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Cited by 372Reproductive Biology and FertilityOvarian function and disordersReproductive Health and Technologies

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report

Goswami, S.K.·2004·Human Reproduction
DOI 10.1093/humrep/deh359
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Abstract

BACKGROUND: Use of letrozole, a selective inhibitor of aromatase, reduces the gonadotrophin dose required to induce follicular maturation. We evaluated whether incorporation of letrozole could be an effective low-cost IVF protocol for poor responders. METHODS: A randomized, controlled, single-blind trial was conducted in the Assisted Reproduction Unit, Institute of Reproductive Medicine, Kolkata, India. Thirty-eight women with a history of poor ovarian response to gonadotrophins were recruited. Thirteen women (Let-FSH group) received letrozole 2.5 mg daily from day 3-7, and recombinant FSH (rFSH) 75 IU/day on days 3 and 8; and 25 women (GnRH-ag-FSH group) underwent long GnRH agonist protocol and stimulated with rFSH (300-450 IU/day). Ovulation was triggered by 10,000 IU of HCG followed by IVF-embryo transfer. The main outcome measures were total dose of rFSH (IU/cycle), terminal estradiol (E2) (pg/ml), numbers of follicles, oocytes retrieved and transferable embryo, endometrial thickness (mm), and pregnancy rate. RESULTS: Compared with the GnRH-ag-FSH group (2865 +/- 228 IU), the Let-FSH group (150 +/- 0 IU) received a significantly (P < 0.001) lower total dose of FSH. Except for terminal E2, which was significantly higher (P < 0.001) in the GnRH-ag-FSH group (380 +/- 46 pg/ml) than the Let-FSH group (227 +/- 45 pg/ml), the treatment outcomes in all other respects, including pregnancy rate, were statistically comparable. CONCLUSIONS: Adjunctive use of letrozole may form an effective means of low-cost IVF protocol in poorly responding women.

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Metadata

Authors
Goswami, S. K.
Affiliations
Institute of Reproductive Medicine (IN)
Corresponding author
Goswami, S.K.
ORCID
Goswami, S.K.
Venue
Human Reproduction
Publisher
Oxford University Press (OUP)
Published
2004-06-24
Volume
19
Issue
9
Pages
2031-2035
ISSN
  • 0268-1161 (ISSN-L)
  • 1460-2350
DOI
10.1093/humrep/deh359
OpenAlex
W2105251513
Cited by
372
References
31
Citations by year
2025: 5 · 2024: 3 · 2023: 6 · 2022: 8 · 2021: 12 · 2020: 14 · 2019: 10 · 2018: 5 · 2017: 40 · 2016: 12 · 2015: 44 · 2014: 37 · 2013: 33 · 2012: 36
FWCI
8.53
Type
journal article
Language
en
Open access
closed
Locations
  • Human Reproduction (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Keywords
letrozole, poor ovarian response, aromatase inhibitors, recombinant FSH, GnRH agonist protocol, oocyte retrieval, pregnancy rate
MeSH terms
Letrozole, Adult, Cost Control, Dose-Response Relationship, Drug, Drug Resistance, Embryo Transfer, Estradiol, Female, Fertilization in Vitro, Follicle Stimulating Hormone, Gonadotropins, Chorionic Gonadotropin, Humans, Gonadotropin-Releasing Hormone, Nitriles, Ovary, Pregnancy, Recombinant Proteins, Triazoles, Single-Blind Method, Treatment Outcome, Pregnancy Rate, Aromatase Inhibitors

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