Anti-Müllerian hormone inhibits initiation of growth of human primordial ovarian follicles in vitro
Abstract
BACKGROUND: Anti-Müllerian hormone (AMH) inhibits the initiation of the development and early growth of mouse ovarian follicles. Furthermore, the ovarian follicle pool diminishes prematurely in AMH-knockout mice. In this study, we examined whether AMH plays a similar role in humans, controlling ovarian follicle growth. METHODS: Human ovarian cortical tissue biopsy specimens were cut into small pieces and cultured for 7 days in medium containing rat recombinant AMH at 0, 10, 30 or 100 ng/ml. The developmental stages and viability of the follicles were evaluated from histological sections. RESULTS: Similar to previous studies, significant initiation of follicle growth was observed in almost all culture media, as demonstrated by a significantly smaller proportion of primordial follicles (14-26%) compared with non-cultured control tissue (56%). The exception was tissue in medium supplemented with AMH at 100 ng/ml. Here, the proportion of primordial follicles was not significantly different from that in non-cultured tissue; furthermore, it was significantly greater than that in vehicle control cultures and cultures containing AMH at 10 ng/ml, indicating the inhibition of growth initiation. Viability was unaffected by the presence of AMH when compared with tissues in control media. CONCLUSIONS: Recombinant AMH at a concentration of 100 ng/ml has an inhibitory effect on early human ovarian follicular development in vitro, suppressing the initiation of primordial follicle growth.
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AMH appears to promote growth of preantral follicles to the antral stage in nonhuman primate ovaries, in contrast to mice where AMH inhibits preantral follicle growth and antral follicle maturation.
“In contrast to mice where AMH inhibits preantral follicle growth and antral follicle maturation, AMH appears to promote growth of preantral follicles to the antral stage in nonhuman primate (NHP) ovaries [11, 12].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [11]
Cites
Weenen, C. (2004) · Molecular Human Reproduction · doi:10.1093/molehr/gah015 · Cited by 1,285 · see citing works
Control of Primordial Follicle Recruitment by Anti-Mullerian Hormone in the Mouse Ovary1
Durlinger, A. L. L., Kramer, P., Karels, B., de Jong, F. H., Uilenbroek, J. T. J., Grootegoed, J. A., & Themmen, A. P. N. (1999) · Endocrinology · doi:10.1210/endo.140.12.7204 · Cited by 1,011 · see citing works
Anti-Mullerian Hormone Inhibits Initiation of Primordial Follicle Growth in the Mouse Ovary
Durlinger, A. L. L., Gruijters, M. J. G., Kramer, P., Karels, B., Ingraham, H. A., Nachtigal, M. W., Uilenbroek, J. T. J., Grootegoed, J. A., & Themmen, A. P. N. (2002) · Endocrinology · doi:10.1210/endo.143.3.8691 · Cited by 842 · see citing works
Yan, C., Wang, P., DeMayo, J. L., DeMayo, F. J., Elvin, J. A., Cariño, C., Prasad, S. V., Skinner, S. M., Dunbar, B. S., Dube, J. L., et al. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.6.0662 · Cited by 833 · see citing works
Anti-Mullerian Hormone Attenuates the Effects of FSH on Follicle Development in the Mouse Ovary
Durlinger, A. L. L., Gruijters, M. J. G., Kramer, P., Karels, B., Kumar, T. R., Matzuk, M. M., Rose, U. M., de Jong, F. H., Uilenbroek, J. T. J., Grootegoed, J. A., et al. (2001) · Endocrinology · doi:10.1210/endo.142.11.8486 · Cited by 772 · see citing works
Dynamics of follicular growth in the human: a model from preliminary results
Gougeon, A. (1986) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a136365 · Cited by 741 · see citing works
Müllerian-inhibiting substance function during mammalian sexual development.
