Ibuprofen Therapy Resulted in Significantly Decreased Tissue Bacillary Loads and Increased Survival in a New Murine Experimental Model of Active Tuberculosis
Abstract
C3HeB/FeJ mice infected with Mycobacterium tuberculosis were used in an experimental animal model mimicking active tuberculosis in humans to evaluate the effect of antiinflammatory agents. No other treatment but ibuprofen was given, and it was administered when the animals' health started to deteriorate. Animals treated with ibuprofen had statistically significant decreases in the size and number of lung lesions, decreases in the bacillary load, and improvements in survival, compared with findings for untreated animals. Because antiinflammatory agents are already on the market, further clinical trials should be done to evaluate this effect in humans as soon as possible, to determine their suitability as coadjuvant tuberculosis treatment.
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Non-steroidal drugs including COX inhibitors (aspirin, ibuprofen) ameliorate PMN-driven necrotic granulomas and M. tuberculosis growth in mice but also abolish mycobacteria-induced lipid body formation and PGE2 production.
“Consequently, non-steroidal drugs including COX inhibitors (aspirin, ibuprofen) ameliorate PMN-driven necrotic granulomas and M. tuberculosis growth in mice but also abolish mycobacteria-induced lipid body formation and PGE2 production (52, 53).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [52]
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- Authors
- Vilaplana, C., Marzo, E., Tapia, G., Diaz, J., Garcia, V., & Cardona, P.-J.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Corresponding author
- Vilaplana, Cristina
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-04-05
- Volume
- 208
- Issue
- 2
- Pages
- 199-202
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2099216140
- Cited by
- 220
- References
- 13
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 8 · 2023: 15 · 2022: 19 · 2021: 24 · 2020: 19 · 2019: 14 · 2018: 22 · 2017: 13 · 2016: 20 · 2015: 19 · 2014: 14 · 2013: 5 · 2012: 1
- FWCI
- 14.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Keywords
- ibuprofen, active tuberculosis, Mycobacterium tuberculosis, anti-inflammatory agents, bacillary load, lung lesions, survival, murine tuberculosis model
- MeSH terms
- Animals, Anti-Inflammatory Agents, Disease Models, Animal, Female, Ibuprofen, Mice, Inbred C3H, Mycobacterium tuberculosis, Tuberculosis, Mice
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