Cited by 141Menopause: Health Impacts and TreatmentsEstrogen and related hormone effectsHormonal and reproductive studies

The DOI matches its Crossref record; 135 of the 138 references it cites were found in a registry or an index.

HRT for women with premature ovarian insufficiency: a comprehensive review

Open access

Webber, Lisa, Anderson, Richard A., Davies, Melanie, Janse, Femi, Vermeulen, Nathalie·2017·Human Reproduction Open

DOI 10.1093/hropen/hox007PMC PMC6276684

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Premature ovarian insufficiency (POI), often and misleadingly referred to as 'premature menopause', is defined as a loss of ovarian activity before the age of 40 years and is characterized by irregular or absent periods and reduced fertility. Symptoms include those associated with the natural menopause (night sweats and vaginal dryness), and with the long-term adverse effects of estrogen deficiency (osteoporosis and cardiovascular disease): the latter is believed to explain the shorter life expectancy associated with POI. OBJECTIVE AND RATIONALE: The objective of the current review was to collect all relevant studies supporting recommendations on the indications, treatment options, and risks of hormone replacement therapy (HRT) (estrogen, progestogens and androgens) for women with POI. SEARCH METHODS: The current review was written based on the best available evidence on the topic collected for the recently published ESHRE guideline on the management of women with POI. PUBMED/MEDLINE and the Cochrane library were searched in a stepwise approach. Relevant references were summarized in evidence tables, with assessment of the quality. OUTCOMES: HRT is strongly recommended for women with POI, mainly for vasomotor and genito-urinary symptom relief. In addition, HRT has been shown to have a role in bone protection and probably also in primary prevention of cardiovascular disease. There is little evidence on the optimal type, regimen and dose of HRT; patient preference for route and method of administration of each component of HRT must be considered when prescribing, as should contraceptive needs. In women with POI, physiological replacement of estrogen (and progesterone) is essential for their health, and the controversies that surround the use of HRT in postmenopausal women do not apply. LIMITATIONS REASONS FOR CAUTION: N/A. WIDER IMPLICATIONS: New areas of study on HRT for women with POI should focus on life expectancy, quality of life and neurological function. Furthermore, randomized controlled trials comparing transdermal estradiol with oral estrogens with regard to efficacy, patient satisfaction and side effects are urgently needed. STUDY FUNDING/COMPETING INTERESTS: The authors received no funding for the review. The costs for the development of the ESHRE guideline were covered by ESHRE. The authors have no conflicts of interest to disclose.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/hropen/hox007

