Cited by 594Dementia and Cognitive Impairment ResearchTraumatic Brain Injury ResearchAlzheimer's disease research and treatments

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Head Trauma as a Risk Factor for Alzheimer's Disease: A Collaborative Re-Analysis of Case-Control Studies

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Mortimer, J A, Van Duijn, C M, Chandra, V, Fratiglioni, L, Graves, A B, Heyman, A, Jorm, A F, Kokmen, E, Kondo, K, Rocca, W A, Shalat, S L, Soininen, H, A Hofman for the Eurodem Risk Factors Research Group·1991·International Journal of Epidemiology

DOI 10.1093/ije/20.supplement_2.s28

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Abstract

A re-analysis of the data from 11 case-control studies was performed to investigate the association between head trauma and Alzheimer's disease (AD). To increase comparability of studies, exposures were limited to head trauma with loss of consciousness (hereafter referred to as 'head trauma') and comparisons were restricted to community (versus hospital) controls. Test for heterogeneity across studies was negative; consequently, data were pooled in subsequent analyses. The pooled relative risk for head trauma was 1.82 (95% confidence interval: 1.26-2.67). Stratified analyses showed stronger associations in cases without a positive family history of dementia and in males (versus females). Adjustment of the pooled relative risk for family history of dementia, education and alcohol consumption did not alter significantly the association between head trauma and AD. There was no interaction effect between head trauma and family history of dementia, suggesting that these risk factors operate independently. Mean age of onset was not significantly different in cases with a history of head trauma compared to cases without such a history. The findings of the pooled analysis support an association between reported head trauma and AD.

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Albayram, Ö., Kondo, A., Mannix, R., Smith, C., Tsai, C.-Y., Li, C., Herbert, M. K., Qiu, J., Monuteaux, M. C., Driver, J. A., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01068-4 · Cited by 154
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Baker, H. F., Ridley, R. M., Duchen, L. W., Crow, T. J., & Bruton, C. J. (1994) · Molecular Neurobiology · doi:10.1007/bf02778005 · Cited by 153
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Mawanda, F., & Wallace, R. B. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxs007 · Cited by 151
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Johnson, V. E., Meaney, D. F., Cullen, D. K., & Smith, D. H. (2015) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52892-6.00008-8 · Cited by 151
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Background
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Graham, D. I., Gentleman, S., Lynch, A., & Roberts, G. (1995) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1995.tb01025.x · Cited by 140
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Millar, K. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.8.1047 · Cited by 146
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O’Keeffe, E., Kelly, E., Liu, Y., Giordano, C., Wallace, E., Hynes, M., Tiernan, S., Meagher, A., Greene, C., Hughes, S. M., et al. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2019.6483 · Cited by 148
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Smith, D. H., Nakamura, M., McIntosh, T. K., Wang, J., Rodríguez, A., Chen, X.-H., Raghupathi, R., Saatman, K. E., Clemens, J., Schmidt, M. L., et al. (1998) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65643-x · Cited by 143
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Background
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McDowell, I. (2001) · Aging Clinical and Experimental Research · doi:10.1007/bf03351474 · Cited by 140
Head injury as a risk factor in Alzheimer's disease.
Rasmusson, D., Brandt, J., Martin, D. B., & Folstein, M. (1995) · Brain Injury · doi:10.3109/02699059509008194 · Cited by 83
What is the Relationship of Traumatic Brain Injury to Dementia?
