The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Assisted reproductive technology and major structural birth defects in the United States
Abstract
BACKGROUND: With >1% of US births occurring following use of assisted reproductive technology (ART), it is critical to examine whether ART is associated with birth defects. METHODS: We analyzed data from the National Birth Defects Prevention Study, a population-based, multicenter, case-control study of birth defects. We included mothers of fetuses or live-born infants with a major birth defect (case infants) and mothers who had live-born infants who did not have a major birth defect (control infants), delivered during the period October 1997-December 2003. We compared mothers who reported ART use (IVF or ICSI) with those who had unassisted conceptions. Multiple logistic regression was used to adjust for the following confounders: maternal race/ethnicity, maternal age, smoking and parity; we stratified by plurality. RESULTS: ART was reported by 1.1% of all control mothers, and by 4.5% of control mothers 35 years or older. Among singleton births, ART was associated with septal heart defects (adjusted odds ratio [aOR] = 2.1, 95% confidence intervals [CI] 1.1-4.0), cleft lip with or without cleft palate (aOR = 2.4, 95% CI 1.2-5.1), esophageal atresia (aOR = 4.5, 95% CI 1.9-10.5) and anorectal atresia (aOR = 3.7, 95% CI 1.5-9.1). Among multiple births, ART was not significantly associated with any of the birth defects studied. CONCLUSIONS: These findings suggest that some birth defects occur more often among infants conceived with ART. Although the mechanism is not clear, couples considering ART should be informed of all potential risks and benefits.
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Cites
The incidence of congenital heart disease.
Hoffman, J. I. E., & Kaplan, S. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01886-7 · Cited by 6,099
The Risk of Major Birth Defects after Intracytoplasmic Sperm Injection and in Vitro Fertilization
Hansen, M., Kurinczuk, J. J., Bower, C., & Webb, S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa010035 · Cited by 1,083
Chandra, A., Martinez, G. M., Mosher, W. D., Abma, J. C., & Jones, J. (2005) · PsycEXTRA Dataset · doi:10.1037/e414702008-001 · Cited by 956
Assisted reproductive technologies and the risk of birth defects—a systematic review
Hansen, M., Bower, C., Milne, E., de Klerk, N., & J.Kurinczuk, J. (2005) · Human Reproduction · doi:10.1093/humrep/deh593 · Cited by 704
The National Birth Defects Prevention Study
Yoon, P., Rasmussen, S., Lynberg, M., Moore, C., Anderka, M., Carmichael, S., Costa, P., Druschel, C., Hobbs, C., Romitti, P., et al. (2001) · Public Health Reports® · doi:10.1093/phr/116.s1.32 · Cited by 692
Self-citationGuidelines for case classification for the national birth defects prevention study
Rasmussen, S. A., Olney, R. S., Holmes, L. B., Lin, A. E., Keppler‐Noreuil, K. M., & Moore, C. A. (2003) · Birth Defects Research Part A: Clinical and Molecular Teratology · doi:10.1002/bdra.10012 · Cited by 581
Self-citationAssisted reproductive technology
Silva, S. G. D., Bertoldi, A. D., Silveira, M. F. D., Domingues, M. R., Evenson, K. R., & Santos, I. S. D. (2019) · Revista de Saúde Pública · doi:10.11606/s1518-8787.2019053000737 · Cited by 513
Assisted reproductive technology in Australia and New Zealand 2007
Wang, A. Y., & Sullivan, E. A. (2009) · UNSWorks (University of New South Wales, Sydney, Australia) · Cited by 511
Assisted reproductive technology in Europe, 2003
Anderssen, A. N., Goossens, V., Gianaroli, L., Felberbaum, R. E., de Mouzon, J., & Nygren, K. G. (2007) · STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) · Cited by 441
Congenital malformations in infants born after IVF: a population-based study
Ericson, A., & Kallen, B. (2001) · Human Reproduction · doi:10.1093/humrep/16.3.504 · Cited by 385
Cited by
Donofrio, M. T., Moon-Grady, A. J., Hornberger, L. K., Copel, J. A., Sklansky, M. S., Abuhamad, A., Cuneo, B. F., Huhta, J. C., Jonas, R. A., Krishnan, A., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437597.44550.5d · Cited by 1,275
DNA methylation and gene expression differences in children conceived in vitro or in vivo
Katari, S., Turan, N., Bibikova, M., Erinle, O., Chalian, R., Foster, M., Gaughan, J. P., Coutifaris, C., & Sapienza, C. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp319 · Cited by 470
Association between maternal age and birth defects of unknown etiology ― United States, 1997–2007
Gill, S. K., Broussard, C., Devine, O., Green, R. F., Rasmussen, S. A., Reefhuis, J., & Study, A. T. N. B. D. P. (2012) · Birth Defects Research Part A: Clinical and Molecular Teratology · doi:10.1002/bdra.23049 · Cited by 153
Self-citationGonadotrophin replacement for induction of fertility in hypogonadal men
Dwyer, A. A., Raivio, T., & Pitteloud, N. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.10.005 · Cited by 114
van de Putte, R., Wijers, C. H. W., Reutter, H., Vermeulen, S. H., Marcelis, C. L. M., Brosens, E., Broens, P. M. A., Homberg, M., Ludwig, M., Jenetzky, E., et al. (2019) · PLOS ONE · doi:10.1371/journal.pone.0217477 · Cited by 6
Metadata
- Authors
- Reefhuis, J., Honein, M. A., Schieve, L. A., Correa, A., Hobbs, C. A., Rasmussen, S. A., & Study, T. N. B. D. P.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-02-01
- Volume
- 24
- Issue
- 2
- Pages
- 360-366
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W1985699255
- Cited by
- 306
- References
- 33
- FWCI
- 16.84
- Type
- journal article
- Language
- en
- Open access
- closed
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