The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Sperm pathology: a step beyond descriptive morphology. Origin, characterization and fertility potential of abnormal sperm phenotypes in infertile men
Abstract
Sperm pathology is presented as the discipline of characterizing structural and functional deficiencies in abnormal spermatozoa. This concept complements that of sperm morphology mainly concerned with the appearance of spermatozoa. These two notions collaborate in providing correlations of prognostic value with sperm fertilizing capacity, explaining the mechanisms of sperm inefficiency, suggesting strategies to improve fertilization and opening a door to molecular genetic studies. Phenotypes of genetic origin involving sperm heads, flagella and the neck region are presented describing their clinical manifestations, sperm structure, cytochemistry and genetic background. When available, animal models are used to highlight possible genetic mechanisms. Sperm pathologies secondary to andrological conditions or environmental factors are described, stressing the non-specific nature of the sperm response to noxious agents. The available literature on the prognostic value of sperm pathologies in ICSI is also reviewed. Flagellar anomalies bear a good prognosis, but those affecting the acrosome, sperm chromatin and the neck region entail an increasing chance of failure, which highlights the differential roles played by specific sperm components in fertilization, implantation and early embryonic development. A final discussion is devoted to genetic counselling and the risks involved in using immotile or abnormal spermatozoa in assisted reproduction.
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Cites
Predictive value of abnormal sperm morphology in in vitro fertilization
Kruger, T. F., Acosta, A. A., Simmons, K. F., Swanson, R. J., Matta, J. F., & Oehninger, S. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59660-5 · Cited by 1,159
Grow, D. R., Oehninger, S., Seltman, H. J., Toner, J. P., Swanson, R. J., Kruger, T. F., & Muasher, S. J. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56946-5 · Cited by 182
Rybouchkin, A. V., Van der Straeten, F., Quatacker, J., De Sutter, P., & Dhont, M. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00378-6 · Cited by 169
Liu, J., Nagy, Z., Joris, H., Tournaye, H., Devroey, P., & Van Steirteghem, A. (1995) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a136000 · Cited by 138
Chemes, H. E., Carizza, C., Scarinci, F., Brugo, S., Neuspiller, N., & Schwarsztein, L. (1987) · Fertility and Sterility · doi:10.1016/s0015-0282(16)50011-9 · Cited by 100
Self-citationSaïas-Magnan, J., Metzler-Guillemain, C., Mercier, G., Carles-Marcorelles, F., Grillo, J. M., & Guichaoua, M. R. (1999) · Human Reproduction · doi:10.1093/humrep/14.8.1989 · Cited by 37
Cited by
Teratozoospermia: spotlight on the main genetic actors in the human
Coutton, C., Escoffier, J., Martinez, G., Arnoult, C., & Ray, P. F. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv020 · Cited by 352
Berkovitz, A., Eltes, F., Yaari, S., Katz, N., Barr, I., Fishman, A., & Bartoov, B. (2005) · Human Reproduction · doi:10.1093/humrep/deh545 · Cited by 299
Genetic abnormalities leading to qualitative defects of sperm morphology or function
Ray, P. F., Toure, A., Metzler‐Guillemain, C., Mitchell, M. J., Arnoult, C., & Coutton, C. (2017) · Clinical Genetics · doi:10.1111/cge.12905 · Cited by 179
Relationship amongst teratozoospermia, seminal oxidative stress and male infertility
Agarwal, A., Tvrda, E., & Sharma, R. (2014) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-12-45 · Cited by 176
Assessing human sperm morphology: top models, underdogs or biometrics?
Auger, J. (2010) · Asian Journal of Andrology · doi:10.1038/aja.2009.8 · Cited by 90
Metadata
- Authors
- Chemes, H. E.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-09-01
- Volume
- 9
- Issue
- 5
- Pages
- 405-428
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2161682442
- Cited by
- 292
- References
- 6
- FWCI
- 6.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chemes, H. E. (2003). Sperm pathology: a step beyond descriptive morphology. Origin, characterization and fertility potential of abnormal sperm phenotypes in infertile men. Human Reproduction Update. https://doi.org/10.1093/humupd/dmg034
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
