Cited by 594Dementia and Cognitive Impairment ResearchTraumatic Brain Injury ResearchAlzheimer's disease research and treatments

The DOI matches its Crossref record.

Head Trauma as a Risk Factor for Alzheimer's Disease: A Collaborative Re-Analysis of Case-Control Studies

Open access

Mortimer, J A, Van Duijn, C M, Chandra, V, Fratiglioni, L, Graves, A B, Heyman, A, Jorm, A F, Kokmen, E, Kondo, K, Rocca, W A, Shalat, S L, Soininen, H, A Hofman for the Eurodem Risk Factors Research Group·1991·International Journal of Epidemiology

DOI 10.1093/ije/20.supplement_2.s28

Open this paper in CoChat — free account

Abstract

A re-analysis of the data from 11 case-control studies was performed to investigate the association between head trauma and Alzheimer's disease (AD). To increase comparability of studies, exposures were limited to head trauma with loss of consciousness (hereafter referred to as 'head trauma') and comparisons were restricted to community (versus hospital) controls. Test for heterogeneity across studies was negative; consequently, data were pooled in subsequent analyses. The pooled relative risk for head trauma was 1.82 (95% confidence interval: 1.26-2.67). Stratified analyses showed stronger associations in cases without a positive family history of dementia and in males (versus females). Adjustment of the pooled relative risk for family history of dementia, education and alcohol consumption did not alter significantly the association between head trauma and AD. There was no interaction effect between head trauma and family history of dementia, suggesting that these risk factors operate independently. Mean age of onset was not significantly different in cases with a history of head trauma compared to cases without such a history. The findings of the pooled analysis support an association between reported head trauma and AD.

