Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions

R: A Language and Environment for Statistical Computing

R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,893

PLINK: a tool set for whole-genome association and population-based linkage analyses.

Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089

The variant call format and VCFtools

Danecek, P., Auton, A., Abecasis, G. R., Albers, C. A., Banks, E., DePristo, M. A., Handsaker, R. E., Lunter, G. A., Marth, G., Sherry, S. T., et al. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr330 · Cited by 16,450

Second-generation PLINK: rising to the challenge of larger and richer datasets

Chang, C. C., Chow, C. C., Tellier, L. C., Vattikuti, S., Purcell, S. M., & Lee, J. J. (2015) · Gigascience · doi:10.1186/s13742-015-0047-8 · Cited by 12,709

GCTA: a tool for genome-wide complex trait analysis

Yang, J., Lee, S. H., Goddard, M. E., & Visscher, P. M. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.11.011 · Cited by 8,279

Biological insights from 108 schizophrenia-associated genetic loci

Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) · Nature · doi:10.1038/nature13595 · Cited by 7,577

DNA methylation age of human tissues and cell types

Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075

Integrative analysis of 111 reference human epigenomes

Roadmap Epigenomics Consortium, Kundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heravi-Moussavi, A., Kheradpour, P., Zhang, Z., Wang, J., et al. (2015) · Nature · doi:10.1038/nature14248 · Cited by 6,368

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821

GREAT improves functional interpretation of cis-regulatory regions

McLean, C. Y., Bristor, D., Hiller, M., Clarke, S. L., Schaar, B. T., Lowe, C. B., Wenger, A. M., & Bejerano, G. (2010) · Nature Biotechnology · doi:10.1038/nbt.1630 · Cited by 4,502

Psychosis in Alzheimer disease—mechanisms, genetics and therapeutic opportunities

Ismail, Z., Creese, B., Aarsland, D., Kales, H. C., Lyketsos, C. G., Sweet, R. A., & Ballard, C. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-021-00597-3 · Cited by 189

Epigenetic Modifications in Schizophrenia and Related Disorders: Molecular Scars of Environmental Exposures and Source of Phenotypic Variability

Richetto, J., & Meyer, U. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.03.008 · Cited by 189

Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings

Smigielski, L., Jagannath, V., Rössler, W., Walitza, S., & Grünblatt, E. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0601-3 · Cited by 168

Neuronal brain-region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability

Rizzardi, L. F., Hickey, P. F., Rodriguez DiBlasi, V., Tryggvadóttir, R., Callahan, C. M., Idrizi, A., Hansen, K. D., & Feinberg, A. P. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0297-8 · Cited by 146

Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences

Bogdan, R., Baranger, D. A. A., & Arpana Agrawal, A. (2018) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050817-084847 · Cited by 169

DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia

Hannon, E., Dempster, E. L., Mansell, G., Burrage, J., Bass, N., Bohlken, M. M., Corvin, A., Curtis, C. J., Dempster, D., Di Forti, M., et al. (2021) · eLife · doi:10.7554/elife.58430 · Cited by 132

Epigenome-wide meta-analysis of DNA methylation differences in prefrontal cortex implicates the immune processes in Alzheimer’s disease

Zhang, L., Silva, T. C., Young, J. I., Gomez, L., Schmidt, M. A., Hamilton-Nelson, K. L., Kunkle, B. W., Chen, X., Martin, E. R., & Wang, L. (2020) · Nature Communications · doi:10.1038/s41467-020-19791-w · Cited by 139

Systematic underestimation of the epigenetic clock and age acceleration in older subjects

Khoury, L. Y. E., Gorrie-Stone, T. J., Smart, M., Hughes, A., Bao, Y., Andrayas, A., Burrage, J., Hannon, E. J., Meena Kumari, B., Mill, J. S., et al. (2019) · Genome biology · doi:10.1186/s13059-019-1810-4 · Cited by 135

Elevated polygenic burden for autism is associated with differential DNA methylation at birth

Hannon, E. J., Schendel, D., Ladd‐Acosta, C., Grove, J., iPSYCH-Broad ASD Group, Hansen, C. S., Andrews, S. V., HOUGAARD, D. M., Bresnahan, M. A., Mors, O. N., et al. (2018) · Genome Medicine · doi:10.1186/s13073-018-0527-4 · Cited by 121

Hidden Role of Gut Microbiome Dysbiosis in Schizophrenia: Antipsychotics or Psychobiotics as Therapeutics?