Behringer, R., Finegold, M., & Cate, R. (1994) · Cell · doi:10.1016/0092-8674(94)90251-8 · Cited by 706 · see citing works
Baarends, W. M., Uilenbroek, J. T. J., Kramer, P. F., Hoogerbrugge, J. W., van Leeuwen, E. C. M., Themmen, A. P. N., & Grootegoed, J. A. (1995) · Endocrinology · doi:10.1210/endo.136.11.7588229 · Cited by 462 · see citing works
Anti-Müllerian hormone and folliculogenesis
Visser, J. A., & Themmen, A. P. N. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.09.008 · Cited by 462 · see citing works
Meyts, E. R., Jørgensen, N., Græm, N., Müller, J., Cate, R. L., & Skakkebæk, N. E. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6047 · Cited by 375 · see citing works
Initiation in Vitro of Growth of Bovine Primordial Follicles1
Wandji, S.-A., Sršeň, V., Voss, A. K., Eppig, J. J., & Fortune, J. E. (1996) · Biology of Reproduction · doi:10.1095/biolreprod55.5.942 · Cited by 331 · see citing works
Hovatta, O., Silye, R., Abir, R., Krausz, T. N., & Winston, R. M. L. (1997) · Human Reproduction · doi:10.1093/humrep/12.5.1032 · Cited by 294 · see citing works
Meyts, E. R. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.10.3836 · Cited by 291 · see citing works
Hreinsson, J. G., Scott, J. E., Rasmussen, C., Swahn, M.-L., Hsueh, A. J. W., & Hovatta, O. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.1.8185 · Cited by 286 · see citing works
Wright, C., Hovatta, O., Margara, R. A., Trew, G. H., Winston, R. M. L., Franks, S., & Hardy, K. (1999) · Human Reproduction · doi:10.1093/humrep/14.6.1555 · Cited by 248 · see citing works
Hovatta, O., Wright, C., Krausz, T. N., Hardy, K., & Winston, R. M. L. (1999) · Human Reproduction · doi:10.1093/humrep/14.10.2519 · Cited by 237 · see citing works
Control of Primordial Follicle Recruitment by Anti-Mullerian Hormone in the Mouse Ovary
Durlinger, A. L. L. (1999) · Endocrinology · doi:10.1210/en.140.12.5789 · Cited by 206 · see citing works
Anti-Müllerian hormone in early human development
Josso, N., Lamarre, I., Picard, J., Berta, P., Davies, N. P., Morichon-Delvallez, N., Peschanski, M., & Jény, R. (1993) · Early Human Development · doi:10.1016/0378-3782(93)90204-8 · Cited by 199 · see citing works
The Role of the Oocyte in Folliculogenesis
Erickson, G. F., & Shimasaki, S. (2000) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00249-6 · Cited by 141 · see citing works
Mullerian Inhibitory Substance Induces Growth of Rat Preantral Ovarian Follicles1
McGee, E. A., Smith, R., Spears, N., Nachtigal, M. W., Ingraham, H. A., & Hsueh, A. J. W. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.1.293 · Cited by 125 · see citing works
Anti-Müllerian hormone initiates growth of human primordial follicles in vitro
Schmidt, K. L. T., Kryger‐Baggesen, N., Byskov, A. G., & Andersen, C. Y. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.12.010 · Cited by 117 · see citing works
Baarends, W. M. (1995) · Endocrinology · doi:10.1210/en.136.11.4951 · Cited by 104 · see citing works
Rabinovici, J., Spencer, S. J., & Jaffe, R. B. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-5-1396 · Cited by 90 · see citing works
Scott, J. E., Carlsson, I. B., Bavister, B. D., & Hovatta, O. H. (2004) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)62143-8 · Cited by 80 · see citing works
Scott, J. E., Zhang, P., & Hovatta, O. (2004) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60912-1 · Cited by 46 · see citing works
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The Diagnosis of Polycystic Ovary Syndrome during Adolescence
Witchel, S. F., Oberfield, S., Rosenfield, R. L., Codner, E., Bonny, A., Ibáñez, L., Pena, A., Horikawa, R., Gomez-Lobo, V., Joel, D., et al. (2015) · Hormone Research in Paediatrics · doi:10.1159/000375530 · Cited by 3,113 · see citing works
The physiology and clinical utility of anti-Müllerian hormone in women
