Cited by 173Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementGynecological conditions and treatments

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Angiongenesis: a new theory for endometriosis

Healy, D.·1998·Human Reproduction Update

DOI 10.1093/humupd/4.5.736

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Abstract

Excessive endometrial angiogenesis is proposed as an important mechanism in the pathogenesis of endometriosis. Evidence is reviewed for the hypothesis that the endometrium of women with endometriosis has an increased capacity to proliferate, implant and grow in the peritoneal cavity. Data is summarized indicating that the endometrium of patients with endometriosis shows enhanced endothelial cell proliferation. Results are also reviewed indicating that the cell adhesion molecule integrin alphavbeta3 is expressed in more blood vessels in the endometrium of women with endometriosis when compared with normal women. Taken together, these results provide evidence for increased endometrial angiogenesis in women with endometriosis when compared with normal subjects. Endometriosis is one of the family of angiogenic diseases. Other angiogenic diseases include solid tumours, rheumatoid arthritis, psoriasis and diabetic retanopathy. Excessive endometrial angiogenesis suggests novel new medical treatments for endometriosis aimed at the inhibition of angiogenesis.

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Authors: Healy, D.
Affiliations: Monash Medical Centre (AU)
Corresponding author: Healy, D.
Venue: Human Reproduction Update
Publisher: Oxford University Press (OUP)
Published: 1998-09-01
Volume: 4
Issue: 5
Pages: 736-740
ISSN: 1355-4786 (ISSN-L)
1460-2369
DOI: 10.1093/humupd/4.5.736
OpenAlex: W2146205715
Cited by: 173
References: 34
Citations by year: 2025: 6 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 9 · 2013: 5 · 2012: 9
FWCI: 5.05
Type: journal article
Language: en
Open access: closed
Locations: Human Reproduction Update (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords: endometriosis, endometrial angiogenesis, angiogenesis, endothelial cell proliferation, integrin αvβ3, adhesion molecules, peritoneal implantation, endometrial proliferation, anti-angiogenic therapy
MeSH terms: Cell Division, Endometriosis, Endometrium, Endothelium, Vascular, Female, Gene Expression Regulation, Humans, Models, Cardiovascular, Neoplasms, Neovascularization, Pathologic, Receptors, Vitronectin

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Angiongenesis: a new theory for endometriosis

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