Munawar, N., Ahsan, K., Muhammad, K., Ahmad, A., Anwar, M. A., Shah, I., Ameri, A. A., & Mughairbi, F. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147671 · Cited by 107

Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

study, T. A. I. B. A. L., Nabais, M. F., Initiative, T. A. D. N., Laws, S. M., Lin, T., Vallerga, C. L., Armstrong, N. J., Blair, I. P., Kwok, J. B., Mather, K. A., et al. (2021) · Genome Biology · doi:10.1186/s13059-021-02275-5 · Cited by 99

Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic autism in post-mortem human brain tissue

Wong, C. C. Y., Smith, R. G., Hannon, E., Ramaswami, G., Parikshak, N. N., Assary, E., Troakes, C., Poschmann, J., Schalkwyk, L. C., Sun, W., et al. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz052 · Cited by 98

DNA methylation and antipsychotic treatment mechanisms in schizophrenia: Progress and future directions

Ovenden, E. S., McGregor, N. W., Emsley, R. A., & Warnich, L. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.10.004 · Cited by 88

Sexually divergent DNA methylation patterns with hippocampal aging

Masser, D. R., Hadad, N., Porter, H. L., Mangold, C. A., Unnikrishnan, A., Ford, M. M., Giles, C. B., Georgescu, C., Dozmorov, M. G., Wren, J. D., et al. (2017) · Aging Cell · doi:10.1111/acel.12681 · Cited by 70

DNA methylation signatures in panic disorder

Iurato, S., Carrillo-Roa, T., Arloth, J., Czamara, D., Diener-Hölzl, L., Lange, J., Müller-Myhsok, B., Binder, E. B., & Erhardt, A. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0026-1 · Cited by 70

DNA methylation and inflammation marker profiles associated with a history of depression

Crawford, B., Craig, Z., Mansell, G., White, I., Smith, A. R., Spaull, S. R., Imm, J. L., Hannon, E. J., Wood, A. R., Yaghootkar, H., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy199 · Cited by 69

MOSTWAS: Multi-Omic Strategies for Transcriptome-Wide Association Studies

Bhattacharya, A., Li, Y., & Love, M. I. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009398 · Cited by 70

Genome-wide DNA methylation meta-analysis in the brains of suicide completers

Policicchio, S., Washer, S., Viana, J., Iatrou, A., Burrage, J., Hannon, E., Turecki, G., Kaminsky, Z., Mill, J., Dempster, E. L., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0752-7 · Cited by 61

Development of an epigenetic clock resistant to changes in immune cell composition

Tomusiak, A., Floro, A., Tiwari, R., Riley, R. R., Matsui, H., Andrews, N., Kasler, H. G., & Verdin, E. M. (2024) · Communications Biology · doi:10.1038/s42003-024-06609-4 · Cited by 77

Toward personalized medicine in schizophrenia: Genetics and epigenetics of antipsychotic treatment

Lisoway, A. J., Chen, C. C., Zai, C. C. H., Tiwari, A. K., & Kennedy, J. L. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.05.010 · Cited by 65

Sex-specific DNA methylation differences in Alzheimer’s disease pathology

Zhang, L., Young, J. I., Gomez, L., Silva, T. C., Schmidt, M. A., Cai, J., Chen, X., Martin, E. R., & Wang, L. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01177-8 · Cited by 58

Accelerated aging in the brain, epigenetic aging in blood, and polygenic risk for schizophrenia

Teeuw, J., Ori, A. P. S., Brouwer, R. M., de Zwarte, S. M. C., Schnack, H. G., Pol, H. E. H., & Ophoff, R. A. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.04.005 · Cited by 55

DNA methylation age is not accelerated in brain or blood of subjects with schizophrenia

McKinney, B. C., Huang, L., Ding, Y., Lewis, D. A., & Sweet, R. A. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.09.025 · Cited by 54

Parent of origin genetic effects on methylation in humans are common and influence complex trait variation

Zeng, Y., Amador, C., Xia, C., Marioni, R. E., Sproul, D., Walker, R. M., Morris, S. W., Bretherick, A. D., Canela‐Xandri, O., Boutin, T., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09301-y · Cited by 46

