The prevalence of polycystic ovary syndrome in a normal population according to the Rotterdam criteria versus revised criteria including anti-Mullerian hormone
Abstract
Study question What is the prevalence in a normal population of polycystic ovary syndrome (PCOS) according to the Rotterdam criteria versus revised criteria including anti-Müllerian hormone (AMH)? Summary answer The prevalence of PCOS was 16.6% according to the Rotterdam criteria. When replacing the criterion for polycystic ovaries by antral follicle count (AFC) > 19 or AMH > 35 pmol/l, the prevalence of PCOS was 6.3 and 8.5%, respectively. WHAT IS KNOWN ALREADY?: The Rotterdam criteria state that two out of the following three criteria should be present in the diagnosis of PCOS: oligo-anovulation, clinical and/or biochemical hyperandrogenism and polycystic ovaries (AFC ≥ 12 and/or ovarian volume >10 ml). However, with the advances in sonography, the relevance of the AFC threshold in the definition of polycystic ovaries has been challenged, and AMH has been proposed as a marker of polycystic ovaries in PCOS. Study design, size, duration From 2008 to 2010, a prospective, cross-sectional study was performed including 863 women aged 20-40 years and employed at Copenhagen University Hospital, Rigshospitalet, Denmark. Participants/material, setting, methods We studied a subgroup of 447 women with a mean (±SD) age of 33.5 (±4.0) years who were all non-users of hormonal contraception. Data on menstrual cycle disorder and the presence of hirsutism were obtained. On cycle Days 2-5, or on a random day in the case of oligo- or amenorrhoea, sonographic and endocrine parameters were measu…
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PCOS leads to infertility, menstrual problems and clinical manifestations of hyperandrogenism in women of childbearing age.
“PCOS leads to infertility, menstrual problems and clinical manifestations of hyperandrogenism in women of childbearing age [186].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [186]
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- Authors
- Lauritsen, M. P., Bentzen, J. G., Pinborg, A., Loft, A., Forman, J. L., Thuesen, L. L., Cohen, A., Hougaard, D. M., & Nyboe Andersen, A.
- Affiliations
- Copenhagen University Hospital (DK)
- University of Copenhagen (DK)
- Statens Serum Institut (DK)
- Corresponding author
- Lauritsen, M. P.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-01-16
- Volume
- 29
- Issue
- 4
- Pages
- 791-801
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2102272748
- Cited by
- 334
- References
- 5
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 26 · 2023: 41 · 2022: 50 · 2021: 31 · 2020: 34 · 2019: 23 · 2018: 20 · 2017: 28 · 2016: 24 · 2015: 15 · 2014: 12
- FWCI
- 31.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- polycystic ovary syndrome, prevalence, Rotterdam criteria, anti-Müllerian hormone, antral follicle count, polycystic ovary, age-related prevalence, menstrual disorders, hirsutism, hyperandrogenism, oligoanovulation, ovarian volume, women of reproductive age, Denmark
- MeSH terms
- Adult, Age Factors, Cross-Sectional Studies, Denmark, Female, Humans, Polycystic Ovary Syndrome, Prospective Studies, ROC Curve, Ultrasonography, Prevalence, Area Under Curve, Anti-Mullerian Hormone
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