Liposomes with Prolonged Blood Circulation and Selective Localization in Klebsiella pneumoniae-Infected Lung Tissue
Abstract
Studies of two types of small liposomes, differing with respect to their lipid composition in terms of bilayer fluidity, charge, and hydrophilicity of the liposomal surface, were done to evaluate their usefulness for delivery of encapsulated therapeutic agents to sites of infection. The liposomes showed substantial localization in infected lung tissue after intravenous administration. This was demonstrated in a model of unilateral Klebsiella pneumoniae pneumonia in rats, in which the left lung was infected but the right lung of the same animal developed no infection. The degree of localization in the infected left lung was different for the two types of liposomes. For the liposome type with the longer blood residence time, containing a surface coating of polyethylene glycol, localization in the infected left lung was dependent on the liposomal dose, correlated with the intensity of infection, and reached 9% of the injected liposomal dose in severely infected rats.
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The degree of targeting is directly correlated with the severity of infection.
“some studies show that the degree of targeting is directly correlated with the severity of infection 51,52 .”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [51]
The benefit of PEG coating was reduced at low infection severity.
“The benefit of PEG coating was reduced at low infection severity.”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [51]
In rats with the most severe lung infection, PEG-coated liposomes (half-life = 27 h) resulted in approximately fourfold higher concentrations compared with uncoated liposomes (half-life = 19 h).
“Importantly, in rats that had the most severe lung infection, PEG-coated liposomes (half-life = 27 h) resulted in approximately fourfold higher concentrations compared with uncoated liposomes (half-life = 19 h) 51 .”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [51]
Cites
The Role of Polyamines in the Neutralization of Bacteriophage Deoxyribonucleic Acid
Ames, B. N., & Dubin, D. T. (1960) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67936-6 · Cited by 2,580 · see citing works
Allen, T. M., Hansen, C., Martin, F., Redemann, C. T., & Yau‐Young, A. O. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90246-5 · Cited by 1,392 · see citing works
Large unilamellar liposomes with low uptake into the reticuloendothelial system
Allen, T. M., & Chonn, A. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80506-9 · Cited by 729 · see citing works
Liposomes for the sustained drug release in vivo
Blume, G., & Cevc, G. (1990) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(90)90440-y · Cited by 701 · see citing works
Fate and behavior of liposomes in vivo: a review of controlling factors.
Senior, J. H. (1987) · PubMed · Cited by 592 · see citing works
Pharmacokinetics of stealth versus conventional liposomes: effect of dose
Allen, T. M., & Hansen, C. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90201-i · Cited by 579 · see citing works
Senior, J. H., Delgado, C., Fisher, D., Tilcock, C., & Gregoriadis, G. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90337-8 · Cited by 521 · see citing works
Klibanov, A. L., Maruyama, K., Beckerleg, A. M., Torchilin, V. P., & Huang, L. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90385-l · Cited by 480 · see citing works
Allen, T. M., Hansen, C., & Rutledge, J. M. (1989) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(89)90078-3 · Cited by 467 · see citing works
Senior, J., & Gregoriadis, G. C. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90455-6 · Cited by 355 · see citing works
Allen, T. M., Austin, G. A., Chonn, A., Lin, L., & Lee, K. ‐. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90268-d · Cited by 344 · see citing works
The role of surface charge and hydrophilic groups on liposome clearance in vivo
Gabizon, A., & Papahadjopoulos, D. (1992) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(92)90061-p · Cited by 264 · see citing works
Senior, J., Crawley, J. C. W., & Gregoriadis, G. C. (1985) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(85)90174-6 · Cited by 253 · see citing works
Gabizón, A., Price, D. C., Huberty, J. P., et al. (1990) · PubMed · Cited by 250 · see citing works
Versatility in lipid compositions showing prolonged circulation with sterically stabilized liposomes
Woodle, M. C., Matthay, K. K., Newman, M. S., Hidayat, J., Collins, L. R., Redemann, C. T., Martin, F. J., & Papahadjopoulos, D. (1992) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(92)90194-q · Cited by 241 · see citing works
Self-citationGabizón, A., Shiota, R., & Papahadjopoulos, D. (1989) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/81.19.1484 · Cited by 219 · see citing works
Allen, T. M., & Everest, J. M. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21638-x · Cited by 137 · see citing works
Allen, T. M. (1981) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(81)90464-8 · Cited by 134 · see citing works
Hepatic uptake and degradation of unilamellar sphingomyelin/cholesterol liposomes: a kinetic study.