Machine learning in schizophrenia genomics, a case‐control study using 5,090 exomes

Trakadis, Y. J., Sardaar, S., Chen, A., Fulginiti, V., & Krishnan, A. (2018) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32638 · Cited by 50

Tissue-specific DNA methylation loss during ageing and carcinogenesis is linked to chromosome structure, replication timing and cell division rates

Dmitrijeva, M., Ossowski, S., Serrano, L. G., & Schaefer, M. H. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky498 · Cited by 54

Genetic vulnerability to DUSP22 promoter hypermethylation is involved in the relation between in utero famine exposure and schizophrenia

Boks, M. P., Houtepen, L. C., Xu, Z., He, Y., Ursini, G., Maihofer, A. X., Rajarajan, P., Yu, Q., Xu, H., Wu, Y., et al. (2018) · Schizophrenia · doi:10.1038/s41537-018-0058-4 · Cited by 45

Schizophrenia-risk and urban birth are associated with proteomic changes in neonatal dried blood spots

Cooper, J. D., Özcan, S., Gardner, R. M., Rustogi, N., Wicks, S., van Rees, G. F., Leweke, F. M., Dalman, C., Karlsson, H., & Bahn, S. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0027-0 · Cited by 44

Molecular windows into the human brain for psychiatric disorders

Egervári, G., Kozlenkov, A., Dracheva, S. M., & Hurd, Y. L. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0125-2 · Cited by 40

Epigenetic clock analysis of blood samples from Japanese schizophrenia patients

Okazaki, S., Otsuka, I., Numata, S., Horai, T., Mouri, K., Boku, S., Ohmori, T., Sora, I., & Hishimoto, A. (2019) · Schizophrenia · doi:10.1038/s41537-019-0072-1 · Cited by 45

Epigenetic Factors in Schizophrenia: Mechanisms and Experimental Approaches

Föcking, M., Doyle, B., Munawar, N., Dillon, E., Cotter, D., & Cagney, G. (2019) · Complex Psychiatry · doi:10.1159/000495063 · Cited by 45

Are the epigenetic changes predictive of therapeutic efficacy for psychiatric disorders? A translational approach towards novel drug targets

Micale, V., Bartolomeo, M. D., Martino, S. D., Štark, T., Dell’Osso, B. M., Drago, F., & D’Addario, C. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108279 · Cited by 41

Alterations Of Glycerophospholipid And Fatty Acyl Metabolism In Multiple Brain Regions Of Schizophrenia Microbiota Recipient Mice

Liang, W., Huang, Y., Tan, X., Wu, J., Duan, J., Zhang, H., Yin, B., Li, Y., Zheng, P., Wei, H., et al. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s225982 · Cited by 36

An epigenetic basis for an omnigenic model of psychiatric disorders

Peedicayil, J., & Grayson, D. R. (2018) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2018.01.027 · Cited by 35

Map of epigenetic age acceleration: A worldwide analysis

Yusipov, I., Kalyakulina, A., Trukhanov, A., Franceschi, C., & Ivanchenko, M. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102418 · Cited by 43

Biological aging in schizophrenia and psychosis severity: DNA methylation analysis

Dada, O. O., Adanty, C., Dai, N., Jeremian, R., Alli, S. R., Gerretsen, P., Graff, A., Strauss, J., & Luca, V. D. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.113646 · Cited by 30

Hard wiring of normal tissue-specific chromosome-wide gene expression levels is an additional factor driving cancer type-specific aneuploidies

Auslander, N., Heselmeyer‐Haddad, K., Patkar, S., Hirsch, D. D., Camps, J., Brown, M., Bronder, D., Chen, W.-D. D., Lokanga, R. A., Wangsa, D., et al. (2021) · Genome Medicine · doi:10.1186/s13073-021-00905-y · Cited by 33

Psychosis-associated DNA methylomic variation in Alzheimer's disease cortex

Pishva, E., Creese, B., Smith, A. R., Viechtbauer, W., Proitsi, P., van den Hove, D., Ballard, C. G., Mill, J. S., & Lunnon, K. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.01.001 · Cited by 33

Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA methylation and transcription phenotypes share genetic variation with schizophrenia risk

