder, L. I. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1988-04.2004 · Cited by 215 · see citing works
Yu, W., Sun, Y., Guo, S., & Lu, B. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr235 · Cited by 211 · see citing works
Wang, C., Ko, H. S., Thomas, B., Tsang, F., Chew, K. C. M., Tay, S.-P., Ho, M. W. L., Lim, T. M., Soong, T. W., Pletniková, O., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi413 · Cited by 206 · see citing works
Trinchese, F., Fà, M., Liu, S., Zhang, H., Hidalgo, A., Schmidt, S. D., Yamaguchi, H., Yoshii, N., Mathews, P. M., Nixon, R. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34254 · Cited by 205 · see citing works
ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons
Joselin, A. P., Hewitt, S. J., Callaghan, S. M., Kim, R. H., Chung, Y.-H., Mak, T. W., Shen, J., Slack, R. S., & Park, D. S. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds325 · Cited by 205 · see citing works
A role for tau at the synapse in Alzheimer’s disease pathogenesis
Pooler, A. M., Noble, W., & Hanger, D. P. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.09.018 · Cited by 203 · see citing works
BAG5 Inhibits Parkin and Enhances Dopaminergic Neuron Degeneration
Kalia, S. K., Lee, S., Smith, P. D., Liu, L., Crocker, S. J., Thorarinsdottir, T., Glover, J. R., Fon, E. A., Park, D. S., & Lozano, A. M. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.026 · Cited by 201 · see citing works
Mitofusin2 Mutations Disrupt Axonal Mitochondrial Positioning and Promote Axon Degeneration
Misko, A. L., Sasaki, Y., Tuck, E. J., Milbrandt, J., & Baloh, R. H. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6338-11.2012 · Cited by 195 · see citing works
Autophagy in Neuroprotection and Neurodegeneration: A Question of Balance
Cherra, S. J., & Chu, C. T. (2008) · Future Neurology · doi:10.2217/14796708.3.3.309 · Cited by 191 · see citing works
Mutant LRRK2 Elicits Calcium Imbalance and Depletion of Dendritic Mitochondria in Neurons
Cherra, S. J., Steer, E. K., Gusdon, A. M., Kiselyov, K. I., & Chu, C. T. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.10.027 · Cited by 190 · see citing works
Mitochondrial alterations near amyloid plaques in an Alzheimer’s disease mouse model
Xie, H., Guan, J., Borrelli, L. A., Xu, J., Serrano-Pozo, A., & Bacskai, B. J. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1836-13.2013 · Cited by 185 · see citing works
Mitofusin 2 Protects Cerebellar Granule Neurons against Injury-induced Cell Death
Jahani‐Asl, A., Cheung, E. C., Neuspiel, M., MacLaurin, J. G., Fortin, A., Park, D. S., McBride, H. M., & Slack, R. S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703812200 · Cited by 185 · see citing works
Role of the ubiquitin proteasome system in Alzheimer's disease
Upadhya, S. C., & Hegde, A. N. (2007) · BMC Biochemistry · doi:10.1186/1471-2091-8-s1-s12 · Cited by 184 · see citing works
Neurodegeneration as a consequence of failed mitochondrial maintenance
Karbowski, M., & Neutzner, A. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0921-0 · Cited by 182 · see citing works
Calpain Mediates Excitotoxic DNA Fragmentation via Mitochondrial Pathways in Adult Brains
Takano, J., Tomioka, M., Tsubuki, S., Higuchi, M., Iwata, N., Itohara, S., Maki, M., & Saido, T. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414552200 · Cited by 181 · see citing works
Wei, K., Wang, P., & Miao, C. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12005 · Cited by 181 · see citing works
Mitochondrial quality control by the ubiquitin–proteasome system
Taylor, E. B., & Rutter, J. P. (2011) · Biochemical Society Transactions · doi:10.1042/bst0391509 · Cited by 181 · see citing works
Eckert, A., Schmitt, K., & Götz, J. (2011) · Alzheimer's Research & Therapy · doi:10.1186/alzrt74 · Cited by 177 · see citing works
Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons
Lee, S., Sterky, F. H., Mourier, A., Terzioglu, M., Cullheim, S., Olson, L., & Larsson, N. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds352 · Cited by 177 · see citing works
Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons
Quintanilla, R. A., Matthews-Roberson, T. A., Dolan, P. J., & Johnson, G. V. W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808908200 · Cited by 170 · see citing works
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway
Inoue, K., Rispoli, J., Kaphzan, H., Klann, E., Chen, E. I., Kim, J., Komatsu, M., & Abeliovich, A. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-48 · Cited by 168 · see citing works
Why size matters – balancing mitochondrial dynamics in Alzheimer's disease
DuBoff, B., Feany, M. Β., & Götz, J. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.03.002 · Cited by 164 · see citing works
Hegde, A. N., & DiAntonio, A. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn961 · Cited by 158 · see citing works
Higuchi, M., Tomioka, M., Takano, J., Shirotani, K., Iwata, N., Masumoto, H., Maki, M., Itohara, S., & Saido, T. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500939200 · Cited by 154 · see citing works
Increased Autophagic Degradation of Mitochondria in Alzheimer Disease
Moreira, P. I., Siedlak, S. L., Wang, X., Santos, M. S., Oliveira, C. R., Tabaton, M., Nunomura, A., Szweda, L. I., Aliev, G. M., Smith, M. A., et al. (2007) · Autophagy · doi:10.4161/auto.4872 · Cited by 150 · see citing works
Synaptic Mitochondrial Pathology in Alzheimer's Disease
Du, H., Guo, L., & Yan, S. S. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4277 · Cited by 150 · see citing works
Wong, A. S. L., Lee, R. H. K., Cheung, A. Y., Yeung, P. K. K., Chung, S. K., Cheung, Z. H., & Ip, N. Y. (2011) · Nature Cell Biology · doi:10.1038/ncb2217 · Cited by 149 · see citing works
Novel Monoclonal Antibodies Demonstrate Biochemical Variation of Brain Parkin with Age
Pawlyk, A. C., Giasson, B. I., Sampathu, D. M., Perez, F. A., Lim, K. L., Dawson, V. L., Dawson, T. M., Palmiter, R. D., Trojanowski, J. Q., & Lee, V. M. ‐. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306889200 · Cited by 149 · see citing works
Autophagocytosis of Mitochondria Is Prominent in Alzheimer Disease
Moreira, P. I., Siedlak, S. L., Wang, X., Santos, M. S., Oliveira, C. R., Tabaton, M., Nunomura, A., Szweda, L. I., Aliev, G. M., Smith, M. A., et al. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000240476.73532.b0 · Cited by 145 · see citing works
Liu, Z., Meray, R. K., Grammatopoulos, T. N., Fredenburg, R. A., Cookson, M., Liu, Y., Logan, T., & Lansbury, P. T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806474106 · Cited by 141 · see citing works
Regulation of Synaptic Structure by Ubiquitin C-Terminal Hydrolase L1
Cartier, A. E., Djakovic, S. N., Salehi, A., Wilson, S. M., Masliah, E., & Patrick, G. N. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1817-09.2009 · Cited by 141 · see citing works
Wang, Y., Garg, S., Mandelkow, E., & Mandelkow�, E. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380955 · Cited by 139 · see citing works
Chen, F., Sugiura, Y., Myers, K. G., Liu, Y., & Lin, W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911516107 · Cited by 137 · see citing works
Gillardon, F., Rist, W., Kußmaul, L., Vogel, J., Berg, M., Danzer, K. M., Kraut, N., & Hengerer, B. (2007) · PROTEOMICS · doi:10.1002/pmic.200600728 · Cited by 137 · see citing works
Truncated tau and Aβ cooperatively impair mitochondria in primary neurons
Quintanilla, R. A., Dolan, P. J., Jin, Y. N., & Johnson, G. V. W. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.02.007 · Cited by 136 · see citing works
Harris, J. A., Koyama, A., Maeda, S., Ho, K., Devidze, N., Dubal, D. B., Yu, G.-Q., Masliah, E., & Mucke, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045881 · Cited by 135 · see citing works
Domenico, F. D., Coccia, R., Cocciolo, A., Murphy, M. P., Cenini, G., Head, E., Butterfield, D. A., Giorgi, A., Schininà, M. E., Mancuso, C., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.04.013 · Cited by 133 · see citing works
Laar, V. S. V., & Berman, S. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.05.015 · Cited by 133 · see citing works
Avraham, E., Rott, R., Liani, E., Szargel, R., & Engelender, S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608243200 · Cited by 121 · see citing works
Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up?
