Pathogenesis and host responses in human onchocerciasis: impact of Onchocerca filariae and Wolbachia endobacteria

Brattig, N.W.

doi:10.1016/j.micinf.2003.11.003

Cited by 169Parasitic Diseases Research and TreatmentParasites and Host InteractionsResearch on Leishmaniasis Studies

Pathogenesis and host responses in human onchocerciasis: impact of Onchocerca filariae and Wolbachia endobacteria

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Brattig, N.W.·2004·Microbes and Infection

DOI 10.1016/j.micinf.2003.11.003

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Abstract

Onchocerca volvulus is a tissue-invasive parasitic nematode causing skin and eye pathology in human onchocerciasis. The filariae habour abundant intracellular Wolbachia bacteria, now recognised as obligatory symbionts, and therefore emerging as a novel target for chemotherapy. Recent research demonstrates that both the filariae and endobacteria contribute to the pathogenesis of onchocerciasis, and molecules have been identified that promote inflammatory or counter-inflammatory immune mechanisms, divert the host's immune response or procure evasion of the parasite.

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Wolbachia molecules interact with macrophages through TLR2, TLR4, or TLR6 in onchocerciasis and filariasis.
“Interactions between Wolbachia molecules and macrophages occurring through the Toll-like receptor (TLR) family (TLR2, TLR4, or TLR6) have been shown in cases of onchocerciasis and filariasis (60,429).”
From Human and animal dirofilariasis: The emergence of a zoonotic mosaic (2012) · cites this paper as [60]

Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737 · see citing works
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189 · see citing works
Toll-Like Receptors
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143 · see citing works
Allergy, Parasites, and the Hygiene Hypothesis
Yazdanbakhsh, M., Kremsner, P. G., & van Ree, R. (2002) · Science · doi:10.1126/science.296.5567.490 · Cited by 1,527 · see citing works
Toll-like Receptor 2 (TLR2) and TLR4 Differentially Activate Human Dendritic Cells
Re, F., & Strominger, J. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105927200 · Cited by 691 · see citing works
A Novel Host-Parasite Lipid Cross-talk
van der Kleij, D., Latz, E., Brouwers, J. F. H. M., Kruize, Y. C. M., Schmitz, M., Kurt-Jones, E. A., Espevik, T., de Jong, E. C., Kapsenberg, M. L., Golenbock, D. T., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206941200 · Cited by 587 · see citing works
Phylogeny of Wolbachia in filarial nematodes
Bandi, C., Anderson, T., Genchi, C., & Blaxter, M. (1998) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1998.0591 · Cited by 576 · see citing works
The Role of Endosymbiotic Wolbachia Bacteria in the Pathogenesis of River Blindness
André, A. V. S., Blackwell, N. M., Hall, L. R., Hoerauf, A. M., Brattig, N. W., Volkmann, L., Taylor, M. J., Ford, L., Hise, A. G., Lass, J. H., et al. (2002) · Science · doi:10.1126/science.1068732 · Cited by 358 · see citing works
Self-citation
A Filarial Nematode-Secreted Product Signals Dendritic Cells to Acquire a Phenotype That Drives Development of Th2 Cells
Whelan, M., Harnett, M. M., Houston, K. M., Patel, V., Harnett, W., & Rigley, K. P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6453 · Cited by 324 · see citing works
IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype
Loke, P., Nair, M. G., Parkinson, J., Guiliano, D. B., Blaxter, M., & Allen, J. E. (2002) · BMC Immunology · doi:10.1186/1471-2172-3-7 · Cited by 322 · see citing works
Endosymbiotic bacteria in worms as targets for a novel chemotherapy in filariasis
Hoerauf, A. M., Volkmann, L., Hamelmann, C., Adjei, O., Autenrieth, I. B., Fleischer, B., & Büttner, D. W. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02095-x · Cited by 310 · see citing works
Toll‐like receptor 2 (TLR2) and TLR4 differentially activate human mast cells
Varadaradjalou, S., Féger, F., Thiéblemont, N., Benhamouda, N., Pléau, J., Dy, M., & Arock, M. (2003) · European Journal of Immunology · doi:10.1002/eji.200323830 · Cited by 293 · see citing works
Filarial Nematode Parasites Secrete a Homologue of the Human Cytokine Macrophage Migration Inhibitory Factor
Pastrana, D., Raghavan, N., Fitzgerald, P., Eisinger, S. W., Metz, C., Bucala, R., Schleimer, R., Bickel, C., & Scott, A. L. (1998) · Infection and Immunity · doi:10.1128/iai.66.12.5955-5963.1998 · Cited by 253 · see citing works
Molecular evidence for a close relative of the arthropod endosymbiont Wolbachia in a filarial worm
Sironi, M., Bandi, C., Sacchi, L., di Sacco, B., Damiani, G., & Genchi, C. (1995) · Molecular and Biochemical Parasitology · doi:10.1016/0166-6851(95)02494-8 · Cited by 251 · see citing works
Effects of tetracycline on the filarial worms Brugia pahangi and Dirofilaria immitis and their bacterial endosymbionts Wolbachiafn1fn1Note: Nucleotide sequence data reported in this paper are available in the embl, GeneBankTM and DDJB databases under accession number AJ012646.
Bandi, C., McCall, J. W., Genchi, C., Corona, S., Venco, L., & Sacchi, L. (1999) · International Journal for Parasitology · doi:10.1016/s0020-7519(98)00200-8 · Cited by 250 · see citing works
Inflammatory Responses Induced by the Filarial Nematode Brugia malayi Are Mediated by Lipopolysaccharide-like Activity from Endosymbiotic Wolbachia Bacteria
Taylor, M. J., Cross, H. F., & Bilo, K. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.8.1429 · Cited by 249 · see citing works
Wolbachia in filarial nematodes: evolutionary aspects and implications for the pathogenesis and treatment of filarial diseases
Bandi, C., Trees, A. J., & Brattig, N. W. (2001) · Veterinary Parasitology · doi:10.1016/s0304-4017(01)00432-0 · Cited by 233 · see citing works
Self-citation
Antigen-specific T regulatory-1 cells are associated with immunosuppression in a chronic helminth infection (onchocerciasis)
Satoguina, J., Mempel, M., Larbi, J. A., Badusche, M., Löliger, C., Adjei, O., Gachelin, G., Fleischer, B., & Hoerauf, A. M. (2002) · Microbes and Infection · doi:10.1016/s1286-4579(02)00014-x · Cited by 224 · see citing works
Control of allergic reactivity in human filariasis. Predominant localization of blocking antibody to the IgG4 subclass
Hussain, R., Poindexter, R. W., & Ottesen, E. A. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.9.2731 · Cited by 221 · see citing works
A clinical classification and grading system of the cutaneous changes in onchocerciasis
Murdoch, M. E., Hay, R. J., Mackenzie, C. D., et al. (1993) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1993.tb11844.x · Cited by 221 · see citing works
Modulation of host immune responses by nematode cystatins
Hartmann, S., & Lucius, R. (2003) · International Journal for Parasitology · doi:10.1016/s0020-7519(03)00163-2 · Cited by 207 · see citing works
Macrofilaricidal activity of tetracycline against the filarial nematode Onchocerca ochengi : elimination of Wolbachia precedes worm death and suggests a dependent relationship
Langworthy, N. G., Renz, A., Ute Mackenstedt, A., Henkle–Dührsen, K., Bronsvoort, M., Tanya, V. N., Donnelly, M. J., & Trees, A. J. (2000) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2000.1110 · Cited by 207 · see citing works
Toll-Like Receptor Signaling and Regulation of Cytokine Gene Expression in the Immune System
Ozato, K., Tsujimura, H., & Tamura, T. (2002) · BioTechniques · doi:10.2144/oct0208 · Cited by 189 · see citing works
Final report of the Conference on the eradicability of Onchocerciasis
Dadzie, Y., Neira, M., & Hopkins, D. R. (2003) · Filaria Journal · doi:10.1186/1475-2883-2-2 · Cited by 185 · see citing works
Antioxidant enzyme families in parasitic nematodes
Henkle‐Dührsen, K. (2001) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(01)00252-3 · Cited by 184 · see citing works
Neutrophil accumulation around worms and chemotaxis of neutrophils are dependent on endobacteria
Brattig, N. W., Büttner, D. W., & Hoerauf, A. M. (2001) · Microbes and Infection · doi:10.1016/s1286-4579(01)01399-5 · Cited by 182 · see citing works
Self-citation
Immune evasion genes from filarial nematodes
Maizels, R. M., Gomez‐Escobar, N., Gregory, W. F., Murray, J., & Zang, X. (2001) · International Journal for Parasitology · doi:10.1016/s0020-7519(01)00213-2 · Cited by 168 · see citing works
High Levels of Spontaneous and Parasite Antigen-Driven Interieukin-10 Production Are Associated with Antigen-Specific Hyporesponsiveness in Human Lymphatic Filariasis