McKinney, B. C., McClain, L. L., Hensler, C., Wei, Y., Klei, L., Lewis, D. A., Devlin, B., Wang, J., Ding, Y., & Sweet, R. A. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02071-0 · Cited by 32

Differential DNA methylation at birth associated with mental disorder in individuals with 22q11.2 deletion syndrome

Starnawska, A., Hansen, C. S., Sparsø, T., Mazin, W., Olsen, L., Bertalan, M., Buil, A., Bybjerg‐Grauholm, J., Bækvad‐Hansen, M., HOUGAARD, D. M., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.181 · Cited by 28

Methylation age acceleration does not predict mortality in schizophrenia

Kowalec, K., Hannon, E. J., Mansell, G., Burrage, J., Ori, A. P. S., Ophoff, R. A., Mill, J. S., & Sullivan, P. F. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0489-3 · Cited by 26

Chromatin profiling of cortical neurons identifies individual epigenetic signatures in schizophrenia

Gusev, F. E., Reshetov, D. A., Mitchell, A., Андреева, Т. В., Dincer, A., Grigorenko, A. P., Fedonin, G. G., Halene, T. B., Aliseychik, M., Filippova, E., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0596-1 · Cited by 24

Peripheral Blood-Based Gene Expression Studies in Schizophrenia: A Systematic Review

Wagh, V. V., Vyas, P., Agrawal, S., Pachpor, T. A., Paralikar, V. P., & Khare, S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.736483 · Cited by 25

Using Openly Accessible Resources to Strengthen Causal Inference in Epigenetic Epidemiology of Neurodevelopment and Mental Health

Walton, E., Relton, C. L., & Caramaschi, D. (2019) · Genes · doi:10.3390/genes10030193 · Cited by 20

Prenatal maternal stress is associated with increased sensitivity to neuropathic pain and sex-specific changes in supraspinal mRNA expression of epigenetic- and stress-related genes in adulthood

Grégoire, S., Jang, S. H., Szyf, M., & Stone, L. S. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112396 · Cited by 25

Epigenome-wide association study of attention-deficit/hyperactivity disorder in adults

Rovira, P., Sánchez‐Mora, C., Pagerols, M., Vanesa Richarte, B., Montse Corrales, F., Fadeuilhe, C., Vilar‐Ribó, L., Arribas, L., Shireby, G. L., Hannon, E. J., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0860-4 · Cited by 24

Hierarchical deconvolution for extensive cell type resolution in the human brain using DNA methylation

Zhang, Z., Wiencke, J. K., Kelsey, K. T., Koestler, D. C., Molinaro, A. M., Pike, S. C., Karra, P., Christensen, B. C., & Salas, L. A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1198243 · Cited by 23

Longitudinal investigation of DNA methylation changes preceding adolescent psychotic experiences

Roberts, S., Suderman, M. J., Zammit, S., Watkins, S., Hannon, E. J., Mill, J. S., Relton, C. L., Arseneault, L., Wong, C. C. Y., & Fisher, H. L. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0407-8 · Cited by 27

Quantifying the proportion of different cell types in the human cortex using DNA methylation profiles

Hannon, E. J., Dempster, E. L., Davies, J. P., Davies, J. P., Blake, G. E. T., Burrage, J., Policicchio, S. S. S., Franklin, A., Walker, E., Bamford, R. A., et al. (2024) · BMC Biology · doi:10.1186/s12915-024-01827-y · Cited by 25

Cortical cellular diversity and development in schizophrenia

Price, A. J., Jaffe, A. E., & Weinberger, D. R. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0775-8 · Cited by 23

A New Era for Epigenetic Epidemiology

Gunasekara, C., & Waterland, R. A. (2019) · Epigenomics · doi:10.2217/epi-2019-0282 · Cited by 16

Differential methylation of imprinting genes and MHC locus in 22q11.2 deletion syndrome-related schizophrenia spectrum disorders

Carmel, M., Michaelovsky, E., Weinberger, R., Frisch, A., Mekori‐Domachevsky, E., Gothelf, D., & Weizman, A. (2020) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2020.1747113 · Cited by 19

Meta-analysis of epigenetic aging in schizophrenia reveals multifaceted relationships with age, sex, illness duration, and polygenic risk

