Cardiometabolic risk in polycystic ovary syndrome: a comparison of different approaches to defining the metabolic syndrome
Abstract
BACKGROUND: Polycystic ovary syndrome (PCOS) is associated with insulin resistance and features in common with the metabolic syndrome (MetS)--factors shown to predict cardiovascular risk and type 2 diabetes. We investigated the prevalence and characteristics of the MetS in PCOS by three definitions-World Health Organization (WHO), National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP-III) and International Diabetes Federation (IDF)--and compared that with the background population. METHODS: Cross-sectional study of 168 women with PCOS and 883 age-matched controls from the Australian Diabetes, Obesity and Lifestyle (AusDiab) study. RESULTS: Prevalence of the MetS in PCOS subjects was 33% by WHO, 37% by NCEP-ATP-III and 40% by IDF criteria, compared with 10% by NCEP-ATP-III and 13% by IDF in controls (P < 0.001). MetS by WHO criteria was not calculated in the AusDiab population. Age was an independent predictor of MetS in PCOS and controls. The prevalence of MetS was significantly higher among those with PCOS (P = 0.027) in obese women (BMI > 30 kg/m(2)), and higher but not significantly so in overweight (BMI 25-30 kg/m(2)) women (P = 0.052). Dehydroepiandrosterone sulphate was associated with a lower risk of the MetS--Odds ratio 0.86 (95% confidence interval, 0.77-0.97, P = 0.011). CONCLUSIONS: An approximate 4-fold increase in the prevalence of the MetS in women with PCOS compared with the general population, consistent with the proposed major role of insulin and obesity in the syndrome, implies greater risk of cardiometabolic disease in women with PCOS. However, this estimate is likely to vary according to PCOS definition, ethnicity and different aetiological pathways to PCOS.
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Women with PCOS often have increased cardiovascular risk factors (hyperinsulinaemia, dyslipidaemia, hypertension) and increased prevalence of metabolic syndrome.
“Women with PCOS often have increased cardiovascular risk factors (hyperinsulinaemia, dyslipidaemia, hypertension) and increased prevalence of metabolic syndrome 81”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [81]
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- Authors
- Cussons, A. J., Watts, G. F., Burke, V., Shaw, J. E., Zimmet, P. Z., & Stuckey, B. G. A.
- Affiliations
- The University of Western Australia (AU)
- Corresponding author
- Stuckey, B. G.A.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-07-08
- Volume
- 23
- Issue
- 10
- Pages
- 2352-2358
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2153078139
- Cited by
- 140
- References
- 34
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 16 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 9 · 2018: 7 · 2017: 7 · 2016: 4 · 2015: 11 · 2014: 14 · 2013: 4 · 2012: 6
- FWCI
- 13.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Funders
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- polycystic ovary syndrome, metabolic syndrome, cardiometabolic risk, insulin resistance, metabolic syndrome definitions, WHO criteria, NCEP ATP III criteria, IDF criteria, dehydroepiandrosterone sulfate, obesity, type 2 diabetes, cardiovascular risk, women
- MeSH terms
- Adult, Age Factors, Cross-Sectional Studies, Female, Humans, Middle Aged, Polycystic Ovary Syndrome, Regression Analysis, Prevalence, Metabolic Syndrome
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