Mahanty, S., Mollis, S. N., Ravichandran, M., Abrams, J. S., Kumaraswami, V., Jayaraman, K., Ottesen, E. A., & Nutman, T. B. (1996) · Journal of Infectious Diseases · doi:10.1093/infdis/173.3.769 · Cited by 165 · see citing works
Immune Responsiveness And The Pathogenesis Of Human Onchocerciasis
Ottesen, E. A. (1995) · The Journal of Infectious Diseases · doi:10.1093/infdis/171.3.659 · Cited by 162 · see citing works
Modulation of Human T Cell Responses and Macrophage Functions by Onchocystatin, a Secreted Protein of the Filarial Nematode <i>Onchocerca volvulus</i>
Schönemeyer, A., Lucius, R., Sonnenburg, B., Brattig, N., Sabat, R., Schilling, K., Bradley, J., & Hartmann, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3207 · Cited by 155 · see citing works
Self-citation
Severe reactions to filarial chemotherapy and release of Wolbachia endosymbionts into blood
Cross, H. F., Haarbrink, M., Egerton, G., Yazdanbakhsh, M., & Taylor, M. J. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06899-4 · Cited by 128 · see citing works
Bacterial Endosymbionts of Onchocerca volvulus in the Pathogenesis of Posttreatment Reactions
Keiser, P. B., Reynolds, S. M., Awadzi, K., Ottesen, E. A., Taylor, M. J., & Nutman, T. B. (2002) · The Journal of Infectious Diseases · doi:10.1086/339344 · Cited by 124 · see citing works
Immunity To Onchocerciasis: Putative Immune Persons Produce A Thl-Like Response To Onchocerca Volvulus
Elson, L. H., Calvopiña, M., Y., W. P., N., E. A., Bradley, J. E., Guderian, R. H., & Nutman, T. B. (1995) · The Journal of Infectious Diseases · doi:10.1093/infdis/171.3.652 · Cited by 119 · see citing works
The Mazzotti Reaction Following Treatment of Onchocerciasis with Diethylcarbamazine: Clinical Severity as a Function of Infection Intensity
Francis, H. F., Awadzi, K., & Ottesen, E. A. (1985) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1985.34.529 · Cited by 114 · see citing works
Lipopolysaccharide-like molecules derived from endobacteria of the filaria are candidate mediators in the sequence of inflammatory and antiinflammatory responses of human monocytes
Brattig, N. W., Rathjens, U., Ernst, M., Geisinger, F., Renz, A., & Tischendorf, F. W. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)01269-7 · Cited by 113 · see citing works
Self-citation
Resistance and susceptibility in human onchocerciasis – beyond Th1 vs Th2
Hoerauf, A. M., & Brattig, N. W. (2002) · Trends in Parasitology · doi:10.1016/s1471-4922(01)02173-0 · Cited by 110 · see citing works
Self-citation
CTLA-4 in Filarial Infections: Implications for a Role in Diminished T Cell Reactivity
Steel, C., & Nutman, T. B. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.4.1930 · Cited by 105 · see citing works
Immunological genomics of Brugia malayi: filarial genes implicated in immune evasion and protective immunity
Maizels, R. M., Blaxter, M., & Scott, A. L. (2001) · Parasite Immunology · doi:10.1046/j.1365-3024.2001.00397.x · Cited by 104 · see citing works
Murine filariasis: Interleukin 4 and interleukin 5 lead to containment of different worm developmental stages
Volkmann, L., Bain, O., Saeftel, M., Specht, S., Fischer, K., Brombacher, F., Matthaei, K. I., & Hoerauf, A. (2003) · Medical Microbiology and Immunology · doi:10.1007/s00430-002-0155-9 · Cited by 99 · see citing works
Prophylactic Activity of Tetracycline against Brugia pahangi Infection in Jirds (Meriones unguiculatus)
Bosshardt, S. C., McCall, J. W., Coleman, S. U., Jones, K. L., Petit, T. A., & Klei, T. R. (1993) · Journal of Parasitology · doi:10.2307/3283620 · Cited by 98 · see citing works
Identification of Potential Vaccine and Drug Target Candidates by Expressed Sequence Tag Analysis and Immunoscreening ofOnchocerca volvulusLarval cDNA Libraries
Lizotte‐Waniewski, M., Tawe, W., Guiliano, D. B., Lu, W., Liu, J., Williams, S. A., & Lustigman, S. (2000) · Infection and Immunity · doi:10.1128/iai.68.6.3491-3501.2000 · Cited by 97 · see citing works
The population dynamics of Onchocerca volvulus in the human host.
Duke, B. O. L. (1993) · PubMed · Cited by 96 · see citing works
A Novel Member of the Transforming Growth Factor-β (TGF-β) Superfamily from the Filarial NematodesBrugia malayiandB. pahangi
Gomez‐Escobar, N., Lewis, E., & Maizels, R. M. (1998) · Experimental Parasitology · doi:10.1006/expr.1998.4248 · Cited by 93 · see citing works
Antigenic role of the endosymbionts of filarial nematodes: IgG response against the Wolbachia surface protein in cats infected with Dirofilaria immitis
Bazzocchi, C., Ceciliani, F., McCall, J. W., Ricci, I., Genchi, C., & Bandi, C. (2000) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2000.1313 · Cited by 93 · see citing works
Eosinophil degranulation. An immunologic determinant in the pathogenesis of the Mazzotti reaction in human onchocerciasis.
Ackerman, S. J., Kephart, G. M., Francis, H. L., et al. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.10.3961 · Cited by 90 · see citing works
Determination ofWolbachiaGenome Size by Pulsed-Field Gel Electrophoresis
Sun, L. V., Foster, J. M., Tzertzinis, G., Ono, M., Bandi, C., Slatko, B. E., & O’Neill, S. L. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.7.2219-2225.2001 · Cited by 88 · see citing works
wsp Gene Sequences from the Wolbachia of Filarial Nematodes
Bazzocchi, C., Jamnongluk, W., O'Neill, S. L., Anderson, T. J. C., Genchi, C., & Bandi, C. (2000) · Current Microbiology · doi:10.1007/s002840010100 · Cited by 87 · see citing works
Immunomodulatory properties of a phosphorylcholine‐containing secreted filarial glycoprotein
Harnett, W., Deehan, M. R., Houston, K. M., & Harnett, M. M. (1999) · Parasite Immunology · doi:10.1046/j.1365-3024.1999.00267.x · Cited by 83 · see citing works
HLA-D alleles associated with generalized disease, localized disease, and putative immunity in Onchocerca volvulus infection.
Meyer, C. G., Gallin, M. Y., Erttmann, K. D., Brattig, N. W., Schnittger, L., Gelhaus, A., Tannich, E., Begovich, A. B., Erlich, H. A., & Horstmann, R. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7515 · Cited by 83 · see citing works
Self-citation
Angiogenic activity of Onchocerca volvulus recombinant proteins similar to vespid venom antigen 5
Tawe, W., Pearlman, E. M., Unnasch, T. R., et al. (2000) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(00)00231-0 · Cited by 83 · see citing works
Towards a recombinant antigen vaccine against Onchocerca volvulus
Lustigman, S., James, E. R., Tawe, W., et al. (2002) · Trends in Parasitology · doi:10.1016/s1471-4922(01)02211-5 · Cited by 82 · see citing works
Identification of recombinant filarial proteins capable of inducing polyclonal and antigen-specific IgE and IgG4 antibodies
Garraud, O., Nkenfou, C. N., Bradley, J. E., et al. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1316 · Cited by 80 · see citing works
Ivermectin-facilitated immunity in onchocerciasis. Reversal of lymphocytopenia, cellular anergy and deficient cytokine production after single treatment
Soboslay, P. T., Dreweck, C. M., Hoffmann, W. H., et al. (1992) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1992.tb06971.x · Cited by 77 · see citing works
