Cryopreservation of ovarian tissue and in vitro matured oocytes in a female with mosaic Turner syndrome: case report
Abstract
We report a novel approach of fertility preservation in a young woman with mosaic Turner syndrome. A 16-year-old female with 20% 45XO and 80% 46XX karyotype underwent laparoscopic ovarian wedge resection. Before performing ovarian tissue cryopreservation, all visible follicles on the ovarian surface were aspirated. We recovered 11 immature germinal vesicle stage oocytes, which were subjected to in vitro maturation (IVM). Eight oocytes that matured (73% maturation rate) were cryopreserved by vitrification. The combination of ovarian tissue cryobanking and immature oocyte collection from the tissue followed by IVM and vitrification of matured oocytes represent a promising approach of fertility preservation for young women with mosaic Turner syndrome.
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In three of four case reports, follicles were found in cases with a mosaic karyotype.
“Furthermore, in three of four case reports follicles were found in cases with a mosaic karyotype.600,615-617”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [615]
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- Authors
- Huang, J. Y. J., Tulandi, T., Holzer, H., Lau, N. M., MacDonald, S., Tan, S. L., & Chian, R. C.
- Affiliations
- McGill University Health Centre (CA)
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-12-14
- Volume
- 23
- Issue
- 2
- Pages
- 336-339
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2087208863
- Cited by
- 124
- References
- 13
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 12 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 8 · 2016: 4 · 2015: 10 · 2014: 1 · 2013: 6 · 2012: 5
- FWCI
- 9.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McGill University Health Centre
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- Turner syndrome, ovarian tissue cryopreservation, in vitro maturation, immature oocytes, vitrification, fertility preservation, mosaic Turner syndrome, germinal vesicle oocytes
- MeSH terms
- Adolescent, Cells, Cultured, Female, Humans, Mosaicism, Oocytes, Ovary, Turner Syndrome, Cryopreservation, Cellular Senescence
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