Cites

135 of 135 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889
Breast cancer and hormone-replacement therapy in the Million Women Study
Beral, V. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14065-2 · Cited by 2,986
Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52 705 women with breast cancer and 108 411 women without breast cancer
Calle, E. E., Heath Jr., C. W., Coates, R. J., Liff, J. M., Franceschi, S., Talamini, R., Chantarakul, N., Koetsawang, S., Rachawat, D., Morabia, A., et al. (1997) · The Lancet · doi:10.1016/s0140-6736(97)08233-0 · Cited by 2,450
ESHRE guideline: management of women with endometriosis
Dunselman, G. A. J., Vermeulen, N., Becker, C., Calhaz-Jorge, C., D'Hooghe, T., De Bie, B., Heikinheimo, O., Horne, A. W., Kiesel, L., Nap, A., et al. (2014) · Human Reproduction · doi:10.1093/humrep/det457 · Cited by 2,211
Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women’s Health Initiative randomized trials
Manson, J. E., Chlebowski, R. T., Stefanick, M. L., Aragaki, A. K., Rossouw, J. E., Prentice, R. L., Anderson, G., Howard, B. V., Thomson, C. A., LaCroix, A. Z., et al. (2013) · JAMA · doi:10.1001/jama.2013.278040 · Cited by 1,650
ESHRE Guideline: management of women with premature ovarian insufficiency
The ESHRE Guideline Group on POI, Webber, L. J., Davies, M. C., Anderson, R. A., Bartlett, J., Braat, D. D. M., Cartwright, B., Cífková, R., Keizer‐Schrama, S. D. M., Hogervorst, E., et al. (2016) · Human Reproduction · doi:10.1093/humrep/dew027 · Cited by 1,603
Breast cancer and hormone-replacement therapy: the Million Women Study
Beral, V., Banks, E., REEVES, G. K., & Bull, D. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14596-5 · Cited by 1,270
Primary Ovarian Insufficiency
Nelson, L. M. (2009) · New England Journal of Medicine · doi:10.1056/nejmcp0808697 · Cited by 1,189
Incidence of Premature Ovarian Failure
Coulam, C. B., Adamson, S. C., & Annegers, J. F. (1987) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198703000-00020 · Cited by 1,024
Care of girls and women with Turner syndrome: a guideline of the Turner syndrome study group
Bondy, C. A. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1374 · Cited by 1,005
Transdermal testosterone treatment in women with impaired sexual function after oophorectomy.
Shifren, J. L., Braunstein, G. D., Simon, J. A., Casson, P. R., Buster, J. E., Redmond, G. P., Burki, R. E., Ginsburg, E. S., Rosen, R. C., Leiblum, S. R., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009073431002 · Cited by 954
Meta-analysis of Risk Reduction Estimates Associated With Risk-Reducing Salpingo-oophorectomy in BRCA1 or BRCA2 Mutation Carriers
Rebbeck, T. R., Kauff, N. D., & Domchek, S. M. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn442 · Cited by 939
Ovarian cancer and hormone replacement therapy in the Million Women Study
Beral, V. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60534-0 · Cited by 937
Androgen production in women
Burger, H. G. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)02985-0 · Cited by 771 · cited 1×
“In contrast, women who underwent oophorectomy at a young age are probably hypoandrogenic owing to the lack of ovarian androgen production, which makes up 25% of the total production in premenopausal women (Longcope, 1986; Sluijmer et al., 1995; Burger, 2002; Fogle et al., 2007; Janse et al., 2012).”
Background
Local oestrogen for vaginal atrophy in postmenopausal women
Lethaby, A. E., Ayeleke, R. O., & Roberts, H. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001500.pub3 · Cited by 606
Effects of Hormone Therapy on Bone Mineral Density
(1996) · JAMA · doi:10.1001/jama.1996.03540170033029 · Cited by 604
Migraine and Risk of Cardiovascular Disease in Women
Kurth, T., Gaziano, J. M., Cook, N. R., Logroscino, G., Diener, H., & Buring, J. E. (2006) · JAMA · doi:10.1001/jama.296.3.283 · Cited by 597
Long term hormone therapy for perimenopausal and postmenopausal women
Farquhar, C. M., Marjoribanks, J., Lethaby, A. E., Suckling, J. A., & Okonkwo, Q. L. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004143.pub2 · Cited by 587
Hormone replacement therapy and risk of venous thromboembolism in postmenopausal women: systematic review and meta-analysis
Canonico, M., Plu-Bureau, G., Lowe, G. D. O., & Scarabin, P.-Y. (2008) · BMJ · doi:10.1136/bmj.39555.441944.be · Cited by 569
Morbidity in Turner syndrome
Gravholt, C. H., Juul, S., Naeraa, R. W., & Hansen, J. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(97)00237-0 · Cited by 548 · cited 3×
“Short-term studies of HRT in TS women have failed to show a favorable effect on lipid profile (Gravholt et al., 1998; Elsheikh et al., 2000), or on ambulatory arterial stiffness index (Mortensen et al.”
Background
HABITS (hormonal replacement therapy after breast cancer—is it safe?), a randomised comparison: trial stopped
Holmberg, L., & Anderson, H. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15493-7 · Cited by 533
Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Collaborative Group on Hormonal Factors in Breast Cancer.
(1997) · PubMed · Cited by 505
Testosterone for Low Libido in Postmenopausal Women Not Taking Estrogen
Davis, S. R., Moreau, M., Kroll, R., Bouchard, C., Panay, N., Gass, M. L. S., Braunstein, G. D., Hirschberg, A. L., Rodenberg, C. A., Pack, S. E., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707302 · Cited by 490
Biologic Effects of Transdermal Estradiol
Chetkowski, R. J., Meldrum, D. R., Steingold, K. A., Randle, D., Lu, J. K., Eggena, P., Hershman, J. M., Alkjaersig, N. K., Fletcher, A. P., & Judd, H. L. (1986) · New England Journal of Medicine · doi:10.1056/nejm198606193142505 · Cited by 482
Increased cardiovascular mortality after early bilateral oophorectomy
Rivera, C. M., Grossardt, B. R., Rhodes, D. J., Brown, R. D., Roger, V. L., Melton, L. J., & Rocca, W. A. (2009) · Menopause · doi:10.1097/gme.0b013e31818888f7 · Cited by 481
Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder.
Simon, J., Braunstein, G., Nachtigall, L., Utian, W., Katz, M., Miller, S., Waldbaum, A., Bouchard, C., Derzko, C., Buch, A., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1747 · Cited by 475
Biologic effects of transdermal estradiol
Chetkowski, R. J., Meldrum, D., & Ka, S. (1987) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(87)90325-0 · Cited by 467
Safety and Efficacy of a Testosterone Patch for the Treatment of Hypoactive Sexual Desire Disorder in Surgically Menopausal Women: A Randomized, Placebo-Controlled Trial
Braunstein, G. D., Sundwall, D. A., Katz, M., Shifren, J. L., Buster, J. E., Simon, J. A., Bachman, G., Aguirre, O. A., Lucas, J. D., Rodenberg, C., et al. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.14.1582 · Cited by 458
Health-Related Quality of Life and Tamoxifen in Breast Cancer Prevention: A Report From the National Surgical Adjuvant Breast and Bowel Project P-1 Study
Day, R., Ganz, P. A., Costantino, J. P., Cronin, W. M., Wickerham, D. L., & Fisher, B. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.9.2659 · Cited by 438
Testosterone patch for low sexual desire in surgically menopausal women: a randomized trial
Buster, J. E., Kingsberg, S. A., Aguirre, O., Brown, C., Breaux, J. G., Buch, A., Rodenberg, C. A., Wekselman, K., & Casson, P. (2005) · Obstetrics & Gynecology · doi:10.1097/01.aog.0000158103.27672.0d · Cited by 433
Premature menopause in a multi-ethnic population study of the menopause transition
Luborsky, J., Meyer, P., Sowers, M., Gold, E. B., & Santoro, N. F. (2003) · Human Reproduction · doi:10.1093/humrep/deg005 · Cited by 421
Effect of Short-Term Hormone Replacement Therapy on Breast Cancer Risk Reduction After Bilateral Prophylactic Oophorectomy in BRCA1 and BRCA2 Mutation Carriers: The PROSE Study Group
Rebbeck, T. R., Friebel, T. M., Wagner, T. M., Lynch, H. T., Garber, J. E., Daly, M. B., Isaacs, C. J., Olopade, O. I., Neuhausen, S. L., Veer, L. V. ‘., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2004.00.8151 · Cited by 412
Transdermal and oral hormone replacement therapy and the risk of stroke: a nested case-control study
Renoux, C., Dell’Aniello, S., Garbe, E., & Suissa, S. (2010) · BMJ · doi:10.1136/bmj.c2519 · Cited by 383
Local oestrogen for vaginal atrophy in postmenopausal women
Suckling, J. A., Kennedy, R., Lethaby, A. E., & Roberts, H. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001500.pub2 · Cited by 376
1 Adrenal and gonadal androgen secretion in normal females
Longcope, C. (1986) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(86)80021-4 · Cited by 332
Replens versus dienoestrol cream in the symptomatic treatment of vaginal atrophy in postmenopausal women
Bygdeman, M., & Swahn, M. L. (1996) · Maturitas · doi:10.1016/0378-5122(95)00955-8 · Cited by 302
Ovarian Androgen Production in Postmenopausal Women
Fogle, R. H., Stanczyk, F. Z., Zhang, X., & Paulson, R. J. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0581 · Cited by 286
Long term hormone therapy for perimenopausal and postmenopausal women
Marjoribanks, J., Farquhar, C. M., Roberts, H., & Lethaby, A. E. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004143.pub4 · Cited by 286
Impaired Endothelial Function in Young Women with Premature Ovarian Failure: Normalization with Hormone Therapy
Kalantaridou, S. N., Naka, K. K., Papanikolaou, E., Kazakos, N., Kravariti, M., Calis, K. A., Paraskevaidis, E. A., Sideris, D. A., Tsatsoulis, A., Chrousos, G. P., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0015 · Cited by 284
Comparison of oral estrogens and estrogens plus androgen on bone mineral density, menopausal symptoms, and lipid-lipoprotein profiles in surgical menopause
WATTS, N., Notelovitz, M., CHRYSTIETIMMONS, M., ALLENADDISON, W., Wiita, B., & DOWNEY, L. (1995) · Obstetrics and Gynecology · doi:10.1016/0029-7844(94)00448-m · Cited by 270
Postmenopausal Hormone Therapy and Risk of Idiopathic Venous Thromboembolism
Canonico, M., Fournier, A., Carcaillon‐Bentata, L., Olié, V., Plu‐Bureau, G., Oger, E., Mesrine, S., Boutron‐Ruault, M., Clavel‐Chapelon, F., & Scarabin, P. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.196022 · Cited by 270
Serum gonadotropin and steroid patterns during the normal menstrual cycle
Mishell, D. R., Nakamura, R. M., Crosignani, P. G., Stone, S. C., Kharma, K. M., Nagata, Y., & Thorneycroft, I. H. (1971) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(71)90927-6 · Cited by 264
Menopausal Hormone Therapy After Breast Cancer: The Stockholm Randomized Trial
Schoultz, E. V., Rutqvist, L. E., & on Behalf of the Stockholm Breast Cancer Study Group (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji071 · Cited by 250
Efficacy and safety of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial
Davis, S. R., van der Mooren, M. J., van Lunsen, R. H. W., Lopes, P., Ribot, J., Rees, M., Moufarege, A., Rodenberg, C., Buch, A., & Purdie, D. W. (2006) · Menopause · doi:10.1097/01.gme.0000179049.08371.c7 · Cited by 250
The association between early menopause and risk of ischaemic heart disease: influence of hormone therapy
Løkkegaard, E., Jovanovic, Z., Heitmann, B. L., Keiding, N., Ottesen, B., & Pedersen, A. T. (2006) · Maturitas · doi:10.1016/j.maturitas.2005.04.009 · Cited by 243
Mortality and cancer incidence in persons with numerical sex chromosome abnormalities: a cohort study
Swerdlow, A. J., Hermon, C., Jacobs, P. A., Alberman, E. D., Beral, V., Daker, M. G., Fordyce, A., & Youings, S. A. (2001) · Annals of Human Genetics · doi:10.1046/j.1469-1809.2001.6520177.x · Cited by 238
Alcohol Consumption and Breast Cancer Recurrence and Survival Among Women With Early-Stage Breast Cancer: The Life After Cancer Epidemiology Study
