Liposome-encapsulated aminoglycosides in pre-clinical and clinical studies
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Liposome-encapsulated amikacin has recently entered clinical trials. The rationale for liposome encapsulation of aminoglycosides is the possibility to increase the therapeutic index of this class of antibiotics by increasing aminoglycoside concentrations at the site of infection and/or by reducing the toxicity of these drugs. Three approaches can be distinguished: the use of liposomes as a depot formulation for local drug administration; targeting of (relatively) short circulating conventional liposomes to the cells of the mononuclear phagocyte system (MPS) for treating intracellular bacterial infections; and targeting of long-circulating liposomes to infectious foci localized outside the MPS. This review discusses the pre-clinical and clinical data in connection with recent developments in liposome technology.
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Despite early positive results in clinical trials for urinary tract infections and Mycobacterium infections, development of MiKasomes was discontinued in 2000.
“Despite early positive results in clinical trials for urinary tract infections and Mycobacterium infections 15 , development of the formulation was discontinued in 2000.”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [15]
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- Authors
- Schiffelers, R.
- Affiliations
- Utrecht University (NL)
- Corresponding author
- Schiffelers, R.
- ORCID
- Schiffelers, R.
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-09-01
- Volume
- 48
- Issue
- 3
- Pages
- 333-344
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2156636796
- Cited by
- 163
- References
- 114
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 10 · 2020: 4 · 2019: 9 · 2018: 8 · 2017: 8 · 2016: 6 · 2015: 6 · 2014: 9 · 2013: 7 · 2012: 7
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Antimicrobial Chemotherapy (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- amikacin, liposomal drug delivery, therapeutic index, aminoglycoside toxicity, intracellular bacterial infection, long-circulating liposomes, local drug administration
- MeSH terms
- Aminoglycosides, Anti-Bacterial Agents, Clinical Trials as Topic, Drug Carriers, Humans, Infusions, Intravenous, Liposomes, Staphylococcus aureus, Drug Delivery Systems, Treatment Outcome
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