The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Nitric Oxide Synthase Is Not a Constituent of the Antimicrobial Armature of Human Mononuclear Phagocytes
Open accessAbstract
Nitric oxide synthase (NOS) has received immense interest as an antimicrobial and antitumoral effector system of mononuclear phagocytes from rodents. Because there is increasing doubt that an analogous system exists in human macrophages, NOS was reexamined in these cells. Under tightly controlled conditions, with murine macrophages as positive controls, human macrophages failed to secrete nitric oxide (< 0.1 mumol/10(6) cells/24 h), even after activation with endotoxin, interferon-gamma, granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-alpha, bacteria, or proliferating lymphocytes. The discrepancy between murine and human macrophages depended on neither the anatomic source (blood, peritoneum), the agent used for activation, nor the duration of activation. NOS activity was paralleled by metabolization of L-arginine to L-citrulline. Exogenous tetrahydrobiopterin, an essential cofactor of NOS not synthesized by human macrophages, did not support NOS activity in human macrophages. Also, no NOS activity was found in cellular subfractions of human macrophages. It appears that in humans, the inducible high-output NOS is not conserved as an antimicrobial system of macrophages.
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Cites
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Cited by
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Myeloperoxidase: friend and foe
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Metabolic Reprograming in Macrophage Polarization
Galván-Peña, S., & O’Neill, L. A. J. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00420 · Cited by 944
Lymphatic pumping: mechanics, mechanisms and malfunction
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Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight
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Nitric oxide in inflammation and immune response
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Iron: Mammalian defense systems, mechanisms of disease, and chelation therapy approaches
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miR-155 Suppresses Bacterial Clearance in Pseudomonas aeruginosa–Induced Keratitis by Targeting Rheb
Yang, K., Wu, M., Li, M., Li, D., Peng, A., Nie, X., Sun, M., Wang, J., Wu, Y., Deng, Q., et al. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu002 · Cited by 59
Metadata
- Authors
- Schneemann, M., Schoedon, G., Hofer, S., Blau, N., Guerrero, L., & Schaffner, A.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-06-01
- Volume
- 167
- Issue
- 6
- Pages
- 1358-1363
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2112084358
- Cited by
- 333
- References
- 5
- FWCI
- 17.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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