Cited by 79Estrogen and related hormone effectsDiabetes, Cardiovascular Risks, and LipoproteinsOvarian function and disorders

Sex Hormones, Insulin Sensitivity, and Diabetes Mellitus

Bruns, C. M., Kemnitz, J. W.·2004·ILAR Journal

Abstract

Sex differences and the role of gonadal hormones in modulating insulin sensitivity and glucose tolerance are of increasing interest and importance because of the increasing prevalence of type 2 diabetes mellitus and the metabolic abnormalities associated with aging. Body composition is closely associated with insulin sensitivity, and increased body fat, particularly in the visceral compartment, is a risk factor for developing type 2 diabetes mellitus. Sex differences in body composition and/or insulin sensitivity are evident in humans throughout the lifespan. Ovarian hormones influence insulin sensitivity across the menstrual cycle, during pregnancy, and in the menopausal transition. Similarly, estrogens and progestins used for contraception and hormone replacement therapy affect glucoregulation. Nonhuman primates and humans have similar life histories and reproductive characteristics. As a result, nonhuman primates provide a valuable model for investigating factors related to insulin sensitivity. Studies of nonhuman primates have contributed significantly to our understanding of sex differences and the influence of sex steroids in this context. This brief review surveys present knowledge of the sex differences in body composition, insulin sensitivity, and risk for development of type 2 diabetes mellitus derived from studies in humans and nonhuman primates. The influences of endogenous and exogenous gonadal steroids are emphasized.

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Crossref · 10.1093/ilar.45.2.160

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129 of 129 references verified0 citation errors · 0 not checkable

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Authors
Bruns, C. M., & Kemnitz, J. W.
Affiliations
University of Wisconsin–Madison (US)
Venue
ILAR Journal
Published
2004-01-01
Volume
45
Issue
2
Pages
160-169
ISSN
1084-2020 (ISSN-L)
OpenAlex
W1969111819
Cited by
79
References
128
Citations by year
2026: 3 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 8 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 5 · 2012: 7
FWCI
0.38
Type
journal article
Language
en
Open access
closed
Locations
  • ILAR Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords
sex differences, insulin sensitivity, type 2 diabetes, sex hormones, gonadal hormones, body composition, visceral fat, glucose tolerance, ovarian hormones, menstrual cycle, pregnancy, menopause, hormone replacement therapy, estrogen, progestins, non-human primates, glucoregulation, aging
MeSH terms
Age Factors, Animals, Body Composition, Diabetes Mellitus, Type 2, Disease Models, Animal, Female, Glucose, Humans, Insulin, Primates, Risk Factors, Sex Factors, Gonadal Steroid Hormones, Hormone Replacement Therapy

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