Integrity signals

Registry

Crossref · 10.1093/ije/20.supplement_2.s28

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 201–300 of 592

Apolipoprotein E and the Response of the Brain to Injury
Graham, D. I., Horsburgh, K. J., Nicoll, J. A. R., & Teasdale, G. M. (1999) · Acta neurochirurgica. Supplementum · doi:10.1007/978-3-7091-6391-7_15 · Cited by 66
The need for research on dementia in developing countries
Prince, M. J. (1997) · Tropical Medicine & International Health · doi:10.1046/j.1365-3156.1997.d01-156.x · Cited by 64
Outcome following traumatic brain injury in the elderly: a critical review
Rapoport, A. F. M. J. (2000) · Brain Injury · doi:10.1080/026990500413777 · Cited by 65
“In a meta-analysis of 11 case-controlled studies [51], a pooled relative risk of 1.”
The Bidirectional Relationship Between Sleep and Inflammation Links Traumatic Brain Injury and Alzheimer’s Disease
Green, T. R. F., Ortiz, J. B., Wonnacott, S., Williams, R. J., & Rowe, R. K. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00894 · Cited by 68
“Meta-analyses have found that a history of TBI is associated with development of AD (Mortimer et al., 1991; Fleminger et al., 2003).”
Background
Fall‐related brain injuries and the risk of dementia in elderly people: a population‐based study
Luukinen, H., Viramo, P., Herala, M., Kervinen, K., Kesäniemi, Y. A., Savola, O., Winqvist, S., Jokelainen, J. J., & Hillbom, M. (2005) · European Journal of Neurology · doi:10.1111/j.1468-1331.2004.00953.x · Cited by 62
“, 1999), or increase the risk of dementia (Mortimer et al., 1991), or even trigger the onset of dementia (Roberts et al.”
Influential
ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury
Cao, J., Gaamouch, F. E., Meabon, J. S., Meeker, K. D., Zhu, L., Zhong, M. B., Bendik, J., Elder, G., Jing, P., Xia, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-11654-7 · Cited by 62
CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice
Cheng, W. H., Martens, K. M., Bashir, A., Cheung, H., Stukas, S. K., Gibbs, E., Namjoshi, D., Button, E. B., Wilkinson, A., Barrón, C., et al. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0461-0 · Cited by 63
Monitoring of β-Amyloid Dynamics after Human Traumatic Brain Injury
Marklund, N., Farrokhnia, N., Hånell, A., Vanmechelen, E., Enblad, P., Zetterberg, H., Blennow, K., & Hillered, L. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2013.2964 · Cited by 64
Dementia and occupational exposure to magnetic fields
Feychting, M., Pedersen, N., Svedberg, P., Floderus, B., & Gatz, M. (1998) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.277 · Cited by 62
Neurobehavioural consequences of closed head injury in older adults.
Goldstein, F. C., Levin, H. S., Presley, R., et al. (1994) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.8.961 · Cited by 62
Dementia after traumatic brain injury
STARKSTEIN, S. E., & Jorge, R. E. (2005) · International Psychogeriatrics · doi:10.1017/s1041610205001973 · Cited by 61
Traumatic brain injury: future assessment tools and treatment prospects
Flanagan, S. R. (2008) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s1985 · Cited by 63
“…the risk of posttraumatic seizures (Diaz-Arrastia et al 2003) and late onset Alzheimer’s disease after TBI (Mayeux et al 1993; Mortimer et al 1985; Mortimer et al 1991), although there have been confl icting results regarding the latter (Fleminger et al 2003; Nathoo et al 2003; Teasdale et al…”
Background
Prevalence of Traumatic Brain Injury in Early Versus Late-Onset Alzheimer’s Disease
Mendez, M. F., Paholpak, P., Lin, A., Zhang, J. Y., & Teng, E. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-143207 · Cited by 62
Review: The long‐term consequences of microglial activation following acute traumatic brain injury
Smith, C. (2012) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12006 · Cited by 61
Imaging β-amyloid using [18F]flutemetamol positron emission tomography: from dosimetry to clinical diagnosis
Heurling, K., Leuzy, A., Zimmer, E. R., Lubberink, M., & Nordberg, A. K. (2015) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-015-3208-1 · Cited by 59
Prevalence of the Major Mental Disorders among the Korean Elderly
Cho, M. J., Lee, J., Kim, B., Lee, H. W., & Sohn, J. H. (2010) · Journal of Korean Medical Science · doi:10.3346/jkms.2011.26.1.1 · Cited by 59
The Correlation between Inflammatory Biomarkers and Polygenic Risk Score in Alzheimer’s Disease
Morgan, A. R., Touchard, S., O’Hagan, C., Sims, R., Majounie, E., Escott‐Price, V., Jones, L., Williams, J. H., & Morgan, B. P. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160889 · Cited by 60
“History of serious head injury, which typically causes brain inflammation, is known to be a risk factor for AD (Mortimer et al., 1991; Fleminger et al., 2003; Barnes et al., 2014) and systemic infections, another cause of inflammation, also accelerate the disease (Licastro et al., 2104; Bu et al.,…”