Grenier, K., McLelland, G., & Fon, E. A. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00100 · Cited by 120 · see citing works
Butterfield, D. A., Gnjec, A., Poon, H. F., Castegna, A., Pierce, W. M. J., Klein, J. B., & Martins, R. N. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-10407 · Cited by 120 · see citing works
Polydoro, M., Dzhala, V. I., Pooler, A. M., Nicholls, S. B., McKinney, A. P., Sanchez, L., Pitstick, R., Carlson, G. A., Staley, K. J., Spires-Jones, T. L., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1215-5 · Cited by 117 · see citing works
Jahani‐Asl, A., Pilon‐Larose, K., Xu, W., MacLaurin, J. G., Park, D. S., McBride, H. M., & Slack, R. S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.167155 · Cited by 115 · see citing works
Pasinetti, G. M. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1176 · Cited by 111 · see citing works
Spreading of tau pathology in A lzheimer's disease by cell‐to‐cell transmission
Mohamed, N., Herrou, T., Plouffe, V., Piperno, N., & Leclerc, N. M. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12229 · Cited by 110 · see citing works
Zhu, J., Gusdon, A. M., Çimen, H., Houten, B. V., Koç, E., & Chu, C. T. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.46 · Cited by 109 · see citing works
Rao, M. V., Mohan, P. S., Peterhoff, C. M., Yang, D., Schmidt, S., Stavrides, P. H., Campbell, J., Chen, Y., Jiang, Y., Paskevich, P. A., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4119-08.2008 · Cited by 107 · see citing works
Bai, F., & Witzmann, F. A. (2007) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4020-5943-8_6 · Cited by 107 · see citing works
Mitochondrial Dynamics in Alzheimerʼs Disease
Bonda, D., Wang, X., Perry, G. L., Smith, M. A., & Zhu, X. (2010) · Drugs & Aging · doi:10.2165/11532140-000000000-00000 · Cited by 106 · see citing works
Truncation of Tau Protein and its Pathological Significance in Alzheimer's Disease
García‐Sierra, F., Mondragón‐Rodríguez, S., & Basurto‐Islas, G. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14407 · Cited by 101 · see citing works
Reversible Monoubiquitination Regulates the Parkinson Disease-associated Ubiquitin Hydrolase UCH-L1
Meray, R. K., & Lansbury, P. T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611153200 · Cited by 101 · see citing works
Poon, W. W., Carlos, A. J., Aguilar, B. L., Berchtold, N. C., Kawano, C. K., Zograbyan, V., Yaopruke, T., Shelanski, M. L., & Cotman, C. W. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.463711 · Cited by 100 · see citing works
Rao, M. V., McBrayer, M. K., Campbell, J., Kumar, A., Hashim, A. T., Sershen, H. W., Stavrides, P. H., Ohno, M., Hutton, M., & Nixon, R. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1132-14.2014 · Cited by 99 · see citing works
Parkin promotes intracellular A 1-42 clearance
Burns, M. P., Zhang, L., Rebeck, G. W., Querfurth, H. W., & Moussa, C. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp258 · Cited by 98 · see citing works
Chang, C., Huang, H., Lee, H., Hung, K.-C., Wu, R.-T., & Lin, A. M. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00945.x · Cited by 98 · see citing works
Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1
Burbulla, L. F., Fitzgerald, J. C., Stegen, K., Westermeier, J., Thost, A.-K., Kato, H., Mokranjac, D., Sauerwald, J., Martins, L. M., Woitalla, D., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.103 · Cited by 97 · see citing works
Hexokinase activity is required for recruitment of parkin to depolarized mitochondria
McCoy, M. K., Kaganovich, A., Rudenko, I. N., Ding, J., & Cookson, M. R. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddt407 · Cited by 97 · see citing works
Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism
Zheng, X., & Hunter, T. R. (2013) · Cell Research · doi:10.1038/cr.2013.66 · Cited by 94 · see citing works
Amadoro, G., Corsetti, V., Atlante, A., Florenzano, F., Capsoni, S., Bussani, R., Mercanti, D., & Calissano, P. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.08.001 · Cited by 94 · see citing works
Self-citationAmadoro, G., Corsetti, V., Stringaro, A., Colone, M., D’Aguanno, S., Meli, G., Ciotti, M. T., Sancesario, G., Cattaneo, A., Bussani, R., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100120 · Cited by 91 · see citing works
Self-citationLonskaya, I., Shekoyan, A. R., Hebron, M. L., Desforges, N. M., Algarzae, N. K., & Moussa, C. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121141 · Cited by 91 · see citing works
Davison, E. J., Pennington, K., Hung, C., Peng, J., Rafiq, R., Ostareck‐Lederer, A., Ostareck, D. H., Ardley, H. C., Banks, R. E., & Robinson, P. A. (2009) · PROTEOMICS · doi:10.1002/pmic.200900126 · Cited by 87 · see citing works