Variations in Host Responses and the Pathogenesis of Human Onchocerciasis
Mackenzie, C. D., Williams, J. F., Sisley, B. M., et al. (1985) · Clinical Infectious Diseases · doi:10.1093/clinids/7.6.802 · Cited by 74 · see citing works
Divergent roles for macrophages in lymphatic filariasis
Allen, J. E., & Loke, P. (2001) · Parasite Immunology · doi:10.1046/j.1365-3024.2001.00394.x · Cited by 73 · see citing works
Regulation of IL-5 in onchocerciasis. A critical role for IL-2
Steel, C., & Nutman, T. B. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.12.5511 · Cited by 72 · see citing works
The diverse expression of immunity in humans at distinct states of Onchocerca volvulus infection
Soboslay, P. T., Geiger, S. M., Weiss, N., Banla, M., Lüder, C. G. K., Dreweck, C. M., BATCHASSI, E., Boatin, B., STADLER, A., & Schulz-Key, H. (1997) · Immunology · doi:10.1046/j.1365-2567.1997.00210.x · Cited by 70 · see citing works
Clinical, parasitological and serological studies on onchocerciasis in the Yemen Arab Republic.
Dw, B., von Laer, G., Mannweiler, E., et al. (1982) · PubMed · Cited by 69 · see citing works
The variant Arg110Gln of human IL-13 is associated with an immunologically hyper-reactive form of onchocerciasis (sowda)
Hoerauf, A. M., Kruse, S., Brattig, N. W., Heinzmann, A., Mueller-Myhsok, B., & Deichmann, K. A. (2002) · Microbes and Infection · doi:10.1016/s1286-4579(01)01507-6 · Cited by 67 · see citing works
Self-citation
The Serpin Secreted by Brugia malayi Microfilariae, Bm-SPN-2, Elicits Strong, but Short-Lived, Immune Responses in Mice and Humans
Zang, X., Kurniawan, A., Gray, P. E., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.9.5161 · Cited by 67 · see citing works
Human autoantibody to defensin: disease association with hyperreactive onchocerciasis (sowda).
Gallin, M. Y., Jacobi, A. B., Büttner, D. W., et al. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.1.41 · Cited by 67 · see citing works
Eosinophils are the major effector cells of immunity to microfilariae in a mouse model of onchocerciasis
FOLKARD, S. G., Hogarth, P. J., Taylor, M. J., & Bianco, A. E. (1996) · Parasitology · doi:10.1017/s0031182000065847 · Cited by 64 · see citing works
Determinants for resistance and susceptibility to microfilaraemia in Litomosoides sigmodontis filariasis
Hoffmann, W. H., Pfaff, A. W., Schulz-Key, H., et al. (2001) · Parasitology · doi:10.1017/s0031182001007892 · Cited by 62 · see citing works
The profile of IgG and IgG subclasses of onchocerciasis patients
Dafa’alla, T., Ghalib, H. W., Abdelmageed, A., et al. (1992) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1992.tb03070.x · Cited by 61 · see citing works
Immunity to Onchocerciasis: Cells from Putatively Immune Individuals Produce Enhanced Levels of Interleukin-5, Gamma Interferon, and Granulocyte-Macrophage Colony-Stimulating Factor in Response toOnchocerca volvulusLarval and Male Worm Antigens
Turaga, P. S. D., Tierney, T. J., Bennett, K. E., et al. (2000) · Infection and Immunity · doi:10.1128/iai.68.4.1905-1911.2000 · Cited by 61 · see citing works
Early Human Infection withOnchocerca volvulusIs Associated with an Enhanced Parasite‐Specific Cellular Immune Response
Cooper, P. J., Mancero, T., Espinel, M., Sandoval, C. A., Lovato, R., Guderian, R. H., & Nutman, T. B. (2001) · The Journal of Infectious Diseases · doi:10.1086/320709 · Cited by 60 · see citing works
Transmission intensity and human immune responses to lymphatic filariasis
King, C. L. (2001) · Parasite Immunology · doi:10.1046/j.1365-3024.2001.00395.x · Cited by 58 · see citing works
Interleukin-5 and the posttreatment eosinophilia in patients with onchocerciasis.
Limaye, A. P., Abrams, J. S., Silver, J. E., et al. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115449 · Cited by 52 · see citing works
Experimental onchocerciasis in chimpanzees. Cell-mediated immune responses, and production and effects of IL-1 and IL-2 with Onchocerca volvulus infection
Soboslay, P. T., Dreweck, C. M., Taylor, H. R., Brotman, B., Wenk, P., & Greene, B. M. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.1.346 · Cited by 51 · see citing works
The genomes of Onchocerca volvulus
Unnasch, T. R., & Williams, S. A. (2000) · International Journal for Parasitology · doi:10.1016/s0020-7519(99)00184-8 · Cited by 50 · see citing works
River blindness: a role for parasite retinoid-binding proteins in the generation of pathology?
Bradley, J. E., Nirmalan, N. J., Kläger, S., Faulkner, H., & Kennedy, M. W. (2001) · Trends in Parasitology · doi:10.1016/s1471-4922(01)02036-0 · Cited by 50 · see citing works
In utero exposure to Onchocerca volvulus: relationship to subsequent infection intensity and cellular immune responsiveness
Elson, L. H., Days, A., Calvopiña, M., et al. (1996) · Infection and Immunity · doi:10.1128/iai.64.12.5061-5065.1996 · Cited by 50 · see citing works
Onchocerca volvulus–Exposed Persons Fail to Produce Interferon‐γ in Response toO. volvulusAntigen but Mount Proliferative Responses with Interleukin‐5 and IL‐13 Production that Decrease with Increasing Microfilarial Density
Brattig, N. W., Lepping, B., Timmann, C., et al. (2002) · The Journal of Infectious Diseases · doi:10.1086/339820 · Cited by 50 · see citing works
Self-citation
Onchocerca volvulus:Microfilariae Secrete Elastinolytic and Males Nonelastinolytic Matrix-Degrading Serine and Metalloproteases
Haffner, A., Guilavogui, A. Z., Tischendorf, F. W., et al. (1998) · Experimental Parasitology · doi:10.1006/expr.1998.4313 · Cited by 49 · see citing works
Role of IL-10 in allergen-specific immunotherapy and normal response to allergens
Akdiş, C. A., & Blaser, K. (2001) · Microbes and Infection · doi:10.1016/s1286-4579(01)01449-6 · Cited by 48 · see citing works
Differential Cytokine and Antibody Responses to Adult and Larval Stages ofOnchocerca volvulusConsistent with the Development of Concomitant Immunity
Macdonald, A., Turaga, P. S. D., Harmon-Brown, C., et al. (2002) · Infection and Immunity · doi:10.1128/iai.70.6.2796-2804.2002 · Cited by 47 · see citing works
Serum levels of eosinophil cationic protein, eosinophil-derived neurotoxin and myeloperoxidase in infections with filariea and schistosomes
Tischendorf, F. W., Brattig, N. W., Büttner, D. W., Pieper, A., & Lintzel, M. (1996) · Acta Tropica · doi:10.1016/s0001-706x(96)00038-1 · Cited by 46 · see citing works
Self-citation
Eosinophil‐larval‐interaction in onchocerciasis: heterogeneity of in vitro adherence of eosinophils to infective third and fourth stage larvae and microfilariae of Onchocerca volvulus
Brattig, N. W., Tischendorf, F. W., Strote, G., et al. (1991) · Parasite Immunology · doi:10.1111/j.1365-3024.1991.tb00259.x · Cited by 45 · see citing works
Self-citation
Strong Igg Isotypic Antibody Response In Sowdah Type Onchocerciasis
Brattig, N. W., Krawietz, I., Abakar, A. Z., et al. (1994) · The Journal of Infectious Diseases · doi:10.1093/infdis/170.4.955 · Cited by 45 · see citing works