Altered β-APP Metabolism After Head Injury and its Relationship to the Aetiology of Alzheimer’s Disease
Graham, D. I., Gentleman, S., Nicoll, J. A. R., Royston, M. C., McKenzie, J. E., Roberts, G. W., & Griffin, W. S. T. (1996) · Springer eBooks · doi:10.1007/978-3-7091-9465-2_17 · Cited by 59
Alzheimer's disease: pathology to potential treatments?
Royston, M. C., Rothwell, N. J., & Roberts, G. W. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90047-a · Cited by 59
Traumatic brain injury as a risk factor for Alzheimer's disease.
Jellinger, K. A. (2004) · PubMed · Cited by 59
Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study
Mielke, M. M., Savica, R., Wiste, H. J., Weigand, S. D., Vemuri, P., Knopman, D. S., Lowe, V. J., Roberts, R. O., Machulda, M. M., Geda, Y. E., et al. (2013) · Neurology · doi:10.1212/01.wnl.0000438229.56094.54 · Cited by 59
Alzheimer's disease: a review of the disease, its epidemiology and economic impact
Alloul, K., Sauriol, L., Kennedy, W. A., Laurier, C., Tessier, G., Novosel, S., & Contandriopoulos, A. (1998) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(98)00116-2 · Cited by 58
Piezo2—peripheral baroreceptor channel expressed in select neurons of the mouse brain: a putative mechanism for synchronizing neural networks by transducing intracranial pressure pulses
Wang, J., & Hamill, O. P. (2021) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2004085 · Cited by 57
Genetic Factors in Outcome After Traumatic Brain Injury
Diaz-Arrastia, R. R., & Baxter, V. K. (2006) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-200607000-00007 · Cited by 57
Converging and Differential Brain Phospholipid Dysregulation in the Pathogenesis of Repetitive Mild Traumatic Brain Injury and Alzheimer’s Disease
Ojo, J. O., Algamal, M., Leary, P., Abdullah, L. I., Mouzon, B., Evans, J. E., MULLAN, M. J., & Crawford, F. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00103 · Cited by 59
“…a history of repetitive mild TBI (r-mTBI) increases the risk for the development of neurodegenerative diseases such as Alzheimer’s Disease (AD) (Gedye et al., 1989; Mortimer et al., 1991; Schofield et al., 1997; Fleminger et al., 2003; Omalu et al., 2011; McKee et al., 2013; Smith et al., 2013).”
Background
Subjective and objective cognitive function among older adults with a history of traumatic brain injury: A population-based cohort study
Gardner, R. C., Langa, K. M., & Yaffe, K. S. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002246 · Cited by 60
The Bidirectional Link Between Sleep Disturbances and Traumatic Brain Injury Symptoms: A Role for Glymphatic Dysfunction?
Piantino, J. A., Iliff, J. J., & Lim, M. M. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.06.025 · Cited by 60
Traumatic brain injury induces biphasic upregulation of ApoE and ApoJ protein in rats
Iwata, A., Browne, K. D., Chen, X., Yuguchi, T., & Smith, D. H. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20607 · Cited by 53
“Several epidemiologic reports have shown that brain trauma increases a patient’s risk of developing AD (Mortimer et al., 1991; Rasmusson et al., 1995; Schofield et al., 1997; Nemetz et al., 1999).”
Background
Apolipoprotein E ϵ4 and fatal cerebral amyloid angiopathy associated with dementia pugilistica
Jordan, B. D., Kanik, A. B., Horwich, M. S., Sweeney, D., Relkin, N. R., Petito, C. K., & Gandy, S. (1995) · Annals of Neurology · doi:10.1002/ana.410380429 · Cited by 55
Systematic Review, Meta-Analysis, and Population Attributable Risk of Dementia Associated with Traumatic Brain Injury in Civilians and Veterans
Gardner, R. C., Bahorik, A. L., Kornblith, E. S., Allen, I. E., Plassman, B. L., & Yaffe, K. S. (2022) · Journal of Neurotrauma · doi:10.1089/neu.2022.0041 · Cited by 60
“54 5 Ultimately, our meta-analysis did identify a similarly elevated risk of dementia after TBI among U.S. veterans (HR 2.13), and while this point estimate was indeed higher than the point estimate for the other studies of civilians, it was not statistically signiﬁcantly higher.”
Influential
Reversal of amyloid β toxicity in Alzheimer's disease model Tg2576 by intraventricular antiamyloid β antibody
Chauhan, N. B., & Siegel, G. J. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10286 · Cited by 53
Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain Injury
Martínez‐Molina, N., Siponkoski, S., Kuusela, L., Laitinen, S., Holma, M., Ahlfors, M., Jordan-Kilkki, P., Ala-Kauhaluoma, K., Melkas, S., Pekkola, J., et al. (2021) · Neural Plasticity · doi:10.1155/2021/6682471 · Cited by 51
Traumatic Brain Injury, Microglia, and Beta Amyloid
Mannix, R., & Whalen, M. J. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/608732 · Cited by 53
Accumulation of amyloid in cognitive impairment after mild traumatic brain injury