Mendez, M. F. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161002 · Cited by 141
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Background
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Modgil, S., Lahiri, D. K., Sharma, V. L., & Anand, A. (2014) · Translational Neurodegeneration · doi:10.1186/2047-9158-3-9 · Cited by 138
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Transiently lowering tumor necrosis factor-α synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice
Baratz-Goldstein, R., Tweedie, D., Wang, J., Rubovitch, V., Luo, W., Hoffer, B. J., Greig, N. H., & Pick, C. G. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0237-4 · Cited by 136
Chronic Repetitive Mild Traumatic Brain Injury Results in Reduced Cerebral Blood Flow, Axonal Injury, Gliosis, and Increased T-Tau and Tau Oligomers
Ojo, J. O., Mouzon, B., Algamal, M., Leary, P., Lynch, C., Abdullah, L. I., Evans, J., MULLAN, M. J., Bachmeier, C. J., Stewart, W. B., Jr., et al. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw035 · Cited by 134
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White, C., Lawrence, C. B., Brough, D., & Rivers‐Auty, J. (2016) · Brain Pathology · doi:10.1111/bpa.12478 · Cited by 136
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Dardiotis, E., Fountas, K. N., Dardioti, M., Xiromerisiou, G., Kapsalaki, E. Z., Τάσιου, Α., & Hadjigeorgiou, G. M. (2009) · Neurosurgical FOCUS · doi:10.3171/2009.10.focus09215 · Cited by 131
“93 Deposition of A β was detected in approximately 30% of individuals dying shortly after severe TBI, 111 and this may imply a genetic predisposition to A β accumulation.”
Background
Neuronal death in Alzheimer’s disease and therapeutic opportunities
Donev, R., Kolev, M. V., Millet, B., & Thome, J. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00889.x · Cited by 126
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van Duijn, C. M., Clayton, D. G., Chandra, V., Fratiglioni, L., Graves, A. B., Heyman, A., Jorm, A. F., Kokmen, E., Kondo, K., Mortimer, J. A., et al. (1994) · Genetic Epidemiology · doi:10.1002/gepi.1370110609 · Cited by 129
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Moïse, P., Schwarzinger, M., & Um, M. Y. (2004) · OECD health working papers · doi:10.1787/485700737071 · Cited by 131
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Pope, S. K., Shue, V. M., & Beck, C. K. (2003) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.24.100901.141015 · Cited by 132
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Chauhan, N. B. (2014) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-130354 · Cited by 133
“In a meta-analysis of case-control study, a strong association was reported between TBI and AD (Mortimer et al., 1991).”
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Lahiri, D. K., & Maloney, B. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.001 · Cited by 124
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Mrak, R. E., & Griffin, W. S. T. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.6.471 · Cited by 118
A novel, ultrasensitive assay for tau: potential for assessing traumatic brain injury in tissues and biofluids.
Rubenstein, R., Chang, B., Davies, P., Wagner, A. K., Robertson, C. S., & Wang, K. K. W. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2014.3548 · Cited by 116
Health effects of aluminum: a critical review with emphasis on aluminum in drinking water
Nieboer, E., Gibson, B. L., Oxman, A. D., & Kramer, J. R. (1995) · Environmental Reviews · doi:10.1139/a95-002 · Cited by 114
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Testa, J. A., Malec, J. F., Moessner, A. M., & Brown, A. W. (2005) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2005.03.010 · Cited by 115
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Schmidt, R. H., & Grady, M. S. (1995) · Journal of neurosurgery · doi:10.3171/jns.1995.83.3.0496 · Cited by 108
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Miller, T. R. (1993) · Accident Analysis & Prevention · doi:10.1016/0001-4575(93)90011-k · Cited by 106
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Forno, G. D., Rasmusson, D. X., Brandt, J., Carson, K. A., Brookmeyer, R., Troncoso, J., & Kawas, C. H. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550040085017 · Cited by 108
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Weiner, M. W., Harvey, D. J., Hayes, J., Landau, S. M., Aisen, P. S. S., Petersen, R. C., Tosun, D., Veitch, D. P., Jack, C. R., DeCarli, C. S., et al. (2017) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.02.005 · Cited by 106
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Mhatre, M., Nguyen, A., Kashani, S., Pham, T., Adesina, A., & Grammas, P. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.07.007 · Cited by 105
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Background
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Dams-O’Connor, K., Guetta, G., Hahn-Ketter, A. E., & Fedor, A. F. (2016) · Neurodegenerative Disease Management · doi:10.2217/nmt-2016-0017 · Cited by 106
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Washington, P. M., Morffy, N., Parsadanian, M., Zapple, D. N., & Burns, M. P. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2013.3017 · Cited by 103
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Plummer, S. L., van den Heuvel, C., Thornton, E., Corrigan, F., & Cappai, R. (2016) · Aging and Disease · doi:10.14336/ad.2015.0907 · Cited by 103
