The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Prevention of twin pregnancy after in-vitro fertilization or intracytoplasmic sperm injection based on strict embryo criteria: a prospective randomized clinical trial
Open accessAbstract
A prospective randomized study comparing single embryo transfer with double embryo transfer after in-vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) was carried out. First, top quality embryo characteristics were delineated by retrospectively analysing embryos resulting in ongoing twins after double embryo transfer. A top quality embryo was characterized by the presence of 4 or 5 blastomeres at day 2 and at least 7 blastomeres on day 3 after insemination, the absence of multinucleated blastomeres and <20% cellular fragments on day 2 and day 3 after fertilization. Using these criteria, a prospective study was conducted in women <34 years of age, who started their first IVF/ICSI cycle. Of 194 eligible patients, 110 agreed to participate of whom 53 produced at least two top quality embryos and were prospectively randomized. In all, 26 single embryo transfers resulted in 17 conceptions, 14 clinical and 10 ongoing pregnancies [implantation rate (IR) = 42.3%; ongoing pregnancy rate (OPR) = 38.5%] with one monozygotic twin; 27 double embryo transfers resulted in 20 ongoing conceptions with six (30%) twins (IR = 48.1%; OPR = 74%). We conclude that by using single embryo transfer and strict embryo criteria, an OPR similar to that in normal fertile couples can be achieved after IVF/ICSI, while limiting the dizygotic twin pregnancy rate to its natural incidence of <1% of all ongoing pregnancies.
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Cites
High fertilization and implantation rates after intracytoplasmic sperm injection
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Culture and selection of viable blastocysts: a feasible proposition for human IVF?
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Characterization of a top quality embryo, a step towards single-embryo transfer
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The relationship between embryo quality and the occurrence of multiple pregnancies
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Cited by
Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer
Gardner, D. K., Lane, M., Stevens, J., Schlenker, T., & Schoolcraft, W. B. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)00518-5 · Cited by 2,091
Infertility and the provision of infertility medical services in developing countries
Ombelet, W., Cooke, I., Dyer, S., Serour, G., & Devroey, P. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn042 · Cited by 720
Why do couples discontinue in vitro fertilization treatment? a cohort study
Olivius, C., Friden, B., Borg, G., & Bergh, C. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.06.029 · Cited by 377
Trends in the occurrence, determinants, and consequences of multiple births
Blondel, B., & Kaminski, M. (2002) · Seminars in Perinatology · doi:10.1053/sper.2002.34775 · Cited by 331
Elective single embryo transfer and perinatal outcomes: a systematic review and meta-analysis
Grady, R., Alavi, N., Vale, R., Khandwala, M., & McDonald, S. D. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.11.033 · Cited by 174
Metadata
- Authors
- Gerris, J., De Neubourg, D., Mangelschots, K., Van Royen, E., Van de Meerssche, M., & Valkenburg, M.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-10
- Volume
- 14
- Issue
- 10
- Pages
- 2581-2587
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2136983583
- Cited by
- 417
- References
- 19
- FWCI
- 18.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Prevention of twin pregnancy after in-vitro fertilization or intracytoplasmic sperm injection based on strict embryo criteria: a prospective randomized clinical trial. https://app.cochat.ai/papers/10.1093/humrep/14.10.2581
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- Gerris, J., De Neubourg, D., Mangelschots, K., Van Royen, E., Van de Meerssche, M., & Valkenburg, M. (1999). Prevention of twin pregnancy after in-vitro fertilization or intracytoplasmic sperm injection based on strict embryo criteria: a prospective randomized clinical trial. Human Reproduction. https://doi.org/10.1093/humrep/14.10.2581
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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