Kwan, M. L., Kushi, L. H., Weltzien, E. K., Tam, E. K., Castillo, A., Sweeney, C., & Caan, B. J. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.29.2730 · Cited by 233
Comparative study: Replens versus local estrogen in menopausal women
Nachtigall, L. E. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56474-7 · Cited by 232
Age related changes in follicle stimulating hormone, luteinizing hormone, oestradiol and immunoreactive inhibin in women of reproductive age
MacNaughton, J. A., Banah, M., McCloud, P., Hee, J., & Burger, H. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb01457.x · Cited by 220
The Impact of Hormone Replacement Therapy on Menopausal Symptoms in Younger High-Risk Women After Prophylactic Salpingo-Oophorectomy
Madalinska, J. B., van Beurden, M., Bleiker, E. M. A., Valdimarsdottir, H. B., Hollenstein, J., Massuger, L. F. A. G., Gaarenstroom, K. N., Mourits, M. J. E., Verheijen, R. H. M., van Dorst, E. B. L., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.05.1896 · Cited by 218
Hormone replacement therapy and the risk of venous thromboembolism: a population-based study
Renoux, C., Dell’Aniello, S., & Suissa, S. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.03839.x · Cited by 208
Cardiovascular effects of physiological and standard sex steroid replacement regimens in premature ovarian failure
Langrish, J. P., Mills, N. L., Bath, L. E., Warner, P., Webb, D. J., Kelnar, C. J., Critchley, H. O. D., Newby, D. E., & Wallace, W. H. B. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.126516 · Cited by 207
Weight, Physical Activity, Diet, and Prognosis in Breast and Gynecologic Cancers
McTiernan, A., Irwin, M. L., & Vongruenigen, V. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.27.9752 · Cited by 203
Effects of hormone therapy on bone mineral density: results from the postmenopausal estrogen/progestin interventions (PEPI) trial. The Writing Group for the PEPI
(1996) · JAMA · doi:10.1001/jama.276.17.1389 · Cited by 195
Short-term and long-term effects of tibolone in postmenopausal women
Formoso, G., Perrone, E., Maltoni, S., Balduzzi, S., Wilkinson, J., Basevi, V., Marata, A. M., Magrini, N., D’Amico, R., Bassi, M. C., et al. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008536.pub3 · Cited by 194
Hormone therapy in postmenopausal women and risk of endometrial hyperplasia
Furness, S., Roberts, H., Marjoribanks, J., Lethaby, A. E., Hickey, M., & Farquhar, C. M. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000402.pub3 · Cited by 194
Association between hormone replacement therapy and subsequent arterial and venous vascular events: a meta-analysis
Sare, G. M., Gray, L. J., & Bath, P. M. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn299 · Cited by 190
Hormone therapy in postmenopausal women and risk of endometrial hyperplasia
Furness, S., Roberts, H., Marjoribanks, J., & Lethaby, A. E. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000402.pub4 · Cited by 174
Testosterone treatment of HSDD in naturally menopausal women: the ADORE study
Panay, N., Al‐Azzawi, F., Bouchard, C., Davis, S. R., Eden, J., Lodhi, I., REES, M. C. P., Rodenberg, C. A., RYMER, J. M., Schwenkhagen, A., et al. (2010) · Climacteric · doi:10.3109/13697131003675922 · Cited by 173
A two-year, double-blind comparison of estrogen-androgen and conjugated estrogens in surgically menopausal women. Effects on bone mineral density, symptoms and lipid profiles.
Barrett-Connor, E. L., Young, R. L., Notelovitz, M., Sullivan, J., Wiita, B., Yang, H. M., & Nolan, J. C. (1999) · PubMed · Cited by 167
Non-hormonal interventions for hot flushes in women with a history of breast cancer
Gabriel Rada, G., Daniel Capurro, N., Tomás Pantoja, C., Corbalán, J., Moreno, G., Luz María Letelier, S., & Vera, C. M. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004923.pub2 · Cited by 162
Transition to young adulthood in Ullrich-Turner syndrome: Neurodevelopmental changes
Romans, S. M., Stefanatos, G. A., Roeltgen, D. P., Kushner, H., & ROSS, J. L. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19980901)79:2 · Cited by 161
Hormone Replacement Therapy and Life Expectancy After Prophylactic Oophorectomy in Women With BRCA1/2 Mutations: A Decision Analysis
Armstrong, K., Schwartz, J. S., Randall, T. C., Rubin, S. C., & Weber, B. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.06.090 · Cited by 161
Hormone replacement therapy after breast cancer: 10 year follow up of the Stockholm randomised trial
Fahlén, M., Fornander, T., Johansson, H., Johansson, U., Rutqvist, L., Wilking, N. E., & Schoultz, E. V. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2012.07.003 · Cited by 160
Hormone Replacement Therapy Versus the Combined Oral Contraceptive Pill in Premature Ovarian Failure: A Randomized Controlled Trial of the Effects on Bone Mineral Density
Cartwright, B., Robinson, J., Seed, P. T., Fogelman, I., & RYMER, J. M. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-4063 · Cited by 158
Recommendations on the Risk of Ischaemic Stroke Associated With Use of Combined Oral Contraceptives and Hormone Replacement Therapy in Women With Migraine
Bousser, M., Conard, J., Kittner, S. J., Lignieres, B. D., MacGregor, E. A., Massiou, H., Silberstein, S. D., & Tzourio, C. (2000) · Cephalalgia · doi:10.1046/j.1468-2982.2000.00035.x · Cited by 151
Physiological versus standard sex steroid replacement in young women with premature ovarian failure: effects on bone mass acquisition and turnover
Crofton, P. M., Evans, N., Bath, L., Warner, P., Whitehead, T. J., Critchley, H., Kelnar, C. J. H., & Wallace, W. H. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03868.x · Cited by 150
EMAS position statement: Managing women with premature ovarian failure
Vujović, S., Brincat, M., Erel, C. T., Gambacciani, M., Lambrinoudaki, I. V., Moen, M. H., Schenck-Gustafsson, K. G., Trémollières, F., Rozenberg, S., & REES, M. C. P. (2010) · Maturitas · doi:10.1016/j.maturitas.2010.04.011 · Cited by 147
