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Cited by 66Hormonal and reproductive studiesDiabetes, Cardiovascular Risks, and LipoproteinsAdrenal Hormones and Disorders

Effect of Testosterone Replacement on Whole Body Glucose Utilisation and Other Cardiovascular Risk Factors in Males with Idiopathic Hypogonadotrophic Hypogonadism

Tripathy, D., Shah, P., Lakshmy, R., Reddy, K.·1998·Hormone and Metabolic Research
DOI 10.1055/s-2007-978950
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Abstract

BACKGROUND: Excessive testosterone in males or estrogens in females could explain their differences in coronary heart disease event rates. As a contraceptive testosterone is likely to be used at large scale the role of testosterone in increasing the risks of coronary heart disease needs investigation. AIM: To look at the role of testosterone in development of insulin resistance and other cardiovascular risk factors. DESIGN: Prospective, before-after study on ten male subjects with idiopathic hypogonadotrophic hypogonadism pre- and post-testosterone replacement therapy; outcome measures: anthropometry, lipoprotein profile and M value (whole body glucose disposal rates on standard hyperinsulinemic euglycemic clamp; at insulin infusion rate: 40 mU x (m-2)). RESULTS: Pre-treatment serum testosterone was 0.43 (0.515) ng x mL(-1), LH was 1.29 (0.08) IU x L(-1), and FSH was 1.54 (0.08) IU x L(-1). None had glucose intolerance. After replacement testosterone levels increased to 9.4 ng x mL(-1) (p=0.0005); weight increase of 5.0 kg (p=0.140), body mass index increase of 1.2 kg x m(-2) (p=0.28), and the change in waist to hip ratio (p=0.31) were not statistically significant. M-value (mg x kg x min(-1)) did not change after testosterone therapy (5.86 [0.72] vs 5.29 [0.82], p=0.62). Insulin levels (mU x L(-1)) achieved during the clamps were 89.5 (14.2) before and 146 (32.2) after androgen therapy (p=0.127). There was no change in glucose area under curve (mg x min x dL(-1)) (14406 [502.2] vs 12557 [826.5], p=0.312). On testosterone replacement therapy total and LDL cholesterol levels (mg x dL(-1)) declined (122.5 [13.4] vs 91.6 [5.0], p=0.04; 65.9 [9.9] vs 39.4 [7.3], p=0.05); Ratio of total cholesterol to HDL ratio also decreased significantly (p=0.05). Changes of serum triglycerides (p=0.25) and HDL cholesterol (p=0.19) did not attain statistical significance. CONCLUSIONS: Insulin sensitivity does not decrease on testosterone replacement therapy of male subjects with idiopathic hypogonadotrophic hypogonadism. Testosterone replacement was associated with decrease in other cardiovascular risk factors.

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Authors
Tripathy, D., Shah, P., Lakshmy, R., & Reddy, K.
Affiliations
  • All India Institute of Medical Sciences (IN)
  • Mayo Clinic (US)
ORCID
Venue
Hormone and Metabolic Research
Publisher
Georg Thieme Verlag KG
Published
1998-10
Volume
30
Issue
10
Pages
642-645
ISSN
  • 0018-5043 (ISSN-L)
  • 1439-4286
DOI
10.1055/s-2007-978950
OpenAlex
W1975627181
Cited by
66
References
0
Citations by year
2021: 2 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2013: 2 · 2012: 3
FWCI
0.99
Type
journal article
Language
en
Open access
closed
Locations
  • Hormone and Metabolic Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
testosterone replacement therapy, idiopathic hypogonadotropic hypogonadism, insulin resistance, cardiovascular risk factors, hyperinsulinemic-euglycemic clamp, lipoprotein profile, LDL cholesterol, triglycerides, coronary artery disease, male hypogonadism, body mass index, waist-to-hip ratio, hypertriglyceridemia
MeSH terms
Adult, Blood Glucose, Body Constitution, Cardiovascular Diseases, Follicle Stimulating Hormone, Glucose Tolerance Test, Humans, Hypogonadism, Insulin Resistance, Luteinizing Hormone, Cholesterol, HDL, Cholesterol, LDL, Male, Prospective Studies, Risk Factors, Testosterone, Triglycerides, Glucose Clamp Technique, Body Mass Index

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