Development of a method for measuring cell number: Application to CNS primary neuronal cultures
Volonté, C., Ciotti, M. T., & Battistini, L. (1994) · Cytometry · doi:10.1002/cyto.990170311 · Cited by 86 · see citing works
Self-citationAD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons
Amadoro, G., Corsetti, V., Florenzano, F., Atlante, A., Ciotti, M. T., Mongiardi, M. P., Bussani, R., Nicolin, V., Nori, S. L., Campanella, M., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.10.018 · Cited by 85 · see citing works
Self-citationRegulation of parkin and PINK1 by neddylation
Choo, Y. S., Vogler, G., Wang, D., Kalvakuri, S., Iliuk, A. B., Tao, W. A., Bodmer, R., & Zhang, Z. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds070 · Cited by 83 · see citing works
Mitochondrial dismissal in mammals, from protein degradation to mitophagy
Campello, S., Strappazzon, F., & Cecconi, F. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.11.010 · Cited by 83 · see citing works
Autophagy of Mitochondria: A Promising Therapeutic Target for Neurodegenerative Disease
Kamat, P. K., Kalani, A., Kyles, P., Tyagi, S. C., & Tyagi, N. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-014-0006-5 · Cited by 82 · see citing works
Analysis of a membrane‐enriched proteome from postmortem human brain tissue in A lzheimer's disease
Donovan, L. E., Higginbotham, L. A., Dammer, E. B., Gearing, M., Rees, H. D., Xia, Q., Duong, D. M., Seyfried, N. T., Lah, J. J., & Levey, A. I. (2012) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201100068 · Cited by 82 · see citing works
Reifert, J. R., Hartung-Cranston, D., & Feinstein, S. C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.234674 · Cited by 80 · see citing works
Santiago, A. P. S. A., Chaves, E. A., de Oliveira, M. F., & Galina, A. (2008) · Biochimie · doi:10.1016/j.biochi.2008.06.013 · Cited by 80 · see citing works
Amadoro, G., Corsetti, V., Florenzano, F., Atlante, A., Bobba, A., Nicolin, V., Nori, S., & Calissano, P. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00018 · Cited by 80 · see citing works
Self-citationDifferential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity
Walters, B. J., Campbell, S. L., Chen, P. C., Taylor, A. P., Schroeder, D. G., Dobrunz, L. E., Artavanis‐Tsakonas, K., Ploegh, H. L., Wilson, J. A., Cox, G. A., et al. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.07.028 · Cited by 78 · see citing works
Pacheco, C. D., Elrick, M. J., & Lieberman, A. P. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn423 · Cited by 74 · see citing works
Harada, T., Harada, C., Wang, Y.-L., Osaka, H., Amanai, K., Tanaka, K., Takizawa, S., Setsuie, R., Sakurai, M., Sato, Y., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63096-9 · Cited by 73 · see citing works
Cartier, A. E., Ubhi, K. K., Spencer, B. J., Vázquez‐Roque, R. A., Kosberg, K. A., Fourgeaud, L., Kanayson, P., Patrick, C., Rockenstein, E. M., Patrick, G. N., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034713 · Cited by 70 · see citing works
Role of N-terminal tau domain integrity on the survival of cerebellar granule neurons
Amadoro, G., Serafino, A., Barbato, C., Ciotti, M. T., Sacco, A., Calissano, P., & Canu, N. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401314 · Cited by 69 · see citing works
Self-citationA pilot proteomic study of amyloid precursor interactors in Alzheimer's disease
Cottrell, B. A., Galván, V., Banwait, S., Gorostiza, O. F., Lombardo, C. R., Williams, T., Schilling, B., Peel, A. L., Gibson, B. W., Koo, E. H., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20554 · Cited by 68 · see citing works
Effects of UCH‐L1 on α‐synuclein over‐expression mouse model of Parkinson’s disease
Yasuda, T., Nihira, T., Ren, Y., Cao, X., Wada, K., Setsuie, R., Kabuta, T., Wada, K., Hattori, N., Mizuno, Y., et al. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05827.x · Cited by 67 · see citing works
Guglielmotto, M., Monteleone, D., Boido, M., Piras, A., Giliberto, L., Borghi, R., Vercelli, A., Fornaro, M., Tabaton, M., & Tamagno, E. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00854.x · Cited by 66 · see citing works
Mitochondria Are Related to Synaptic Pathology in Alzheimer's Disease
Baloyannis, S. J. (2011) · International Journal of Alzheimer's Disease · doi:10.4061/2011/305395 · Cited by 66 · see citing works
Phosphorylation and cleavage of tau in non-AD tauopathies
Guillozet-Bongaarts, A. L., Glajch, K. E., Libson, E. G., Cahill, M. E., Bigio, E. H., Berry, R. W., & Binder, L. I. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0209-6 · Cited by 65 · see citing works
How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?