Are All Estrogens Created Equal? A Review of Oral vs. Transdermal Therapy
Goodman, M. P. (2011) · Journal of Women s Health · doi:10.1089/jwh.2011.2839 · Cited by 146
Bone Mineral Density in Young Women With Primary Ovarian Insufficiency: Results of a Three-Year Randomized Controlled Trial of Physiological Transdermal Estradiol and Testosterone Replacement
Popat, V., Calis, K. A., Kalantaridou, S., Vanderhoof, V. H., Koziol, D. E., Troendle, J. F., Reynolds, J. C., & Nelson, L. M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4145 · Cited by 142
Endocrine activity of the postmenopausal ovary: the effects of pituitary down-regulation and oophorectomy
Sluijmer, A. V., Heineman, M. J., de Jong, F. H., & Evers, J. L. H. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.7.7608272 · Cited by 134
Impact of Premature Ovarian Failure on Mortality and Morbidity among Chinese Women
Wu, X., Cai, H., Kallianpur, A. R., Li, H., Yang, G., Gao, J., Xiang, Y., Ji, B., Yutang, Zheng, W., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089597 · Cited by 129
Effects of Estrogen on Nonverbal Processing Speed and Motor Function in Girls with Turner’s Syndrome1
ROSS, J. L., Roeltgen, D. P., Feuillan, P., Kushner, H., & Cutler, G. B. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5087 · Cited by 127
Use of postmenopausal hormones and risk of myocardial infarction.
Bain, C., Willett, W. C., Hennekens, C. H., ROSNER, B. A., Belanger, C. F., & Speizer, F. E. (1981) · Circulation · doi:10.1161/01.cir.64.1.42 · Cited by 126
Hormone therapy and risk of myocardial infarction: a national register study
Løkkegaard, E., Andreasen, A. H., Jacobsen, R. K., Nielsen, L. H., Agger, C., & Lidegaard, Ø. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn408 · Cited by 120
Standardized multidisciplinary evaluation yields significant previously undiagnosed morbidity in adult women with Turner syndrome
Freriks, K., Timmermans, J., Beerendonk, C. C. M., Verhaak, C. M., Netea-Maier, R. T., Otten, B. J., Braat, D. D. M., Smeets, D. F. C. M., Kunst, D. H. P. M., Hermus, A. R. M. M., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0346 · Cited by 120 · cited 1×
“In adult TS women, the focus of treatment changes from growth and puberty induction to maintenance of health, including bone health (Davies, 2010; Freriks et al., 2011).”
Background
Premenopausal Ovariectomy-Related Bone Loss: A Randomized, Double-Blind, One-Year Trial of Conjugated Estrogen or Medroxyprogesterone Acetate
Prior, J. C., Vigna, Y. M., Wark, J. D., Eyre, D. R., Lentle, B. C., Li, D. K. B., Ebeling, P. R., & Atley, L. M. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.11.1851 · Cited by 119
Obesity and risk of venous thromboembolism among postmenopausal women: differential impact of hormone therapy by route of estrogen administration. The ESTHER Study
Canonico, M., Oger, E., Conard, J., Meyer, G., Levesque, H., Trillot, N., Barrellier, M. ‐., Wahl, D. G., Emmerich, J., & Scarabin, P. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01933.x · Cited by 113
Premature ovarian failure
Maclaran, K., & Panay, N. (2011) · Journal of Family Planning and Reproductive Health Care · doi:10.1136/jfprhc.2010.0015 · Cited by 107
A dose‐response study of hormone replacement in young hypogonadal women: effects on intima media thickness and metabolism
Ostberg, J. E., Storry, C., Donald, A. E., Hosseinzadeh‐Attar, M. J., Halcox, J., & Conway, G. S. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02772.x · Cited by 106
Cognition and the Sex Chromosomes: Studies in Turner Syndrome
ROSS, J. L., Roeltgen, D. P., & Zinn, A. R. (2006) · Hormone Research in Paediatrics · doi:10.1159/000090698 · Cited by 102
Effects of Estrogen on Nonverbal Processing Speed and Motor Function in Girls with Turner's Syndrome
ROSS, J. L. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.9.3198 · Cited by 96
Hormone use for menopausal symptoms and risk of breast cancer. A Danish cohort study
Ewertz, M., Mellemkjær, L., Poulsen, A. H., Friis, S., Sørensen, H. T., Pedersen, L. H., McLaughlin, J. K., & Olsen, J. H. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602472 · Cited by 92
BRCA Carriers, Prophylactic Salpingo-Oophorectomy and Menopause: Clinical Management Considerations and Recommendations
Finch, A., Evans, D. G., & Narod, S. A. (2012) · Women s Health · doi:10.2217/whe.12.41 · Cited by 91
Comparison of Transdermal to Oral Estradiol Administration on Hormonal and Hepatic Parameters in Women with Premature Ovarian Failure
Steingold, K. A., Matt, D. W., DeZiegler, D., Sealey, J. E., Fratkin, M. J., & REZNIKOV, S. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-2-275 · Cited by 91
The Effect of Hormone Replacement Therapy on Cardiovascular Hemodynamics in Women with Turner's Syndrome
Elsheikh, M., Bird, R., Casadei, B., Conway, G. S., & Wass, J. A. H. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.2.6384 · Cited by 86
Postmenopausal hormone replacement therapy and cardiovascular disease: the value of transdermal estradiol and micronized progesterone
Mueck, A. O. (2012) · Climacteric · doi:10.3109/13697137.2012.669624 · Cited by 83
The Use of Herbs and Dietary Supplements in Gynecology: An Evidence‐Based Review
Dennehy, C. E. (2006) · Journal of Midwifery & Women s Health · doi:10.1016/j.jmwh.2006.01.004 · Cited by 79
Cognitive Ability and Everyday Functioning in Women with Turner Syndrome
Downey, J. I., Elkin, E. J., Ehrhardt, A. Α., Meyer‐Bahlburg, H. F. L., BELL, J. J., & Morishima, A. (1991) · Journal of Learning Disabilities · doi:10.1177/002221949102400107 · Cited by 76
Quality of life and health status after prophylactic salpingo-oophorectomy in women who carry a BRCA mutation: A review
