The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Retracted: Regional Differences in Brain-Derived Neurotrophic Factor Levels and Dendritic Spine Density Confer Resilience to Inescapable Stress
Open accessAbstract
BACKGROUND: In the learned helplessness (LH) paradigm, approximately 35% of rats are resilient to inescapable stress. METHODS: The roles of brain-derived neurotrophic factor (BDNF) and dendritic spine density in the brain regions of LH (susceptible) and non-LH rats (resilient) were examined. Western blot analysis and Golgi staining were performed. RESULTS: BDNF levels in the medial prefrontal cortex, CA3, and dentate gyrus (DG) were significantly lower in the LH group than in the control and non-LH groups, whereas BDNF levels in the nucleus accumbens (NAc) in the LH group but not the non-LH group were significantly higher than those in the control group. Furthermore, spine density in the prelimbic cortex, CA3, and DG was significantly lower in the LH group than in the control and non-LH groups, although spine density in the NAc was significantly higher in the LH group than in the control and non-LH groups. CONCLUSIONS: The results suggest that regional differences in BDNF levels and spine density in rat brain may contribute to resilience to inescapable stress.
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“MSN spine density is also increased in rats susceptible to learned helplessness [155].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [155]
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Metadata
- Authors
- Yang, C., Shirayama, Y., Zhang, J.-C., Ren, Q., & Hashimoto, K.
- Affiliations
- Chiba University (JP)
- Corresponding author
- Hashimoto, Kenji
- Venue
- International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-03-04
- Volume
- 18
- Issue
- 7
- Pages
- pyu121-pyu121
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- PMC
- PMC4540100
- OpenAlex
- W2163193735
- Cited by
- 103
- References
- 28
- Citations by year
- 2025: 6 · 2024: 3 · 2023: 2 · 2022: 8 · 2021: 9 · 2020: 12 · 2019: 11 · 2018: 12 · 2017: 14 · 2016: 18 · 2015: 7
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- gold
- doi.org
- Licence
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Eli Lilly and Company
- Pfizer
- Uehara Memorial Foundation
- Eisai
- Astellas Pharma
- Japan Society for the Promotion of Science (24116006)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Keywords
- brain-derived neurotrophic factor, dendritic spine density, learned helplessness, stress resilience, inescapable stress, medial prefrontal cortex, CA3, dentate gyrus, nucleus accumbens, prelimbic cortex
- MeSH terms
- Animals, Behavior, Animal, Brain, Helplessness, Learned, Male, Nucleus Accumbens, Stress, Psychological, Blotting, Western, Silver Staining, Rats, Sprague-Dawley, Prefrontal Cortex, Dentate Gyrus, Brain-Derived Neurotrophic Factor, Dendritic Spines, Rats, CA3 Region, Hippocampal
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