Ziviani, E., & Whitworth, A. J. (2010) · Autophagy · doi:10.4161/auto.6.5.12242 · Cited by 64 · see citing works
Corsetti, V., Amadoro, G., Gentile, A., Capsoni, S., Ciotti, M. T., Cencioni, M. T., Atlante, A., Canu, N., Rohn, T. T., Cattaneo, A., et al. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.03.011 · Cited by 64 · see citing works
Self-citationKumar, P., Pradhan, K., Ramani, K., Ambasta, R. K., & Querfurth, H. W. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07588.x · Cited by 61 · see citing works
Profiling of Parkin-Binding Partners Using Tandem Affinity Purification
Zanon, A., Raković, A., Blankenburg, H., Doncheva, N. T., Schwienbacher, C., Serafin, A., Alexa, A., Weichenberger, C. X., Albrecht, M., Klein, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078648 · Cited by 60 · see citing works
Dynamic survey of mitochondria by ubiquitin
Escobar‐Henriques, M., & Langer, T. (2014) · EMBO Reports · doi:10.1002/embr.201338225 · Cited by 60 · see citing works
Schoch, K. M., Evans, H. N., Brelsfoard, J., Madathil, S. K., Takano, J., Saido, T. C., & Saatman, K. E. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.04.022 · Cited by 53 · see citing works
Xue, S., & Jia, J. (2006) · Brain Research · doi:10.1016/j.brainres.2006.02.121 · Cited by 49 · see citing works
The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells
Kyratzi, E., Pavlaki, M., & Stefanis, L. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn115 · Cited by 48 · see citing works
Bizzi, A., Schaetzle, B., Patton, A., Gambetti, P. L., & AUTILIO‐GAMBETTI, L. (1991) · Brain Research · doi:10.1016/0006-8993(91)91135-n · Cited by 48 · see citing works
Kabuta, T., & Wada, K. (2008) · Autophagy · doi:10.4161/auto.6560 · Cited by 42 · see citing works
Amadoro, G., Corsetti, V., Sancesario, G. M., Lubrano, A., Melchiorri, G., Bernardini, S., Calissano, P., & Sancesario, G. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140267 · Cited by 41 · see citing works
Self-citationParkin Deficiency Delays Motor Decline and Disease Manifestation in a Mouse Model of Synucleinopathy
Fournier, M., Vitte, J., Garrigue, J., Langui, D., Dullin, J.-P., Saurini, F., Hanoun, N., Pérez-Díaz, F., Cornilleau, F., Joubert, C., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006629 · Cited by 40 · see citing works
The Dying of the Light: Mitochondrial Failure in Alzheimer's Disease
Young, K. J., McArdle, M. J., & Bennett, J. P. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111487 · Cited by 39 · see citing works
Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory
Pristerà, A., Saraulli, D., Vecchioli, S. F., Strimpakos, G., Costanzi, M., Certo, M. G. D., Cannas, S., Ciotti, M. T., Tirone, F., Mattei, E., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.05.010 · Cited by 39 · see citing works
Self-citationHung, K.-C., Huang, H.-J., Lin, M., Lei, Y.-P., & Lin, A. M.-Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091074 · Cited by 38 · see citing works
Pittaluga, A., Feligioni, M., Longordo, F., Luccini, E., & Raiteri, M. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.09.004 · Cited by 37 · see citing works
Self-citationParkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice
Rodríguez‐Navarro, J. A., Gómez, A., Rodal, I., Perucho, J., Martínez, A., Furió, V., Ampuero, I., Casarejos, M. J., Solano, R. M., de Yébenes, J. G., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn210 · Cited by 36 · see citing works
Koyano, F., Okatsu, K., Ishigaki, S., Fujioka, Y., Kimura, M., Sobue, G., Tanaka, K., & Matsuda, N. (2013) · Genes to Cells · doi:10.1111/gtc.12066 · Cited by 35 · see citing works
Tzeng, Y.-C., Lee, L. Y., Chao, P., Lee, H., Wu, R. T., & Lin, A. M. Y. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.06.004 · Cited by 30 · see citing works