Self-citation
Immune mechanisms in Onchocerca volvulus‐mediated corneal disease (river blindness)
Pearlman, E. M., & Hall, L. R. (2000) · Parasite Immunology · doi:10.1046/j.1365-3024.2000.00345.x · Cited by 42 · see citing works
Strong Association of Interleukin‐6 and Lipopolysaccharide‐Binding Protein with Severity of Adverse Reactions after Diethylcarbamazine Treatment of Microfilaremic Patients
Haarbrink, M., Abadi, G. K., Buurman, W. A., et al. (2000) · The Journal of Infectious Diseases · doi:10.1086/315735 · Cited by 40 · see citing works
Immunity to Onchocerca spp. in animal hosts
Abraham, D., Lucius, R., & Trees, A. J. (2002) · Trends in Parasitology · doi:10.1016/s1471-4922(02)02245-6 · Cited by 39 · see citing works
Variation and polymorphism in helminth parasites
Maizels, R. M., & Kurniawan, A. (2002) · Parasitology · doi:10.1017/s0031182002001890 · Cited by 38 · see citing works
Down-Regulated Lymphoproliferation Coincides with Parasite Maturation and with the Collapse of Both Gamma Interferon and Interleukin-4 Responses in a Bovine Model of Onchocerciasis
Graham, S. P., Trees, A. J., Collins, R. A., Moore, D. M., Guy, F. M., Taylor, M. J., & Bianco, A. E. (2001) · Infection and Immunity · doi:10.1128/iai.69.7.4313-4319.2001 · Cited by 37 · see citing works
Onchocerca volvulus:Ultrastructural Localization of Two GlutathioneS-Transferases
Wildenburg, G., Liebau, E., & Henkle‐Dührsen, K. (1998) · Experimental Parasitology · doi:10.1006/expr.1998.4189 · Cited by 36 · see citing works
Differences in Cytokine Responses toOnchocerca volvulusExtract and Recombinant Ov33 and OvL3–1 Proteins in Exposed Subjects with Various Parasitologic and Clinical States
Brattig, N. W., Nietz, C., Hounkpatin, S., Lucius, R., Seeber, F., Pichlmeier, U., & Pogonka, T. (1997) · The Journal of Infectious Diseases · doi:10.1086/517317 · Cited by 35 · see citing works
Self-citation
Immune Responses Directed against Microfilariae Correlate with Severity of Clinical Onchodermatitis and Treatment History
Ali, M. M., Baraka, O. Z., AbdelRahman, S. I., et al. (2003) · The Journal of Infectious Diseases · doi:10.1086/367709 · Cited by 34 · see citing works
HLA-DQ Alleles Associate with Cutaneous Features of Onchocerciasis
Murdoch, M. E., Payton, A., Abiose, A. O., Thomson, W., Panicker, V. K., Dyer, P. A., Jones, B. R., Maizels, R. M., & Ollier, W. (1997) · Human Immunology · doi:10.1016/s0198-8859(97)00089-x · Cited by 33 · see citing works
Onchocerca volvulus: in vitro cytotoxic effects of human neutrophils and serum on third-stage larvae.
Johnson, E. H., Irvine, M., Kass, P. H., et al. (1994) · PubMed · Cited by 33 · see citing works
Cutaneous pathology in onchocerciasis associated with pronounced systemic T-helper 2-type responses to Onchocerca volvulus
Timmann, C., Abraha, R. S., Hamelmann, C., et al. (2003) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2003.05556.x · Cited by 32 · see citing works
Towards a vaccine for onchocerciasis
Cook, J. A., Steel, C., & Ottesen, E. A. (2001) · Trends in Parasitology · doi:10.1016/s1471-4922(01)02115-8 · Cited by 29 · see citing works
Involvement of Toll-like receptor 4 in the embryogenesis of the rodent filaria Litomosoides sigmodontis
Pfarr, K. M., Fischer, K., & Hoerauf, A. M. (2003) · Medical Microbiology and Immunology · doi:10.1007/s00430-002-0159-5 · Cited by 28 · see citing works
Mast cells in onchocercomas from patients with hyperreactive onchocerciasis (sowda)
Korten, S., Wildenburg, G., Darge, K., et al. (1998) · Acta Tropica · doi:10.1016/s0001-706x(98)00029-1 · Cited by 27 · see citing works
A major allergen of lymphatic filarial nematodes is a parasite homolog of the gamma-glutamyl transpeptidase.
Lobos, E., Zahn, R., Weiss, N., et al. (1996) · PubMed · Cited by 25 · see citing works
Experimental onchocerciasis in chimpanzees
Soboslay, P. T., Weiss, N., Dreweck, C. M., et al. (1992) · Experimental Parasitology · doi:10.1016/0014-4894(92)90199-k · Cited by 25 · see citing works
Macro- and microfilariae in nodules from onchocerciasis patients in the Yemen Arab Republic.
Dw, B., & Rácz, P. (1983) · PubMed · Cited by 25 · see citing works
A stochastic model for the aggregation of Onchocerca volvulus in nodules
Duerr, H.-P., Dietz, K., Büttner, D. W., et al. (2001) · Parasitology · doi:10.1017/s0031182001008186 · Cited by 22 · see citing works
Experimental Interstitial Keratitis Induced by Onchocerca volvulus Antigens
Gallin, M. Y., Murray, D. L., Lass, J. H., et al. (1988) · Archives of Ophthalmology · doi:10.1001/archopht.1988.01060140611033 · Cited by 21 · see citing works
The River Blindness Genome Project
Williams, S. A., Laney, S. J., Lizotte‐Waniewski, M., et al. (2002) · Trends in Parasitology · doi:10.1016/s1471-4922(01)02197-3 · Cited by 20 · see citing works
A Major Allergen of Lymphatic Filarial Nematodes Is a Parasite Homolog of the γ-Glutamyl Transpeptidase
Lobos, E., Zahn, R., Weiss, N., et al. (1996) · Molecular Medicine · doi:10.1007/bf03401655 · Cited by 20 · see citing works
An aspartate aminotransferase of Wolbachia endobacteria from Onchocerca volvulus is recognized by IgG1 antibodies from residents of endemic areas
Fischer, P., Bonow, I., Büttner, D. W., et al. (2003) · Parasitology Research · doi:10.1007/s00436-002-0813-2 · Cited by 16 · see citing works
The secretory Onchocerca volvulus protein OvS1/Ov20 exhibits the capacity to compete with serum albumin for the host’s long-chain fatty acids
Mpagi, J. L., Erttmann, K. D., & Brattig, N. W. (2000) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(99)00191-7 · Cited by 15 · see citing works
Self-citation
Wolbachia endosymbionts of Onchocerca volvulus express a putative periplasmic HtrA-type serine protease
Jolodar, A., Fischer, P., Büttner, D. W., et al. (2004) · Microbes and Infection · doi:10.1016/j.micinf.2003.10.013 · Cited by 15 · see citing works
Differences in eosinophil and neutrophil chemotactic responses in sowda and generalized form of onchocerciasis
Krömer, M., la Garza, C. E. M., & Brattig, N. W. (1995) · Acta Tropica · doi:10.1016/0001-706x(95)00099-z · Cited by 13 · see citing works
Self-citation
Immunopathologic aspects in human onchocercal lymphadenitis.
Rácz, P., Tenner‐Racz, K., Luther, B., et al. (1983) · PubMed · Cited by 12 · see citing works
Similar blackfly attraction by onchocerciasis patients and individuals putatively immune to Onchocerca volvulus
Kruppa, T. F., & Burchard, G. D. (1999) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(99)90117-7 · Cited by 11 · see citing works
Delayed-type hypersensitivity reactions to Onchocerca volvulus antigens in exposed and non-exposed African individuals
Burchard, G., Brattig, N. W., Kruppa, T. F., et al. (1999) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(99)90199-2 · Cited by 9 · see citing works
Self-citation
Onchocerciasis-associated morbidity: hypothesis
Mawson, A. R., & WaKabongo, M. (2002) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(02)90434-7 · Cited by 9 · see citing works