Ori, A. P. S., Loohuis, L. M. O., Guintivano, J., Hannon, E. J., Dempster, E. L., Clair, D. S., Bass, N. J., McQuillin, A., Mill, J. S., Sullivan, P. F., et al. (2024) · Clinical Epigenetics · doi:10.1186/s13148-024-01660-8 · Cited by 26

Comparative analysis reveals distinctive epigenetic features of the human cerebellum

Guevara, E. E., Hopkins, W. D., Hof, P. R., Ely, J. J., Bradley, B. J., & Sherwood, C. C. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009506 · Cited by 21

Schizophrenia is associated with altered DNA methylation variance

Kiltschewskij, D. J., Reay, W. R., & Cairns, M. J. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02749-5 · Cited by 19

Epigenetic clocks in relapse after a first episode of schizophrenia

Segura, À. G., Prohens, L., Mezquida, G., Amoretti, S., Bioque, M., Ribeiro, M., Gurriarán, X., Rementería, L., Bergé, D., Rodríguez–Jiménez, R., et al. (2022) · Schizophrenia · doi:10.1038/s41537-022-00268-2 · Cited by 16

Integrative In Silico Analysis of Genome-Wide DNA Methylation Profiles in Schizophrenia

Forero, D. A., & González‐Giraldo, Y. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01585-w · Cited by 16

Schizophrenia: a classic battle ground of nature versus nurture debate

Clair, D. S., & Lang, B. (2021) · 中国科学通报：英文版 · doi:10.1016/j.scib.2021.01.032 · Cited by 20

Bioinformatics and network-based approaches for determining pathways, signature molecules, and drug substances connected to genetic basis of schizophrenia etiology

Khan, U., Rahman, M. H., Khan, M. S., Hossain, M. S., & Billah, M. M. (2022) · Brain Research · doi:10.1016/j.brainres.2022.147889 · Cited by 14

Variability of DNA Methylation within Schizophrenia Risk Loci across Subregions of Human Hippocampus

Ruzicka, W. B., Subburaju, S., & Benes, F. M. (2017) · Genes · doi:10.3390/genes8050143 · Cited by 14

Development of a novel epigenetic clock resistant to changes in immune cell compositionPreprint

Tomusiak, A., Floro, A., Tiwari, R., Riley, R. R., Matsui, H., Andrews, N., Kasler, H. G., & Verdin, E. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.01.530561 · Cited by 15

Epigenetic analysis suggests aberrant cerebellum brain aging in old-aged adults with autism spectrum disorder and schizophrenia

Liu, L., Qi, X., Cheng, S., Meng, P., Yang, X., Pan, C., Zhang, N., Chen, Y., Li, C., Zhang, H., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02233-6 · Cited by 14

Methylomic signature of current cannabis use in two first-episode psychosis cohorts

Dempster, E. L., Wong, C. C. Y., Burrage, J., Hannon, E. J., Quattrone, D., Trotta, G., Rodríguez, V., Alameda, L., Spinazzola, E., Tripoli, G., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02689-0 · Cited by 12

Epigenetics of Ageing and Psychiatric Disorders

Coliță, C.-I., Udriștoiu, I., Ancuța, D.-L., Hermann, D. M., Coliță, D., Coliță, E., Glăvan, D., & Popa‐Wagner, A. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2301013 · Cited by 12

DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes

Garcia‐Ruiz, B., de Moura, M. C., Muntané, G., Martorell, L., Bosch, E., Esteller, M., Canales-Rodríguez, E. J., Pomarol‐Clotet, E., Jiménez, E., Vieta, E., et al. (2021) · Epigenomics · doi:10.2217/epi-2021-0006 · Cited by 12

High polygenic burden is associated with blood DNA methylation changes in individuals with suicidal behavior

Cabrera‐Mendoza, B., Martínez‐Magaña, J. J., Mendoza, A. D. G., Sarmiento, E., Ruíz-Ramos, D., Tovilla‐Zárate, C. A., González‐Castro, T. B., Juárez‐Rojop, I. E., la Cruz, D. D. G.-D., López‐Armenta, M., et al. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.01.008 · Cited by 11

A perspective on epigenomic aging processes in the human brain and their plasticity in patients with mental disorders – a systematic review

Postberg, J., Schubert, M. T., Nin, V., Wagner, L., & Piefke, M. (2024) · Neurogenetics · doi:10.1007/s10048-024-00771-x · Cited by 9

Epigenetics: a missing link in understanding psychiatric disorders?