Cai, Q., Zakaria, H. M., & Sheng, Z. (2012) · Autophagy · doi:10.4161/auto.20218 · Cited by 28 · see citing works
αCaMKII autophosphorylation levels differ depending on subcellular localization
Davies, K. D., Alvestad, R. M., Coultrap, S. J., & Browning, M. D. (2007) · Brain Research · doi:10.1016/j.brainres.2007.05.008 · Cited by 27 · see citing works
Cuadrado‐Tejedor, M., Cabodevilla, J. F., Zamarbide, M., et al. (2013) · Current Alzheimer Research · doi:10.2174/1567205011310040005 · Cited by 25 · see citing works
Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD Mice
Varghese, M., Zhao, W., Wang, J., Cheng, A., Qian, X., Chaudhry, A., Ho, L., & Pasinetti, G. M. (2011) · Translational Neuroscience · doi:10.2478/s13380-011-0011-8 · Cited by 22 · see citing works
Pittaluga, A., Segantini, D., Feligioni, M., et al. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705960 · Cited by 21 · see citing works
Self-citationAssessing Neuronal Bioenergetic Status
Zeiger, S. L. H., Stankowski, J. N., & McLaughlin, B. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-170-3_15 · Cited by 17 · see citing works
Solano, R., Casarejos, M., Gómez, A., Perucho, J., de Yébenes, J. G., & Mena, M. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-120406 · Cited by 13 · see citing works
Fournier, M., Roux, A., Garrigue, J., Muriel, M., Blanche, P., Lashuel, H. A., Anderson, J. P., Barbour, R., Huang, J., du Montcel, S. T., et al. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-135 · Cited by 7 · see citing works
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Roles of tau protein in health and disease
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Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy
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Cheng, D., Yang, S., Zhao, X., & Wang, G. (2022) · Drug Design, Development and Therapy · doi:10.2147/dddt.s348055 · Cited by 84 · see citing works
- Authors
- Corsetti, V., Florenzano, F., Atlante, A., Bobba, A., Ciotti, M. T., Natale, F., Della Valle, F., Borreca, A., Manca, A., Meli, G., Ferraina, C., Feligioni, M., D'Aguanno, S., Bussani, R., Ammassari-Teule, M., Nicolin, V., Calissano, P., & Amadoro, G.
- Affiliations
- Istituto di Farmacologia Traslazionale (IT)
- European Brain Research Institute (IT)
- Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IT)
- Fondazione Santa Lucia (IT)
- Ospedale di Cattinara (IT)
- University of Trieste (IT)
- Corresponding author
- Amadoro, G.
- ORCID
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-02-15
- Volume
- 24
- Issue
- 11
- Pages
- 3058-3081
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2110862168
- Cited by
- 129
- References
- 161
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 11 · 2023: 12 · 2022: 14 · 2021: 22 · 2020: 14 · 2019: 10 · 2018: 10 · 2017: 9 · 2016: 7 · 2015: 4
- FWCI
- 7.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Molecular Genetics (publishedVersion)
- PubMed (publishedVersion)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion, other-oa)
- Funders
- Fondazione Roma (2010M2JARJ-003)
- Directorate for Biological Sciences
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- tau truncation, Alzheimer's disease, mitophagy, Parkin, UCHL1, synaptic mitochondria, neuronal cell death, mitochondrial quality control, autophagy, ubiquitin homeostasis, ADP/ATP exchange, hippocampal neurons, cerebrospinal fluid biomarkers
- MeSH terms
- Alzheimer Disease, Animals, HeLa Cells, Humans, Mice, Inbred C57BL, Mice, Transgenic, Neurons, tau Proteins, Rats, Wistar, Protein Transport, Mitochondrial Proteins, Ubiquitin Thiolesterase, Ubiquitin-Protein Ligases, Mitophagy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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