Yang, S.-T., Hsiao, I.-T., Hsieh, C.-J., Chiang, Y.-H., Yen, T.-C., Chiu, W.-T., Lin, K.-J., & Hu, C.-J. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.12.032 · Cited by 53
“reanalysis of case–control studies showed that TBI increases the risk of developing AD [9].”
Background
The International Rugby Board (IRB) Pitch Side Concussion Assessment trial: a pilot test accuracy study
Fuller, G. W., Kemp, S. P. T., & Decq, P. (2014) · British Journal of Sports Medicine · doi:10.1136/bjsports-2014-093498 · Cited by 53
Genetic Influences in Traumatic Brain Injury
Laskowitz, D., & Grant, G. A. (2015) · CRC Press eBooks · doi:10.1201/b18959-14 · Cited by 54
A critical review of radiotracers in the positron emission tomography imaging of traumatic brain injury: FDG, tau, and amyloid imaging in mild traumatic brain injury and chronic traumatic encephalopathy
Ayubcha, C., Revheim, M.-E. R., Newberg, A. B., Moghbel, M. C., Rojulpote, C., Werner, T. J., & Alavi, A. A. (2020) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-020-04926-4 · Cited by 56
Recent Advances in the Genetics of Alzheimer's Disease and Vascular Dementia with an Emphasis on Gene‐Environment Interactions
Plassman, B. L., & Breitner, J. C. S. (1996) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1996.tb01377.x · Cited by 53
Head or brain injuries and Alzheimer's disease: a nested case-control register study
Tolppanen, A., Taipale, H., & Hartikainen, S. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.04.010 · Cited by 53
Localized cortical chronic traumatic encephalopathy pathology after single, severe axonal injury in human brain
Shively, S. B., Edgerton, S. L., Iacono, D., Purohit, D. P., Qu, B.-X., Haroutunian, V., Davis, K. L., Diaz-Arrastia, R., & Perl, D. P. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1649-7 · Cited by 52
Long-Term Cognitive Correlates of Traumatic Brain Injury across Adulthood and Interactions with APOE Genotype, Sex, and Age Cohorts
Eramudugolla, R., Bielak, A. A. M., Bunce, D. J., Easteal, S., Cherbuin, N., & Anstey, K. J. (2014) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617714000174 · Cited by 51
“Previous reports also indicate greater history of TBI among males with Alzheimer’s disease, but not in females (Fleminger et al., 2003; Mortimer et al., 1991).”
Result
Disordered APP metabolism and neurovasculature in trauma and aging: Combined risks for chronic neurodegenerative disorders
Ikonomović, M. D., Mi, Z., & Abrahamson, E. E. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.11.003 · Cited by 53
Dementias
Sacuiu, S. F. (2016) · Handbook of clinical neurology · doi:10.1016/b978-0-12-802973-2.00008-2 · Cited by 57
The Prevalence, Correlates and Impact of Dementia in Cuba
Rodríguez, J. J. L., Valhuerdi, A., Sanchez, I. I., Reyna, C., Guerra, M., Copeland, J. R. M., McKeigue, P., Ferri, C. P., & Prince, M. J. (2008) · Neuroepidemiology · doi:10.1159/000165362 · Cited by 49
The Delayed Neuropathological Consequences of Traumatic Brain Injury in a Community-Based Sample
Postupna, N. O., Rose, S. E., Gibbons, L. E., Coleman, N., Hellstern, L. L., Ritchie, K., Wilson, A. M., Cudaback, E., Li, X., Melief, E. J., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.624696 · Cited by 51
“Because there is a potential effect of previous neurotrauma on the development of AD (21, 66, 67) and other neurodegenerative diseases (26, 27, 68, 69), we chose not to match our subjects on markers of AD neuropathologic change or other neurodegenerative disease pathologies.”
Background
Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation
Dean, T., Mendiola, A. S., Yan, Z., Meza-Acevedo, R., Cabriga, B., Akassoglou, K., & Ryu, J. K. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03092-w · Cited by 53
“Indeed, it is widely accepted that TBI increases the risk for dementia [43, 44], although whether the pathogenic features of post-traumatic dementia precisely recapitulate those of idiopathic AD is a matter of debate [45].”
Background
Altered Neuroinflammation and behavior after traumatic brain injury in a mouse model of Alzheimer’s disease
Kokiko-Cochran, O., Ransohoff, L., Veenstra, M., Lee, S., Saber, M., Sikora, M., Teknipp, R., Xu, G., Bemiller, S., Wilson, G., et al. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2015.3970 · Cited by 49
Neurotropic viruses and Alzheimer disease
Lin, W.-R., Shang, D., & Itzhaki, R. (1996) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815215 · Cited by 28
Are tobacco and alcohol use related to Alzheimer's disease? A critical assessment of the evidence and its implications
Tyas, S. L. (1996) · Addiction Biology · doi:10.1080/1355621961000124856 · Cited by 49
Age and functioning after mild traumatic brain injury: the acute picture
Rapoport, M. J., & Feinstein, A. (2001) · Brain Injury · doi:10.1080/02699050110065303 · Cited by 53
