The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Angiongenesis: a new theory for endometriosis
Abstract
Excessive endometrial angiogenesis is proposed as an important mechanism in the pathogenesis of endometriosis. Evidence is reviewed for the hypothesis that the endometrium of women with endometriosis has an increased capacity to proliferate, implant and grow in the peritoneal cavity. Data is summarized indicating that the endometrium of patients with endometriosis shows enhanced endothelial cell proliferation. Results are also reviewed indicating that the cell adhesion molecule integrin alphavbeta3 is expressed in more blood vessels in the endometrium of women with endometriosis when compared with normal women. Taken together, these results provide evidence for increased endometrial angiogenesis in women with endometriosis when compared with normal subjects. Endometriosis is one of the family of angiogenic diseases. Other angiogenic diseases include solid tumours, rheumatoid arthritis, psoriasis and diabetic retanopathy. Excessive endometrial angiogenesis suggests novel new medical treatments for endometriosis aimed at the inhibition of angiogenesis.
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“Pelvic endometriosis is associated with a low-grade inflammation of the peritoneal cavity with higher concentrations of activated macrophages and thus with higher concentrations of the many different cytokines (68-72) and angiogenic factors (73)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91).”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [76]
Citations
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Metadata
- Authors
- Healy, D.
- Affiliations
- Monash Medical Centre (AU)
- Corresponding author
- Healy, D.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-09-01
- Volume
- 4
- Issue
- 5
- Pages
- 736-740
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2146205715
- Cited by
- 173
- References
- 34
- Citations by year
- 2025: 6 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 9 · 2013: 5 · 2012: 9
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction Update (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, endometrial angiogenesis, angiogenesis, endothelial cell proliferation, integrin αvβ3, adhesion molecules, peritoneal implantation, endometrial proliferation, anti-angiogenic therapy
- MeSH terms
- Cell Division, Endometriosis, Endometrium, Endothelium, Vascular, Female, Gene Expression Regulation, Humans, Models, Cardiovascular, Neoplasms, Neovascularization, Pathologic, Receptors, Vitronectin
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