Neuroprotection by nicotine against hypoxia-induced apoptosis in cortical cultures involves activation of multiple nicotinic acetylcholine receptor subtypes
Hejmadi, M. V., Dajas‐Bailador, F., Barns, S. M., Jones, B. J., & Wonnacott, S. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00244-6 · Cited by 104
A critical review of chronic traumatic encephalopathy
Iverson, G. L., Gardner, A. J., McCrory, P., Zafonte, R., & Castellani, R. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.008 · Cited by 103
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Yin, X., Wright, J., Wall, T., & Grammas, P. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090406 · Cited by 104
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Janssen, P. H. H., Mandrekar, J. N., Mielke, M. M., Ahlskog, J. E., Boeve, B. F., Josephs, K. A., & Savica, R. (2016) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.09.004 · Cited by 106
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Smith, D. H., Hicks, R. R., Johnson, V. E., Bergstrom, D. A., Cummings, D. M., Noble‐Haeusslein, L. J., Hovda, D. A., Whalen, M. J., Ahlers, S. T., LaPlaca, M. C., et al. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2014.3861 · Cited by 105
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Spires‐Jones, T. L., & Hannan, A. J. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.04677.x · Cited by 102
Epidemiology of the dementias: recent developments and new approaches.
van Duijn, C. M. (1996) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.60.5.478 · Cited by 102
Self-citation
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Raymont, V., Greathouse, A. D., Reding, K. M., Lipsky, R. H., Salazar, A. Μ., & Grafman, J. H. (2007) · Brain · doi:10.1093/brain/awm300 · Cited by 104
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Background
Education and dementia
Orrell, M., & Sahakian, B. (1995) · BMJ · doi:10.1136/bmj.310.6985.951 · Cited by 98
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Hayes, J. P., Logue, M. W., Sadeh, N., Spielberg, J. M., Verfaellie, M. H., Hayes, S. M., Reagan, A., Salat, D. H., Wolf, E. J., McGlinchey, R. E., et al. (2017) · Brain · doi:10.1093/brain/aww344 · Cited by 106
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BackgroundResultInfluential
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Dua, M., Makhija, D., Manasa, P., & Mishra, P. (2020) · Journal of Medical and Biological Engineering · doi:10.1007/s40846-020-00556-1 · Cited by 102
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MURAKAMI, N., YAMAKI, T., IWAMOTO, Y., SAKAKIBARA, T., KOBORI, N., FUSHIKI, S., & UEDA, S. (1998) · Journal of Neurotrauma · doi:10.1089/neu.1998.15.993 · Cited by 100
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Reitz, C. (2016) · Annals of Translational Medicine · doi:10.21037/atm.2016.03.05 · Cited by 100
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Nathoo, N. (2003) · Molecular Pathology · doi:10.1136/mp.56.3.132 · Cited by 96
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Bayly, P. V., Clayton, E. H., & Genin, G. M. (2012) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071811-150032 · Cited by 100
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Anderson, E. N., Gochenaur, L., Singh, A., Grant, R., Patel, K., Watkins, S., Wu, J. Y., & Pandey, U. B. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy047 · Cited by 96
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Craft, J. M., Watterson, D. M., Hirsch, E., & Van Eldik, L. J. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-15 · Cited by 96
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Nicoll, J. A. R., Roberts, G. W., & Graham, D. I. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb34431.x · Cited by 96
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Tweedie, D., Milman, A., Holloway, H., Li, Y.-Z., Harvey, B., Shen, H., Pistell, P., Lahiri, D., Hoffer, B., Wang, Y., et al. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21160 · Cited by 96
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BackgroundInfluential
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Background
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Collins-Praino, L. E., & Corrigan, F. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.09.027 · Cited by 95
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BackgroundResultInfluential
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Dixon, C. E., Bao, J., Long, D. A., & Hayes, R. L. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02069-1 · Cited by 93
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Finan, J. D., Sundaresh, S. N., Elkin, B. S., McKhann, G. M., & Morrison, B. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.03.037 · Cited by 92
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LoBue, C., Wadsworth, H., Wilmoth, K., Clem, M., Hart, J., Womack, K. B., Didehbani, N., Lacritz, L. H., Rossetti, H. C., & Cullum, C. M. (2017) · The Clinical Neuropsychologist · doi:10.1080/13854046.2016.1257069 · Cited by 90
“While these results differ from previous studies reporting no association between a history of TBI and earlier AD onset (Guo et al., 2000; Mortimer et al., 1991; Plassman et al., 2000; Rasmusson et al., 1995), the degree of this association (i.”