Age at injury and genotype modify acute inflammatory and neurofilament-light responses to mild CHIMERA traumatic brain injury in wild-type and APP/PS1 mice
Cheng, W. H., Stukas, S. K., Martens, K. M., Namjoshi, D., Button, E. B., Wilkinson, A., Bashir, A., Robert, J., Cripton, P. A., & Wellington, C. L. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.12.007 · Cited by 46
“Moderatesevere TBI is reported to increase risk of dementia, including AD, by approximately 1.5–1.8 fold (Fleminger et al., 2003; Mortimer et al., 1991; Gardner et al., 2014), however, the relationship of mild TBI (mTBI) to dementia risk is less clear (reviewed in Gardner and Yaffe,…”
Influential
Short review: Air pollution, noise and lack of greenness as risk factors for Alzheimer's disease- epidemiologic and experimental evidence
Oudin, A. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104646 · Cited by 48
The association of traumatic brain injury with rate of progression of cognitive and functional impairment in a population-based cohort of Alzheimer’s disease: the cache county dementia progression study
Gilbert, M., Snyder, C., Corcoran, C., Norton, M. C., Lyketsos, C. G., & Tschanz, J. T. (2014) · International Psychogeriatrics · doi:10.1017/s1041610214000842 · Cited by 48
Genetics and Brain Injury: Apolipoprotein E
Samatovicz, R. A. (2000) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-200006000-00002 · Cited by 45
DNA repair deficiency and senescence in concussed professional athletes involved in contact sports
Schwab, N., Grenier, K., & Hazrati, L.-N. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0822-3 · Cited by 47
Positron emission tomography of tau in Iraq and Afghanistan Veterans with blast neurotrauma
Robinson, M. E., McKee, A. C., Salat, D. H., Rasmusson, A. M., Radigan, L. J., Catana, C., Milberg, W., & McGlinchey, R. E. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101651 · Cited by 47
“…defined by the symptoms present at the time of the event) may increase the risk for individuals to present with Alzheimer's dementia in late life, (Mortimer et al., 1991; Sivanandam and Thakur, 2012) and that repetitive milder injuries (concussive or even subconcussive) may produce a different…”
Neurodevelopmental sequelae of pediatric acute lymphoblastic leukemia and its treatment
Janzen, L. A., & Spiegler, B. J. (2008) · Developmental Disabilities Research Reviews · doi:10.1002/ddrr.24 · Cited by 47
Inflammaging, cellular senescence, and cognitive aging after traumatic brain injury
Lu, Y., Jarrahi, A., Moore, N. D., Bartoli, M., Brann, D. W., Baban, B., & Dhandapani, K. M. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106090 · Cited by 52
Traumatic Brain Injury as a Risk Factor for Dementia and Alzheimer Disease: Critical Review of Study Methodologies
Hicks, A. J., James, A. C., Spitz, G., & Ponsford, J. L. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6346 · Cited by 45
THE CLINICAL EPIDEMIOLOGY OF ALZHEIMER'S DISEASE
Keefover, R. W. (1996) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70260-7 · Cited by 47
Trehalose improves traumatic brain injury-induced cognitive impairment
Portbury, S. D., Hare, D. J., Finkelstein, D. I., & Adlard, P. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183683 · Cited by 46
Targeting Thrombin: An Inflammatory Neurotoxin in Alzheimer's Disease
Grammas, P., & Martinez, J. M. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141557 · Cited by 42
“In addition, traumatic brain injury where neurons are exposed to high thrombin levels is associated with an increased incidence of AD [67–69].”
Genetic Epidemiology of Alzheimer Disease
Slooter, A. J. C., & van Duijn, C. M. (1997) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a017933 · Cited by 44
“Besides age, previous head injury, depression, low educational level, atherosclerosis, and exposure to aluminum were found to be risk factors (7-9).”
BackgroundSelf-citation
Mild Traumatic Brain Injuries and Future Risk of Developing Alzheimer’s Disease: Systematic Review and Meta-Analysis
Graham, A., Livingston, G., Purnell, L., & Huntley, J. D. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220069 · Cited by 47
“There are contradictory ﬁndings about TBI and the risk of Alzheimer’s disease (AD) speciﬁcally, with one meta-analysis and a further, more recent study,reportingthatindividualswithanyseverityTBI hadanincreasedriskofAD[19,20].”
Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males
Abou‐El‐Hassan, H., Rezende, R. M., Izzy, S., Gabriely, G., Yahya, T., Tatematsu, B. K., Habashy, K. J., Lopes, J. R., de Oliveira, G. L. V., Maghzi, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39857-9 · Cited by 45
The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer’s disease
Collins, J. M., King, A. E., Woodhouse, A., Kirkcaldie, M. T. K., & Vickers, J. C. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.02.034 · Cited by 43
