The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Retracted: Regional Differences in Brain-Derived Neurotrophic Factor Levels and Dendritic Spine Density Confer Resilience to Inescapable Stress
Open accessAbstract
BACKGROUND: In the learned helplessness (LH) paradigm, approximately 35% of rats are resilient to inescapable stress. METHODS: The roles of brain-derived neurotrophic factor (BDNF) and dendritic spine density in the brain regions of LH (susceptible) and non-LH rats (resilient) were examined. Western blot analysis and Golgi staining were performed. RESULTS: BDNF levels in the medial prefrontal cortex, CA3, and dentate gyrus (DG) were significantly lower in the LH group than in the control and non-LH groups, whereas BDNF levels in the nucleus accumbens (NAc) in the LH group but not the non-LH group were significantly higher than those in the control group. Furthermore, spine density in the prelimbic cortex, CA3, and DG was significantly lower in the LH group than in the control and non-LH groups, although spine density in the NAc was significantly higher in the LH group than in the control and non-LH groups. CONCLUSIONS: The results suggest that regional differences in BDNF levels and spine density in rat brain may contribute to resilience to inescapable stress.
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“MSN spine density is also increased in rats susceptible to learned helplessness [155].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [155]
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The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959
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Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429 · cited 3×
“Changes in dendritic length and spine density in the PFC and hippocampus contribute to the neurobiology of stress-related depression (McEwen, 2007; Magariños et al., 2011; Duman and Li, 2012).”
BackgroundThe Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,588
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375
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The mesolimbic dopamine reward circuit in depression
Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654
Self-citationPsychobiology and molecular genetics of resilience
Feder, A., Nestler, E. J., & Charney, D. S. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2649 · Cited by 1,272
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Longitudinal Genome-Wide Study Reveals Genetic Architecture of Resilience Using a Novel PhenotypePreprint
Cahill, S., Mekli, K., & Hager, R. (2025) · Research Square · doi:10.21203/rs.3.rs-4861048/v1
Studying the genetics of behavior in the genomics era
Tiwari, T., Brenman‐Suttner, D. B., Kent, C. F., Rose, S. A., Patel, H., Conflitti, I. M., & Zayed, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29068-8.00133-1
Saputrana, A. S., Andriana, M., Pawana, I. P. A., Thaha, M., & Melaniani, S. (2025) · doi:10.56984/8zg7d19spw0
Metadata
- Authors
- Yang, C., Shirayama, Y., Zhang, J.-C., Ren, Q., & Hashimoto, K.
- Affiliations
- Chiba University (JP)
- Corresponding author
- Hashimoto, Kenji
- Venue
- International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-03-04
- Volume
- 18
- Issue
- 7
- Pages
- pyu121-pyu121
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- PMC
- PMC4540100
- OpenAlex
- W2163193735
- Cited by
- 103
- References
- 28
- Citations by year
- 2025: 6 · 2024: 3 · 2023: 2 · 2022: 8 · 2021: 9 · 2020: 12 · 2019: 11 · 2018: 12 · 2017: 14 · 2016: 18 · 2015: 7
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- gold
- doi.org
- Licence
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Eli Lilly and Company
- Pfizer
- Uehara Memorial Foundation
- Eisai
- Astellas Pharma
- Japan Society for the Promotion of Science (24116006)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Keywords
- brain-derived neurotrophic factor, dendritic spine density, learned helplessness, stress resilience, inescapable stress, medial prefrontal cortex, CA3, dentate gyrus, nucleus accumbens, prelimbic cortex
- MeSH terms
- Animals, Behavior, Animal, Brain, Helplessness, Learned, Male, Nucleus Accumbens, Stress, Psychological, Blotting, Western, Silver Staining, Rats, Sprague-Dawley, Prefrontal Cortex, Dentate Gyrus, Brain-Derived Neurotrophic Factor, Dendritic Spines, Rats, CA3 Region, Hippocampal
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