Dewailly, D., Andersen, C. Y., Balen, A. H., Broekmans, F. J., Dilaver, N., Fanchin, R. R. F., Griesinger, G., Kelsey, T., Marca, A. L., Lambalk, C. B., et al. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt062 · Cited by 1,056 · see citing works
Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART)
Marca, A. L., Sighinolfi, G., Radi, D., Argento, C., Baraldi, E., Artenisio, A. C., Stabile, G., & Volpe, A. (2009) · Human Reproduction Update · doi:10.1093/humupd/dmp036 · Cited by 955 · see citing works
Ovarian damage from chemotherapy and current approaches to its protection
Spears, N., Lopes, F., Stefansdottir, A., Rossi, V., Felici, M. D., Anderson, R. A., & Klinger, F. G. (2019) · Human Reproduction Update · doi:10.1093/humupd/dmz027 · Cited by 665 · see citing works
Witchel, S. F., Oberfield, S. E., & Peña, A. S. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00078 · Cited by 653 · see citing works
The Menopause Transition: Signs, Symptoms, and Management Options
Santoro, N. F., Roeca, C. M., Peters, B. A., & Neal-Perry, G. S. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa764 · Cited by 645 · see citing works
Dewailly, D., Robin, G., Peigné, M., Decanter, C., Pigny, P., & Catteau-Jonard, S. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw027 · Cited by 537 · see citing works
Molecular Mechanisms Underlying the Activation of Mammalian Primordial Follicles
Adhikari, D., & Liu, K. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0048 · Cited by 483 · see citing works
Hagen, C. P., Aksglaede, L., Sørensen, K., Main, K. M., Boas, M., Cleemann, L., Holm, K., Gravholt, C. H., Andersson, A.-M., Pedersen, A. T., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0930 · Cited by 383 · see citing works
Smitz, J. E. J., Dolmans, M., Donnez, J., Fortune, J. E., Hovatta, O., Jewgenow, K., Picton, H. M., Plancha, C. E., Shea, L. D., Stouffer, R. L., et al. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmp056 · Cited by 306 · see citing works
Zhang, H., & Liu, K. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv037 · Cited by 274 · see citing works
Mechanisms maintaining the dormancy and survival of mammalian primordial follicles
Reddy, P., Zheng, W., & Liu, K. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.10.001 · Cited by 268 · see citing works
Anti-Müllerian hormone: an ovarian reserve marker in primary ovarian insufficiency
Visser, J. A., Schipper, I., Laven, J. S. E., & Themmen, A. P. N. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.224 · Cited by 268 · see citing works
Gougeon, A. (2010) · Annales d'Endocrinologie · doi:10.1016/j.ando.2010.02.021 · Cited by 257 · see citing works
The primordial pool of follicles and nest breakdown in mammalian ovaries
Tingen, C. M., Kim, A., & Woodruff, T. K. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap073 · Cited by 246 · see citing works
Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics
Hart, R. J. (2016) · Physiological Reviews · doi:10.1152/physrev.00023.2015 · Cited by 231 · see citing works
Merhi, Z. O., Doswell, A., Krebs, K., & Cipolla, M. J. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4161 · Cited by 226 · see citing works
Anti-Müllerian hormone and ovarian dysfunction
Broekmans, F. J., Visser, J. A., Laven, J. S. E., Broer, S. L., Themmen, A. P. N., & Fauser, B. C. J. M. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.08.002 · Cited by 220 · see citing works
Amorim, C. A., Langendonckt, A. V., David, A., Dolmans, M., & Donnez, J. (2008) · Human Reproduction · doi:10.1093/humrep/den343 · Cited by 219 · see citing works
Jadoul, P., Dolmans, M., & Donnez, J. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq010 · Cited by 211 · see citing works
Anti-Müllerian hormone and polycystic ovary syndrome: a mountain too high?