Finch, A., & Narod, S. A. (2011) · Maturitas · doi:10.1016/j.maturitas.2011.08.001 · Cited by 73
A Longitudinal Study of the Effect of Subcutaneous Estrogen Replacement on Bone in Young Women With Turner's Syndrome
Khastgir, G., Studd, J. W. W., Fox, S. W., Jones, J., Alaghband‐Zadeh, J., & Chow, J. W. M. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.5.925 · Cited by 72
Age at menopause, reproductive history, and venous thromboembolism risk among postmenopausal women
Canonico, M., Plu‐Bureau, G., O’Sullivan, M. J., Stefanick, M. L., Cochrane, B. B., Scarabin, P., & Manson, J. E. (2013) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31829752e0 · Cited by 71
Systematic review: Hormone therapy and cardiovascular disease: a systematic review and meta‐analysis
Magliano, D. J., Rogers, S., Abramson, M. J., & Tonkin, A. M. (2005) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2005.00797.x · Cited by 70
Physiological sex steroid replacement in premature ovarian failure: randomized crossover trial of effect on uterine volume, endometrial thickness and blood flow, compared with a standard regimen
O'Donnell, R. L., Warner, P., Lee, R. J., Walker, J., Bath, L., Kelnar, C. J. H., Wallace, W. H., & Critchley, H. (2012) · Human Reproduction · doi:10.1093/humrep/des004 · Cited by 68
Safety and Efficacy of a Testosterone Patch for the Treatment of Hypoactive Sexual Desire Disorder in Surgically Menopausal Women: a Randomized, Placebo-Controlled Trial
Braunstein, G. D., Sundwall, D. A., Katz, M., Shifren, J. L., Buster, J. E., Simon, J. A., Bachman, G., Aguirre, O., Lucas, J. D., Rodenberg, C. A., et al. (2006) · The Journal of Urology · doi:10.1016/s0022-5347(05)00380-0 · Cited by 67
Hormone Therapy and Different Ovarian Cancers: A National Cohort Study
Mørch, L. S., Løkkegaard, E., Andreasen, A. H., Kjær, S. K., & Lidegaard, Ø. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kwr446 · Cited by 64
Ovarian failure following cancer treatment: current management and quality of life
Absolom, K. L., Eiser, C., Turner, L., Ledger, W. J., Ross, R. J. M., Davies, H., Coleman, R., Hancock, B. W., Snowden, J. A., Greenfield, D., et al. (2008) · Human Reproduction · doi:10.1093/humrep/den285 · Cited by 63
Androgen-Responsive Aspects of Cognition in Girls with Turner Syndrome
ROSS, J. L., Roeltgen, D. P., Stefanatos, G. A., Feuillan, P., Kushner, H., Bondy, C. A., & Cutler, G. B. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021000 · Cited by 62
Intelligence, behaviour and psychosocial development in Turner syndrome. A cross-sectional study of 50 pre-adolescent and adolescent girls (4-20 years).
Swillen, A., Fryns, J. P., Kleczkowska, A., Massa, G., Vanderschueren‐Lodeweyckx, M., & BERGHE, H. V. D. (1993) · PubMed · Cited by 59
Modification of blood pressure in postmenopausal women: role of hormone replacement therapy
Cagnacci, A., & Cannoletta, M. (2014) · International Journal of Women s Health · doi:10.2147/ijwh.s61685 · Cited by 58
A randomized trial of the effect of testosterone and estrogen on verbal fluency, verbal memory, and spatial ability in healthy postmenopausal women
Kočoska-Maraš, L., Zethraeus, N., Rådestad, A. F., Ellingsen, T., von Schoultz, B., Johannesson, M., & Hirschberg, A. L. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.05.062 · Cited by 55
Assessing and addressing cardiovascular risk in adults with Turner syndrome
Turtle, E. J., Sule, A. A., Bath, L., Denvir, M. A., Gebbie, A. E., Mirsadraee, S., & Webb, D. J. (2012) · Clinical Endocrinology · doi:10.1111/cen.12104 · Cited by 54
Testosterone concentrations, using different assays, in different types of ovarian insufficiency: a systematic review and meta-analysis
Janse, F., Tanahatoe, S., Eijkemans, M. J. C., & Fauser, B. C. J. M. (2012) · Human Reproduction Update · doi:10.1093/humupd/dms013 · Cited by 51
Estrogen therapy initiated at an early age increases bone mineral density in Turner syndrome patients
Kodama, M., Komura, H., Kodama, T., Nishio, Y., & Kimura, T. (2011) · Endocrine Journal · doi:10.1507/endocrj.ej11-0267 · Cited by 50
Short and long term effects of tibolone in postmenopausal women
Formoso, G., Perrone, E., Maltoni, S., Balduzzi, S., D’Amico, R., Bassi, M. C., Basevi, V., Marata, A. M., Magrini, N., & Maestri, E. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008536.pub2 · Cited by 49
Dosage of estradiol, bone and body composition in Turner syndrome: a 5-year randomized controlled clinical trial
Cleemann, L., Holm, K., Kobbernagel, H., Kristensen, B., Skouby, S. O., Jensen, A. K., & Gravholt, C. H. (2017) · European Journal of Endocrinology · doi:10.1530/eje-16-0582 · Cited by 48
New Issues in the Diagnosis and Management of Turner Syndrome
Bondy, C. A. (2005) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-005-6185-z · Cited by 47
Testosterone improves verbal learning and memory in postmenopausal women: results from a pilot study
Davison, S. L., Bell, R. J., Gavrilescu, M., Searle, K., Maruff, P., Gogos, A., Rossell, S. L., Adams, J., Egan, G. F., & Davis, S. R. (2011) · Maturitas · doi:10.1016/j.maturitas.2011.08.006 · Cited by 47
Normalization of serum luteinizing hormone levels in women with 46,XX spontaneous primary ovarian insufficiency
Popat, V., Vanderhoof, V. H., Calis, K. A., Troendle, J. F., & Nelson, L. M. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.02.032 · Cited by 45
Evaluation of High-Dose Estrogen and High-Dose Estrogen plus Methyltestosterone Treatment on Cognitive Task Performance in Postmenopausal Women
Wisniewski, A. B., Nguyen, T. T., & Dobs, A. S. (2002) · Hormone Research in Paediatrics · doi:10.1159/000064491 · Cited by 45
Management of premature menopause
Writing Group for the British Menopause Society Council (2007) · Menopause International · doi:10.1258/175404507780456719 · Cited by 45
Menopausal Symptoms in Young Survivors of Breast Cancer: A Growing Problem without an Ideal Solution
