Ischemic lesions localized to the medial prefrontal cortex produce selective deficits in measures of executive function in rats
Abstract
Ischemic stroke is one of the leading causes of neurological disability worldwide, and it has been estimated that about one quarter of stroke survivors experience some measurable long-term cognitive impairments. Many higher order cognitive deficits occur because of damage to the prefrontal cortex (PFC), which is one of the main areas of the brain responsible for executive functioning in mammals. Currently, there are few animal models that examine the effects of stroke on executive function. In this study we used bilateral micro-injections (1μl) of the vasoconstricting peptide endothelin-1 (ET-1) into the medial PFC in male Sprague-Dawley rats (or vehicle control, N=17-18 per group) in order to model ischemic lesions in the medial PFC. The effects of these lesions on executive function were assessed using tests of set-shifting and temporal object recognition. ET-1 injections in the medial PFC resulted in replicable and specific lesions within the PFC with an average infarct volume of 16.63±2.71mm(3). The ischemic lesions resulted in specific contextual set-shifting deficits within the maze, including an increased number of trials to criterion and a significant difference in learning curves. However, no deficits in temporal order memory processing were noted between sham and stroke animals. We conclude that ischemic lesions localized to the mPFC result in selective but not generalized deficits in executive function in rats.
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TOM deficits are not found in an animal model of ischemic lesion in the mPFC.
“However, TOM deficits were not found in an animal model of ischemic lesion in the mPFC (Deziel et al., 2015).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Deziel et al., 2015
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The role of the medial prefrontal cortex in cognition, ageing and dementia
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- Authors
- Déziel, R. A., Ryan, C. L., & Tasker, R. A.
- Affiliations
- University of Prince Edward Island (CA)
- Corresponding author
- Tasker, R. Andrew
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 293
- Pages
- 54-61
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W780794378
- Cited by
- 30
- References
- 46
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 1 · 2019: 6 · 2018: 5 · 2017: 1 · 2016: 3
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Atlantic Innovation Fund (193639)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- ischemic stroke, medial prefrontal cortex, executive function, endothelin-1, vasoconstriction, set-shifting, temporal order memory, cognitive impairment, animal models of stroke, infarct size
- MeSH terms
- Analysis of Variance, Animals, Attention, Brain Ischemia, Cognition Disorders, Male, Neuropsychological Tests, Set, Psychology, Time Factors, Rats, Sprague-Dawley, Prefrontal Cortex, Maze Learning, Endothelin-1, Brain Infarction, Recognition, Psychology, Rats, Executive Function
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