“(2015), http://dx.doi.org/1 Discussion Traumatic brain injury has been proposed to be a risk factor for the development of AD (Mortimer et al., 1991; Nemetz et al., 1999; Guo et al., 2000; Plassman et al., 2000; Fleminger et al., 2003), but the mechanisms underlying this relationship remain to be…”
Sex, race, and risk of dementia diagnosis after traumatic brain injury among older veterans
Kornblith, E. S., Peltz, C. B., Xia, F., Plassman, B. L., Novakovic-Agopain, T., & Yaffe, K. S. (2020) · Neurology · doi:10.1212/wnl.0000000000010617 · Cited by 44
Prevention of Mental Disorder in the Elderly: Current Perspectives and Future Prospects
Rabins, P. V. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb01968.x · Cited by 42
Pharmacological blockers of CCR5 and CXCR4 improve recovery after traumatic brain injury.
Friedman-Levi, Y., Liraz-zaltsman, S., Shemesh, C., Rosenblatt, K., Kesner, E. L., Gincberg, G., Carmichael, S., Silva, A. J., & Shohami, E. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113604 · Cited by 35
Differential Changes in Phosphorylation of Tau at PHF-1 and 12E8 Epitopes During Brain Ischemia and Reperfusion in Gerbils
Gordon‐Krajcer, W., Koźniewska, E., Łazarewicz, J. W., & Ksiȩżak-Reding, H. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9199-3 · Cited by 41
Basal and scopolamine-evoked release of hippocampal acetylcholine following traumatic brain injury in rats
Dixon, C. E., Bao, J., Johnson, K. M., Yang, K., Whitson, J. S., Clifton, G. L., & Hayes, R. L. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11979-7 · Cited by 42
Sleep Disturbances in Traumatic Brain Injury: Associations With Sensory Sensitivity
Elliott, J. E., Opel, R. A., Weymann, K. B., Chau, A. Q., Papesh, M. A., Callahan, M. L., Storzbach, D. M., & Lim, M. M. (2018) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7220 · Cited by 43
Possible factors in the etiology of Alzheimer's disease
Itzhaki, R. F. (1994) · Molecular Neurobiology · doi:10.1007/bf02816099 · Cited by 41
Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesisPreprint
Bolte, A. C., Hurt, M. E., Smirnov, I., Kovacs, M. A., McKee, C. A., Natale, N. R., Ennerfelt, H. E., Frost, E. L., Lammert, C. R., Kipnis, J., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/817023 · Cited by 41
Traumatic brain injury and late-life dementia
Plassman, B. L., & Grafman, J. H. (2015) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63521-1.00044-3 · Cited by 44
Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms
Tweedie, D., Fukui, K., Li, Y., Yu, Q.-S., Barak, S., Tamargo, I. A., Rubovitch, V., Holloway, H. W., Lehrmann, E., Wood, W. H., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156493 · Cited by 41
Polymorphism in genes involved in adrenergic signaling associated with Alzheimer’s
Bullido, M. J., Ramos, M. C., Ruiz‐Gómez, A., Tutor, A. S., Sastre, I., Frank, A., Coria, F., Gil, P., Mayor, F., & Valdivieso, F. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.10.006 · Cited by 41
Adverse psychological impact, glutamatergic dysfunction, and risk factors for Alzheimer's disease
Myhrer, T. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(98)00039-6 · Cited by 40
Alzheimer's disease risk factors as related to cerebral blood flow
Crawford, J. G. (1996) · Medical Hypotheses · doi:10.1016/s0306-9877(96)90189-9 · Cited by 40
Early onset senescence and cognitive impairment in a murine model of repeated mTBI
Schwab, N., Ju, Y., & Hazrati, L.-N. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01190-x · Cited by 39
“In particular, repeated mTBI (rmTBI) has been identified as a major risk factor for neurodegenerative diseases including Alzheimer’s disease (AD) [100], Parkinson’s disease (PD) [68] amyotrophic lateral sclerosis (ALS) [21, 2], fronto-temporal dementia (FTD) [126, 124], and chronic traumatic encephalopathy (CTE) [95].”
Background
Sensory Sensitivity in TBI: Implications for Chronic Disability
Callahan, M. L., & Lim, M. M. (2018) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-018-0867-x · Cited by 43
Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor κB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E
Petegnief, V., Saura, J., DeGregorio‐Rocasolano, N., & Paul, S. M. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00046-x · Cited by 39
The Neuropsychology of Alzheimer’s Disease
Salmon, D. P., & Bondi, M. W. (1997) · Critical issues in neuropsychology · doi:10.1007/978-1-4899-1857-4_10 · Cited by 39
Chronic Traumatic Encephalopathy as a Preventable Environmental Disease
Buckland, M. E., Affleck, A. J., Pearce, A. J., & Suter, C. M. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.880905 · Cited by 37
Thrombin, a Key Driver of Pathological Inflammation in the Brain
Iannucci, J., & Grammas, P. (2023) · Cells · doi:10.3390/cells12091222 · Cited by 40
Neurochemical Profile of Dementia Pugilistica