Murthy, V., & Chamberlain, R. S. (2012) · Cancer Control · doi:10.1177/107327481201900408 · Cited by 42
Management of leiomyomas in perimenopausal women
Ciarmela, P., Ciavattini, A., Giannubilo, S. R., Lamanna, P., Fiorini, R., Tranquilli, A. L., Christman, G. M., & Castellucci, M. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.04.011 · Cited by 42
The Effect of Transdermal Testosterone on Mammographic Density in Postmenopausal Women Not Receiving Systemic Estrogen Therapy
Davis, S. R., Hirschberg, A. L., Wagner, L. K., Lodhi, I., & von Schoultz, B. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1523 · Cited by 42
Hormone Replacement and the Risk of Breast Cancer in Turner's Syndrome
Bõsze, P., Tóth, A. D., & Török, M. (2006) · New England Journal of Medicine · doi:10.1056/nejmc062795 · Cited by 41
Effect of oral administration of dydrogestrone versus vaginal administration of natural micronized progesterone on the secretory transformation of endometrium and luteal endocrine profile in patients with premature ovarian failure: a proof of concept
Fatemi, H. M., Bourgain, C., Donoso, P., Blockeel, C., Papanikolaou, E. G., Popovic-Todorovic, B., & Devroey, P. (2007) · Human Reproduction · doi:10.1093/humrep/del520 · Cited by 40
Effect of hormone replacement therapies and selective estrogen receptor modulators in postmenopausal women with uterine leiomyomas:a literature review
Ang, W.-E. C., Farrell, E., & Vollenhoven, B. (2001) · Climacteric · doi:10.1080/cmt.4.4.284.292 · Cited by 38
Hormone replacement therapy and the adolescent
DiVasta, A. D., & Gordon, C. M. (2010) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e32833e4a35 · Cited by 37
Hormonal replacement therapy after stem cell transplantation
Piccioni, P., Scirpa, P., D’Emilio, I., Sorà, F., Scarciglia, M. L., Laurenti, L., Matteis, S. D., Sica, S., Leone, G. G. M., & Chiusolo, P. (2004) · Maturitas · doi:10.1016/j.maturitas.2004.02.015 · Cited by 37
Safety of hormone therapy after breast cancer: a qualitative systematic review
Antoine, C., Liebens, F., Carly, B., Pastijn, A., Neusy, S., & Rozenberg, S. (2006) · Human Reproduction · doi:10.1093/humrep/del393 · Cited by 37
Cognitive behavioral therapy and physical exercise for climacteric symptoms in breast cancer patients experiencing treatment-induced menopause: design of a multicenter trial
Duijts, S. F. A., Oldenburg, H. S. A., van Beurden, M., & Aaronson, N. K. (2009) · BMC Women s Health · doi:10.1186/1472-6874-9-15 · Cited by 36
Use of Levonorgestrel-Releasing Intrauterine System in the Prevention and Treatment of Endometrial Hyperplasia
Ewies, A. A. A., & Alfhaily, F. (2012) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0b013e318273570b · Cited by 26
Modification of blood pressure in postmenopausal women: role of hormone replacement therapy
Cannoletta, M., & Cagnacci, A. (2014) · Dove Medical Press (Taylor and Francis Group) · Cited by 26
HRT: Some Unresolved Clinical Issues in Breast Cancer, Endometrial Cancer and Premature Ovarian Insufficiency
Davey, D. A. (2012) · Women s Health · doi:10.2217/whe.12.61 · Cited by 24
Risk of stroke in healthy postmenopausal women during and after hormone therapy
Gu, H., Zhao, X., Zhao, X., Yang, Y., & Lv, X. (2014) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000227 · Cited by 19
Bleeding profiles and effects on the endometrium for women using a novel combination of transdermal oestradiol and natural progesterone cream as part of a continuous combined hormone replacement regime
Vashisht, A., Wadsworth, F., Carey, A. H., Carey, B., & Studd, J. W. W. (2005) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2005.00689.x · Cited by 19
Breast density in women with premature ovarian failure or postmenopausal women using hormone therapy: analytical cross-sectional study
Soares, P. M., Cabello, C., Magna, L. A., Tinóis, E., & Benetti‐Pinto, C. L. (2010) · Sao Paulo Medical Journal · doi:10.1590/s1516-31802010000400007 · Cited by 17
Breast density in women with premature ovarian failure using hormone therapy
Benetti‐Pinto, C. L., Soares, P. M., Magna, L. A., Petta, C. A., & dos Santos, C. C. (2008) · Gynecological Endocrinology · doi:10.1080/09637480701690543 · Cited by 17
Migraine, the menopause and hormone replacement therapy: a clinical review
MacGregor, E. A. (2007) · Journal of Family Planning and Reproductive Health Care · doi:10.1783/147118907782101986 · Cited by 17
What is the best management strategy for a 20‐year‐old woman with premature ovarian failure?
Davies, M. C., & Cartwright, B. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04408.x · Cited by 15
Ambulatory Arterial Stiffness Index in Turner Syndrome: The Impact of Sex Hormone Replacement Therapy
Mortensen, K., Hansen, K. W., Erlandsen, M., Christiansen, J. S., & Gravholt, C. (2009) · Hormone Research in Paediatrics · doi:10.1159/000232495 · Cited by 14
A service evaluation of women attending the menopause/premature ovarian failure clinic of a tertiary referral centre
Cartwright, B., Holloway, D., Grace, J., Robinson, J., & RYMER, J. M. (2012) · Journal of Obstetrics and Gynaecology · doi:10.3109/01443615.2012.663635 · Cited by 12
Lost in transition: the needs of adolescents with Turner syndrome
Davies, M. C. (2009) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2009.02410.x · Cited by 10
Comparing the effects of intrauterine progestin system and oral progestin on health‐related quality of life and Kupperman index in hormone replacement therapy
Pirimoğlu, Z. M., Alper, A. G. Ö., Kars, B., Büyükbayrak, E. E., Solak, Y., Karşıdağ, A. Y. K., Ünal, O., & Turan, M. C. (2011) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2011.01541.x · Cited by 8
Current perspectives on testosterone therapy for women
Davis, S. R., & Davison, S. L. (2012) · Sexuality, reproduction & menopause · Cited by 6