Ryan, J. L., Saffery, R., & Patton, G. C. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30481-9 · Cited by 9

A Novel Schizophrenia Diagnostic Model Based on Statistically Significant Changes in Gene Methylation in Specific Brain Regions

Zou, D., Qiu, Y., Li, R., Meng, Y., & Wu, Y. (2020) · BioMed Research International · doi:10.1155/2020/8047146 · Cited by 9

Genome-wide DNA methylation profiles of autism spectrum disorder

Sun, L., Wang, X., Wang, X., Cui, X., Li, G., Wang, L., Wang, L., Song, M., & Yu, L. (2022) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000314 · Cited by 9

The Neuroepigenome: Implications of Chemical and Physical Modifications of Genomic DNA in Schizophrenia

Girdhar, K., Rahman, S., Dong, P., Fullard, J. F., & Roussos, P. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.04.018 · Cited by 9

Epigenetic studies of schizophrenia: current status and future directions

Migdalska‐Richards, A., & Mill, J. S. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.12.003 · Cited by 9

DNA Methylation Differences in Cortical Grey and White Matter in Schizophrenia

van Berlekom, A. B., Notman, N., Sneeboer, M. A. M., Snijders, G. J. L., Houtepen, L. C., Nispeling, D. M., He, Y., Dracheva, S. M., Hol, E. M., Kahn, R. S., et al. (2021) · Epigenomics · doi:10.2217/epi-2021-0077 · Cited by 9

Properties of the epigenetic clock and age accelerationPreprint

Khoury, L. Y. E., Gorrie-Stone, T. J., Smart, M., Hughes, A., Bao, Y., Andrayas, A., Burrage, J., Hannon, E. J., Meena Kumari, B., Mill, J. S., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/363143 · Cited by 8

Transcriptomic Data Analysis Reveals a Down-Expression of Galectin-8 in Schizophrenia Hippocampus

Petralia, M. C., Ciurleo, R., Bramanti, A., Bramanti, P., Saraceno, A., Mangano, K., Quattropani, M. C. A., Nicoletti, F., & Fagone, P. (2021) · Brain Sciences · doi:10.3390/brainsci11080973 · Cited by 7

30 SCHIZOPHRENIA IS CHARACTERIZED BY AGE- AND SEX-SPECIFIC EFFECTS ON EPIGENETIC AGING

Ori, A. P. S., Loohuis, L. M. O., Guintivano, J., Clair, D. S., McQuillin, A., Mill, J. S., Sullivan, P. F., Kahn, R. S., Horvath, S., & Ophoff, R. A. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.07.171 · Cited by 6

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Ori, A. P. S., Loohuis, L. M. O., Guintivano, J., Hannon, E. J., Dempster, E. L., Clair, D. S., Bass, N. J., McQuillin, A., Mill, J. S., Sullivan, P. F., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/727859 · Cited by 7

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Clifton, N. E., Policicchio, S. S. S., Walker, E., Castanho, I., Bosworth, M. L., Saravanaraj, K. S., Burrage, J., Hall, J., Dempster, E. L., Hannon, E. J., et al. (2025) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaf091 · Cited by 6

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Boström, A. E. D., Jamshidi, E., Manu, D.-M., Kular, L., Schiöth, H. B., Åsberg, M., & Jokinen, J. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.02.025 · Cited by 6

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Garcia‐Ruiz, B., Jiménez, E., Aranda, S., Verdolini, N., Gutiérrez‐Zotes, A., Sáez, C., Losantos, E., Alonso-Lana, S., Fatjó‐Vilas, M., Sarró, S., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02522-8 · Cited by 6

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Kouhsar, M. P., Weymouth, L. S., Smith, A. R., Imm, J. L., Bredemeyer, C., Wedatilake, Y., Torkamani, A., Bergh, S., Selbæk, G., Mill, J. S., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14501 · Cited by 8

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Алфимова, М. В., Kondratyev, N. V., Golov, A. K., & Голимбет, В. Е. (2020) · Scientific Reports · doi:10.1038/s41598-020-61671-2 · Cited by 6

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Yusipov, I., Kalyakulina, A., Franceschi, C., & Ivanchenko, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.17.585398 · Cited by 6

