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Cited by 47Menopause: Health Impacts and TreatmentsHormonal and reproductive studiesEstrogen and related hormone effects

Testosterone improves verbal learning and memory in postmenopausal women: results from a pilot study

Davison, Sonia L., Bell, Robin J., Gavrilescu, Maria, Searle, Karissa, Maruff, Paul, Gogos, Andrea, Rossell, Susan L., Adams, Jenny +2 more·2011·Maturitas
DOI 10.1016/j.maturitas.2011.08.006
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Abstract

Objective To explore the effects of testosterone on cognitive performance in healthy postmenopausal women.Study design Open-label pilot study. Nine postmenopausal women on non-oral hormone replacement therapy, aged 47-60 years received transdermal testosterone spray for 26 weeks. A control group of 30 women provided normative data for comparison.Main outcome measures Scores from a computerized cognitive test battery performed pre- and post treatment, at 0 and 26 weeks.Results There were no differences between treatment/normative groups in any parameter at baseline. At week 26 scores for the International Shopping list task including delayed recall (verbal learning and memory) and the continuous paired associate learning task (visual learning and memory) were significantly higher in the treatment group as compared to the normative group (p<0.05). Significant improvements from baseline were observed for the International Shopping list delayed recall (verbal learning and memory) and Groton Maze recall tasks (visual learning and memory) for the treatment group (both p<0.05), after 26 weeks. There were no significant differences between baseline and week 26 in the normative group. In the regression analysis which modeled the score at week 26, and which included a bootstrapping approach, the beta coefficient for the treatment group was statistically significant when age and baseline score were taken into account for the International Shopping list task including delayed recall (both p<0.02).Conclusion Testosterone improved cognitive performance in the domain of verbal learning and memory in a pilot study of healthy postmenopausal women and is worthy of further exploration in a randomized placebo controlled study.

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  • In women, testosterone administration appears to improve verbal fluency, verbal learning and memory, while response inhibition performance decreases.

    “Further, verbal fluency, verbal learning and memory appear to improve with administration of T in women (Davison et al., 2011; Drake et al., 2000), whereas response inhibition performance decreases (Bjork et al., 2001).”

    From Reproductive steroids and ADHD symptoms across the menstrual cycle (2018) · cites this paper as Davison et al., 2011

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Authors
Davison, S. L., Bell, R. J., Gavrilescu, M., Searle, K., Maruff, P., Gogos, A., Rossell, S. L., Adams, J., Egan, G. F., & Davis, S. R.
Affiliations
  • Monash University (AU)
  • The University of Melbourne (AU)
  • Mental Health Research Institute (AU)
  • The Alfred Hospital (AU)
Corresponding author
Davison, Sonia L.
ORCID
Venue
Maturitas
Publisher
Elsevier BV
Published
2011-11
Volume
70
Issue
3
Pages
307-311
ISSN
0378-5122 (ISSN-L)
DOI
10.1016/j.maturitas.2011.08.006
OpenAlex
W2089544972
Cited by
47
References
33
Citations by year
2025: 1 · 2024: 2 · 2023: 1 · 2022: 7 · 2021: 3 · 2019: 2 · 2018: 1 · 2017: 6 · 2016: 3 · 2015: 6 · 2014: 6 · 2013: 7 · 2012: 2
FWCI
3.93
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Maturitas (publishedVersion)
  • PubMed (publishedVersion)
  • Swinburne figshare (Swinburne University of Technology) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
testosterone, postmenopausal women, verbal learning, memory, cognitive performance, hormone replacement therapy, visual learning, delayed recall, menopause
MeSH terms
Aged, Androgens, Female, Humans, Memory, Middle Aged, Pilot Projects, Testosterone, Verbal Learning, Postmenopause

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