Indicators for metabolic disturbances in anovulatory women with polycystic ovary syndrome diagnosed according to the Rotterdam consensus criteria

Goverde, A.J.; van Koert, A.J.B.; Eijkemans, M.J.; Knauff, E.A.H.; Westerveld, H.E.; Fauser, B.C.J.M.; Broekmans, F.J.

doi:10.1093/humrep/den433

Cited by 136Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGenetic and Kidney Cyst Diseases

Indicators for metabolic disturbances in anovulatory women with polycystic ovary syndrome diagnosed according to the Rotterdam consensus criteria

Goverde, A.J., van Koert, A.J.B., Eijkemans, M.J., Knauff, E.A.H., Westerveld, H.E., Fauser, B.C.J.M., Broekmans, F.J.·2008·Human Reproduction

DOI 10.1093/humrep/den433

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Abstract

BACKGROUND: Polycystic ovary syndrome (PCOS) is associated with metabolic abnormalities. It is debated whether all women with PCOS should be screened for metabolic abnormalities as these may vary with PCOS phenotype, age and ethnicity. The aims of this study were to assess the prevalence of metabolic abnormalities in Dutch anovulatory PCOS women and to define criteria for metabolic screening. METHODS: Anovulatory patients, diagnosed with PCOS according to the Rotterdam consensus criteria, underwent metabolic screening. Through stepwise multivariate analysis patient characteristics associated with metabolic syndrome (MetS) and insulin resistance (IR) were evaluated for their use as selection parameters for metabolic screening. RESULTS: Overall, prevalence of MetS and IR was 15.9% (n = 25) and 14% (n = 22), respectively, in 157 PCOS women (age 29.0 +/- 4.8 years, BMI 26.1 +/- 6.7 kg/m(2)). Anovulatory hyperandrogenic women (with or without polycystic ovaries) had more often MetS and IR (with, 20.8 and 19.8%; without, 100 and 40%, respectively) than non-hyperandrogenic PCOS women (0 and 1.8%; P < 0.001). Waist circumference >83.5 cm along with increased free androgen index (FAI) had the most powerful association with the presence of MetS and IR (area under the receiver operating characteristic curve 0.912) and offered a reduction in the necessity of screening for metabolic derailments of about 50%. CONCLUSIONS: The hyperandrogenic PCOS phenotypes are highly linked to the presence of MetS and IR in Dutch PCOS women. Waist circumference combined with FAI was identified as an efficient combination test to select those PCOS women who should be screened for the presence of MetS and/or IR.

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Subjects with hyperandrogenism have a higher level of insulin resistance compared with those without hyperandrogenism.
“Subjects with hyperandrogenism have a higher level of IR compared with those without hyperandrogenism [16].”
From From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management (2020) · cites this paper as [16]

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Authors: Goverde, A. J., van Koert, A. J. B., Eijkemans, M. J., Knauff, E. A. H., Westerveld, H. E., Fauser, B. C. J. M., & Broekmans, F. J.
Affiliations: University Medical Center Utrecht (NL)
University of Groningen (NL)
ORCID: Goverde, A.J.
Eijkemans, M.J.
Fauser, B.C.J.M.
Broekmans, F.J.
Venue: Human Reproduction
Publisher: Oxford University Press (OUP)
Published: 2008-12-04
Volume: 24
Issue: 3
Pages: 710-717
ISSN: 0268-1161 (ISSN-L)
1460-2350
DOI: 10.1093/humrep/den433
OpenAlex: W2113552399
Cited by: 135
References: 43
Citations by year: 2026: 1 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 9 · 2020: 13 · 2019: 4 · 2018: 7 · 2017: 8 · 2016: 9 · 2015: 12 · 2014: 11 · 2013: 8 · 2012: 8
FWCI: 10.42
Type: journal article
Language: en
Open access: closed
Locations: Human Reproduction (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords: polycystic ovary syndrome, metabolic syndrome, insulin resistance, anovulation, hyperandrogenism, metabolic screening, free androgen index, waist circumference, PCOS phenotypes
MeSH terms: Adolescent, Adult, Androgens, Anovulation, Female, Humans, Insulin Resistance, Netherlands, Phenotype, Polycystic Ovary Syndrome, Sensitivity and Specificity, Multivariate Analysis, Treatment Outcome, Metabolic Syndrome, Waist Circumference

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Indicators for metabolic disturbances in anovulatory women with polycystic ovary syndrome diagnosed according to the Rotterdam consensus criteria

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About these checks