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Hagenbeek, F. A., Pool, R., Asselt, A. J. V., Ehli, E. A., Smit, A. B., Bartels, M., Hottenga, J., Dolan, C. V., van Dongen, J., & Boomsma, D. I. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02981-7 · Cited by 6

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Wu, X., Huai, C., Shen, L., Li, M., Yang, C., Zhang, J., Chen, L., Zhu, W., Fan, L., Zhou, W., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102894 · Cited by 6

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Emanetci, E., & Çakır, T. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01807-9 · Cited by 5

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Rizzardi, L. F., Hickey, P. F., DiBlasi, V. R., Tryggvadóttir, R., Callahan, C. M., Idrizi, A., Hansen, K. D., & Feinberg, A. P. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/120386 · Cited by 5

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Montel Hayes, R., Mason, C. E., & Miller, J. J. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1671122 · Cited by 5

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Yang, Y. A., Wang, Q., Wang, C., Buxbaum, J. D., & Ionita‐Laza, I. (2024) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2024.05.003 · Cited by 4

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D’Addario, C., & Bartolomeo, M. D. (2025) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-75980-2_5 · Cited by 3

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Hannon, E. J., Dempster, E. L., Chioza, B. A., Davies, J. P., Blake, G. E. T., Burrage, J., Policicchio, S. S. S., Franklin, A., Walker, E., Bamford, R. A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.23.545974 · Cited by 3

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Rachana, R., Devtalla, H., Rana, K., Panda, S. P., Agrawal, A., Kadyan, S., Jindal, D., Pancham, P., Yadav, D., Jha, N. K., et al. (2023) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14374 · Cited by 4

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Dahrendorff, J., & Uddin, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823577-5.00031-3 · Cited by 2

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Michels, K. B., Gunasekara, C. J., & Waterland, R. A. (2022) · Springer eBooks · doi:10.1007/978-3-030-94475-9_6 · Cited by 2

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Boiko, D. I., Zhyvotovska, L. V., Боднарь, Л. А., Rud, V. O., Vasylyeva, G. Y., & Skrypnikov, A. M. (2024) · Springer eBooks · doi:10.1007/978-981-96-0259-9_5 · Cited by 1

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Chaney, S., Marks, S., & Wynter, R. (2024) · Wellcome Open Research · doi:10.12688/wellcomeopenres.20628.2 · Cited by 2

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Iatrou (2018) · Research Publications (Maastricht University) · doi:10.26481/dis.20180712ai · Cited by 1

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Hannon, E. J., Dempster, E. L., Mansell, G., Burrage, J., Bass, N. J., Bohlken, M. M., Corvin, A. P., Curtis, C. J. C., Dempster, D. W., Forta, M. D., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.05.026211 · Cited by 1

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van Berlekom, A. B. (2022) · Utrecht University Repository (Utrecht University) · doi:10.33540/1269 · Cited by 1

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Chang, W.-J., Maduranga, U., Gunasekara, C., Yang, A., Hirschtritt, M. E., Rodriguez, K., Coarfa, C., Jun, G., Hanis, C. L., Flanagan, J. M., et al. (2025) · medRxiv · doi:10.1101/2025.02.10.25322021 · Cited by 1

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Hannon, E. J., Dempster, E. L., Viana, J. F., Burrage, J., Smith, A. R., Macdonald, R., Clair, D. S., Mustard, C. J., Breen, G. D., Therman, S., et al. (2016) · Utrecht University Repository (Utrecht University) · doi:10.6084/m9.figshare.c.3618014

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Hannon, E. J., Dempster, E. L., Burrage, J., McQuillin, A., Clair, D. S., Morris, D. W., Forti, M. D., Gaughran, F., MacCabe, J. H., Breen, G. D., et al. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.08.006 · Cited by 3

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Mandell, K. A. P., Eagles, N. J., Wilton, R. N., Price, A. J., Semick, S. A., Collado‐Torres, L., Ulrich, W. S., Tao, R., Han, S., Szalay, A. S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25517-3 · Cited by 66

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Pidsley, R., Viana, J., Hannon, E., Spiers, H., Troakes, C., Al-Saraj, S., Mechawar, N., Turecki, G., Schalkwyk, L. C., Bray, N. J., et al. (2014) · Genome biology · doi:10.1186/s13059-014-0483-2 · Cited by 157

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Viana, J. F. (2016) · Figshare