BackgroundResultInfluential
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Kenney, K., Iacono, D., Edlow, B. L., Katz, D. I., Diaz-Arrastia, R. R., Dams-O’Connor, K., Daneshvar, D. H., Stevens, A. A., Moreau, A. L., Tirrell, L. S., et al. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx101 · Cited by 91
Brain Trauma in Aged Transgenic Mice Induces Regression of Established Aβ Deposits
Nakagawa, Y., Reed, L., Nakamura, M., McIntosh, T. K., Smith, D. H., Saatman, K. E., Raghupathi, R., Clemens, J., Saido, T. C., Lee, V. M.-Y., et al. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7375 · Cited by 91
Untitled work
Nakagawa (1999) · doi:10.1002/(sici)1096-9861(19990830)411:3
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Ojo, J. O., Mouzon, B., & Crawford, F. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.06.003 · Cited by 89
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Strack, S., Zaucha, J. A., Ebner, F. F., Colbran, R. J., & Wadzinski, B. E. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980323)392:4 · Cited by 181
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Vincent, A. S., Roebuck‐Spencer, T., & Cernich, A. N. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.04.006 · Cited by 92
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Hefter, D., & Draguhn, A. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00022 · Cited by 97
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Background
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Schwab, J. M., Beschorner, R., Meyermann, R., Gözalan, F., & Schluesener, H. J. (2002) · Journal of neurosurgery · doi:10.3171/jns.2002.96.5.0892 · Cited by 85
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Horsburgh, K. J., Cole, G. M., Yang, F., Savage, M. J., Greenberg, B., Gentleman, S. M., Graham, D. I., & Nicoll, J. A. R. (2000) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2000.026002124.x · Cited by 88
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Gentleman, S. M., Graham, D. I., & Roberts, G. W. (1993) · Progress in brain research · doi:10.1016/s0079-6123(08)63270-7 · Cited by 87
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Roses, A. D. (1997) · Neurobiology of Disease · doi:10.1006/nbdi.1997.0161 · Cited by 86
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Lovell, M. A. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0992 · Cited by 87
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Johnson, V. E., Stewart, W., Trojanowski, J. Q., & Smith, D. H. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0909-9 · Cited by 87
Distinct temporal and anatomical distributions of amyloid-β and tau abnormalities following controlled cortical impact in transgenic mice
Tran, H. T., Sanchez, L., Esparza, T. J., & Brody, D. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025475 · Cited by 86
Overexpression of the Neuritotrophic Cytokine S100β Precedes the Appearance of Neuritic β‐Amyloid Plaques in APPV717F Mice
Sheng, J. G., Mrak, R. E., Bales, K. R., Cordell, B., Paul, S. M., Jones, R. A., Woodward, S., Zhou, X. Q., McGinness, J. M., & Griffin, W. S. T. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0740295.x · Cited by 82
“Head trauma is an established risk for the later development of Alzheimer’s disease (Mortimer et al., 1991; Mayeux et al., 1993), and S100b overexpression occurs acutely following severe closed head injury (Griffin et al., 1997) along with overexpression ofbAPP and interleukin-1 (Griffin et al.,…”
Background
Factors Influencing Clinical Correlates of Chronic Traumatic Encephalopathy (CTE): a Review
Asken, B. M., Sullan, M. J., Snyder, A., Houck, Z. M., Bryant, V. E., Hizel, L. P., McLaren, M. E., Dede, D. E., Jaffee, M. S., DeKosky, S. T., et al. (2016) · Neuropsychology Review · doi:10.1007/s11065-016-9327-z · Cited by 90
“8 times increased risk of developing clinically diagnosed AD, with significantly elevated risk apparently applying to males only (Mortimer et al. 1991; Fleminger et al. 2003).”
