The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Bone mineral density during long-term use of the progestagen contraceptive implant Implanon® compared to a non-hormonal method of contraception
Abstract
An open, prospective, comparative study was done in healthy women, aged between 18 and 40 years, to study the effects of long-term etonogestrel treatment on bone mineral density (BMD). The control group used a non-hormone-medicated intrauterine device (IUD). The BMD was measured using a dual energy X-ray absorptiometry instrument. Measurements included the lumbar spine (L(2)-L(4)), the proximal femur (femoral neck, Ward's triangle, trochanter) and distal radius. The period of treatment was 2 years and 44 women in the Implanon group and 29 in the IUD group provided data. Groups were comparable at baseline with respect to age, weight, body mass index, BMD and 17beta-oestradiol status. Changes from baseline in BMD in the Implanon group were not essentially different from those in the IUD group. There was no relationship between 17beta-oestradiol concentrations and changes in BMD in this study population. The results of the present study indicate that Implanon((R)) can safely be used in young women who have not yet achieved their peak bone mass.
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“The effect of ENG-implant on BMD was compared to a non-hormone medicated IUS. Changes from baseline on the ENG-group were comparable from those in the IUS group.”
From Oral and depot progestin therapy for endometriosis: towards a personalized medicine (2017) · cites this paper as [98]
Citations
Cites
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Self-citationA multicentre efficacy and safety study of the single contraceptive implant Implanon
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Bone Mineral Density in Women Using Depot Medroxyprogesterone Acetate for Contraception
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Spinal Bone Density in Women Using Depot Medroxyprogesterone Contraception
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U.S. Medical Eligibility Criteria for Contraceptive Use, 2016
Curtis, K. M., Tepper, N. K., Jatlaoui, T. C., Berry-Bibee, E., Horton, L. G., Zapata, L. B., Simmons, K. B., Pagano, H. P., Jamieson, D. J., & Whiteman, M. K. (2016) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr6503a1 · Cited by 1,456
Ott, M. A., Sucato, G. S., COMMITTEE ON ADOLESCENCE, Braverman, P. K., Adelman, W. P., Alderman, E. M., Breuner, C. C., Levine, D. A., Marcell, A. V., & O’Brien, R. F. (2014) · PEDIATRICS · doi:10.1542/peds.2014-2300 · Cited by 402
Strategies to prevent unintended pregnancy: increasing use of long-acting reversible contraception
Blumenthal, P. D., Voedisch, A. J., & Gemzell‐Danielsson, K. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq026 · Cited by 290
“BMD normalizes after study drug discontinuation, although a concern in adolescents is that peak bone mass is never reached.”
BackgroundInfluentialU.S. Medical Eligibility Criteria for Contraceptive Use, 2024
Nguyen, A. T., Curtis, K. M., Tepper, N. K., Kortsmit, K., Brittain, A. W., Snyder, E. M., Cohen, M. A., Zapata, L. B., Whiteman, M. K., Contributors, et al. (2024) · MMWR Recommendations and Reports · doi:10.15585/mmwr.rr7304a1 · Cited by 288
Practice Bulletin No. 186: Long-Acting Reversible Contraception: Implants and Intrauterine Devices
(2017) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000002400 · Cited by 213
Metadata
- Authors
- Beerthuizen, R., van Beek, A., Massai, R., Mäkäräinen, L., Hout, J. I., & Bennink, H. C.
- Affiliations
- Streekziekenhuis Koningin Beatrix (NL)
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-01
- Volume
- 15
- Issue
- 1
- Pages
- 118-122
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2101744447
- Cited by
- 127
- References
- 13
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 10
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- bone mineral density, Implanon, etonogestrel, contraceptive implants, progestogens, intrauterine devices, non-hormonal contraception, osteoporosis risk, estradiol, young women, peak bone mass
- MeSH terms
- Adolescent, Adult, Body Weight, Contraceptive Agents, Female, Drug Implants, Estradiol, Female, Femur, Humans, Intrauterine Devices, Prospective Studies, Radius, Vinyl Compounds, Absorptiometry, Photon, Bone Density, Desogestrel, Progesterone Congeners
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