Pellatt, L. J., Rice, S., & Mason, H. D. (2010) · Reproduction · doi:10.1530/rep-09-0415 · Cited by 209 · see citing works
Advances in human primordial follicle activation and premature ovarian insufficiency
Ford, E. A., Beckett, E., Roman, S. D., McLaughlin, E. A., & Sutherland, J. M. (2019) · Reproduction · doi:10.1530/rep-19-0201 · Cited by 203 · see citing works
Nilsson, E. E., Rogers, N., & Skinner, M. K. (2007) · Reproduction · doi:10.1530/rep-07-0119 · Cited by 201 · see citing works
Anti-Müllerian Hormone in Female Reproduction
di Clemente, N., Racine, C., Pierre, A., & Taieb, J. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab012 · Cited by 201 · see citing works
Postnatal Developmental Changes in the Pituitary-Ovarian Axis in Preterm and Term Infant Girls
Kuiri‐Hänninen, T., Kallio, S., Seuri, R. M., Tyrväinen, E., Liakka, A., Tapanainen, J. S., Sankilampi, U., & Dunkel, L. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1502 · Cited by 194 · see citing works
Anti-Müllerian hormone as a predictor of IVF outcome
Lekamge, D. N., Barry, M., Kolo, M., Lane, M., Gilchrist, R. B., & Tremellen, K. P. (2007) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)61053-x · Cited by 193 · see citing works
Nardo, L. G., Yates, A. P., Roberts, S. A., Pemberton, P. W., & Laing, I. (2009) · Human Reproduction · doi:10.1093/humrep/dep225 · Cited by 188 · see citing works
FOXL2: a central transcription factor of the ovary
Georges, A. B., Auguste, A., Bessière, L., Vanet, A., Todeschini, A., & Veitia, R. A. (2013) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0159 · Cited by 187 · see citing works
Development of morulae from the oocytes of cultured sheep preantral follicles
Arunakumari, G., Shanmugasundaram, N., & Rao, V. H. (2010) · Theriogenology · doi:10.1016/j.theriogenology.2010.04.013 · Cited by 183 · see citing works
Making a good egg: human oocyte health, aging, and in vitro development
Telfer, E. E., Grosbois, J., Odey, Y. L., Rosario, R., & Anderson, R. A. (2023) · Physiological Reviews · doi:10.1152/physrev.00032.2022 · Cited by 175 · see citing works
Jiao, X., Meng, T., Zhai, Y., Zhao, L., Luo, W., Liu, P., & Qin, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.601752 · Cited by 171 · see citing works
The role of Amh signaling in teleost fish – Multiple functions not restricted to the gonads
Pfennig, F., Standke, A., & Gutzeit, H. O. (2015) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2015.09.025 · Cited by 169 · see citing works
Involvement of androgens in ovarian health and disease
Lebbe, M., & Woodruff, T. K. (2013) · Molecular Human Reproduction · doi:10.1093/molehr/gat065 · Cited by 165 · see citing works
Sonigo, C., Beau, I., Grynberg, M., & Binart, N. (2018) · The FASEB Journal · doi:10.1096/fj.201801089r · Cited by 159 · see citing works
Chen, M., Yang, W., Chen, C., Wu, M., Yang, Y., & Ho, H. (2008) · Human Reproduction · doi:10.1093/humrep/den015 · Cited by 156 · see citing works
Chang, E. M., Lim, E., Yoon, S.-Y., Jeong, K., Bae, S., Lee, D. R., Yoon, T. K., Choi, Y., & Lee, W. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144245 · Cited by 154 · see citing works
Fertility preservation during cancer treatment: clinical guidelines
Oktay, K., & Rodriguez‐Wallberg, K. A. (2014) · Cancer Management and Research · doi:10.2147/cmar.s32380 · Cited by 147 · see citing works
Female fertility preservation: past, present and future
Fisch, B., & Abir, R. (2018) · Reproduction · doi:10.1530/rep-17-0483 · Cited by 140 · see citing works
The role of anti-Müllerian hormone (AMH) in ovarian disease and infertility
Bedenk, J., Bokal, E. V., & Virant‐Klun, I. (2019) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-019-01622-7 · Cited by 139 · see citing works
Xu, J., Bernuci, M. P., Lawson, M. S., Yeoman, R. R., Fisher, T. E., Zelinski, M. B., & Stouffer, R. L. (2010) · Reproduction · doi:10.1530/rep-10-0284 · Cited by 134 · see citing works
Campbell, B. K., Clinton, M., & WEBB, R. (2012) · Endocrinology · doi:10.1210/en.2012-1158 · Cited by 134 · see citing works
de Kat, A. C., van der Schouw, Y. T., Eijkemans, M. J. C., Herber-Gast, G.-C. M., Visser, J. A., Verschuren, W. M. M., & Broekmans, F. J. (2016) · BMC Medicine · doi:10.1186/s12916-016-0699-y · Cited by 128 · see citing works
Orisaka, M., Miyazaki, Y., Shirafuji, A., Tamamura, C., Tsuyoshi, H., Tsang, B. K., & Yoshida, Y. (2021) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12371 · Cited by 126 · see citing works
Kevenaar, M. E., Themmen, A. P. N., Laven, J. S. E., Sonntag, B., Fong, S. L., Uitterlinden, A. G., de Jong, F. H., Pols, H. A. P., Simoni, M., & Visser, J. A. (2007) · Human Reproduction · doi:10.1093/humrep/dem036 · Cited by 120 · see citing works
Anti-Mullerian Hormone: Above and Beyond Conventional Ovarian Reserve Markers
Jamil, Z., Fatima, S. S., Ahmed, K., & Malik, R. (2016) · Disease Markers · doi:10.1155/2016/5246217 · Cited by 117 · see citing works
Portrait of an oocyte: our obscure origin
Gosden, R. G., & Lee, B. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41294 · Cited by 117 · see citing works
Molecular Mechanism and Prevention Strategy of Chemotherapy- and Radiotherapy-Induced Ovarian Damage
Kim, S., Kim, S. W., Han, S.-J., Lee, S., Park, H., Song, J. Y., & Kim, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147484 · Cited by 112 · see citing works
Lemos, N. A., Arbo, E., Scalco, R., Weiler, E., Rosa, V., & Cunha-Filho, J. S. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.04.048 · Cited by 110 · see citing works
Pathogenic Anti-Müllerian Hormone Variants in Polycystic Ovary Syndrome
Gorsic, L. K., Kosova, G., Werstein, B., Sisk, R. K., Legro, R. S., Hayes, M. G., Teixeira, J. M., Dunaif, A. E., & Urbanek, M. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00612 · Cited by 103 · see citing works
Kristensen, S. G., Andersen, K. L., Clement, C. A., Franks, S., Hardy, K., & Andersen, C. Y. (2013) · Molecular Human Reproduction · doi:10.1093/molehr/gat089 · Cited by 103 · see citing works
Lande, Y., Fisch, B., Tsur, A., Farhi, J., Prag-Rosenberg, R., Ben‐Haroush, A., Kessler‐Icekson, G., Zahalka, M. A., Ludeman, S. M., & Abir, R. (2016) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2016.10.005 · Cited by 101 · see citing works
Kevenaar, M. E., Themmen, A. P. N., Rivadeneira, F., Uitterlinden, A. G., Laven, J. S. E., van Schoor, N. M., Lips, P. T. A. M., Pols, H. A. P., & Visser, J. A. (2007) · Human Reproduction · doi:10.1093/humrep/dem176 · Cited by 99 · see citing works
Vanacker, J., Camboni, A., Dath, C., Langendonckt, A. V., Dolmans, M., Donnez, J., & Amorim, C. A. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.05.075 · Cited by 96 · see citing works
Park, H. T., Cho, G. J., Ahn, K. H., Shin, J., Kim, Y. T., Hur, J. Y., Kim, S. H., Lee, K. W., & Kim, T. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03614.x · Cited by 95 · see citing works
Anckaert, E., Smitz, J. E. J., Schiettecatte, J., Klein, B. M., & Arce, J. (2012) · Human Reproduction · doi:10.1093/humrep/des101 · Cited by 94 · see citing works
Anckaert, E., Öktem, M., Thies, A., Cohen-Bacrie, M., Daan, N. M. P., Schiettecatte, J., Müller, C., Topçu, D. İ., Gröning, A., Ternaux, F., et al. (2015) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2015.10.008 · Cited by 91 · see citing works
Hao, X., Anastácio, A., Liu, K., & Rodriguez‐Wallberg, K. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194720 · Cited by 90 · see citing works
Control of ovarian primordial follicle activation
Kim, J. Y. (2012) · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine · doi:10.5653/cerm.2012.39.1.10 · Cited by 89 · see citing works
Gorsic, L. K., Dapas, M., Legro, R. S., Hayes, M. G., & Urbanek, M. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02178 · Cited by 89 · see citing works
Arbo, E., Vettori, D. V., Jiménez, M. F., de Freitas, F. M., Lemos, N. A., & Cunha‐Filho, J. S. (2007) · Human Reproduction · doi:10.1093/humrep/dem258 · Cited by 88 · see citing works
Anti-Müllerian hormone (AMH): Regulator and marker of ovarian function
van Houten, E. L. A. F., Themmen, A. P. N., & Visser, J. A. (2010) · Annales d Endocrinologie · doi:10.1016/j.ando.2010.02.016 · Cited by 88 · see citing works
Regulation of the ovarian reserve by members of the transforming growth factor beta family
Pangas, S. A. (2012) · Molecular Reproduction and Development · doi:10.1002/mrd.22076 · Cited by 87 · see citing works