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Human and animal dirofilariasis: The emergence of a zoonotic mosaic
Simón, F., Siles-Lucas, M., Morchón, R., González-Miguel, J., Mellado, I., Carretón, E., & Montoya-Alonso, J. A. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00012-12 · Cited by 834 · see citing works
Lymphatic filariasis and onchocerciasis
Taylor, M. J., Hoerauf, A., & Bockarie, M. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60586-7 · Cited by 686 · see citing works
What is happening outside North America regarding human dirofilariasis?
Simón, F., López-Belmonte, J., Marcos-Atxutegi, C., Morchón, R., & Martín-Pacho, J. R. (2005) · Veterinary Parasitology · doi:10.1016/j.vetpar.2005.03.033 · Cited by 126 · see citing works
Immunopathology of Dirofilaria immitis infection
Simón, F., Kramer, L. H., Román, A., Blasini, W., Morchón, R., Marcos-Atxutegi, C., Grandi, G., & Genchi, C. (2007) · Veterinary Research Communications · doi:10.1007/s11259-006-3387-0 · Cited by 66 · see citing works
Filarial nematode secreted product ES-62 is an anti-inflammatory agent: Therapeutic potential of small molecule derivatives and ES-62 peptide mimetics
Harnett, W., & Harnett, M. M. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04400.x · Cited by 56 · see citing works
Killing filarial nematode parasites: Role of treatment options and host immune response
Kwarteng, A., Ahuno, S. T., & Akoto, F. O. (2016) · Infectious Diseases of Poverty · doi:10.1186/s40249-016-0183-0 · Cited by 37 · see citing works