BackgroundInfluential
Long-term consequences of recurrent sports concussion
Decq, P., Gault, N., Blandeau, M., Kerdraon, T., Berkal, M., Helou, A. E., Dusfour, B., & Peyrin, J.-C. (2015) · Acta Neurochirurgica · doi:10.1007/s00701-015-2681-4 · Cited by 91
Risk of hospitalization with neurodegenerative disease after moderate-to-severe traumatic brain injury in the working-age population: A retrospective cohort study using the Finnish national health registries
Raj, R., Kaprio, J. A., Korja, M., Mikkonen, E. D., Jousilahti, P., & Siironen, J. O. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002316 · Cited by 82
Serum Metabolic Profiling Reveals Altered Metabolic Pathways in Patients with Post-traumatic Cognitive Impairments
Yi, L., Shi, S., Wang, Y., Huang, W., Xia, Z.-A., Xing, Z., Peng, W., & Wang, Z. (2016) · Scientific Reports · doi:10.1038/srep21320 · Cited by 80
sAPPα rescues deficits in amyloid precursor protein knockout mice following focal traumatic brain injury
Corrigan, F., Vink, R., Blumbergs, P. C., Masters, C. L., Cappai, R., & van den Heuvel, C. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07761.x · Cited by 88
Repetitive mild traumatic brain injury in mice triggers a slowly developing cascade of long-term and persistent behavioral deficits and pathological changes
Xu, X., Cowan, M. F., Beraldo, F. H., Schranz, A. L., McCunn, P., Geremia, N. M., Brown, Z., Patel, M. A., Nygard, K. L., Khazaee, R., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01161-2 · Cited by 70
Potential of the Antibody Against cis–Phosphorylated Tau in the Early Diagnosis, Treatment, and Prevention of Alzheimer Disease and Brain Injury
Lu, K. P., Kondo, A., Albayram, Ö., Herbert, M. K., Liu, H., & Zhou, X. Z. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.2027 · Cited by 74
Thrombin, a Mediator of Coagulation, Inflammation, and Neurotoxicity at the Neurovascular Interface: Implications for Alzheimer’s Disease
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“TBI, a condition in which neurons are exposed to high thrombin levels, is associated with an increased incidence of AD (Mortimer et al., 1991; Nemetz et al., 1999).”
Background
Anaesthesia in Elderly Patients with Neurodegenerative Disorders
Burton, D. A., Nicholson, G., & Hall, G. (2004) · Drugs & Aging · doi:10.2165/00002512-200421040-00002 · Cited by 71
Differential responses in three thalamic nuclei in moderately disabled, severely disabled and vegetative patients after blunt head injury.
Maxwell, W., Pennington, K., MacKinnon, M., Smith, D. H., McIntosh, T., Wilson, J. T. L., & Graham, D. (2004) · Brain : a journal of neurology · doi:10.1093/brain/awh294 · Cited by 83
“…clinical studies suggest that TBI may accelerate or exacerbate cognitive decline associated with normal ageing (Stuss et al., 1989) and induce Alzheimer’s disease-like neurodegeneration (Mortimer et al., 1991; Gentleman et al., 1993; Mayeux et al., 1993; Nicoll et al., 1995; Geddes et al., 1996).”
Background
New Perspectives on Amyloid-β Dynamics After Acute Brain Injury
Magnoni, S., & Brody, D. L. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.214 · Cited by 74
Traumatic brain injury in women across lifespan
Blaya, M. O., Raval, A. P., & Bramlett, H. M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105613 · Cited by 69
Traumatic Brain Injury and Risk of Alzheimer’s Disease and Related Dementias in the Population
Mielke, M. M., Ransom, J. E., Mandrekar, J. N., Turcano, P., Savica, R., & Brown, A. W. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220159 · Cited by 76
Improved measurement of brain deformation during mild head acceleration using a novel tagged MRI sequence
Knutsen, A. K., Magrath, E., McEntee, J., et al. (2014) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2014.09.010 · Cited by 70
“The effects of brain trauma may lead to neurodegenerative diseases— for example, TBI is an established risk factor for Alzheimer’s disease, especially in combination with the ε4 allele of apolipoprotein E (Mayeux et al., 1993; Mortimer et al., 1991).”
Background
Association of traumatic brain injury and Alzheimer disease onset: A systematic review
Julien, J., Joubert, S., Ferland, M. C., Frenette, L. C., Boudreau-Duhaime, M.-M., Malo-Véronneau, L., & de Guise, É. (2017) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2017.03.009 · Cited by 70
Rivastigmine, a Brain-Selective Acetylcholinesterase Inhibitor, Ameliorates Cognitive and Motor Deficits Induced by Closed-Head Injury in the Mouse
Chen, Y., Shohami, E., Constantini, S., & Weinstock, M. (1998) · Journal of Neurotrauma · doi:10.1089/neu.1998.15.231 · Cited by 70
“Moreover, head trauma is one ofthe possible causes of Alzheimer's disease (Mortimer et al., 1991; Gentleman et al., 1993), in which there are decreases in cortical and hippocampal cholinergic transmission (Vogels et al., 1990; Whitehouse et al., 1982).”
Significance of Blood and Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease: Sensitivity, Specificity and Potential for Clinical Use
d’Abramo, C., D'adamio, L., & Giliberto, L. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10030116 · Cited by 71
Environmental risk factors for Alzheimer's disease: their relationship to age of onset and to familial or sporadic types
Henderson, A. S., Jorm, A. F., Korten, A. E., Creasey, H. M., McCusker, E. A., Broe, G. A., Longley, W. A., & Anthony, J. C. (1992) · Psychological Medicine · doi:10.1017/s0033291700030373 · Cited by 67
Self-citation
Involvement of free oxygen radicals in β-amyloidosis: An hypothesis
Friedlich, A. L., & Butcher, L. L. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90076-0 · Cited by 67

Authors: Mortimer, J. A., Van Duijn, C. M., Chandra, V, Fratiglioni, L., Graves, A. B., Heyman, A., Jorm, A. F., Kokmen, E., Kondo, K., Rocca, W. A., Shalat, S. L., Soininen, H., & A Hofman for the Eurodem Risk Factors Research Group
Affiliations: Minneapolis VA Medical Center (US)
Erasmus University Rotterdam (NL)
Corresponding author: Mortimer, J A
ORCID: Fratiglioni, L
Jorm, A F
Rocca, W A
Shalat, S L
Venue: International Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 1991-01-01
Volume: 20
Issue: Supplement 2
Pages: S28-S35
ISSN: 0300-5771 (ISSN-L)
1464-3685
DOI: 10.1093/ije/20.supplement_2.s28
OpenAlex: W2142046013
Cited by: 594
References: 0
Citations by year: 2026: 4 · 2025: 9 · 2024: 10 · 2023: 16 · 2022: 28 · 2021: 23 · 2020: 21 · 2019: 35 · 2018: 16 · 2017: 28 · 2016: 37 · 2015: 31 · 2014: 22 · 2013: 11 · 2012: 21
FWCI: 12.29
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
Locations: International Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
RePub (Erasmus University Rotterdam) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: head trauma, Alzheimer's disease, risk factors, loss of consciousness, family history of dementia, sex differences, age of onset, pooled relative risk, case-control study
MeSH terms: Alzheimer Disease, Australia, Europe, Female, Craniocerebral Trauma, Humans, Male, Risk, Risk Factors, United States, Meta-Analysis as Topic, Case-Control Studies

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Head Trauma as a Risk Factor for Alzheimer's Disease: A Collaborative Re-Analysis of Case-Control Studies

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