Boudjenah, R., Molina‐Gomes, D., Torre, A., Bergère, M., Bailly, M., Boitrelle, F., Taieb, S., Wainer, R., Benahmed, M., de Mazancourt, P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038700 · Cited by 82 · see citing works
Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles
Zhao, Y., Feng, H., Zhang, Y., Zhang, J. V., Wang, X., Liu, D., Wang, T., Li, R., Ng, E. H. Y., Yeung, W. S. B., et al. (2021) · Cells · doi:10.3390/cells10061491 · Cited by 82 · see citing works
Meinsohn, M.-C., Saatcioglu, H. D., Wei, L., Li, Y., Horn, H., Chauvin, M. Y., Kano, M., Nguyen, N. M., Nagykery, N. G., Kashiwagi, A., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2100920118 · Cited by 81 · see citing works
Rosenfield, R. L., Wroblewski, K., Padmanabhan, V., Littlejohn, E., Mortensen, M., & Ehrmann, D. A. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.03.059 · Cited by 80 · see citing works
Li, J., & Ge, W. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110778 · Cited by 78 · see citing works
A putative role for anti-Müllerian hormone (AMH) in optimising ovarian reserve expenditure
Pankhurst, M. W. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0522 · Cited by 77 · see citing works
Yang, M. Y., Cushman, R. A., & Fortune, J. E. (2017) · Molecular Human Reproduction · doi:10.1093/molehr/gax010 · Cited by 75 · see citing works
Anti Müllerian Hormone: More than a biomarker of female reproductive function
Victoria, M., Labrosse, J., Krief, F., Cédrin‐Durnerin, I., Comtet, M., & Grynberg, M. (2018) · Journal of Gynecology Obstetrics and Human Reproduction · doi:10.1016/j.jogoh.2018.10.015 · Cited by 73 · see citing works
Xu, F., Lawson, M. S., Bean, Y. T., Ting, A. Y., Pejovic, T. B., Geest, K. D., Moffitt, M. N., Mitalipov, S. M., & Xu, J. (2021) · Human Reproduction · doi:10.1093/humrep/deab003 · Cited by 72 · see citing works
Yan, Y., Batzel, P., Titus, T. A., Sydes, J., Desvignes, T., Bremiller, R., Draper, B. W., & Postlethwait, J. H. (2019) · Genetics · doi:10.1534/genetics.119.302365 · Cited by 71 · see citing works
Sex Determination and Differentiation in Teleost: Roles of Genetics, Environment, and Brain
Rajendiran, P., Jaafar, F., Kar, S., Sudhakumari, C.-C., Senthilkumaran, B., & Parhar, I. S. (2021) · Biology · doi:10.3390/biology10100973 · Cited by 69 · see citing works
Mortensen, M., Ehrmann, D. A., Littlejohn, E., & Rosenfield, R. L. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2771 · Cited by 69 · see citing works
Implications of Nonphysiological Ovarian Primordial Follicle Activation for Fertility Preservation
Grosbois, J., Devos, M., & Demeestere, I. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa020 · Cited by 68 · see citing works
Reproductive Longevity and Aging: Geroscience Approaches to Maintain Long-Term Ovarian Fitness
Llarena, N. C., & Hine, C. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa204 · Cited by 68 · see citing works
Lipid profiles and ovarian reserve status: a longitudinal study
Tehrani, F. R., Erfani, H., Cheraghi, L., Tohidi, M., & Azizi, F. (2014) · Human Reproduction · doi:10.1093/humrep/deu249 · Cited by 68 · see citing works
Puberty and its disorders in the female
Rosenfield, R. L., Cooke, D. W., & Radovick, S. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-4858-7.00024-x · Cited by 67 · see citing works
Female Reproductive Decline Is Determined by Remaining Ovarian Reserve and Age
Wilkosz, P., Greggains, G. D., Tanbo, T. G., & Fedorcsák, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108343 · Cited by 68 · see citing works
Zhang, Z., Zhu, B., Chen, W., & Ge, W. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110963 · Cited by 65 · see citing works
Lee, S., Özkavukçu, S., & Ku, S. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00517-2 · Cited by 65 · see citing works
Dole, G., Nilsson, E. E., & Skinner, M. K. (2008) · Reproduction · doi:10.1530/rep-07-0405 · Cited by 65 · see citing works
The hormonal composition of follicular fluid and its implications for ovarian cancer pathogenesis
Emori, M. M., & Drapkin, R. (2014) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-12-60 · Cited by 64 · see citing works