Sorted by citations

Premature ovarian insufficiency: an international menopause society white paper
Panay, N., Anderson, R. A., Nappi, R. E., Vincent, A. J., Vujovic, S., Webber, L., & Wolfman, W. (2020) · Climacteric · doi:10.1080/13697137.2020.1804547 · Cited by 297
Clinical practice guidelines for the care of girls and women with Turner syndrome.
Gravholt, C. H., Andersen, N. H., Christin-Maitre, S., Davis, S. M., Duijnhouwer, A., Gawlik, A., Maciel-Guerra, A. T., Gutmark-Little, I., Fleischer, K., Hong, D., et al. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae050 · Cited by 224
Biomechanical forces and signals operating in the ovary during folliculogenesis and their dysregulation: implications for fertility
Fiorentino, G., Cimadomo, D., Innocenti, F., Soscia, D. M., Vaiarelli, A., Ubaldi, F. M., Gennarelli, G., Garagna, S., Rienzi, L. F., & Zuccotti, M. (2022) · Human Reproduction Update · doi:10.1093/humupd/dmac031 · Cited by 190
Vascular remodeling by placenta-derived mesenchymal stem cells restores ovarian function in ovariectomized rat model via the VEGF pathway
Cho, J., Kim, T., Seok, J., Jun, J. H., Park, H., Kweon, M., Lim, J., & Kim, G. J. (2020) · Laboratory Investigation · doi:10.1038/s41374-020-00513-1 · Cited by 89
Human Umbilical Cord Mesenchymal Stem Cells Improve Ovarian Function in Chemotherapy-Induced Premature Ovarian Failure Mice Through Inhibiting Apoptosis and Inflammation via a Paracrine Mechanism
Deng, T., He, J., Yao, Q. Y., Wu, L., Xue, L., Wu, M., Wu, D., Li, C., & Li, Y. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00499-1 · Cited by 86

See all 141

Authors: Webber, L., Anderson, R. A., Davies, M., Janse, F., & Vermeulen, N.
Affiliations: University College Hospital (GB)
MRC Centre for Reproductive Health (GB)
University Medical Center Utrecht (NL)
European Society of Human Reproduction and Embryology (BE)
Corresponding author: Webber, Lisa
ORCID: Webber, Lisa
Anderson, Richard A.
Davies, Melanie
Vermeulen, Nathalie
Venue: Human Reproduction Open
Publisher: Oxford University Press (OUP)
Published: 2017
Volume: 2017
Issue: 2
Pages: hox007-hox007
ISSN: 2399-3529 (ISSN-L)
DOI: 10.1093/hropen/hox007
PMC: PMC6276684
OpenAlex: W2735417387
Cited by: 141
References: 138
Citations by year: 2026: 26 · 2025: 10 · 2024: 19 · 2023: 20 · 2022: 21 · 2021: 30 · 2020: 11 · 2019: 4
FWCI: 0.60
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/4.0/ (vor, 192 d)
Locations: Human Reproduction Open (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
Funders: European Society of Human Reproduction and Embryology
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: premature ovarian insufficiency, hormone replacement therapy, estrogen deficiency, vasomotor symptoms, genitourinary symptoms, bone protection, cardiovascular disease prevention, progestogens, androgens, transdermal estradiol, oral estrogen, ESHRE guidelines, life expectancy, quality of life

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

HRT for women with premature ovarian insufficiency: a comprehensive review

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks