Marked variation in antiphospholipid antibodies during pregnancy: relationships to pregnancy outcome
Abstract
Variations in blood concentrations of antiphospholipid antibodies (APA) were investigated through the course of pregnancy in women who had a history of recurrent pregnancy loss, and were related to changes in pregnancy outcome. Serial measurements of APA were made in 16 women with antiphospholipid syndrome (APS) and 16 with negative APA tests pre-pregnancy. There was considerable intraindividual variation in test results through pregnancy. There was a significantly higher ratio of dilute Russell's viper venom time and IgG ACA titre in the first trimester compared with results pre-pregnancy in women with APS. Furthermore, transiently positive APA results were noted in the control group during pregnancy and some women with antiphospholipid syndrome tested negative for APA in mid- and late pregnancy. We have demonstrated clinically important variations in the results of tests for APA during pregnancy in women with APS.
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LA positivity can fluctuate over time, with or without systemic lupus erythematosus, and during pregnancy it may decrease or increase.
“LA positivity may fluctuate over time with or without the presence of systemic lupus erythematosus 22,23 and during pregnancy, either decreasing or increasing.22,24,25”
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- Authors
- Topping, J.
- Affiliations
- Liverpool Women's Hospital (GB)
- Corresponding author
- Topping, J.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-01-01
- Volume
- 14
- Issue
- 1
- Pages
- 224-228
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2154024195
- Cited by
- 57
- References
- 27
- Citations by year
- 2026: 3 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2014: 1 · 2012: 2
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- antiphospholipid antibodies, antiphospholipid syndrome, pregnancy, recurrent pregnancy loss, pregnancy outcomes, within-person variability, dilute Russell's viper venom time, anticardiolipin antibodies, first trimester
- MeSH terms
- Abortion, Habitual, Adult, Female, Humans, Pregnancy, Pregnancy Outcome, Cohort Studies, Antibodies, Antiphospholipid, Antibodies, Anticardiolipin
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