Kokjohn, T. A., Maarouf, C. L., Daugs, I. D., Hunter, J. M., Whiteside, C. M., Malek-Ahmadi, M., Rodriguez, E., Kalback, W., Jacobson, S. A., Sabbagh, M. N., et al. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2012.2699 · Cited by 39
Traumatic brain injury accelerates amyloid-β deposition and impairs spatial learning in the triple-transgenic mouse model of Alzheimer’s disease
Shishido, H., Kishimoto, Y., Kawai, N., Toyota, Y., Ueno, M., Kubota, T., Kirino, Y., & Tamiya, T. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.06.066 · Cited by 38
Factors Associated with Alzheimer's Disease: An Overview of Reviews
Rochoy, M., Rivas, V., Chazard, E., Decarpentry, E., Saudemont, G., Hazard, P.-A., Puisieux, F. L., Gautier, S., & Bordet, R. (2019) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2019.7 · Cited by 38
Persistent Neurovascular Unit Dysfunction: Pathophysiological Substrate and Trigger for Late-Onset Neurodegeneration After Traumatic Brain Injury
Zhou, Y., Chen, Q., Wang, Y., Wu, H., Xu, W., Pan, Y., Gao, S., Dong, X., Zhang, J. H., & Shao, A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00581 · Cited by 36
“…evidence has suggested that TBI is a significant risk factor for a variety of neurodegenerative diseases such as Alzheimer’s disease (AD) (Mortimer et al., 1991; Fleminger et al., 2003; Hayes et al., 2017; LoBue et al., 2019), Parkinson’s disease (PD) (Goldman et al., 2006; Jafari et…”
Background
Analysis of long-term gene expression in neurons of the hippocampal subfields following traumatic brain injury in rats.
Shimamura, M., Garcia, J. M., Prough, D., Dewitt, D., Uchida, T., Shah, S. A., Avila, M. A., & Hellmich, H. L. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.041 · Cited by 33
Disruption in Brain Phospholipid Content in a Humanized Tau Transgenic Model Following Repetitive Mild Traumatic Brain Injury
Ojo, J. O., Algamal, M., Leary, P., Abdullah, L. I., Mouzon, B., Evans, J. E., MULLAN, M. J., & Crawford, F. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00893 · Cited by 34
“…such as Alzheimer’s disease, and chronic traumatic encephalopathy (CTE) typified by immunoreactive tau aggregates in the depths of the sulci (Gedye et al., 1989; Mortimer et al., 1991; Schofield et al., 1997; Fleminger et al., 2003; McKee et al., 2013; Omalu et al., 2011; Smith et al., 2013).”
Background
Long-term outcome of serious traumatic brain injury
Wood, R. L. (2008) · European Journal of Anaesthesiology · doi:10.1017/s0265021507003432 · Cited by 35
“Seven studies had already been the subject of an earlier meta-analysis conducted by Mortimer and colleagues [22].”
The essential role of inflammation and induced gene expression in the pathogenic pathway of Alzheimer s disease
Potter, H. (1998) · Frontiers in bioscience · doi:10.2741/a290 · Cited by 35
The social construction of the human brain
Eisenberg, L. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.11.1563b · Cited by 35
Institution Type-Dependent High Prevalence of Dementia in Long-Term Care Units
Chen, T., Chiu, M., Tang, L., Chiu, Y., Chang, S.-F., Su, C.-L., Chen, S.-J., Lin, C.-W., Shih, W.-Y., Chen, T. H.-H., et al. (2007) · Neuroepidemiology · doi:10.1159/000102142 · Cited by 34
Surgery Performed Under Propofol Anesthesia Induces Cognitive Impairment and Amyloid Pathology in ApoE4 Knock-In Mouse Model
Kim, J. H., Jung, H., Lee, Y., & Sohn, J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.658860 · Cited by 33
Altered Expression of Amyloid Precursor Proteins After Traumatic Brain Injury in Rats: In Situ Hybridization and Immunohistochemical Study
MASUMURA, M., HATA, R., URAMOTO, H., MURAYAMA, N., OHNO, T., & SAWADA, T. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.123 · Cited by 34
“…factors for the subsequent jor transcripts of the APP gene in mammals are dis-development of Alzheimer's disease (AD)-type neu-cemible as alternatively spliced forms, and translated into ropathology (Mortimer et al., 1991; Schofield et al., APP variants: APP695, APP751, and APP770 (Apelt et 1997).”
Chemokine Receptors CC Chemokine Receptor 5 and C-X-C Motif Chemokine Receptor 4 Are New Therapeutic Targets for Brain Recovery after Traumatic Brain Injury
Zaltsman, S. L., Friedman‐Levi, Y., Shabashov-Stone, D., Gincberg, G., Atrakcy-Baranes, D., Joy, M. T., Carmichael, S. T., Silva, A. J., & Shohami, E. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2020.7015 · Cited by 34
Cellular Senescence in Traumatic Brain Injury: Evidence and Perspectives
Schwab, N., Leung, E., & Hazrati, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.742632 · Cited by 37
Influence of denture treatment on brain function activity
Hosoi, T., Morokuma, M., Shibuya, N., & Yoneyama, Y. (2010) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2010.09.001 · Cited by 33
“Similar results have been reported by many researchers [3—10].”
Result