[Filariae of rodents useful for the experimental study of human onchocerciasis].
Bain, O., Petit, G., Ngoc, P. V., et al. (1985) · PubMed · Cited by 4 · see citing works
Histochemical enzyme variation in Onchocerca volvulus microfilariae from rain-forest and Sudan-savanna areas of the Onchocerciasis Control Programme in West Africa.
Ms, O., Prost, A., & Tf, M. (1982) · PubMed · Cited by 7 · see citing works
Studies on factors influencing the transmission of onchocerciasis. VII. A comparison of the Onchocerca volvulus transmission potentials of Simulium damnosum populations in four Cameroon rain-forest villages and the pattern of onchocerciasis associated therewith.
Duke, B. O. L., Moore, P. J., & Anderson, J. D. (1972) · PubMed · Cited by 26 · see citing works
Anthropophily of Simulium damnosum s.l. and its rôle as a vector of human onchocerciasis in the Yemen Arab Republic.
Garms, R., & Kerner, M. E. (1982) · PubMed · Cited by 12 · see citing works
Onchocerca armillata contains the endosymbiotic bacterium Wolbachia and elicits a limited inflammatory response
Neary, J. M., Trees, A. J., Ekale, D. D., Tanya, V. N., Hetzel, U., & Makepeace, B. L. (2010) · Veterinary Parasitology · doi:10.1016/j.vetpar.2010.08.031 · Cited by 11 · see citing works