Veiga‐Lopez, A., Ye, W., & Padmanabhan, V. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.12.028 · Cited by 64 · see citing works
Yang, Q., Zhu, L., & Jin, L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00548 · Cited by 62 · see citing works
Adamczak, R., Ukleja-Sokołowska, N., Lis, K., & Dubiel, M. (2021) · Medicina · doi:10.3390/medicina57111251 · Cited by 60 · see citing works
David, A., Langendonckt, A. V., Gilliaux, S., Dolmans, M., Donnez, J., & Amorim, C. A. (2012) · Human Reproduction · doi:10.1093/humrep/des013 · Cited by 60 · see citing works
Emerging Roles of Anti-Müllerian Hormone in Hypothalamic-Pituitary Function
Barbotin, A., Peigné, M., Malone, S. A., & Giacobini, P. (2019) · Neuroendocrinology · doi:10.1159/000500689 · Cited by 60 · see citing works
The Factors and Pathways Regulating the Activation of Mammalian Primordial Follicles in vivo
Chen, Y., Yang, W., Shi, X., Zhang, C., Song, G., & Huang, D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.575706 · Cited by 59 · see citing works
Sönmezer, M., Taşkın, S., Gemici, A., Kahraman, K., Özmen, B., Berker, B., & Atabekoğlu, C. S. (2013) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-012-2704-9 · Cited by 58 · see citing works
Moran, L., Noakes, M., Clifton, P. M., & Norman, R. J. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1188 · Cited by 58 · see citing works
Kallio, S., Aittomäki, K., Piltonen, T., Veijola, R., Liakka, A., Vaskivuo, T. E., Dunkel, L., & Tapanainen, J. S. (2012) · Human Reproduction · doi:10.1093/humrep/der473 · Cited by 57 · see citing works
Is AMH a regulator of follicular atresia?
Seifer, D. B., & Merhi, Z. O. (2014) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-014-0328-7 · Cited by 57 · see citing works
Roness, H., Spector, I., Leichtmann‐Bardoogo, Y., Savino, A. M., Derech-Haim, S., & Meirow, D. (2019) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-019-01507-9 · Cited by 57 · see citing works
LATS1 phosphorylates forkhead L2 and regulates its transcriptional activity
Pisarska, M. D., Kuo, F., Bentsi-Barnes, I. K., Khan, S., & Barlow, G. M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00534.2009 · Cited by 54 · see citing works
Kushnir, V. A., Seifer, D. B., Barad, D. H., Sen, A., & Gleicher, N. (2017) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-017-0977-4 · Cited by 50 · see citing works
Presence of anti-Müllerian hormone (AMH) during follicular development in the porcine ovary
de Almeida, F. R. C. L., Costermans, N. G. J., Soede, N. M., Bunschoten, A., Keijer, J., Kemp, B., & Teerds, K. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197894 · Cited by 50 · see citing works
Xu, H., Zhang, M., Zhang, H., Alpadi, K., Wang, L., Li, R., & Qiao, J. (2021) · The Innovation · doi:10.1016/j.xinn.2021.100091 · Cited by 50 · see citing works
IVF outcomes of women with discrepancies between age and serum anti-Müllerian hormone levels
Zhang, B., Meng, Y., Jiang, X., Liu, C., Zhang, H., Cui, L., & Chen, Z. (2019) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-019-0498-3 · Cited by 49 · see citing works
Kona, S. S. R., Chakravarthi, V. P., Kumar, A. V. N. S., Srividya, D., Padmaja, K., & Rao, V. H. (2015) · Theriogenology · doi:10.1016/j.theriogenology.2015.09.022 · Cited by 48 · see citing works
- Authors
- Carlsson, I. B.
- Affiliations
- Karolinska University Hospital (SE)
- Corresponding author
- Carlsson, I.B.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-06-03
- Volume
- 21
- Issue
- 9
- Pages
- 2223-2227
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2131854962
- Cited by
- 294
- References
- 25
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 10 · 2023: 15 · 2022: 9 · 2021: 26 · 2020: 17 · 2019: 23 · 2018: 14 · 2017: 13 · 2016: 12 · 2015: 17 · 2014: 21 · 2013: 16 · 2012: 16
- FWCI
- 10.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Keywords
- anti-Müllerian hormone, primordial follicles, ovarian follicle development, folliculogenesis, ovarian cortical tissue, follicle viability, human ovary
- MeSH terms
- Adult, Animals, Female, Glycoproteins, Ovarian Follicle, Humans, Ovary, Testicular Hormones, Mice, Knockout, Cell Culture Techniques, Cell Proliferation, Mice, Rats, Anti-Mullerian Hormone
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