Cited by 57Systemic Lupus Erythematosus ResearchReproductive System and PregnancyBlood Coagulation and Thrombosis Mechanisms

Marked variation in antiphospholipid antibodies during pregnancy: relationships to pregnancy outcome

Topping, J.·1999·Human Reproduction

Abstract

Variations in blood concentrations of antiphospholipid antibodies (APA) were investigated through the course of pregnancy in women who had a history of recurrent pregnancy loss, and were related to changes in pregnancy outcome. Serial measurements of APA were made in 16 women with antiphospholipid syndrome (APS) and 16 with negative APA tests pre-pregnancy. There was considerable intraindividual variation in test results through pregnancy. There was a significantly higher ratio of dilute Russell's viper venom time and IgG ACA titre in the first trimester compared with results pre-pregnancy in women with APS. Furthermore, transiently positive APA results were noted in the control group during pregnancy and some women with antiphospholipid syndrome tested negative for APA in mid- and late pregnancy. We have demonstrated clinically important variations in the results of tests for APA during pregnancy in women with APS.

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Crossref · 10.1093/humrep/14.1.224

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Authors
Topping, J.
Affiliations
Liverpool Women's Hospital (GB)
Corresponding author
Topping, J.
Venue
Human Reproduction
Published
1999-01-01
Volume
14
Issue
1
Pages
224-228
ISSN
  • 0268-1161 (ISSN-L)
  • 1460-2350
OpenAlex
W2154024195
Cited by
57
References
27
Citations by year
2026: 3 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2014: 1 · 2012: 2
FWCI
2.74
Type
journal article
Language
en
Open access
closed
Locations
  • Human Reproduction (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Keywords
antiphospholipid antibodies, antiphospholipid syndrome, pregnancy, recurrent pregnancy loss, pregnancy outcomes, within-person variability, dilute Russell's viper venom time, anticardiolipin antibodies, first trimester
MeSH terms
Abortion, Habitual, Adult, Female, Humans, Pregnancy, Pregnancy Outcome, Cohort Studies, Antibodies, Antiphospholipid, Antibodies, Anticardiolipin

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