Cited by 8Prenatal Substance Exposure EffectsSmoking Behavior and CessationNicotinic Acetylcholine Receptors Study

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Effects of pre-and neonatal nicotine exposure in rodents: inconsistent evidence

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Sobrian, S. K., Holson, R. R.·2011·ILAR Journal

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Abstract

This review presents an analysis of the literature on behavioral effects of developmental exposure to nicotine, as assessed in rodent models that mimic the consequences for human offspring of maternal cigarette smoking. Despite the frequency of reports of low birth weight, hyperactivity, cognitive deficits, and psychiatric problems, inconsistencies exist in both the clinical and experimental literature. Confounding socioeconomic and other demographic variables may account for discrepancies in clinical reports, and the choice of developmental exposure period and the method of nicotine administration may explain differences in experimental outcomes. Analysis of a number of variables (e.g., physical, behavioral, and cognitive) shows that fetal exposure to nicotine does not consistently cause growth retardation or decreased birth weight, nor reliably affect motor activity. But combined pre- and neonatal exposure is likely to result in delayed reflex development, global impairments in learning and memory, and an increased incidence of symptoms that model psychiatric illness. There is also support for increased self-administration of nicotine and other drugs of abuse in animals exposed developmentally to nicotine, as well as potent effects on offspring responses to drug challenges. Unlike reports in the clinical literature, sexually dimorphic effects were not evident in most animal models. Possible neuroanatomical and cholinergic mechanisms responsible for behavioral changes are briefly discussed. Statistical and design considerations are provided to increase the translational value of this research and, most importantly, enhance the replicability of reported findings.

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Authors: Sobrian, S. K., & Holson, R. R.
Affiliations: Howard University (US)
Corresponding author: Sobrian, S. K.
Venue: ILAR Journal
Publisher: Oxford University Press (OUP)
Published: 2011-01-01
Volume: 52
Issue: 3
Pages: 251-294
ISSN: 1084-2020 (ISSN-L)
DOI: 10.1093/ilar.52.3.251
OpenAlex: W2145815038
Cited by: 8
References: 262
Citations by year: 2026: 3 · 2019: 1 · 2017: 1 · 2016: 2
FWCI: 0.05
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: ILAR Journal (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: prenatal nicotine exposure, maternal smoking, low birth weight, hyperactivity, cognitive impairment, learning and memory, psychiatric symptoms, nicotine self-administration, cholinergic mechanisms, sexual dimorphism, rodent models, translational research, replicability
MeSH terms: Animals, Humans, Learning, Memory, Nicotine, Prenatal Exposure Delayed Effects

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Effects of pre-and neonatal nicotine exposure in rodents: inconsistent evidence

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