Authors: Brattig, N. W.
Affiliations: Bernhard Nocht Institute for Tropical Medicine (DE)
Corresponding author: Brattig, N.W.
ORCID: Brattig, N.W.
Venue: Microbes and Infection
Publisher: Elsevier BV
Published: 2004-01
Volume: 6
Issue: 1
Pages: 113-128
ISSN: 1286-4579 (ISSN-L)
DOI: 10.1016/j.micinf.2003.11.003
OpenAlex: W2019301599
Cited by: 169
References: 108
Citations by year: 2026: 7 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 14 · 2015: 8 · 2014: 8 · 2013: 5 · 2012: 9
FWCI: 0.86
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 7305 d)
Locations: Microbes and Infection (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Science and Technology
Alexander von Humboldt-Stiftung
Deutsche Forschungsgemeinschaft
Topics: Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
Keywords: onchocerciasis, Onchocerca volvulus, Wolbachia, endobacteria, pathogenesis, host immune response, inflammatory mechanisms, immune evasion, symbiotic bacteria, chemotherapeutic target
MeSH terms: Animals, Humans, Immunity, Cellular, Immunity, Innate, Inflammation, Larva, Onchocerca, Onchocerciasis, Symbiosis, Virulence, Wolbachia

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Pathogenesis and host responses in human onchocerciasis: impact of Onchocerca filariae and Wolbachia endobacteria

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