Hwang, K. J., Luk, K., & Beaumier, P. L. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.7.4030 · Cited by 94 · see citing works
Enhanced localization of liposomes with prolonged blood circulation time in infected lung tissue
Bakker-Woudenberg, I. A. J. M., Lokerse, A. F., ten Kate, M. T., & Storm, G. (1992) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(92)90010-k · Cited by 89 · see citing works
Self-citationGabizon, A., Hliberty, J., Straubinger, R. M., et al. (1988) · Journal of Liposome Research · doi:10.3109/08982108809035986 · Cited by 82 · see citing works
Targeting of Liposomes to Tumor Cells in Vivoa
Papahadjopoulos, D., & Gabizon, A. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb45792.x · Cited by 82 · see citing works
Preparation and use of Liposomes in the Treatment of Microbial Infections
Swenson, C. E., Popescu, M. C., Ginsberg, R. S., & Juliano, R. L. (1988) · CRC Critical Reviews in Microbiology · doi:10.3109/10408418809104463 · Cited by 78 · see citing works
Roerdink, F. H., & Kroon, A. M. (1989) · Cited by 71 · see citing works
Coune, A. (1988) · Infection · doi:10.1007/bf01644088 · Cited by 65 · see citing works
Gangliosides reduce leakage of aqueous-space markers from liposomes in the presence of human plasma
Allen, T. M., Ryan, J. L., & Papahadjopoulos, D. (1985) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(85)90571-1 · Cited by 65 · see citing works
Uptake of small liposomes by non-reticuloendothelial tissues
Hwang, K. J., Padki, M. M., Chow, D. D., Essien, H., Lai, J. Y., & Beaumier, P. L. (1987) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(87)90259-8 · Cited by 64 · see citing works
Lång, J., Vigo‐Pelfrey, C., & Martin, F. J. (1990) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(90)90137-g · Cited by 45 · see citing works
Liposomes in treatment of infectious diseases
Emmen, F., & Storm, G. (1987) · Pharmacy World & Science · doi:10.1007/bf01967536 · Cited by 45 · see citing works
Self-citationBakker‐Woudenberg, I. A. J. M., van den Berg, J. C., & MICHEL, M. F. (1982) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.22.6.1042 · Cited by 43 · see citing works
Self-citationBakker‐Woudenberg, I. A. J. M., Lokerse, A. F., & Roerdink, F. H. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20723-6 · Cited by 32 · see citing works
Self-citationImpact of dosage schedule of antibiotics on the treatment of serious infections
Bakker‐Woudenberg, I. A. J. M., & Roosendaal, R. (1990) · Intensive Care Medicine · doi:10.1007/bf01709706 · Cited by 31 · see citing works
Self-citationMelissen, P. M. B., van Vianen, W., Rijsbergen, Y., et al. (1992) · Infection and Immunity · doi:10.1128/iai.60.1.95-101.1992 · Cited by 24 · see citing works
Liposomes and lipid carriers in the treatment of microbial infections.
Bakker‐Woudenberg, I. A. J. M., & Lokerse, A. F. (1990) · PubMed · Cited by 14 · see citing works
Self-citationLiposomes as drug carriers in the therapy of infectious diseases.
Rl, J. (1989) · PubMed · Cited by 12 · see citing works
Drug-targeting in antimicrobial chemotherapy by means of liposomes
Bakker-Woudenberg, I. A. J. M., Lokerse, A. F., den Berg, J. C. V.-V., et al. (1985) · Antonie van Leeuwenhoek · doi:10.1007/bf00404596 · Cited by 8 · see citing works
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Sorted by citations
Nanotechnology approaches for global infectious diseases
Kirtane, A. R., Verma, M., Karandikar, P., Furin, J., Langer, R., & Traverso, G. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00866-8 · Cited by 520 · see citing works
Liposome-encapsulated aminoglycosides in pre-clinical and clinical studies
Schiffelers, R. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/48.3.333 · Cited by 163 · see citing works
Liposomes for scintigraphic detection of infection and inflammation
Laverman, P. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00095-7 · Cited by 93 · see citing works
- Authors
- Bakker-Woudenberg, I. A. J. M., Lokerse, A. F., Kate, M. T. T., Mouton, J. W., Woodle, M. C., & Storm, G.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-07
- Volume
- 168
- Issue
- 1
- Pages
- 164-171
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2139326763
- Cited by
- 129
- References
- 36
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 1 · 2015: 1 · 2014: 2 · 2012: 3
- FWCI
- 11.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
- Keywords
- liposomes, Klebsiella pneumoniae pneumonia, pulmonary infection, targeted drug delivery, polyethylene glycol coating, blood circulation time, lipid bilayer fluidity, liposome surface charge, intravenous administration
- MeSH terms
- Animals, Drug Carriers, Female, Klebsiella Infections, Klebsiella pneumoniae, Liposomes, Lung, Pneumonia, Polyethylene Glycols, Rats
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