Authors: Mortimer, J. A., Van Duijn, C. M., Chandra, V, Fratiglioni, L., Graves, A. B., Heyman, A., Jorm, A. F., Kokmen, E., Kondo, K., Rocca, W. A., Shalat, S. L., Soininen, H., & A Hofman for the Eurodem Risk Factors Research Group
Affiliations: Minneapolis VA Medical Center (US)
Erasmus University Rotterdam (NL)
Corresponding author: Mortimer, J A
ORCID: Fratiglioni, L
Jorm, A F
Rocca, W A
Shalat, S L
Venue: International Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 1991-01-01
Volume: 20
Issue: Supplement 2
Pages: S28-S35
ISSN: 0300-5771 (ISSN-L)
1464-3685
DOI: 10.1093/ije/20.supplement_2.s28
OpenAlex: W2142046013
Cited by: 594
References: 0
Citations by year: 2026: 4 · 2025: 9 · 2024: 10 · 2023: 16 · 2022: 28 · 2021: 23 · 2020: 21 · 2019: 35 · 2018: 16 · 2017: 28 · 2016: 37 · 2015: 31 · 2014: 22 · 2013: 11 · 2012: 21
FWCI: 12.29
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
Locations: International Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
RePub (Erasmus University Rotterdam) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: head trauma, Alzheimer's disease, risk factors, loss of consciousness, family history of dementia, sex differences, age of onset, pooled relative risk, case-control study
MeSH terms: Alzheimer Disease, Australia, Europe, Female, Craniocerebral Trauma, Humans, Male, Risk, Risk Factors, United States, Meta-Analysis as Topic, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Head Trauma as a Risk Factor for Alzheimer's Disease: A Collaborative Re-Analysis of Case-Control Studies

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks